Search clinical trials for: Severe respiratory distress

Total 70907 results

Restem, LLC.

Completed

Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS (ULSC)

Covid19 | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

United States
MiNK Therapeutics

Completed

Evaluate the Safety of agenT-797 in Participants With Moderate to Severe Difficulty Breathing Secondary to SARS-CoV-2

Respiratory Distress Syndrome, Adult

United States
Northern State Medical University

Completed

The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality

ARDS, Human | Sepsis, Severe

Russian Federation
Boehringer Ingelheim

Completed

A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19 (TRISTARDS)

Acute Respiratory Distress Syndrome

Spain, Germany, Italy, Belgium, Mexico, Netherlands, India, France, Malaysia, Austria, Brazil, Russian Federation, Turkey
Enlivex Therapeutics Ltd.

Terminated

A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)

Covid19

Israel
Intermountain Health Care, Inc.

Completed

Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure (IMPROVENT)

Severe Acute Respiratory Syndrome | Respiratory Insufficiency | Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome | ARDS | Shock Lung | Respiratory Distress Syndrome, Acute

United States
University Hospital Ostrava

Completed

Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure

COVID-19 | ARDS

Czechia
Arch Biopartners Inc.

Completed

LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)

Severe Acute Respiratory Syndrome | Acute Kidney Injury | COVID | Acute Respiratory Distress Syndrome | Sars-CoV2

United States, Turkey, Canada
NeuroBo Pharmaceuticals Inc.

Completed

Study of Niclosamide in Moderate and Severe Hospitalized Coronavirus-19 (COVID-19) Patients

COVID-19

United States
Hôpital Européen Marseille

Active, not recruiting

Pulmonary Fibrosis During Severe COVID-19 Pneumonia (FIBRO-COVID)

Pulmonary Fibrosis | Acute Respiratory Distress Syndrome | Severe Acute Respiratory Syndrome Coronavirus 2

France
Federal University of Rio Grande do Sul
Hospital de Clinicas de Porto Alegre; Conselho Nacional de Desenvolvimento... and other collaborators

Completed

Lung Function, Exercise Capacity and Health-Related Quality of Life After Severe COVID-19

COVID-19 | SARS-CoV-2 Infection

Brazil
University Hospital of Patras

Completed

Tocilizumab Versus Baricitinib in Patients With Severe COVID-19

COVID-19

Greece
University Hospital, Ghent
UCB Pharma

Completed

Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure (ZILU-COV)

COVID-19

Belgium
aTyr Pharma, Inc.

Completed

Study to Evaluate the Safety and Efficacy of ATYR1923 (Efzofitimod) In Participants With Severe Pneumonia Related to COVID-19

SARS-CoV-2 (COVID-19) Severe Pneumonia

United States, Puerto Rico
Ophirex, Inc.
Premier Research Group plc

Terminated

Study of Varespladib in Patients Hospitalized With Severe COVID-19 (STAIRS)

Coronavirus Disease 2019 | Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2

United States
King's College London
Guy's & St Thomas NHS Foundation Trust

Withdrawn

LIBERATE Trial in COVID-19 (LIBERATE)

Respiratory Distress Syndrome | SARS-CoV Infection | Coronavirus

United Kingdom
Peking Union Medical College Hospital

Completed

Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS

Covid19 | ARDS: Acute Respiratory Distress Syndrome

China
EyePoint Pharmaceuticals, Inc.
Medical Technology Enterprise Consortium (MTEC)

Terminated

Evaluation of the Safety and Efficacy of Razuprotafib in Hospitalized Subjects With Coronavirus Disease 2019 (RESCUE)

COVID-19 | Acute Respiratory Distress Syndrome (ARDS)

United States
Oxford University Clinical Research Unit, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Completed

Awake Prone Positioning in Moderate to Severe COVID-19

COVID-19 | SARS-CoV2 Infection | Respiratory Distress Syndrome, Adult | Acute Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome

Vietnam
Groupe Hospitalier Paris Saint Joseph

Completed

Effectiveness of an Exercise Re-training Program on Dyspnea in Patients After Acute Respiratory Distress Syndrome Secondary to Severe COVID-19 Pneumonia in Post-ICU (RECOVER)

Dyspnea

France
Milton S. Hershey Medical Center

Withdrawn

Inhaled GM-CSF for Respiratory Virus-Associated Severe Pneumonia (iGRASP)

Pneumonia | Acute Respiratory Distress Syndrome | Respiratory Virus Infection
Soroka University Medical Center
Roche Pharma AG

Completed

Treatment With Pirfenidone for COVID-19 Related Severe ARDS

Covid19 | ARDS

Israel
Centre Hospitalier Universitaire, Amiens

Completed

Serum and Bronchoalveolar Inflammatory Parameters in Patients With Severe Adult Respiratory Distress Syndrome (ARDS)

H1N1 Influenza
University Hospital, Tours
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Health cAre woRkers exposeD to COVID-19 (HARD-COVID19)

Depression | Burnout, Professional | Post Traumatic Stress Disorder

France
University of Giessen

Completed

GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia (GI-COVID)

COVID-19 Pneumonia | Severe Acute Respiratory Syndrome (SARS) Pneumonia

Germany
Groupe Hospitalier Pitie-Salpetriere
CMC Ambroise Paré; Centre Hospitalier Intercommunal Robert Ballanger; Centre...

