Search clinical trials for: Platelet-Derived Growth Factor Receptor Alpha

Total 61779 results

Eli Lilly and Company
University of Colorado, Denver; Quintiles, Inc.; PPD; Parexel; Laboratory Corporation... and other collaborators

Completed

First-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-Cisplatin (INSPIRE)

Non Small Cell Lung Cancer

Belgium, Brazil, Russian Federation, United Kingdom, Australia, Germany, Hungary, Italy, Romania, United States, Austria, Canada, Croatia, France, Greece, Poland, Portugal, Slovakia, South Africa, Spain
Chul Kim
Bristol-Myers Squibb; AstraZeneca; Walter Reed National Military Medical Center; Hackensack Meridian Health

Active, not recruiting

Dasatinib and Osimertinib (AZD9291) in Advanced Non-Small Cell Lung Cancer With EGFR Mutations

Nonsmall Cell Lung Cancer | EGFR Gene Mutation

United States
Sun Yat-sen University
Guilin Medical University, China; First People's Hospital of Foshan

Terminated

ADjuVant Apatinib in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy (ADVANCE)

Nasopharyngeal Neoplasms

China
Novartis Pharmaceuticals

Completed

A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data

Heart Failure

United States
Hoffmann-La Roche

Completed

A Study to Evaluate the Efficacy and Safety of Pertuzumab + Trastuzumab + Docetaxel Versus Placebo + Trastuzumab + Docetaxel in Previously Untreated Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (PUFFIN)

Breast Cancer

China
Genentech, Inc.

Completed

A Study of Pertuzumab With High-Dose Trastuzumab for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) With Central Nervous System (CNS) Progression Post-Radiotherapy

Metastatic Breast Cancer

United States
Hospital Clinic of Barcelona

Completed

Risk Factors for AD-Associated Switch to Mania

Bipolar Disorder

Spain
Pfizer

Terminated

Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer

Early Breast Cancer

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Ability of TNFR:Fc to Decrease the Amount of IL-6 (Interleukin-6) and TNF-alpha (Tumor Necrosis Factor) in HIV-Infected Patients

HIV Infections

United States
Novartis Pharmaceuticals

Completed

Lapatinib and Bevacizumab for Metastatic Breast Cancer

Neoplasms, Breast

United States
Daiichi Sankyo Co., Ltd.
AstraZeneca; Daiichi Sankyo, Inc.

Completed

DS-8201a in Human Epidermal Growth Factor Receptor2 (HER2)-Expressing Colorectal Cancer (DESTINY-CRC01)

Colorectal Neoplasm

United States, Spain, Japan, Italy, United Kingdom
Novartis Pharmaceuticals

Completed

Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast Cancer

Advanced Metastatic Breast Cancer

Germany
Cancer Research UK
AstraZeneca

Completed

A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)

Cancer | Non Small Cell Lung Cancer

United Kingdom
NSABP Foundation Inc
Washington University School of Medicine; Breast Cancer Research Foundation

Active, not recruiting

NSABP Biospecimen Discovery Project

Breast Cancer

United States
Daiichi Sankyo, Inc.
Daiichi Sankyo UK Ltd.

Terminated

A Study of DS-2248 in Participants With Advanced Solid Tumors

Non-small Cell Lung Carcinoma | Solid Tumors

United States
Sheba Medical Center

Withdrawn

Evaluation of the Roll of IV Fluids in the Treatment of Renal Colic

Renal Colic
University Hospital, Ioannina
INTERNAL MEDICINE DEPARTMENT, 1ST WARD

Completed

COVID-19 Disease and Coagulopathy: Assessment of Clotting Factor Levels in Patients With SARS-CoV-2 Infection

COVID-19 Disease | SARS-COV2 Infection | Hospitalized Patients

Greece
Renske Altena

Terminated

Improving Pre-operative Systemic Therapy for Human Epidermal Growth Factor Receptor 2 (HER2) Amplified Breast Cancer (PREDIXIIHER2)

HER2-positive Breast Cancer | Early-stage Breast Cancer

Sweden
Mansoura University

Active, not recruiting

Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University

Coronary Artery Disease | Pain, Postoperative | Pain, Acute | Valve Disease, Heart

Egypt
Novartis Pharmaceuticals
Breast International Group; SOLTI Breast Cancer Research Group

Completed

Neo ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation) Study (Neo ALTTO)

Neoplasms, Breast

France, Spain, United Kingdom, Belgium, Argentina, Czechia, Germany, Italy, Norway, Russian Federation, Sweden, Taiwan, Hong Kong, Brazil, Hungary, India, Korea, Republic of, Pakistan, Peru, Romania, South Africa, Ukraine, Canada, Lit...
Hoffmann-La Roche

Completed

A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer (BERENICE)

Breast Cancer

United States, Canada, Denmark, France, Italy, Poland, Portugal, Spain, United Kingdom, Norway, Germany, Mexico
OmicsWay Corp.
Oncobox Ltd., Russia; Vitamed LLC, Russia; Republican Oncological Dispensary...

Active, not recruiting

Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer

HER2-positive Breast Cancer

United States, Russian Federation
Dartmouth-Hitchcock Medical Center
Dartmouth College

Completed

A Microdose Evaluation Study of ABY-029 in Primary Sarcoma

Primary Soft-tissue Sarcoma

United States
Ariad Pharmaceuticals

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-Tumor Activity of the Oral Anaplastic Lymphoma Kinase (ALK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Brigatinib (AP26113)

Carcinoma, Non-Small-Cell Lung | Lymphoma, Large-Cell, Anaplastic
Daiichi Sankyo, Inc.
Bristol-Myers Squibb; AstraZeneca

Active, not recruiting

Trastuzumab Deruxtecan With Nivolumab in Advanced Breast and Urothelial Cancer

Breast Cancer | Urothelial Carcinoma

United States, Spain, Italy, Belgium, France, Germany, United Kingdom
University of Saskatchewan

Completed

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

Pathologic Processes | Postoperative Complications | Sleep Disordered Breathing | Anesthesia | Ketamine | General Anesthesia | Dexmedetomidine | Tonsillectomy | Respiratory Depression | Analgesics, Opioid | Pulse Oximetry | Lidocaine | Analgesics | Gabapentin | Narcotics | Obstructive Sleep Apnea of Child | Physiologic Effects...

Canada
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Multiple-dose Tolerability and Pharmacokinetic of IBI362 in Chinese Patients With T2DM

Type 2 Diabetes

China
Dartmouth-Hitchcock Medical Center
Dartmouth College

Completed

A Microdose Evaluation Study of ABY-029 in Recurrent Glioma (ABY-029)

Glioma

United States
Marker Therapeutics, Inc.

Completed

Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer

Breast Cancer

United States
Korea University Guro Hospital
Chong Kun Dang Pharmaceutical Corp.

Active, not recruiting

Retreatment With Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase Inhibitor in EGFR Mutation Positive Patients

EGFR Positive Non-small Cell Lung Cancer

Korea, Republic of
Centre Leon Berard

Completed

Satisfaction and Quality of Life Comparison Between Patients Using Cicaplast Baume B5 Versus Dexeryl for the Management of Cutaneous Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors (iEGFR) (CICAFIX)

Colorectal Cancer | Non Small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Epidermal Growth Factor Receptor Inhibitor

France
Pfizer

Terminated

Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)

Non-Small Cell Lung Cancer

United States, Korea, Republic of, Australia, Japan
Tanta University

Completed

Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery

PONV | Opioid Sparing Anaesthesia

Egypt
AstraZeneca
iOMEDICO AG, Freiburg, Germany

Completed

PANORAMA - Real World Molecular Testing, Treatment Patterns, and Clinical Outcomes EGFR Mutation-Positive NSCLC (PANORAMA)

Carcinoma, Non-Small-Cell Lung

Germany
NeuroRx, Inc.
Massachusetts General Hospital; Target Health Inc.

Completed

Sequential Therapy for the Treatment of Severe Bipolar Depression. (STABIL-B)

Suicidal Ideation | Suicide, Attempted | Bipolar Depression | Suicidal Ideas

United States
Sun Yat-sen University

Completed

Aprepitant vs. Desloratadine in EGFR-TKIs Related Pruritus Treatment (EGFR-TKIs)

Non-small Cell Lung Cancer

China
Fondazione IRCCS Istituto Nazionale dei Tumori,...

Completed

PF-03446962 in Relapsed or Refractory Urothelial Cancer

Transitional Cell Carcinoma of Bladder

Italy
Exelixis

Completed

Study of Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib (CELESTIAL)

Hepatocellular Carcinoma

Belgium, Hong Kong, Korea, Republic of, Canada, France, Taiwan, United States, Germany, Spain, United Kingdom, Singapore, Australia, Italy, Netherlands, Poland, Turkey, Ireland, New Zealand, Romania
AbbVie

Completed

A Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of ABBV-321 in Subjects With Advanced Solid Tumors Associated With Overexpression of the Epidermal Growth Factor Receptor (EGFR)

Advanced Solid Tumors Cancer

United States, Australia, Israel
ISU Abxis Co., Ltd.

Active, not recruiting

Study of ISU104, Targeting ERBB3 in Patients With Advanced Solid Tumors

Solid Tumor

Korea, Republic of
Bayer

Completed

Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib)

Neoplasms

France, United States, Spain, Singapore, Germany, Korea, Republic of, Switzerland
Pfizer

Completed

Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee

Osteoarthritis, Knee | Osteoarthritis, Hip

United States, Puerto Rico, Canada
Exelixis

Completed

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma (METEOR)

Renal Cell Carcinoma

United States, Belgium, Spain, Taiwan, Canada, Germany, Korea, Republic of, France, Austria, Chile, Australia, Hungary, Russian Federation, Italy, Turkey, Netherlands, Sweden, United Kingdom, Czechia, Ireland, Slovakia, Argentina, D... and more
Hoffmann-La Roche

Completed

A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer (SafeHER)

Breast Neoplasms

Hungary, Italy, United Kingdom, Canada, Czechia, Bulgaria, Croatia, Dominican Republic, France, Germany, Greece, Guatemala, Hong Kong, Indonesia, Ireland, Korea, Republic of, Netherlands, Panama, Peru, Poland, Portugal, Slovakia, Spain and more
Becton, Dickinson and Company

Completed

Evaluation of the Antimicrobial Effectiveness of an Antimicrobial Cloth

Preoperative Skin Preparation

United States
AbbVie

Terminated

UNITE Study: Understanding New Interventions With GBM ThErapy

Glioblastoma Multiforme

United States, Australia, Germany, Netherlands, United Kingdom
Daiichi Sankyo, Inc.
ArQule, Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary...

Terminated

Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

Non Squamous, Non-small-cell Lung Cancer

Poland, France, Germany, Italy, Spain, Canada, United States, Argentina, Belgium, Mexico, Australia, Russian Federation, Netherlands, Peru, Brazil, Austria, United Kingdom, Sweden, Czechia, Chile, Denmark, Hungary, Romania
Mofya Diallo

Withdrawn

Remifentanil-dexmedetomidine Anesthesia With a Caudal for Elective Surgery. (Remi-dex) (Remi-dex)

Anesthesia
Hoffmann-La Roche

Completed

A Study of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Who Have Received Prior Treatment With Trastuzumab and a Taxane

HER2 Positive Breast Cancer, Metastatic Breast Cancer, Locally Advanced Breast Cancer

India
The Affiliated Hospital of Qingdao University

Completed

Pharmacokinetic Study of Recombinant Monoclonal Antibody Against Human Epidermal Growth Factor Receptor Injection

Healthy Volunteers

China

Search clinical trials for: Platelet-Derived Growth Factor Receptor Alpha

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