Search clinical trials for: Resistant Major Depression

Total 15827 results

Azienda Ospedaliero-Universitaria Careggi

Recruiting

Sumor as Adjuvant Therapy in Treatment-resistant Major Depression (SUSCA)

Major Depressive Disorder

Italy
National Institute of Mental Health (NIMH)
Taisho Pharmaceutical Co., Ltd.

Recruiting

Antidepressant Effects of TS-161 in Treatment-Resistant Depression

Depression | Major Depressive Disorder | Treatment-Resistant Depression

United States
University of Calgary
Cumming school of medicine; The W. Garfield Westin Foundation

Recruiting

The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder

Depression | Treatment Resistant Depression

Canada
Mark Niciu

Recruiting

University of Iowa Interventional Psychiatry Service Patient Registry

Obsessive-Compulsive Disorder | Bipolar Disorder | Major Depression | Bipolar Depression | Major Depressive Disorder | Treatment Resistant Depression | Major Depressive Episode

United States
Vanderbilt University Medical Center
University of Pittsburgh; Emory University; Rutgers University; University of Pittsburgh...

Recruiting

Dopaminergic Dysfunction in Late-Life Depression (D3)

Depressive Disorder, Treatment-Resistant | Cognitive Decline | Late Life Depression | Gait Impairment | Levodopa

United States
Mclean Hospital

Recruiting

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Major Depressive Disorder

United States
Weill Medical College of Cornell University
National Institute of Mental Health (NIMH); Stanford University

Recruiting

Biomarker-guided rTMS for Treatment Resistant Depression (BioTMS)

Major Depressive Disorder | Treatment Resistant Depression

United States
University of Minnesota
Minneapolis Veterans Affairs Medical Center

Recruiting

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

Major Depressive Disorder | Post-Traumatic Stress Disorders

United States
University Hospital, Bonn
Maximilian Kiebs, M.S.; Clemens Mielacher, M.S.

Recruiting

Repetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major Depression (NAIV)

Major Depressive Disorder

Germany
NeuroQore Inc.
Children's Hospital of Eastern Ontario

Not yet recruiting

Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One Day

Treatment Resistant Depression

Canada
National Institute of Mental Health (NIMH)

Recruiting

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Depression | Major Depression | Major Depressive Disorder

United States
Mapreg
Eurofins Optimed

Recruiting

RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode

Depression

France
University Hospital Freiburg
Boston Scientific Corporation

Recruiting

Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression (FORESEE III)

Treatment-resistant Depression

Germany, France
University of Pittsburgh

Recruiting

Neurofeedback for Treatment Resistant Depression

Treatment Resistant Depression

United States
University Hospital, Toulouse
Institut National de la Santé Et de la Recherche Médicale, France

Recruiting

Cerebral Neuroinflammation During Major Depressive Episode (InflaDep)

Depressive Disorder

France
Tianjin Anding Hospital

Recruiting

N-Acetyl Cysteine Supplementation in Therapy Refractory Major Depressive Disorders

Major Depressive Disorders

China
Mark Niciu
National Institute of Mental Health (NIMH)

Recruiting

Ketamine Alcohol (in Treatment-Resistant Depression)

Alcoholism | Major Depression | Magnetic Resonance Imaging

United States
Mayo Clinic

Active, not recruiting

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

Bipolar Depression | Major Depressive Disorder | Treatment Resistant Depression

United States
The University of Texas Health Science Center,...
Medtronic

Active, not recruiting

Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

Major Depressive Disorder | Treatment Resistant Depression

United States
Maimonides Medical Center

Completed

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Analgesia | Depressive Symptoms | Major Depressive Disorder | Treatment Resistant Depression | Ketamine | Physiological Effects of Drugs | Analgesics, Non-Narcotic | Peripheral Nervous System Agents | Central Nervous System Depressants | Neurotransmitter Agents | Sensory System Agents | Anti-Inflammatory Agents and other conditions

United States
Medical University of Gdansk
Perception Neuroscience

Completed

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Major Depressive Disorder | Treatment-Resistant Depression

Poland
University of Sao Paulo General Hospital

Suspended

Selenium as Augmentation Treatment for Sertraline Resistant Major Depression

Major Depression

Brazil
Janssen-Cilag Ltd.

Active, not recruiting

A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment (ESCAPE-LTE)

Depressive Disorder, Major

Taiwan, Turkey, Malaysia, Germany, Czechia, Korea, Republic of, Poland, Hungary, Argentina, Belgium, Bulgaria, Finland, Greece, South Africa
Unity Health Toronto
Unity Health Toronto

Completed

Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial (SMILE)

Major Depressive Disorder | Treatment Resistant Depression

Canada
ReST Therapeutics

Withdrawn

First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)

Brain Diseases | PTSD | Alzheimer Disease | Major Depressive Disorder | Treatment Resistant Depression | Neuro-Degenerative Disease

Belgium
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD)

Treatment-Resistant Depression

Spain, Japan, Poland, United States
Emory University
The Dana Foundation

Active, not recruiting

Deep Brain Stimulation for Treatment Resistant Depression

Major Depressive Disorder

United States
University of Sao Paulo

Completed

TBS Treatment for Treatment-Resistant Depression (TTT)

Major Depressive Disorder | Unipolar Depression

Brazil
First Affiliated Hospital of Chongqing Medical...

