Search clinical trials for: severe renal impairment

Total 29455 results

AstraZeneca
Bristol-Myers Squibb

Completed

Renal Impairment in Type 2 Diabetic Subjects

Diabetes Mellitus, Type 2

United States
Par Pharmaceutical, Inc.
Covance; SFBC Anapharm

Terminated

Effect of Renal Impairment on the Pharmacokinetics, and Safety of Megestrol Acetate Concentrated Suspension

Healthy

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function

Solid Tumours

Belgium, France, Netherlands, United Kingdom, Denmark
University Hospital Birmingham NHS Foundation Trust

Active, not recruiting

What Are the Determinations of Adult Progressive CKD? The Renal Impairment In Secondary Care (RIISC) Study (RIISC)

Chronic Kidney Disease

United Kingdom
Massachusetts General Hospital

Completed

The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA)

Atherosclerosis | Renal Impairment | Contrast Induced Nephropathy

United States
University Hospital, Brest

Completed

Outcomes of Critically Ill Patients With Severe Acute Kidney Injury Requiring Renal Replacement Therapy (PROVEER)

Critical Illness | Acute Kidney Injury

France
Wockhardt
Clinartis

Completed

A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

Renal Impairment

United States
Hospital Clinic of Barcelona

Completed

Midodrine and Albumin for Cirrhotic Patients With Functional Renal Impairment (MAFRI)

Renal Failure | Cirrhosis

Spain
Hoffmann-La Roche

Completed

A Study of Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) Combination Therapy in Participants With Chronic Hepatitis C (CHC) and Various Degrees of Renal Impairment

Hepatitis C, Chronic

Sweden, New Zealand, United States, France, Brazil
Cardiovascular Center Frankfurt

Completed

Reintervention-study After Previous Renal Denervation in Non-responding Patients With Severe Hypertension (RETREAT)

Hypertension, Resistant to Conventional Therapy

Germany
Cubist Pharmaceuticals LLC

Terminated

Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections

Soft Tissue Infections

United States
Polyphor Ltd.

Completed

Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment

Renal Impairment

Germany
Intarcia Therapeutics

Completed

Study to Evaluate Pharmacokinetics of ITCA 650 in Subjects With Renal Impairment Compared to Normal Subjects

Renal Insufficiency

Germany, United States
Universitaire Ziekenhuizen KU Leuven

Completed

Prematurity as Predictor of Children's Cardiovascular-renal Health (PREMATCH)

Renal Impairment | Ventricular Dysfunction, Left | Endothelial Dysfunction | Visual Disturbances and Blindness | Sublingual Capillary Glycocalyx and Density

Belgium
Guy's and St Thomas' NHS Foundation Trust

Completed

Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT

Acute Kidney Failure
University Hospital, Toulouse
Ministry of Health, France

Terminated

Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism) (MECCORT)

Cholesterol Embolism Systemic

France
Trius Therapeutics LLC

Completed

A Pharmacokinetics and Safety Study in Subjects With Renal Impairment

Renal Impairment

United States
Gilead Sciences

Completed

Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

HIV Infections | Acquired Immunodeficiency Syndrome

Puerto Rico, United States, United Kingdom, Canada, Germany, Austria, Australia, Dominican Republic, Mexico
Sun Yat-sen University

Completed

The Effect and Safety of Hemodialysis and Hemoperfusion on Severe Renal Osteopathy and Itching in Uremia Patients

Hyperparathyroidism | Insomnia | Refractory Pruritus | Ostalgia

China
Johns Hopkins University

Completed

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Wrinkles | Photodamaged Skin

United States
Shanghai University of Traditional Chinese Medicine
Fudan University; RenJi Hospital; Ruijin Hospital; Xinhua Hospital, Shanghai Jiao... and other collaborators

Unknown

Integrative Medicine of IgA Nephropathy

Primary IgA Nephropathy

China
Pfizer

Completed

A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function

Pneumonia

Belgium, United States
Sahlgrenska University Hospital, Sweden

Completed

NAG-excretion During Cardiopulmonary Bypass (CPBNAG)

Renal Impairment

Sweden
Ottawa Hospital Research Institute
The Ottawa Hospital

Unknown

Safety Study of Enoxaparin Prophylaxis in Critically Ill Adults With Severe Renal Insufficiency

Hemorrhage

Canada
AbbVie

Completed

Pharmacokinetics and Safety of ABT-493 and ABT-530 in Subjects With Normal and Impaired Renal Function

Renal Impairment

United States, New Zealand
Bayer

Completed

Safety of Gadovist in Renally Impaired Patients (GRIP)

Fibrosis | Renal Impairment

Italy, Spain, Korea, Republic of, Germany, Canada, France, Austria, Thailand, Australia, Switzerland
Alkermes, Inc.

