Clinical Trials Sponsored by Jason Sperry

Total 405 results

Sierra Oncology, Inc.

Completed

Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis (Simplify 1)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, France, Germany, Spain, Israel, Bulgaria, Romania, Japan, Taiwan, Korea, Republic of, Australia, Belgium, Canada, Netherlands, Singapore, Poland, Hungary, Denmark, Sweden, United Kingdom, Czechia, Austria
Sierra Oncology, Inc.

Completed

A Study of PNT2258 in Patients With Advanced Solid Tumors

Melanoma | Lymphoma | Cancer | Prostate Cancer

United States
Sierra Oncology, Inc.

Terminated

Safety and Efficacy of Momelotinib in Subjects With Polycythemia Vera or Essential Thrombocythemia

Polycythemia Vera | Essential Thrombocythemia

United States, France, Germany, Canada, Australia
Perry Renshaw

Completed

Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder

Major Depressive Disorder

United States
Perry Renshaw

Completed

Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder

Major Depressive Disorder

United States
Perry Renshaw

Terminated

Open-Label Creatine Study for Female Meth Users

Depression | Substance Use | Dual Diagnosis

United States
Jason Stubbs, MD

Completed

Rifaximin Therapy in Chronic Kidney Disease

Chronic Kidney Disease

United States
Jason Robert Gotlib
Novartis; Novartis Pharmaceuticals

Completed

Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia

Systemic Mastocytosis, Aggressive (ASM) | Leukemia, Mast Cell | Hematological Non-mast Cell Lineage Disease (AHNMD)

United States
Spero Therapeutics

Completed

A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants

Healthy Volunteers

United States
Spero Therapeutics

Completed

Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Dr. Stephen Perry

Completed

Hallux Valgus and Custom Orthotic Prescription

Hallux Valgus

Canada
Sierra Oncology, Inc.

Completed

Efficacy of Momelotinib Versus Best Available Therapy in Anemic or Thrombocytopenic Subjects With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF (Simplify 2)

Primary Myelofibrosis (PMF) | Post-essential Thrombocythemia Myelofibrosis (Post-ET MF) | Post-polycythemia Vera (Post-PV)

United States, Canada, France, Italy, Germany, Spain, Israel, United Kingdom
Sierra Oncology, Inc.

Completed

Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis

Primary Myelofibrosis | Post-Polycythemia Vera | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada
Sierra Oncology, Inc.

Completed

Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada, Australia
Sierra Oncology, Inc.

Terminated

Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase

Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung Cancer

United States
Jason J. Luke, MD
Array BioPharma

Active, not recruiting

Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

Melanoma | Renal Cell Carcinoma | Solid Tumor | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma

United States
Sierra Oncology, Inc.

Terminated

Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma

Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma

United States
Sierra Oncology, Inc.

Terminated

Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)

EGFR Mutated EGFR TKI Naive Metastatic NSCLC

United States
Sierra Oncology, Inc.

Completed

Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada, Australia
Keira Mason

Completed

The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy

Anesthesia

United States
Plexus Worldwide
George Mason University

Unknown

The Acute Effect of Grains of Paradise (Aframomum Melegueta) on REE

Obesity
Spero Therapeutics

Completed

A Study to Compare Two Bioanalytical Assays for Tebipenem

Healthy Volunteers

United States
Spero Therapeutics

Completed

Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (ADAPT-PO)

Acute Pyelonephritis | Complicated Urinary Tract Infection

Bulgaria, Georgia, United States, Czechia, Estonia, Hungary, Latvia, Moldova, Republic of, Poland, Romania, Russian Federation, Serbia, Slovakia, South Africa, Ukraine
Spero Therapeutics

Terminated

Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Mycobacterium Avium Complex | Non-tuberculous Mycobacterium Pulmonary Disease

United States
Spero Therapeutics

Completed

Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function

Renal Impairment

United States
Spero Therapeutics

Completed

Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Spear Pharmaceuticals

Completed

Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and Placebo

Acne

United States
Dr. Stephen Perry

Completed

Foot Skin Temperature and Balance Control

Mechanoreceptor | Perpherial Hypothermia

Canada
Spero Therapeutics

Recruiting

A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)

United States
Spero Therapeutics

Completed

A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Healthy Volunteer

United States
Spear Pharmaceuticals

Completed

Bioequivalence Study of Tretinoin Gel 0.05% to Brand Tretinoin Gel

Acne
Spear Pharmaceuticals

Completed

Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and Placebo

Acne

United States
Spear Pharmaceuticals

Completed

Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo

Actinic Keratoses
Professor Jason Halford
American Beverage Association

Completed

EffectS of Non-nutritive sWeetened Beverages on appetITe During aCtive weigHt Loss (SWITCH)

Weight

United Kingdom
Jason Andrade
Baylis Medical Company

Completed

Conventional Versus RF Needle Transseptal Puncture for Cryoballoon Ablation (CRYO-LATS)

Atrial Fibrillation

Canada
Jason Robert Gotlib
National Cancer Institute (NCI)

Terminated

Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis

Systemic Mastocytosis | Mast Cell Leukemia | Aggressive Systemic Mastocytosis

United States
Kyle A Perry

Completed

Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery (Reletex)

Nausea and Vomiting Post-foregut Surgery

United States
Katz, Sherri Lynne, M.D.

Completed

Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention

Childhood Obesity | Childhood Obstructive Sleep Apnea

Canada
Jason J. Luke, MD
Bristol-Myers Squibb

Recruiting

Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors

Melanoma | Carcinoma, Renal Cell | Unresectable Solid Tumors

United States
Jason K Rivers, MD, FRCPC, FAAD
Cutera Inc.

Completed

Chart Review of the Efficacy of the GenesisPlus 1064 nm Nd:YAG Laser in the Treatment of Onychomycosis

Onychomycosis
Spero Therapeutics
GlaxoSmithKline

Recruiting

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (PIVOT-PO)

Urinary Tract Infection | Acute Pyelonephritis

Moldova, Republic of, Georgia, United States, Serbia, Bulgaria, Romania, South Africa, Bosnia and Herzegovina, Croatia, Hungary, Poland, Slovakia
Spero Therapeutics
Covance

Completed

Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects

Healthy Volunteers

United States
Bagel, Jerry, M.D.

Completed

A Single-Center, Prospective, Pilot Study to Compare the Effect of Diet in Overweight or Obese Patients With Psoriasis on Light Therapy

Psoriasis
Jason Sperry
Vanderbilt University; University of Texas; Case Western Reserve University; University... and other collaborators

Completed

PreHospital Air Medical Plasma Trial (PAMPer)

Hemmorhagic Shock During Air Medical Transport

United States
Larkin Community Hospital
George Mason University

Withdrawn

Proteomic Analysis of Sweat in Cutaneous Conditions

Application Site Perspiration

United States
Ross Mason
Nova Scotia Health Authority

Unknown

Exercise-based Pre-habilitation in Bladder Cancer Patients Prior to Radical Cystectomy: a Feasibility Study

Bladder Cancer | Urothelial Carcinoma
Jason J. Luke, MD
Bristol-Myers Squibb

Active, not recruiting

Safety and Efficacy in Participants With Metastatic BRAF-mutant Melanoma Treated With Encorafenib With and Without Binimetinib in Combination With Nivolumab and Low-dose Ipilimuma (QUAD01)

Melanoma

United States
Jason R. Brown
Merck Sharp & Dohme LLC; Hoosier Cancer Research Network

Active, not recruiting

Neoadjuvant Pembrolizumab in Combination With Gemcitabine Therapy in Cis-eligible/Ineligible UC Subjects

Bladder Cancer | Urothelial Carcinoma

United States
Jason Stubbs, MD
American Heart Association

Withdrawn

Impact of Rifaximin Therapy on Intestinal Byproducts in End-Stage Renal Disease

End Stage Renal Disease

United States
Spero Therapeutics
Celerion

Completed

A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy Subjects

TQT Study

United States

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