Search clinical trials for: KRAS, HRAS, or NRAS Mutations

Total 205722 results

British Columbia Cancer Agency
BC Cancer Foundation

Completed

The Oncopanel Pilot (TOP) Study

Gastrointestinal Stromal Tumors | Colorectal Cancer Metastatic | Advanced Melanoma | Advanced Non-Small Cell Lung Carcinoma | Patients With Diagnosed Malignancies Being Considered for Clinical Trials

Canada
Rigshospitalet, Denmark

Completed

MRI on Persons With Mutations in POMT2 Gene (LGMD2N)

Limb-girdle Muscular Dystrophy

Denmark
Georgetown University
National Cancer Institute (NCI)

Completed

Genetic Counseling in Women at Risk for BRCA1 or BRCA2 Mutations

Breast Cancer
City of Hope Medical Center
OSI Pharmaceuticals

Completed

Erlotinib Hydrochloride With or Without Celecoxib in Treating Patients With Stage IIIB-IV Non-Small Cell Lung Cancer

Stage IIIB Non-small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer

United States
Medical University of Vienna

Unknown

Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations (RISC_7T)

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus | Healthy Volunteers | Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Familiar Hypocalcuric Hypercalcemia

Austria
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer

Head and Neck Cancer

United States
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx

Head and Neck Cancer

United States
Vejle Hospital

Completed

Combination Chemotherapy Plus Panitumumab or Bevacizumab for Inoperable Cholangiocarcinoma Without KRAS Mutations (GOC-B-P)

Cholangiocarcinoma

Denmark
Chinese Society of Lung Cancer
Guangdong Provincial People's Hospital

Completed

Phase III Trial to Evaluate the Elortinib vs Gefitinib in Advanced NSCLC With EGFR Exon 19 or 21 Mutations

Thoracic Neoplasms

China
Singapore General Hospital

Completed

Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy

Chronic Myeloid Leukemia

Singapore
Alexandru Eniu
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival

To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer

Romania
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France

Completed

Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter (HEPHYGI)

Heterozygous Carriers of Gitelman Syndrome

France
Hoffmann-La Roche

Withdrawn

A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients With Metastatic Colorectal Cancer With or Without K-RAS Mutations, and Comparison to Cetuximab

Colorectal Cancer
Xinhua Hospital, Shanghai Jiao Tong University...

Unknown

Etiological Diagnosis of Urinary Stone in Chinese Children

Urinary Stone

China
Hans Smit
Rijnstate Hospital; Prof. Dr. Jaap Swieringa stichting; Mr. Willem Bakhuys Roozeboomstichting

Unknown

Prevalence of Spontaneous Pneumothorax in BHD

Spontaneous Pneumothorax

Netherlands
Hoffmann-La Roche

Terminated

BRIM-P: A Study of Vemurafenib in Pediatric Patients With Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations

Malignant Melanoma

United States, France, Australia, United Kingdom, Italy, Spain, Germany, Israel, Poland, Slovakia
Memorial Sloan Kettering Cancer Center
Cardiff Oncology

Completed

Detection of Oncogenic Tumor Mutations in the Urine and Blood of Lung and Colorectal Cancer Patients

Colorectal Cancer | Lung Cancer

United States
AstraZeneca

Completed

Europe-Japan Diagnostic Study for EGFR Testing (ASSESS)

EGFR Mutation Status in aNSCLC Patients (Locally Advanced and/or Metastatic Disease) With Adenocarcinoma and Non-adenocarcinoma Histologies.

Italy, Spain, United Kingdom, Sweden, Japan, Netherlands, Germany, France
Boehringer Ingelheim

Completed

LUX Lung 2 Phase II Single Arm BIBW 2992 "Afatinib" in NSCLC With EGFR Activating Mutations

Carcinoma, Non-Small-Cell Lung

United States, Taiwan
Chang Gung Memorial Hospital
Sanofi

Unknown

Fabry Disease in Cerebrovascular Disease

Fabry Disease

Taiwan
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Gene Expression in Samples From Patients With Rhabdoid Tumors

Kidney Cancer | Brain and Central Nervous System Tumors
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

Ovarian Cancer | Leydig Cell Tumor | Childhood Germ Cell Tumor
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Gene Mutations in Patients With Advanced Prostate Cancer That Is Not Responsive to Hormone Therapy

Prostate Cancer

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer

Sarcoma | Kidney Cancer | Brain and Central Nervous System Tumors | Neuroblastoma | Liver Cancer | Pleuropulmonary Blastoma | Hereditary Wilms Tumor
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy

Diarrhea | Colorectal Cancer | Neutropenia

United States, Canada, Puerto Rico
University of South Florida
Friedreich's Ataxia Research Alliance; Edison Pharmaceuticals Inc

Completed

EPI-743 in Friedreich's Ataxia Point Mutations

Friedreich's Ataxia

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Cancer Genome Study Using Samples From Patients With Stage I or Stage II Non-Small Cell Lung Cancer Treated on Clinical Trial ACOSOG-Z0030

Lung Cancer
CHU de Reims

Unknown

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia (MUTA-GR)

General Glucocorticoid Resistance

France
National Heart Centre Singapore
Singapore General Hospital; Duke-NUS Graduate Medical School

Completed

Identification and Metabolic Characterization of a Cohort of Human Subjects With Mutations in PRDM-16

Obesity | Diabetes | Dyslipidemia | Mutation
Cancer Research UK

Completed

Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer

Breast Cancer | Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United Kingdom
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Blood and Tumor Tissue Samples From Patients With Wilms Tumor

Kidney Cancer | Renal Failure
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1

Sarcoma
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial

Leukemia
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression

Testicular Germ Cell Tumor | Ovarian Cancer | Extragonadal Germ Cell Tumor | Childhood Germ Cell Tumor
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Blood and Tissue Samples From Patients With Epstein-Barr Virus-Positive Hodgkin Lymphoma

Lymphoma | Nonneoplastic Condition
University of California, San Francisco
The Bluefield Project to Cure Frontotemporal Dementia

Completed

Dose Finding Study of Nimodipine for the Treatment of Progranulin Insufficiency From GRN Gene Mutations

Progranulin Mutation Carriers

United States
Novartis Pharmaceuticals

Terminated

LDE225 for Patients With PTCH1 or SMO Mutated Tumors (SIGNATURE)

PTCH1 or SMO Activated Solid and Hematologic Tumors

United States
AstraZeneca
Myriad Genetic Laboratories, Inc.

Withdrawn

Olaparib Maintenance Treatment Versus Placebo in Patients With PSR Ovarian Cancer Who Are in CR or PR to Platinum-based Chemotherapy and Whose Tumours Carry sBRCAm or HRR-associated Genes Mutations

Platinum Sensitive Relapsed Ovarian Cancer

United States, Korea, Republic of, Peru, United Kingdom, Philippines
QLT Inc.

Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Leber Congenital Amaurosis (LCA) | Retinitis Pigmentosa (RP)

United States, Canada, Denmark, Germany, Netherlands, Switzerland, United Kingdom
Rigshospitalet, Denmark

Completed

MRI and Muscle Involvement in Patients With Mutations in GMPPB

Limb-girdle Muscular Dystrophy

Denmark
Technical University of Munich

Completed

Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)

Gastrointestinal Stromal Tumors

Germany
Hoffmann-La Roche

Terminated

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Hepatitis C, Chronic

France, United States, Canada, New Zealand, Spain, Germany, United Kingdom, Australia, Italy, Brazil, Mexico, Slovakia, Poland, Puerto Rico, Austria
Institut National de la Santé Et de la Recherche...

Terminated

PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors (PRECARDIA)

Dilated Cardiomyopathy

France, Denmark, Germany, Italy, Netherlands, Spain, United Kingdom
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception (CCN011)

Contraceptive Usage

United States
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in Patients With Locally Advanced, Metastatic or Recurrent Non-Small Cell Cancer Who Present Epidermal Growth Factor Receptor Mutations

Non-Squamous Non-Small Cell Lung Cancer

Bulgaria
Hoffmann-La Roche

Completed

A Study of Tarceva (Erlotinib) in First Line in Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With EGFR Mutations

Non-Squamous Non-Small Cell Lung Cancer

Hungary, Latvia, Turkey
Memorial Sloan Kettering Cancer Center

Withdrawn

Clinical Outcomes in Hereditary Cancer

Breast Cancer | Pancreatic Cancer

United States
Massachusetts General Hospital
Boston Children's Hospital

Unknown

Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia

Congenital Diaphragmatic Hernia

United States
AstraZeneca

Completed

A Non-interventional Study (NIS) Registry for the Epidemiological and Scientific Evaluation of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC) (Stage IIIB/IV Non-small Cell Lung Cancer). (REASON)

Non Small Cell Lung Cancer

Greece
Memorial Sloan Kettering Cancer Center
Ascenta Therapeutics

Terminated

Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Lung Cancer

United States

Search clinical trials for: KRAS, HRAS, or NRAS Mutations

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Papua New Guinea

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations