The Acute Effect of Grains of Paradise (Aframomum Melegueta) on REE

The Acute Effect of Grains of Paradise (Aframomum Melegueta) on Resting Energy Expenditure in Lean, Healthy, Adults

Sponsors

Lead Sponsor: Plexus Worldwide

Collaborator: George Mason University

Source Plexus Worldwide
Brief Summary

Grains of paradise (Aframomumu melegueta) (GP), also known as Guinea pepper or Alligator pepper, belongs to the Zingiberaceae family, which is native to West Africa. GP seeds are used as a spice and also have wide-ranging ethnobotanical uses. GP seeds are very rich in non-volatile pungent compounds such as 6-paradol, 6-gingerol, 6-shogaol and related compounds. This feature may equip them with the power to activate the Sympathetic Nervous System and thereby increase EE, which has been demonstrated in rodents. Research suggest that ingestion of GP extract can result in sustained elevation of EE and a consequent reduction in body fat. Thus, there is some evidence that GP may have a potential thermogenic effect that could be useful as part of a weight loss treatment. However, there is no information on whether GP has the potential of improving and prolonging the thermogenic effects of bioactives known to elevate fatty acid mobilization and subsequent fat oxidation. This proposal will fill a void in the literature by testing for the first time in healthy, normal weight, human volunteers whether the ingestion of GP in combination with a commercially available complex containing caffeine, green tea, and forskolin has an enhanced acute effect on REE, the largest and most stable component of EE, as well as the ratio of fat:carbohydrate oxidation. This project will provide pilot data to support larger studies such as prospective studies and studies to compare the thermogenic effect with currently available compounds.

Overall Status Unknown status
Start Date 2019-10-01
Completion Date 2020-05-01
Primary Completion Date 2020-03-01
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Resting metabolic Rate (Liters of oxygen consumed per minute) 3 weeks
Secondary Outcome
Measure Time Frame
Resting substrate oxidation 3 weeks
Enrollment 15
Condition
Intervention

Intervention Type: Dietary Supplement

Intervention Name: Grains of Paradise (Aframomum Melegueta)

Description: This is a randomized, double blind, crossover design testing the effect of grains of paradise on resting energy metabolism

Eligibility

Criteria:

Inclusion Criteria: - Ages 18-65 years - Men and women - Able to provide written consent in English - A body mass index between 18.5 and 30 kg/m2 Exclusion Criteria: - Current smoker - Claustrophobia - Use of any prescribed or over-the-counter medication affecting metabolism - Suffering from cardiac, hepatic, renal, pulmonary, endocrine or hematological disease - Currently pregnant or breastfeeding - Consuming more than 300mg of caffeine per day - Consuming more than 2 alcoholic beverages per day. - Performing more than 3 hrs/week of strenuous exercise - Weight loss of more than 5% of body weight over the past 6 months - Not willing to abstain from alcohol, caffeine and exercise for 24hr before each test day. - Suffering from heartburn or a sensitivity to pungent compounds in foods

Gender:

All

Minimum Age:

18 Years

Maximum Age:

65 Years

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Contact Contact information is only displayed when the study is recruiting subjects.
Verification Date

2019-03-01

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Number Of Arms 2
Arm Group

Label: Grains of Paradise

Type: Experimental

Label: Placebo

Type: Placebo Comparator

Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Primary Purpose: Prevention

Masking: Triple (Participant, Investigator, Outcomes Assessor)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Research News