Search clinical trials for: placebo MTX

Total 55933 results

Chugai Pharmaceutical

Completed

Comparative Study (Double-Blind) of MRA for Rheumatoid Arthritis (RA)

Rheumatoid Arthritis
Mozart Therapeutics Australia Pty Ltd

Not yet recruiting

Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients

Type 1 Diabetes | Celiac Disease | Healthy Volunteers

Australia
Mediar Therapeutics
ICON plc

Recruiting

A First-in-Human Safety Trial of MTX-463

Healthy

United States
Abbott

Completed

Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)

Arthritis, Juvenile Idiopathic

United States, Belgium, Czech Republic, France, Germany, Italy, Slovakia, Spain
Memo Therapeutics AG

Completed

To Assess the Safety and Tolerability of MTx-COVAB36 as a Therapeutic and Prophylactic Treatment Against COVID-19.

SARS-CoV-2 Infection

Australia
Guang'anmen Hospital of China Academy of Chinese...

Unknown

Efficacy and Safety of Traditional Chinese Medicine (TCM) Comprehensive Therapy in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

China
Abbott

Completed

Safety and Efficacy of Adalimumab to Methotrexate and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis (CHAMPION)

Psoriasis

United States
Gilead Sciences
Galapagos NV

Completed

Filgotinib Alone and in Combination With Methotrexate (MTX) in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Are Naive to MTX Therapy (FINCH 3)

Rheumatoid Arthritis

United States, Italy, Poland, Ukraine, Belgium, Hong Kong, Taiwan, Spain, Bulgaria, India, Malaysia, Romania, Serbia, South Africa, Korea, Republic of, Japan, Australia, Chile, Russian Federation, Argentina, Germany, New Zealand, Th... and more
Hoffmann-La Roche

Completed

An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy

Rheumatoid Arthritis

China
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety of ITX 5061 in Treatment-Naive Hepatitis C (HCV)-Infected Adults

Hepatitis C

United States, Puerto Rico
Guang'anmen Hospital of China Academy of Chinese...

Unknown

A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid Arthritis

Rheumatoid Arthritis

China
CymaBay Therapeutics, Inc.

Completed

Safety and Tolerability Study of MBX-2044 in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

United States
Stealth BioTherapeutics Inc.
ICON Clinical Research

Completed

Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events (EMBRACE)

Reperfusion Injury | STEMI

United States, Hungary, Germany, Poland
Sidney Kimmel Comprehensive Cancer Center at Johns...
Greater Washington Community Foundation

Terminated

Muscadine Plus (MPX) In Men With Prostate Cancer

Adenocarcinoma of the Prostate

United States
Motric Bio

Recruiting

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Stroke | Multiple Sclerosis | Cerebral Palsy | Spinal Cord Injuries | Dystonia | Muscle Spasticity | Hereditary Spastic Paraplegia | Hypertonia, Muscle

United States
Maxinovel Pty., Ltd.

Not yet recruiting

A Study to Evaluate the Safety of MAX-40070 in Healthy Subjects

Alopecia Areata
4D pharma plc

Terminated

A Study of MRx-4DP0004 in Asthma

Asthma

United States, United Kingdom
Palvella Therapeutics, Inc.

Unknown

Phase 2/3 Study Evaluating the Safety and Efficacy of PTX-022 in Treatment of Adults With Pachyonychia Congenita

Pachyonychia Congenita

United States
Celtaxsys, Inc.

Completed

EMPIRE CF: A Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of CTX-4430 in Adult Cystic Fibrosis (CF) Patients

Cystic Fibrosis

United States, United Kingdom, Canada, Belgium, France, Germany, Italy
Turino, Gerard, M.D.
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety Study of CTX-100 Inhalation Solution (Formerly ETX-100)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Grünenthal GmbH

Active, not recruiting

Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee

Osteoarthritis

Spain, United States, Portugal, United Kingdom, Denmark
Sorrento Therapeutics, Inc.

Withdrawn

Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed

Osteoarthritis, Knee | Osteo Arthritis Knee | Knee Pain Chronic
Celtaxsys, Inc.
Clinical Network Services (CNS) Pty Ltd; Celtaxsys Aus Pty Limited

Completed

CTX-4430 for the Treatment of Moderate to Severe Facial Acne Vulgaris

Acne Vulgaris

Australia, New Zealand
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure

Congestive Heart Failure

Bulgaria
Grünenthal GmbH

Active, not recruiting

Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis

Osteoarthritis

France, Poland, Japan, Czechia, Mexico, Canada, Netherlands, Germany, Italy
Eliem Therapeutics (UK) Ltd.

