Search clinical trials for: Guideline Directed Medical Therapy [GDMT]

Total 151259 results

Montreal Heart Institute
Abbott Medical Devices

Unknown

MitraClip for the Treatment of Moderate Functional Mitral Regurgitation: EVOLVE-MR (EVOLVE-MR)

Heart Failure | Mitral Regurgitation | Mitral Valve Regurgitation Due to Cardiomyopathy (Disorder)

Canada
Gabriele Baldini, MD, MSc, Assistant Professor

Completed

Goal Directed Fluid Therapy and Postoperative Ileus

Postoperative Ileus

Canada
Harbin Medical University
Shanghai Shenqi Medical Technology Co., Ltd

Not yet recruiting

RESTORE Imaging: an OCT-IVUS Imaging Substudy of RESTORE Trial

Acute Coronary Syndrome (ACS)

China
Accelerated Cure Project for Multiple Sclerosis
Charite University, Berlin, Germany; United States Department of Defense; US... and other collaborators

Not yet recruiting

Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis (CAFE-MS)

Multiple Sclerosis | Fatigue
Harbin Medical University
Shanghai Shenqi Medical Technology Co., Ltd

Recruiting

Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial)

Acute Coronary Syndrome (ACS)

China
University Health Network, Toronto

Not yet recruiting

RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders

Irritable Bowel Syndrome | Gastrointestinal Dysfunction | Ehlers-Danlos Syndrome | Hypermobility Syndrome

Canada
Academic and Community Cancer Research United

Not yet recruiting

Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy

Primary Mediastinal Large B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

United States
Mountain Home Research & Education Corporation
Congressionally Directed Medical Research Programs

Not yet recruiting

Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI

Dizziness | Mild Traumatic Brain Injury
Tianjin Medical University
Tianjin Hospital

Recruiting

Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Emergency Laparotomy (ERAS)

Acute Abdomen | Abdominal Trauma | Emergency Surgery

China
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
Case Comprehensive Cancer Center
National Institutes of Health (NIH)

Recruiting

MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)

Prostate Cancer | Malignant Neoplasm of Prostate | Secondary Malignant Neoplasm of Prostate

United States
Tokyo Medical and Dental University

Recruiting

Metastasis-directed Therapy for Oligometastases of Breast Cancer (OLIGAMI)

Breast Cancer | Metastatic Breast Cancer | Oligometastasis

Japan
Yi Yang

Not yet recruiting

Safety and Efficacy of Urinary Kallidinogenase for Large Artery Atherosclerosis Acute Ischemic Stroke

Acute Ischemic Stroke

China
City of Hope Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer

Breast Carcinoma | Colorectal Carcinoma

United States
Persephone Biosciences
Kroger Health

Recruiting

Ambrosia: Evaluating the Effects of a Food-As-Medicine Platform on Gut Microbiome Composition and Metabolism

Impact of Dietary Chages Directed by Medical Nutrition Therapy on Gut Microbiome Composition

United States
VA Office of Research and Development

Not yet recruiting

Evaluating Treatments for Suicidal Veterans With PTSD

Post-traumatic Stress Disorder (PTSD) | Self-directed Violence

United States
Fred Hutchinson Cancer Center
Faron Pharmaceuticals Ltd

Not yet recruiting

Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell Therapy

Recurrent Mantle Cell Lymphoma | Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Refractory Mantle Cell Lymphoma

United States
Checkpoint Surgical Inc.
Congressionally Directed Medical Research Programs

Recruiting

Promoting Healing of Injured Nerves With Electrical Stimulation Therapy (PHINEST)

Nerve Injury | Peripheral Nerve Injuries | Nerve Palsy | Peripheral Nerve Injury Upper Limb

United States
Amgen

Recruiting

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-ASCEND)

Atopic Dermatitis

United States, Japan, Korea, Republic of, Australia, Taiwan, Spain, Switzerland, Germany, Croatia, Austria, Bulgaria, France, Denmark, China, Netherlands, Hungary, Czechia, Poland, Brazil, Greece, Portugal, Italy, Finland, Argentina, Sl... and more
Radboud University Medical Center
Edwards Lifesciences

Not yet recruiting

Post Anaesthesia Care Hypotension Prevention (PACH-1)

Hypotension During Surgery
Samsung Medical Center

Recruiting

Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction (RESTORE-PCI)

Heart Failure With Reduced Ejection Fraction | Ischemic Cardiomyopathy

Korea, Republic of
Northwestern University
National Cancer Institute (NCI); Varian Medical Systems

Recruiting

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

Lung Non-Small Cell Carcinoma | Lung Carcinoma | Stage II Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage I Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Lung

United States
IGLESIAS Juan Fernando
Clinical Trials Unit University of Bern

Not yet recruiting

STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT (STARS DAPT)

ST Elevation Myocardial Infarction

Switzerland
Juventas Cell Therapy Ltd.

Recruiting

A Study of CNCT19 Treatment in Children and Adolescent r/r ALL Patients(Pediatric)

B-cell Acute Lymphoblastic Leukemia

China
Johns Hopkins University
Department of Defense Congressionally Directed Medical Research Program

Recruiting

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Depression | Insomnia | Sleep | Traumatic Brain Injury | Memory Impairment | Head Injury | Cognitive Behavioral Therapy | Concussion, Brain | Post-traumatic Stress | Brain Injury Traumatic Mild

United States
Nektar Therapeutics

Recruiting

NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma

Non-Hodgkin Lymphoma | Relapsed/Refractory Diffuse Large B-cell Lymphoma

United States
Biofrontera Bioscience GmbH

Recruiting

Study to Evaluate the Safety, Tolerability and Efficacy of BF-200 ALA (Ameluz®) in the Field-directed Treatment of Actinic Keratosis (AK) on the Extremities and Neck/Trunk With Photodynamic Therapy (PDT) Using a RhodoLED Lamp

Actinic Keratoses

United States
Washington University School of Medicine
Varian Medical Systems

Recruiting

Adaptive Stereotactic Body Radiation Therapy to the Prostate and Pelvic Nodes With Simultaneous Integrated Boost to the MR-detected Nodule for Patients With High-risk and Unfavorable Intermediate-risk Prostate Cancer

Prostate Cancer | Cancer of the Prostate

United States
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy (PE-TRACT)

Pulmonary Embolism

United States
National Cancer Institute (NCI)

Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Anatomic Stage III Breast Cancer AJCC v8 | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Anatomic Stage IV Breast Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Locally Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid... and other conditions

United States, Puerto Rico
St. Jude Children's Research Hospital

Recruiting

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Medulloblastoma

United States
Pan Xiangbin

Not yet recruiting

To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment

Mitral Valve Insufficiency

China
University of Alabama at Birmingham
Congressionally Directed Medical Research Programs

Recruiting

Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI

Gulf War Illness

United States
Rutgers, The State University of New Jersey
Natera, Inc.; BioGene Pharmaceutical Ltd.

Recruiting

Tislelizumab Consolidation After Liver-Directed Therapy for Hepatocellular Carcinoma

Carcinoma, Hepatocellular | Liver Cell Carcinoma

United States
Naval Health Research Center
United States Naval Medical Center, San Diego; Walter Reed National Military... and other collaborators

Recruiting

Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI (VR4VPT)

Dysfunction of Vestibular System | MTBI - Mild Traumatic Brain Injury

United States
Sheba Medical Center

Recruiting

Study of CAR-BCMA, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA in Subjects With Multiple Myeloma

Multiple Myeloma | Relapse Multiple Myeloma

Israel
Asahi Kasei Pharma Corporation

Recruiting

Value of Glycated Albumin in Intervention of Glycemic Control in Chinese Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

China
University of Arizona
Inari Medical

Recruiting

Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus Anticoagulation Alone (VQPE)

Pulmonary Hypertension | Pulmonary Embolism | Chronic Thromboembolic Pulmonary Hypertension

United States
Medical College of Wisconsin

Recruiting

Maintenance Belantamab Mafodotin (Blenrep®) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple Myeloma (EMBRACE)

Refractory Multiple Myeloma | Relapse Multiple Myeloma

United States
Ottawa Heart Institute Research Corporation
Novartis; AstraZeneca; Servier

Recruiting

Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT) (VIGILANT)

Heart Failure

Canada
Brian Henick, MD

Recruiting

Liver Directed RT + Chemo-immunotherapy for ES-SCLC

Small-cell Lung Cancer

United States
Janssen Research & Development, LLC

Recruiting

A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy (CARTITUDE-5)

Multiple Myeloma

United States, Korea, Republic of, Denmark, Czechia, Israel, Switzerland, Belgium, United Kingdom, Japan, Argentina, Sweden, Canada, Spain, Germany, Netherlands, France, Brazil, Greece, Poland, Ireland, Hungary, Portugal, Australia, F... and more
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Refractory Chronic Lymphocytic Leukemia | Recurrent Chronic Lymphocytic Leukemia | Refractory Small Lymphocytic Lymphoma | Recurrent Transformed Chronic Lymphocytic Leukemia | Refractory...

United States
Medical College of Wisconsin
H. Jean Khoury Cure CML Consortium

Recruiting

Protocol Number: HJKC3-0003. Treatment Free Remission After Combination Therapy With Asciminib (ABL001) Plus Tyrosine Kinase Inhibitors (TKI) in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation

Chronic Phase Chronic Myelogenous Leukemia

United States
Miltenyi Biomedicine GmbH

Recruiting

DALY II USA/ MB-CART2019.1 for DLBCL

Central Nervous System Lymphoma | Transformed Lymphoma | Refractory Diffuse Large B Cell Lymphoma (DLBCL) | Primary Mediastinal B-cell Lymphoma (PMBCL) | High Grade B-cell Lymphoma (HGBCL) | Relapsed Diffuse Large B Cell Lymphoma

United States
VA Office of Research and Development

Recruiting

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer (VA STARPORT)

Recurrent Prostate Cancer | Prostate Cancer | Metastatic Prostate Cancer | Oligometastasis | Oligorecurrence | De Novo Prostate Cancer

United States
University Hospital, Tours
European Academy of Dermatology and Venerology

Not yet recruiting

SerUM Markers in MERkel Cell Carcinoma Patients: a Longitudinal moniTorIng Study for optiMization of European Guidelines (SUMMERTIME)

Merkel Cell Carcinoma

United Kingdom, Austria, Finland, France, Germany, Italy, Netherlands, Romania, Sweden, Turkey
Population Health Research Institute

Recruiting

Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (SCHOLAR-2)

Heart Failure | Breast Cancer

Canada, Brazil, Russian Federation
Checkpoint Surgical Inc.
Congressionally Directed Medical Research Programs

Recruiting

Promoting Healing Of Nerves Through Electrical Stimulation (PHONES)

Nerve Injury | Ulnar Neuropathies | Cubital Tunnel Syndrome | Nerve Compression

United States
Yale University
Congressionally Directed Medical Research Programs

Recruiting

Behavior Therapy for Irritability in Autism (BTIA)

Anger | Aggression | Autism Spectrum Disorder | Irritability | Asperger Syndrome | Pervasive Developmental Disorder | Disruptive Behavior

United States

Search clinical trials for: Guideline Directed Medical Therapy [GDMT]

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