Search clinical trials for: Phase I/II dose escalation trial

Total 72481 results

National Center for Research Resources (NCRR)
James Whitcomb Riley Hospital for Children

Completed

Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes

Thrombocytopenia | Dyskeratosis Congenita | Fanconi's Anemia | Shwachman Syndrome
Glaxo Wellcome

Completed

Trial of an Alternative Dosing Regimen of Oral Retrovir in Patients With AIDS or Advanced ARC

HIV Infections

United States, Puerto Rico
Pfizer

Completed

Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study

HIV Infections | Cryptosporidiosis

United States
Gilead Sciences

Completed

The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined With Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs

HIV Infections

United States, Puerto Rico
Immunobiology Research Institute

Completed

Double Blind Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients

HIV Infections

United States
Gathe, Joseph, M.D.

Unknown

Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment

HIV Infections

United States
SmithKline Beecham

Completed

A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis

HIV Infections | Protozoan Infections

United States
National Center for Research Resources (NCRR)
University of Pennsylvania

Completed

Phase I Study of Ex Vivo Liver-Directed Gene Therapy for Familial Hypercholesterolemia

Familial Hypercholesterolemia
Shaman Pharmaceuticals

Completed

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Orally Administered SP-303 for the Treatment of Diarrhea in Acquired Immunodeficiency Syndrome (AIDS) Patients

HIV Infections | Diarrhea

United States, Puerto Rico
Amgen

Completed

A Randomized, Controlled, Multicenter Trial of Filgrastim (Recombinant-Methionyl Human Granulocyte Colony Stimulating Factor; G-CSF) for the Prevention of Grade 4 Neutropenia in Patients With HIV Infection.

HIV Infections | Cytopenias

United States, Canada
National Center for Research Resources (NCRR)

Completed

A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)

Diabetes Mellitus | Insulin Resistance

United States
University of Southern California

Completed

Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

HIV Infections | Salmonella Infections

United States
Glaxo Wellcome

Completed

Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

HIV Infections

United States, Canada, Argentina, Brazil, Puerto Rico
Oxo Chemie GmbH

Completed

A Study of WF 10 IV Solution in Patients With Advanced HIV Disease

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

A Study on the Safety and Effectiveness of L-756423 Plus Indinavir in HIV-Positive Patients Who Have Previously Taken Indinavir

HIV Infections

United States
Sequus Pharmaceuticals

Completed

Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma

HIV Infections | Sarcoma, Kaposi

United States
Hoffmann-La Roche

Completed

A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of Amprenavir in Patients With Protease Inhibitor-Related Complications

HIV Infections

United States
Glaxo Wellcome

Unknown

Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Pittsburgh

Unknown

Phase II Study of Glucocerebrosidase in Patients With Gaucher Disease

Gaucher's Disease

United States
Glaxo Wellcome

Completed

An Open-Label Study to Evaluate the Efficacy and Safety of Amprenavir (141W94) and Abacavir Combination Therapy in Protease Inhibitor Experienced Subjects With HIV-1 Infection Who Are Failing Their Current Antiretroviral Treatment Regimen

HIV Infections

United States
Pfizer

Completed

A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems

HIV Infections | Candidiasis, Esophageal

United States, Canada
Aaron Diamond AIDS Research Center

Completed

Placebo-Controlled Trial of Safety and Efficacy of Thalidomide in Patients With Infections Due to Mycobacterium and/or HIV

HIV Infections | Mycobacterium Avium-Intracellulare Infection | Tuberculosis, Mycobacterium Infection

United States
Anderson Clinical Research
Ligand Pharmaceuticals

Completed

A Study of ALRT 1057 Topical Gel in Patients With AIDS-Related Kaposi's Sarcoma

HIV Infections | Sarcoma, Kaposi
National Center for Research Resources (NCRR)
Mayo Clinic

Completed

Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
National Eye Institute (NEI)

Unknown

Early Manifest Glaucoma Trial (EMGT)

Open-Angle Glaucoma

Sweden
National Center for Research Resources (NCRR)

Completed

Double-Blind, Placebo-Controlled Trial of Vitamin E as Add-on Therapy for Children With Epilepsy

Epilepsy

United States
Parexel

Completed

The Safety and Effectiveness of Retrovir Plus HIVID Combined With Either Nevirapine or Invirase in the Treatment of HIV Infection

HIV Infections

United States
Astra USA

Completed

A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States
Jacobus Pharmaceutical

Completed

Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
National Center for Research Resources (NCRR)
University of California, San Diego

Completed

Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity

5'-Nucleotidase Syndrome
National Institute of Neurological Disorders and...
Seattle Children's Hospital

Unknown

Phase II Randomized Study of Selective Dorsal Rhizotomy and Physiotherapy Vs Physiotherapy Alone for Spastic Diplegia

Spastic Diplegia
Pharmacia

Completed

A Study of Thymic Humoral Factor (THF Gamma 2) in HIV-Infected Patients

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex

HIV Infections

United States
Argus Pharmaceuticals

Completed

Pharmacokinetics of Nystatin LF I.V. in Patients With Acquired Immune Deficiency Syndrome-Related Complex (ARC)

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Texas

Completed

Phase I Study of Heme Arginate With or Without Tin Mesoporphyrin in Patients With Acute Attacks of Porphyria

Porphyria
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University...

Completed

Phase III Randomized, Double-Blind Study of Potassium Phosphate Vs Potassium Citrate for Absorptive Hypercalciuria

Kidney Calculi | Hypercalciuria
Janssen, LP

Completed

Evaluation of Galantamine in the Treatment of Alzheimer's Disease

Alzheimer Disease

United States
Novartis

Completed

Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)

Alzheimer Disease | Cognition Disorders

United States
Advanced Peptides

Completed

Intranasal Peptide T in the Treatment of Painful Peripheral Neuropathy of AIDS

HIV Infections | Peripheral Nervous System Disease

United States
Free Radical Sciences

Completed

A Double-Blind, Randomized Parallel Group Study Comparing Procysteine to Placebo in HIV-Infected Patients Who Are Taking Antiretroviral Nucleosides

HIV Infections
Sequus Pharmaceuticals

Unknown

A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma

HIV Infections | Sarcoma, Kaposi

United States
University of Minnesota

Unknown

Phase I Pilot Study of CD34 Enriched, Fanconi's Anemia Complementation Group C Gene Transduced Autologous Peripheral Blood Stem Cell Transplantation in Patients With Fanconi's Anemia

Fanconi's Anemia
Dupont Merck

Completed

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
GlaxoSmithKline

Unknown

Comparison of Two Dosing Regimens of GW433908/Ritonavir Versus Lopinavir/Ritonavir for 48 Weeks in HIV Patients Who Have Taken Protease Inhibitors and Experienced Virological Failure

HIV Infections

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Alternate-Day Buprenorphine Administration. Phase I - 3

Opioid-Related Disorders

United States
R W Johnson Pharmaceutical Research Institute

Completed

Treatment Program for Anemia in AIDS Patients

HIV Infections | Cytopenias

United States
Hoffmann-La Roche

Completed

A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States, Canada
Glaxo Wellcome

Completed

A Prospective Double-Blind Study of Retrovir in Early HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

A Randomized Trial to Evaluate the Safety and Efficacy of Combination Therapy With Retrovir ( AZT ) and HIVID ( ddC ) Versus Retrovir, HIVID, and Wellferon ( Interferon Alfa-n1 ) for the Treatment of HIV Infection

HIV Infections

United States

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