Search clinical trials for: Advanced Disease

Total 389267 results

Rigshospitalet, Denmark
Odense University Hospital

Not yet recruiting

Enhancing Referral Decision-making for Advanced Treatment in Parkinson's Disease Through Objective Measurements and Patient Reported Outcomes. (PD-DigiCare)

Parkinson Disease

Denmark
Lin Chen

Recruiting

Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer

Efficacy | Safety | HER2 Negative | Locally Advanced Gastric Carcinoma

China
Fudan University

Recruiting

Modified TOMOX-HAIC in Combination With Sintilimab and Bevacizumab Biosimilar for First-line Treatment of Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Federico II University

Recruiting

Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy (CHOLINET)

Hypercholesterolemia

Italy
Sun Yat-sen University

Recruiting

Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma

Efficacy | Toxicity | Esophageal Squamous Cell Carcinoma

China
Fudan University

Not yet recruiting

CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer (TORCH-iTNT)

Neoadjuvant Therapy | Locally Advanced Rectal Cancer

China
The First Affiliated Hospital of Xinxiang Medical...

Not yet recruiting

Recombinant Human Endostatin Combined With Envafolimab and Synchronal Radiochemotherapy

Locally Advanced Squamous Non-small Cell Lung Cancer
Erasmus Medical Center

Recruiting

A Dried Blood Spot Sampling Method for Vancomycin and Creatinine Monitoring for OPAT (ADVANCEDOPAT)

Infection, Bacterial

Netherlands
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis

Bronchiectasis

Spain, United Kingdom, Israel, Japan, Turkey, Chile, United States, Canada, Denmark
Azienda Ospedaliera di Perugia

Not yet recruiting

Impact of Anti PD-1 Therapy in Children, Adolescents and Young Adults (CAYA) Melanoma Patients (MELCAYA)

Advanced Melanoma | Early Melanoma

Italy, Sweden, France, Germany, Netherlands, Poland, Spain
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Not yet recruiting

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Advanced Small Cell Lung Cancer

Small Cell Lung Cancer | Neuroendocrine Cancer

China
Jazz Pharmaceuticals

Recruiting

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Biliary Tract Cancer | HER2 Gene Mutation

United States, Puerto Rico
Fujian Medical University

Recruiting

A Study on the Safety and Efficacy of the Combination of Candenizumab, Lenvatinib, and SOX Regimen in the Treatment of HER2 Negative Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Patients

Overall Response Rate

China
Centre Hospitalier Universitaire Dijon

Recruiting

Trial Evaluating Modified FOLFIRINOX and Modified FOLFOX in the Treatment of Locally Advanced or Metastatic Small Bowel Adenocarcinoma (FOLFORINOX SBA)

Locally Advanced or Metastatic Small Bowel Adenocarcinoma

France
Tongji University
Shanghai Pulmonary Hospital, Shanghai, China

Not yet recruiting

A Study of Camrelizumab Combined With Chemotherapy ± Thalidomide in First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)

Lung Cancer | Camrelizumab
Mahidol University

Recruiting

Efficacy and Durability of Hepatitis A Vaccination in Patients With Advanced Fibrosis and Cirrhosis

Cirrhosis | Vaccination | Hep A

Thailand
University of Hull
Hull University Teaching Hospitals NHS Trust

Not yet recruiting

Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer

Locally Advanced Rectal Carcinoma
HRYZ Biotech Co.

Not yet recruiting

MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma

Leiomyosarcoma | Fibrosarcoma | Liposarcoma | Angiosarcoma | Synovial Sarcoma | Endometrial Stromal Sarcoma | Undifferentiated Pleomorphic Sarcoma | Epithelioid Sarcoma | Desmoplastic Small Round Cell Tumor | Malignant Peripheral Nerve Sheath Tumors | Pleomorphic Rhabdomyosarcoma

China
Xencor, Inc.

Recruiting

Phase 1, Safety and Tolerability Study of XmAb®541 in Advanced Solid Tumors

Testicular Germ Cell Tumor | Ovarian Cancer | Endometrial Cancer | Ovarian Germ Cell Tumor | Germ Cell Tumor

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection (PENALTY)

Progressive Multifocal Leukoencephalopathy

France
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Disitamab Vedotin + Pyrotinib Versus THP in the First-line Treatment for HER2+ Advanced Breast Cancer Clinical Trial

First-line Treatment | HER2-positive Metastatic Breast Cancer

China
Chengdu New Radiomedicine Technology Co. LTD.

Not yet recruiting

Safety and Efficacy of NRT6008 in Patients With Unresectable Locally Advanced Pancreatic Cancer (LAPC)

Unresectable Pancreatic Cancer

China
Vejle Hospital

Recruiting

The Diagnostic Accuracy of Advanced Imaging in Identifying Suspected Skin Cancer (Basal Cell Carcinoma) Around the Eyes (dOCT-pBCC)

Skin Diseases | Eyelid Diseases | Eyelid Tumor | BCC | BCC - Basal Cell Carcinoma

Denmark
ANRS, Emerging Infectious Diseases

Not yet recruiting

Impact of Long-acting Injectable Cabotegravir for HIV PrEP in MSM in France. (CABOPrEP)

Prevention

France
Nantes University Hospital

Not yet recruiting

Study of OCT Peripapillary Angiography in Patients With Advanced Glaucoma (OGA)

Glaucoma

France
Dizal Pharmaceuticals

Recruiting

DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29)

Non-small Cell Lung Cancer

China
UMC Utrecht
Radboud University Medical Center; Catharina Ziekenhuis Eindhoven; Amsterdam... and other collaborators

Not yet recruiting

Locally Advanced Pancreatic Cancer After Systemic Therapy: Ablative MR-guided Radiotherapy (LAPSTAR)

Locally Advanced Pancreatic Adenocarcinoma

Netherlands
AstraZeneca
Daiichi Sankyo Co., Ltd.

Recruiting

A Study of T-DXd in Patients With Selected HER2-overexpressing Tumors

Advanced Solid Tumors (Excluding Gastric Cancer and Breast Cancer)

China
Hacettepe University

Not yet recruiting

The Comparison of Different Root Coverage Techniques Using the Anatomical Recession Area Approach

Gingival Recession

Turkey
Ikena Oncology

Recruiting

Study of IK-595 in RAS- or RAF-altered Advanced Tumors

Colorectal Cancer | Pancreatic Cancer | Thyroid Carcinoma | Solid Tumor, Adult | Malignant Melanoma | Non-Small Cell Lung Carcinoma | BRAF Gene Mutation | Gliomas, Malignant | Ras (Kras or Nras) Gene Mutation | CRAF Gene Mutation

United States
Novo Nordisk A/S

Recruiting

A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4) (COMBINE 4)

Type 2 Diabetes

United States, China, Italy, Japan, India, Poland, South Africa, Turkey, Greece, Puerto Rico
Pliant Therapeutics, Inc.

Recruiting

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

Metastatic Solid Tumor

United States
The Mediterranean Institute for Transplantation...

Not yet recruiting

Graphic Novel for Patients Undergoing EUS-FNB

Stress | Pancreatic Cancer | Anxiety | Pancreatic Cystic Lesions

Italy
Bristol-Myers Squibb

Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease (TargetTau-1)

Alzheimer Disease, Early Onset

United States, Australia, Belgium, Canada, France, Japan, Korea, Republic of, Netherlands, Singapore, Spain, Sweden, United Kingdom
Public Health Vaccines LLC
Biomedical Advanced Research and Development Authority

Recruiting

Study to Evaluate the Recombinant Vesicular Stomatitis Virus (rVSV)-Marburg Virus Vaccine Candidate (PHV01) in Healthy Adult Subjects (PHV01)

Marburg Virus Disease

United States
GeneMedicine Co., Ltd.

Recruiting

GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors

Renal Cell Carcinoma | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Malignant Melanoma

Korea, Republic of
Kyowa Kirin, Inc.

Recruiting

A Study of KK2269 in Adult Participants With Solid Tumors

Gastric Adenocarcinoma | Non Small Cell Lung Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | Esophageal Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

Japan
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Evaluation of the Performance of Direct Portal Pressure Measurement by Endoscopic Ultrasound in a Large Cohort of Patients With Advanced Chronic Liver Disease of Different Etiologies and Newly Diagnosed Clinically Significant Portal Hypertension (EVADIPP) (EVADIPP)

Portal Hypertension

Italy
West China Hospital

Not yet recruiting

SOX Combined With Tislelizumab and LDRT for Neoadjuvant Treatment of Locally Advanced Gastric Cancer

Gastric Cancer
University of Texas Southwestern Medical Center
Merck Sharp & Dohme LLC

Recruiting

Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)

Cervical Cancer | Cervix Cancer

United States
Mayo Clinic

Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

Malignant Solid Neoplasm | Renal Cell Carcinoma | Hepatocellular Carcinoma | Metastatic Cutaneous Melanoma | Unresectable Cutaneous Melanoma | Lung Non-Small Cell Carcinoma | Urothelial Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Recurrent Head and Neck Squamous... and other conditions

United States
NiKang Therapeutics, Inc.

Recruiting

A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors

Small Cell Lung Carcinoma | Gastric Cancer | Ovarian Neoplasms | Ovarian Cancer | Solid Tumor | Endometrial Neoplasms | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Advanced Solid Tumor | Endometrial Cancer | Small-cell Lung Cancer | Platinum-resistant Ovarian Cancer | Ovarian Carcinoma | Solid... and other conditions

United States
National Institute of Allergy and Infectious Diseases...
Duke University; National Institutes of Health (NIH); Department of Health and... and other collaborators

Not yet recruiting

A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum

HIV

United States, South Africa
Advanced Bionics AG

Recruiting

Hearing and Structure Preservation Via ECochG (PRESERVE)

Hearing Loss, Sensorineural | Severe-to-profound Hearing Loss

Belgium, France, Germany, Italy, Poland, United Kingdom
Replimune Inc.

Not yet recruiting

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs (IGNYTE-3)

Advanced Melanoma
Hospices Civils de Lyon

Not yet recruiting

First Observatory of Precocious Puberty. (PAPPEL)

Puberty, Precocious

France
Reshma L. Mahtani, D.O.
Gilead Sciences

Recruiting

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW MBC (SERIES)

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Hormone-receptor-positive Breast Cancer | Human Epidermal Growth Factor 2 Low Breast Cancer

United States
Novartis Pharmaceuticals

Recruiting

Special Drug Use-results Surveillance of Tafinlar/Mekinist

BRAF V600E Mutation-positive Unresectable Advanced or Recurrent Solid Tumor

Japan
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Transcriptional and Epimetabolic Profile of Breast Carcinoma With Luminal or HER2+ or Locally Advanced Triple-negative Histotype in Patients With/Without Previous Clinical History of Metabolic Syndrome (PROMETA)

Breast Cancer | Metabolic Syndrome

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Multidisciplinary Assesssment of Structured Report for Cervical Cancer Staging (STRECC)

Cervical Cancer

Italy

Search clinical trials for: Advanced Disease

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Czech Republic

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations