Search clinical trials for: Switch of therapy

Total 437765 results

Cutera Inc.

Completed

Comparison Study of Picosecond and Nanosecond Pulse Durations Using a Q-switched Nd:YAG Laser for Tattoo Removal

Tattoo Removal

United States
NEAT ID Foundation
ViiV Healthcare

Completed

An Open-Label, Multi-Centre, Randomised, Switch Study to Evaluate the Virological Efficacy Over 96 Weeks Of 2-Drug Therapy With DTG/RPV FDC in Antiretroviral Treatment-Experienced HIV-1 Infected Subjects Virologically Suppressed With NNRTIs Resistance Mutation K103N (WISARD)

HIV-1-infection

Spain, Belgium, France, Germany, Italy, United Kingdom
Ottawa Hospital Research Institute
Gilead Sciences; CIHR Canadian HIV Trials Network

Completed

HIV Drug Switch Followed by HCV Therapy in HIV-HCV Co-Infection (CTN289)

Hepatitis C, Chronic | Human Immunodeficiency Virus

Canada
University of Vermont

Completed

Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

Tobacco Use Disorder

United States
University of California, San Francisco
National Institute of Mental Health (NIMH)

Completed

An Adaptive Intervention for Depression Among Latinos Living With HIV (Latino-SMART)

Depression

United States
Sanofi

Completed

Comparison of Two Treatment Regimens in Patients With Type 2 Diabetes After Short-term Intensive Insulin Therapy (SWITCH)

Type 2 Diabetes Mellitus

China
Concern GRANIT
Samara State Medical University

Completed

Clinical Trial of a Medical Device "Device for Non-invasive Electromagnetic Therapy "TOR" in the Treatment of COVID-19"

Coronavirus Infection COVID-19

Russian Federation
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children

HIV Infections

United States, Puerto Rico
AIO-Studien-gGmbH
Bristol-Myers Squibb

Terminated

Study in Which Therapy is Either Switched to Nivolumab After 3 Months of Treatment or Therapy is Continued With a Tyrosine Kinase Inhibitor in Patients With Metastatic Renal Cell Carcinoma (RCC) and Disease Control (NIVOSWITCH)

Metastatic Renal Cell Carcinoma

Austria, Germany
Hospitales Universitarios Virgen del Rocío
Instituto de Salud Carlos III

Completed

Tripe Versus Dual Antiretroviral Therapy in HIV-infected Patients With Virological Suppression (Tridual) (Tridual)

HIV Infections

Spain
Franciscus Gasthuis
Erasmus Medical Center

Completed

Reduction of Intravenous Antibiotics In Neonates (RAIN)

Neonatal Infection | Neonatal SEPSIS

Netherlands
AbbVie

Terminated

A Study to Assess Effectiveness and Safety of Fixed Dose Combination of Lopinavir/Ritonavir (LPV/r) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Patients After Switching From Kaletra in the Routine Clinical Settings of Russian Federation (COPI)

HIV-1 Infection

Russian Federation
PENTA Foundation
Institut National de la Santé Et de la Recherche Médicale, France; Program... and other collaborators

Active, not recruiting

A Randomised Trial of Dolutegravir (DTG)-Based Antiretroviral Therapy vs. Standard of Care (SOC) in Children With HIV Infection Starting First-line or Switching to Second-line ART

HIV Infection

United Kingdom, Spain, Portugal, South Africa, Thailand, Uganda, Germany, Zimbabwe
Julio Ramirez
University of Louisville

Terminated

Patients Response to Early Switch To Oral:Osteomyelitis Study (PRESTO:Osteo)

Osteomyelitis

United States
Gia Dinh People Hospital

Completed

The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy

Skin and Subcutaneous Tissue Infection

Vietnam
GlaxoSmithKline
PPD

Completed

Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

Spain, Germany, Hungary, Italy, Philippines, France, United States, Mexico, Brazil, South Africa, Korea, Republic of, Canada, Poland, United Kingdom
Thomas Jefferson University
University of Illinois at Chicago; University of California, San Francisco; Nova... and other collaborators

Completed

The Incidence and Severity of Drug Interactions Before and After Switching Antiretroviral Therapy to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Treatment Experienced Patients

HIV/AIDS

United States
The First Affiliated Hospital with Nanjing Medical...

Unknown

OPTImal Management of Antithrombotic Agents: OPTIMA-5

Acute Coronary Syndrome (ACS)

China
Alma Lasers Inc.

Completed

Laser 360iQ: Optimal Light-laser Combination Therapy

Photodamage

United States
Haitian Group for the Study of Kaposi's Sarcoma...
Harvard Medical School (HMS and HSDM); Brigham and Women's Hospital; Weill Medical... and other collaborators

Unknown

Continuation of Protease-Inhibitor Based Second-Line Therapy vs. Switch to B/F/TAF in Virologically Suppressed Adults

Antiretroviral Therapy | HIV-1-infection

Haiti
Korea University

Unknown

Maintaining Antiviral Efficacy After Switching to Generic Entecavir 1 mg for Chronic Hepatitis B

Chronic Hepatitis B

Korea, Republic of
Rabin Medical Center
Juvenile Diabetes Research Foundation; University of Padova; Jaeb Center for... and other collaborators

Completed

Personalized Automated Determination of Insulin Pump Setting for Subjects With Type 1 Diabetes Switching From MDI to Pump Therapy and Vice Versa- Safety and Efficacy Feasibility Study

Type1diabetes

Israel
Saskatchewan Health Authority - Regina Area
Gilead Sciences

Unknown

Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy

Hepatitis C, Chronic | HIV/AIDS | Bone Diseases, Metabolic | Opioid Dependence | HIV-1-infection | HCV Coinfection | Buprenorphine Dependence | Methadone Dependence | Co-infection

Canada
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia

Sickle Cell Anemia

United States
Seng Gee Lim
Merck Sharp & Dohme LLC; Singapore General Hospital; Tan Tock Seng Hospital; Changi... and other collaborators

Completed

Efficacy of Switching or Adding Pegylated Interferon in Chronic Hepatitis B Patients on Long Term Oral Antiviral Therapy (SWAP)

Chronic Hepatitis B

Singapore
Thomas Jefferson University

Completed

Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen

Hyperglycemia | Cardiovascular Diseases | Metabolic Syndrome | Weight Gain | HIV-1-infection | Renal Function Abnormal

United States
Medtronic Diabetes

Completed

SWITCH - Sensing With Insulin Pump Therapy to Control HbA1c (SWITCH)

Diabetes Mellitus, Type 1

Netherlands, Slovenia, Denmark, Austria, Italy, Luxembourg, Spain
Calmy Alexandra

Completed

Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV) (Simpl'HIV)

Antiretroviral Therapy | HIV-1-infection | Maintenance Therapy

Switzerland
A.O. Ospedale Papa Giovanni XXIII
San Raffaele University Hospital, Italy

Unknown

RPV+DRV/Cobi Dual Therapy in Subjects With HIV Controlled Infection (PROBE2)

HIV Infection

Italy
AstraZeneca
Quintiles, Inc.

Completed

Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

United States
Sanofi

Terminated

Cabazitaxel Versus the Switch to Alternative AR Targeted Therapy Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Primary Resistant Patients to Abiraterone or Enzalutamide (PRIMCAB)

Prostate Cancer Metastatic

Canada, United States
Fundación Pública Andaluza Progreso y Salud

Unknown

Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Acute Coronary Syndrome

Spain
Allergan

Completed

An Observational Study of Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Who Switched IOP-lowering Treatments

Ocular Hypertension | Glaucoma, Open-Angle

Turkey
Merck Sharp & Dohme LLC

Terminated

Evaluation of Renal Function, Efficacy, and Safety When Switching From Tenofovir/Emtricitabine Plus a Protease Inhibitor/Ritonavir, to a Combination of Raltegravir (MK-0518) Plus Nevirapine Plus Lamivudine in HIV-1 Participants With Suppressed Viremia and Impaired Renal Function (MK-0518-284) (RANIA)

HIV Infections
MicroPort CRM
Sorin Group France SAS

Terminated

Efficacy of the ATP Switch Automatic Programming in Implantable Cardioverter Defibrillator (ICD) and Cardiac Resynchronization Therapy Defibrillator (CRT-D) Implanted Patients (ASAP)

Ventricular Arrythmias

France
Gilead Sciences

Completed

Efficacy, Safety, and Tolerability of Ledipasvir/Sofosbuvir (LDV/SOF) Treatment for HIV/HCV Co-infected Participants Who Switch to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) or Emtricitabine/Rilpivirine/Tenofovir Alafenamide (F/R/TAF) Prior to LDV/SOF HCV Treatment (Co-STARs)

HIV-1 Infection | HCV Infection

United States, Puerto Rico
Pfizer

Completed

Switchover Trial From Imiglucerase to Plant Cell Expressed Recombinant Human Glucocerebrosidase

Gaucher Disease

United Kingdom, Canada, Israel, United States, Australia, Spain
Mahidol University

Completed

Efficacy of Rilpivirine-based Regimens as Switch Therapy From Nevirapine-based Regimens in HIV-infected Patients

Efficacy of Rilpivirine-based Regimens as Switch Therapy

Thailand
Gilead Sciences

Completed

Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children

HIV Infections

United States, United Kingdom, Panama
Samsung Medical Center

Completed

Prospective Study for Patient Perception of Treatment Satisfaction After Switching to Mirabegron in Patients With Overactive Bladder Who Were Unsatisfied With Efficacy of Antimuscarinic Therapy or Adverse Event.

Overactive Bladder

Korea, Republic of
Pfizer
Forest Laboratories

Completed

Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)

Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis

Croatia, Brazil, Bulgaria, Korea, Republic of, Russian Federation, Hungary, Poland, Romania, Ukraine, Argentina, Israel, Portugal, Greece, Taiwan, Japan, Slovakia, Serbia, United States, Mexico, Germany, Turkey, Czechia
Pfizer
Forest Laboratories

Completed

Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)

Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis

Croatia, Bulgaria, Korea, Republic of, Mexico, Peru, Poland, Russian Federation, Spain, Romania, Ukraine, United States, Argentina, Czechia, Israel, Taiwan, Germany, Italy
Massachusetts General Hospital
Gilead Sciences; Brigham and Women's Hospital

Completed

Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy and Switch to an Elvitegravir-based Regimen

HIV Disease

United States
Massachusetts General Hospital
Merck Sharp & Dohme LLC

Completed

Advanced Neuroimaging Evaluation of CNS Changes Associated With Efavirenz Therapy Switch to an Raltegravir-based Regimen

HIV | Neurotoxicity | HIV-associated Neurocognitive Disorder

United States
Chinese University of Hong Kong

Completed

A Randomized Controlled Trial on the Efficacy of Tenofovir Disoproxil Fumarate (TDF)-Switch Therapy in Chronic Hepatitis B Patients With Incomplete Response to Entecavir

Chronic Heptitis B

Hong Kong
Bayer

Completed

A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice (CAPTURE)

Hypertension, Pulmonary

Japan, Germany, Sweden, Colombia, Turkey, Belgium, Canada
Therapeutic Concepts

Completed

Nucleoside Switch Pilot for Virologically Controlled HIV Subjects With Decreasing CD4 Cells Who Have Received TDF-based ARV Therapy (EPZSwitch)

HiV1- Positive

United States
Ortho-McNeil Janssen Scientific Affairs, LLC
Bayer

Completed

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

Arthritis | Osteoarthritis, Knee | Thromboembolism | Osteoarthritis, Hip

United States
Pfizer

Completed

Assial - Anti Tnf Treatment in Ankylosing Spondylitis: an Observational Cohort Study in Italy (ASSIAL)

Ankylosing Spondylitis

Italy
Indivior Inc.

Completed

Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P05444)

Opioid-Related Disorders | Drug Abuse | Opiate Dependence

Austria

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