Completed

Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression

Major Depressive Disorder | Psychiatric Disorder | Metabolic Disorder

China
Ruijin Hospital

Active, not recruiting

The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant Depression

Major Depressive Disorder | Deep Brain Stimulation

China
Actuate Therapeutics Inc.

Active, not recruiting

9-ING-41 in Patients With Advanced Cancers

Sarcoma | Cancer | Breast Neoplasms | Neoplasm Metastasis | Pancreatic Neoplasms | Pancreatic Cancer | Pancreatic Adenocarcinoma | Bone Cancer | Malignant Glioma | Bone Metastases | Pancreas Cancer | Renal Cancer | Refractory Non-Hodgkin Lymphoma | Bone Neoplasm | Neoplasm, Breast | Refractory Cancer | Refractory Neoplasm | Resistant... and other conditions

United States, Belgium, Canada, Spain, France, Netherlands, Portugal
Unity Health Toronto

Completed

Stellate Ganglion Block for Major Depressive Disorder.

Major Depressive Disorder | Treatment Resistant Depression

Canada
University of Alabama at Birmingham

Active, not recruiting

Vagal Nerve Stimulation for Treatment Resistant Major Depression

Major Depressive Disorder

United States
Jessica Harder
Columbia University

Terminated

Salicylic Augmentation in Depression (SAD)

Depressive Disorder | Depression | Major Depressive Disorder | Treatment Resistant Depression

United States
University Ghent
University Hospital, Ghent

Completed

Stepped Care aiTBS 2 Depression Study (Ghent) (aiTBS2-Ghent)

Depressive Disorder, Major | Treatment Resistant Depression | Melancholia

Belgium
Massachusetts General Hospital
COMPASS Pathways

Withdrawn

The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD

Treatment-Resistant Major Depressive Disorder

United States
University of Alberta
Alberta Health services

Active, not recruiting

NESBID: Neuro-Stimulation of the Brain in Depression (NESBID)

Depressive Disorder, Major | Depressive Disorder, Treatment-Resistant | Electric Stimulation Therapy | Transcranial Direct Current Stimulation

Canada
Helen Mayberg, MD
National Institute of Neurological Disorders and Stroke (NINDS); Emory University and other collaborators

Active, not recruiting

DBS for TRD With the Medtronic Summit RC+S

Major Depressive Disorder | Treatment Resistant Depression

United States
VA Office of Research and Development

Withdrawn

VA Aripiprazole vs Esketamine for Treatment Resistant Depression (VAST-D II)

Depressive Disorder, Major

United States
Relmada Therapeutics, Inc.
Syneos Health

Completed

Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD

Depressive Disorder, Major | Depressive Disorder, Treatment-Resistant

United States
Janssen-Cilag International NV

Completed

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder (ESCAPE-TRD)

Depressive Disorder, Major

Israel, Hungary, Korea, Republic of, Taiwan, Portugal, Turkey, Germany, Malaysia, Denmark, Bulgaria, Czechia, Belgium, Poland, Brazil, Netherlands, Argentina, Finland, Greece, South Africa, Austria, Kazakhstan, Norway, Sweden, United...
Centre for Addiction and Mental Health
National Institute of Mental Health (NIMH)

Active, not recruiting

RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) (ONR)

Depression | Dementia | Mild Cognitive Impairment | Major Depressive Disorder | Treatment Resistant Depression | Treatment-Refractory Depression | Late Life Depression | Geriatric Depression

United States, Canada
Central Institute of Mental Health, Mannheim
Charite University, Berlin, Germany; German Federal Ministry of Education and... and other collaborators

Active, not recruiting

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression (EPIsoDE)

Treatment-resistant Depression

Germany
Bo Hu
Patient-Centered Outcomes Research Institute

Completed

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D)

Depression | Major Depressive Disorder | Treatment Resistant Depression | Ketamine | Psychiatric Disorder | Unipolar Depression | Major Depressive Episode | Electroconvulsive Therapy | ECT

United States
Medical University of Gdansk

Completed

A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders (GDKet)

Bipolar Depression | Major Depressive Disorder | Treatment Resistant Depression | Ketamine

Poland
Wayne Goodman MD

Active, not recruiting

DBS of the Lateral Habenula in Treatment-Resistant Depression

Treatment Resistant Major Depressive Disorder

United States
GH Research Ireland Limited

Completed

Clinical Study of GH001 in Depression

Depression | Major Depressive Disorder | Treatment Resistant Depression

Netherlands
Brain and Cognition Discovery Foundation
Usona Institute; Braxia Scientific Corp.

Completed

Psilocybin for Treatment-Resistant Depression

Treatment Resistant Depression

Canada
Centre for Addiction and Mental Health

Completed

MAO-B Occupancy in Depressed Patients (MOCP)

Major Depressive Disorder | Treatment Resistant Depression

Canada
Centre Hospitalier Universitaire de Besancon
University Hospital, Grenoble; Rennes University Hospital; Clinical Investigation... and other collaborators

Completed

tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients (STICODEP)

Bipolar Disorder | Unipolar Depression | Resistant Depression | Moods Disorders

France

Search clinical trials for: Resistant Major Depression

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