Completed

Pharmacokinetics and Safety of ALKS 5461 in Subjects With Renal Impairment and Normal Renal Function

Renal Impairment

United States
Boehringer Ingelheim

Completed

Afatinib in Subjects With Kidney Dysfunction

Renal Insufficiency

Germany
University of Oklahoma

Completed

Effects of Power Mobility on Young Children With Severe Motor Impairments

Cerebral Palsy | Spinal Muscular Atrophy | Arthrogryposis | Other Central Nervous System or Musculoskeletal Disorders

United States
Takeda

Completed

Pharmacokinetics, Safety and Tolerability of Vortioxetine in Normal Hepatic Function or Severe Hepatic Impairment

Severe Hepatic Impairment

United States
Gilead Sciences

Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function

Long QT Syndrome

United States, Romania, Moldova, Republic of
Pierre Fabre Medicament

Completed

JAVLOR Association Study in CDDP-unfit Patients With Advanced Transitional Cell Carcinoma: Gemcitabine Versus Carboplatin (JASINT1)

Bladder Transitional Cell Carcinoma Stage IV

France
University of Ulm
University of Wuerzburg

Completed

BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients (BICUK)

Sepsis | Acute Renal Failure | Critically Ill | SIRS | Multiple Organ Dysfunction Syndrome

Germany
Stealth BioTherapeutics Inc.

Completed

A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function

Normal and Impaired Renal Function

United States
Bristol-Myers Squibb

Completed

Pharmacokinetic and Safety Study of Daclatasvir in Patients With Renal Impairment

Hepatitis C

United States
H. Lundbeck A/S

Completed

Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function

Alzheimer Disease

Germany
University of Florida

Withdrawn

Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis (IMPRESS)

Hypertension | Chronic Kidney Disease | Acute Kidney Injury
Novartis Pharmaceuticals

Completed

Pharmacokinetics of LCZ696 in Subjects With Mild and Moderate Renal Impairment Compared to Healthy Subjects With Normal Renal Function

Mild and Moderate Renal Impairment

Russian Federation, Germany, Serbia
Novartis Pharmaceuticals

Completed

Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients

Acute Heart Failure

Japan
Northwestern University
U.S. Department of Education

Completed

The Effect of Resistance to Participant-Supported Reaching on Workspace of the Hand in Severe Chronic Stroke

Stroke

United States
Boehringer Ingelheim

Completed

Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery

Thromboembolism | Arthroplasty, Replacement

Austria, France, Germany, Italy, Spain, Sweden, United Kingdom
Massachusetts General Hospital

Withdrawn

Calcium, Phosphate, Renal Impairment and Coronary Artery Disease in the Cardio-renal Syndrome, The CAPRICORN-CRS Study (CAPRICORN)

Heart Failure

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Renal Impaired

United States
Dong-A ST Co., Ltd.

Completed

PK//PD/Tolerability Study of DA-1229(Evogliptin) in Renal Impaired Patients

Renal Impairment

Korea, Republic of
FORUM Pharmaceuticals Inc
PRA Health Sciences

Completed

EVP-6124 Renal Impairment Study

Renal Impairment

Czech Republic, Hungary
Merck Sharp & Dohme LLC

Completed

A Study on the Effect of Kidney Disease on a Diabetes Medication (0431-008)

Renal Insufficiency | Hemodialysis
Merck Sharp & Dohme LLC

Completed

A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)

Vaginosis, Bacterial | Candidiasis, Vulvovaginal
Charite University, Berlin, Germany

Withdrawn

Drugmonitoring of Antiinfective Drugs in Patients Receiving Continous Veno-venous Hemodiafiltration (ABx-CVVHDF)

Need for Renal Replacement Therapy and Anti-infective Therapy Due to Severe Infection

Germany
Cubist Pharmaceuticals LLC
Syneos Health

Terminated

Single Oral Dose of Bevenopran in Patients With Varying Degrees of Renal Impairment

Renal Impairment

United States
Air Force Military Medical University, China

Unknown

Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia

Critically Ill | Hypernatremia

China

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