Completed

Efficacy and Safety of ETX-018810 in Subjects With Lumbosacral Radicular Pain

Lumbosacral Radiculopathy

United States
Eliem Therapeutics (UK) Ltd.

Completed

Efficacy and Safety of ETX-018810 for the Treatment of Diabetic Peripheral Neuropathic Pain

Diabetic Peripheral Neuropathic Pain | Diabetic Peripheral Neuropathy

United States
Teijin America, Inc.

Completed

Phase 2 Study of TMX-049 in Subjects With Type 2 Diabetes and Albuminuria

Diabetic Kidney Disease

United States
4D pharma plc

Withdrawn

A Study for Efficacy and Safety of Live Biotherapeutic MRx4DP0004 to Treat COVID-19

COVID-19

United Kingdom
Celsus Therapeutics PLC

Terminated

Double-Blind, Trial to Evaluate the Safety and Efficacy of MRX-6 Cream 2% (C012013)

Atopic Dermatitis

Israel
Stealth BioTherapeutics Inc.

Withdrawn

A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bendavia™ (MTP-131) in Patients With Heart Failure

Heart Failure

Bulgaria
GTx

Completed

Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.

Cachexia

United States, Canada
Mitos Pharmaceuticals

Terminated

Safety and Preliminary Efficacy Study of MTS-01 for the Prevention of Alopecia Induced by WHole Brain Radiotherapy

Alopecia
Stealth BioTherapeutics Inc.

Completed

A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome (TAZPOWER)

Barth Syndrome

United States
Grünenthal GmbH

Completed

Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain

Osteoarthritis, Knee

Belgium
Antares Pharma Inc.

Completed

Comparison of Methotrexate (MTX) and the VIBEX™ MTX Device

Rheumatoid Arthritis (RA)

United States
MBX Biosciences

Completed

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of MBX 2109 in Healthy Adult Subjects

Healthy

United States
Steno Diabetes Center Copenhagen
DSM Nutritional Products, Inc.

Completed

Effects of Probiotics and Fibers on Albuminuria in Persons With Type 1 Diabetes (ProFOS)

Type 1 Diabetes | Diabetic Kidney Disease | Albuminuria | Nephropathy

Denmark
Alimentiv Inc.
Abbott

Terminated

Pharmacokinetics of Adalimumab With Methotrexate for Treatment of Patients With Ulcerative Colitis (UC)

Ulcerative Colitis
Sorrento Therapeutics, Inc.

Withdrawn

A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee

Osteoarthritis, Knee | Knee Pain Chronic
GTx

Completed

Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence (ASTRID)

Stress Urinary Incontinence

United States
Biogen

Completed

STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis (IPF)

United States
XBiotech, Inc.

Not yet recruiting

Natrunix Versus Methotrexate in Rheumatoid Arthritis

Rheumatoid Arthritis
SinoMab BioScience Ltd

Recruiting

A Study Assessing the Efficacy and Safety of SM03 in Patients With Active Rheumatoid Arthritis Receiving MTX

Rheumatoid Arthritis(RA)

China
Janssen Research & Development, LLC

Completed

A Study of the Effectiveness and Safety of Ustekinumab (STELARA) and CNTO 1959 Administered Under the Skin of Patients With Active Rheumatoid Arthritis, Despite Existing Methotrexate Therapy

Arthritis, Rheumatoid

Poland, Ukraine, Colombia, Bulgaria, United States, Singapore, Russian Federation, Argentina, Hungary, Chile, Czech Republic
Zhejiang Hisun Pharmaceutical Co. Ltd.

Completed

Phase III Clinical Trial Comparing the Safety, Efficacy, and Immunogenicity of Recombinant Anti-interleukin-6 Receptor Humanized Monoclonal Antibody Injection in Combination With Methotrexate and Jamelor ® in the Treatment of Moderate to Severe Rheumatoid Arthritis

Moderate to Severe Active Rheumatoid Arthritis

China
The Children's Hospital of Zhejiang University...

Completed

Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies (HDMTX)

Methotrexate Adverse Reaction

China
GTx

Completed

Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum

Non-Small Cell Lung Cancer | Muscle Wasting

United States
Stealth BioTherapeutics Inc.

Completed

A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failure

Heart Failure

Spain, Hungary, Netherlands, United Kingdom, Serbia, France, Latvia, Belgium, Bulgaria, Poland
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study (MMPOWER-2)

Primary Mitochondrial Disease

United States

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