Completed

Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study

Pneumonia | Covid-19 | ARDS

France
Rigshospitalet, Denmark
Aarhus University Hospital

Completed

Use of Prone Position Ventilation in Danish Patients With COVID-19 Induced Severe ARDS Treated With VV-ECMO

Extracorporeal Membrane Oxygenation | ARDS, Human | Adverse Event | Prone Position | COVID-19 Acute Respiratory Distress Syndrome

Denmark
Organicell Regenerative Medicine

Available

Expanded Access to Zofin for Patients With COVID-19

Covid19 | Acute Respiratory Distress Syndrome | Corona Virus Infection | SARS (Severe Acute Respiratory Syndrome)
University Hospital, Ghent
Belgium Health Care Knowledge Centre

Completed

Treatment of COVID-19 Patients With Anti-interleukin Drugs (COV-AID)

COVID-19

Belgium
Brno University Hospital
European Society of Intensive Care Medicine; European Society of Anaesthesiology...

Completed

Corticosteroids in Severe COVID-19 (ASAP-ESICM/ESAIC Study) (ASAPESICMESAIC)

Severe COVID-19

Czechia
University of British Columbia
Canadian Institutes of Health Research (CIHR)

Terminated

Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection? (ARBs CORONA II)

Covid19 | SARS-CoV Infection

Canada, France
Ashvattha Therapeutics, Inc.

Terminated

A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients (PRANA)

COVID-19

United States
Centre Hospitalier Intercommunal de Toulon La Seyne...

Completed

Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome (SONIC-19)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

France
Prof. Dr. Jörg Leuppi

Completed

High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study (VitCov)

Covid19 | Vitamin D Deficiency | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

Switzerland
APR Applied Pharma Research s.a.

Withdrawn

Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19 (AVICOVID-3)

SARS-CoV 2 | COVID | ARDS | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Dyspnea | ALI
Masonic Cancer Center, University of Minnesota

Active, not recruiting

Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)

Acute Respiratory Distress Syndrome | COVID-19 Pneumonia | ARDS (Moderate or Severe)

United States
Regeneron Pharmaceuticals

Completed

Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19

COVID-19

United States, Mexico, Romania, Brazil, Chile, Moldova, Republic of
Centre Hospitalier de Saint-Brieuc

Completed

Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients

Acute Respiratory Distress Syndrome | Ventilator-Induced Lung Injury

France
Biotest

Completed

Efficacy and Safety of Trimodulin in Subjects With Severe COVID-19 (ESsCOVID)

Covid19

Brazil, France, Russian Federation, Spain
Karolinska Institutet
University of California, San Diego; The Swedish Research Council; University... and other collaborators

Terminated

Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 (COVID-19-HBO)

COVID-19 | Cytokine Storm | SARS (Severe Acute Respiratory Syndrome) | Acute Respiratory Failure | ARDS, Human | Sars-CoV2

Sweden, Germany
Pliant Therapeutics, Inc.

Terminated

Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Acute Respiratory Distress Syndrome (ARDS) Associated With at Least Severe COVID-19

Acute Respiratory Distress Syndrome | SARS-CoV-2

United States
University Hospital, Ghent
Flanders Institute of Biotechnology

Completed

Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC) (SARPAC)

COVID-19

Belgium
Veru Inc.

Completed

COVID-19 Treatment of Severe Acute Respiratory Syndrome With Veru-111

Respiratory Distress Syndrome, Adult

United States
International Centre for Diarrhoeal Disease Research...
University of Edinburgh; Dhaka Medical College

Completed

Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study (Adult-bCPAP)

Covid19 | Acute Respiratory Distress Syndrome | Severe Pneumonia

Bangladesh
Guy's and St Thomas' NHS Foundation Trust

Withdrawn

Effect of PEEP on Lung Recruitment and Homogeneity Over Time in Moderate to Severe ARDS (APRV)

Critical Illness | ARDS | Ventilator-Induced Lung Injury

United Kingdom
Catholic University of the Sacred Heart

Suspended

Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS. (ALTERPRONE)

Acute Respiratory Distress Syndrome

Italy
Instituto Nacional de Enfermedades Respiratorias

Terminated

Glycine Supplement for Severe COVID-19

COVID-19 | Pneumonia, Viral | SARS-CoV Infection | SARS (Severe Acute Respiratory Syndrome) | ARDS, Human | SARS Pneumonia

Mexico
Consorcio Centro de Investigación Biomédica en...
Carlos III Health Institute; Barcelona Supercomputing Center

Completed

One Year Follow-ups of Patients Admitted to Spanish Intensive Care Units Due to COVID-19

Respiratory Failure | Acute Respiratory Distress Syndrome | Severe Pneumonia

Spain
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Completed

Efficacy of Respiratory Physiotherapy on Severe ICU-admitted COVID-19 Patients.

COVID-19 Acute Respiratory Distress Syndrome

Italy
Celularity Incorporated
Lung Biotechnology PBC; California Institute for Regenerative Medicine (CIRM); ID...

Active, not recruiting

Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 (CYNKCOVID)

Coronaviridae Infections | Nidovirales Infections | RNA Virus Infections | Respiratory Tract Infections | Coronavirus Infection | Pneumonia, Viral | Pneumonia | Lung Diseases | ARDS | Coronavirus | Severe Acute Respiratory Syndrome Coronavirus 2 | Respiratory Tract Disease | Virus Disease | Physiological Effects of... and other conditions

United States

Search clinical trials for: Severe respiratory distress

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burundi

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations