Clinical Trials Sponsored by The Vaccine Company

Total 559 results

The Mentholatum Company

Completed

Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye

Dry Eye | Dry Eye Syndromes

United States
The Medicines Company

Completed

Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH (BRAVO 2/3)

Transcatheter Aortic Valve Replacement | Aortic Valve Replacement | Severe Aortic Stenosis

Netherlands, Germany, United Kingdom, Canada, France, Italy, Switzerland
The Medicines Company

Completed

European Ambulance Acute Coronary Syndrome (ACS) Angiography Trial (EUROMAX)

Acute Coronary Syndrome

Denmark, Netherlands, Italy, France, Germany, Poland, Austria, Czech Republic, Slovenia
The Medicines Company

Completed

Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) (ACCELERATE)

Hypertension | Hemorrhage

United States, Germany
The Medicines Company

Terminated

A Clinical Trial to Demonstrate the Efficacy of Cangrelor (PCI)

Myocardial Infarction (MI) | Acute Coronary Syndromes (ACS)

United States
The Medicines Company

Completed

Maintenance of Platelet Inhibition With Cangrelor (Bridge)

Acute Coronary Syndrome (ACS)

United States
The Medicines Company

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MDCO-2010 in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery

Cardiopulmonary Bypass | Coronary Artery Bypass Graft
The Medicines Company

Completed

Utilisation of Angiox® in European Practice (EURO-vision)

Stable Angina (SA) | NSTE-ACS (NSTEMI and UA) | STEMI (STE-ACS)

France, Germany
The Medicines Company

Completed

Pharmacokinetics/Pharmacodynamics (PK/PD) of Cangrelor

Healthy

United States
The Boeing Company

Completed

Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort

Acute Mountain Sickness
The Medicines Company

Completed

Bivalirudin in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary PCI

Myocardial Infarction

United States
The Medicines Company

Completed

A Study to Evaluate the Safety of a Single Intravenous (IV) Dose of Orbactiv (Oritavancin) in Participants on Chronic Warfarin Therapy Being Treated For Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Acute Bacterial Skin and Skin Structure Infection

United States
The Medicines Company

Completed

Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein Cholesterol (ORION-11)

Risk Factor, Cardiovascular | Elevated Cholesterol | ASCVD

Germany, Czechia, Hungary, Poland, South Africa, Ukraine, United Kingdom
The Medicines Company

Completed

A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH) (ORION-2)

Homozygous Familial Hypercholesterolemia

United States, Netherlands, South Africa
The Medicines Company

Completed

Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) (ORION-1)

Diabetes | Familial Hypercholesterolemia | Atherosclerotic Cardiovascular Disease

Canada, Netherlands, United States, United Kingdom, Germany
The Medicines Company

Terminated

Bivalirudin Infusion for Ventricular Infarction Limitation (BIVAL)

Acute Myocardial Infarction

Netherlands, France
The Medicines Company

Terminated

Phase II Study to Compare MDCO-2010 vs Placebo and Tranexamic Acid in Patients Undergoing Cardiac Surgery

Bleeding

Germany, Switzerland
The Medicines Company

Completed

Cangrelor Prasugrel Transition Study

Coronary Artery Disease

United States
The Medicines Company

Completed

Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT) (SPRINT)

Hypertension

United States
The Medicines Company

Completed

Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-1) (ESCAPE-1)

Hypertension

United States
The Medicines Company

Completed

Cangrelor Ticagrelor Transition Study

Coronary Artery Disease

United States
The Medicines Company

Terminated

Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition. (Platform)

Atherosclerosis | Acute Coronary Syndrome (ACS)

United States
The Medicines Company

Completed

Assess the Effect of Cangrelor at the Therapeutic Dose and a Supratherapeutic Dose Level on the QT/QTc Interval in Healthy Volunteers

Healthy

United States
The Medicines Company

Completed

Angiomax in Patients With HIT/HITTS Type II Undergoing CPB (HIT/TS)

Cardiovascular Disease | Coronary Artery Bypass Surgery

United States
U.S. Army Medical Research and Development Command
The PATH Malaria Vaccine Initiative (MVI)

Withdrawn

A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic Reagents (AdBa)

Healthy | Malaria

United States
Sanaria Inc.
The PATH Malaria Vaccine Initiative (MVI)

Completed

Clinical Trial of the PfSPZ Vaccine

Plasmodium Falciparum

United States
The Eye Machine Canada Inc.

Completed

Transpalpebral Micro-Current Electrical Stimulation for the Treatment of Dry Age-Related Macular Degeneration

Age-Related (Dry) Macular Degeneration

Canada
The Medicines Company
The Cleveland Clinic

Completed

MDCO-216 Infusions Leading to Changes in Atherosclerosis: A Novel Therapy in Development to Improve Cardiovascular Outcomes - Proof of Concept Intravascular Ultrasound (IVUS), Lipids, and Other Surrogate Biomarkers Trial (PILOT)

Acute Coronary Syndrome

Poland, Netherlands, Hungary, Canada, Czechia
Databean
The Insides Company

Recruiting

Chyme Reinfusion for Type 2 Intestinal Failure (REINFUSE)

Ileostomy - Stoma | Intestinal Failure | Enterocutaneous Fistula

United Kingdom, United States
The Cleveland Clinic
The Surgical Company

Recruiting

Heat Loss in Humans Covered With Full-Body Blankets Connected to Different Warming Devices

Heat Transfer by Clinical Warming Devices

United States
The Emmes Company, LLC
The Emmes Company, LLC

Completed

Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections

Necrotizing Enterocolitis | Intra-abdominal Infection

United States
The Coca-Cola Company

Completed

Evaluation of a New Orange-Based Beverage Enriched With Polyphenols in Adult Humans (BIONAOS)

Obesity | Overweight

Spain
David Ho
Bill and Melinda Gates Foundation; International AIDS Vaccine Initiative; The...

Completed

10E8.4/iMab Bispecific Antibody in HIV-uninfected and HIV-infected Adults

HIV-1-infection

United States
The Searle Company Limited Pakistan

Completed

Clinical Response of Syrup Hydryllin® in Pakistani Subjects With Cough in Routine Practice (HYD-EFFECT)

Cough

Pakistan
The Searle Company Limited Pakistan

Completed

Safety & Efficacy of Nuberol Forte® in Pain Management (NFORT-EFFECT)

Pain Management | Musculoskeletal Disorder

Pakistan
Columbia University
The Medicines Company

Withdrawn

The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients

Hypertension
The Coca-Cola Company
CreaBIO

Completed

Effects of Low Calorie Sweeteners on Dietary Intakes, Hunger, Appetite and Satiety

Eating Behavior

France
Alnylam Pharmaceuticals
The Medicines Company

Completed

A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Hypercholesterolemia

United Kingdom
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Completed

Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F (TB31F)

Malaria,Falciparum

Netherlands
GlaxoSmithKline
Crucell Holland BV; The PATH Malaria Vaccine Initiative (MVI)

Completed

Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults

Malaria

United States
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Terminated

Safety and Efficacy of NF135 CPS Immunization (CPS135)

Malaria,Falciparum | Controlled Human Malaria Infection | Immunization; Infection

Netherlands
Stanford University
The Clorox Company

Completed

Probiotic Supplement and Microbiome, Immune System and Metabolic Syndrome

Inflammation | Metabolic Syndrome | Microbiome | Immune Function

United States
PATH
The Emmes Company, LLC

Completed

Safety and Immunogenicity Study of Trivalent P2-VP8 Subunit Rotavirus Vaccine in Adults, Toddlers and Infants

Healthy

South Africa
Methodist Healthcare
The Medicines Company

Withdrawn

The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy

Hypertension | Subarachnoid Hemorrhage | Intracranial Hemorrhage

United States
Ryerson University
The Hershey Company

Completed

Mid-morning Gel Snacks on Subjective Appetite, Glycemic and Insulin Responses, and Food Intake

Food Intake | Satiety

Canada
Duke University
The Medicines Company

Withdrawn

Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / Dissection (Clevidipine)

Aorta Aneurysm | Dissection of Aorta

United States
The Archer-Daniels-Midland Company

Recruiting

Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals (KOBI)

Obesity | Abdominal Obesity

Korea, Republic of
The Cleveland Clinic
Gebauer Company

Completed

Vapocoolant (Pain Ease) Use for Venipuncture

Pain

United States
The Cleveland Clinic
Gebauer Company

Completed

Vapocoolant (Pain Ease Medium Stream) for Intravenous Lines in Emergency Department Patients

Pain

United States
Medtrade
The Clinical Trial Company

Unknown

Safety and Performance of 032-11 Haemostat in Cardiac and Thoracic Aortic Surgery

C.Surgical Procedure; Cardiac | Haemorrhage.

United Kingdom

Clinical Trials Sponsored by The Vaccine Company

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