Patients Response to Early Switch To Oral:Osteomyelitis Study (PRESTO:Osteo)

Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics

Based on the current literature, investigators hypothesize that patients with osteomyelitis who are treated with the standard approach of intravenous antibiotics for the full duration of therapy will have the same clinical outcomes as patients treated with the experimental approach of intravenous antibiotics with early switch to oral antibiotics.

The primary objective of this study is to compare patients with osteomyelitis treated with the standard approach of intravenous antibiotics for the full duration of therapy versus patients treated with intravenous antibiotics with an early switch to oral antibiotics in relation to clinical outcomes at 12 months after discontinuation of antibiotic therapy. Secondary objectives of the study include the evaluation of adverse events related to the use of antibiotics as well as the cost of care evaluated from the hospital perspective.

Study Overview

• Status: Terminated
• Conditions: Osteomyelitis
• Intervention / Treatment: Procedure: intravenous antibiotics; Drug: oral antibiotics

Detailed Description

1.1. Background Information Osteomyelitis is a common disease associated with significant morbidity and high cost (1). The treatment of osteomyelitis can be challenging requiring prolonged administration of antibiotics and extensive surgical procedures. Even when the infection is treated, the relapse rate is as high as 20% (2). When a bone is infected, the local multiplication of bacteria produces a local inflammatory response with presence of neutrophils and macrophages with areas of microthrombi and avascular necrosis. If a significant area of avascular necrosis develops, a segment of the bone without any blood supply can become separated and form a sequestrum. Since infection of sequestrum occurs in most patients with osteomyelitis, it is considered that in addition to antibiotic treatment, the patient requires surgical intervention for removal of necrotic bone.

1.2. Scientific Rationale There is agreement regarding the minimal duration of antibiotic therapy for patients with osteomyelitis. Since an infected bone may take 3 to 4 weeks to re--- vascularize, the duration of therapy should be a minimum of 4 to 6 weeks of antibiotics. Because different organisms can cause osteomyelitis, the initial antibiotic therapy during hospitalization should include broad---spectrum antibiotics to cover the most likely organisms. As part of the initial management, a bone biopsy is regularly performed to identify the particular etiologic agent. Once the organism and its antimicrobial susceptibilities are known, the spectrum of antibiotic therapy is narrowed, and the antimicrobial therapy continues with an antibiotic that is targeted according to the susceptibility of the identified pathogen. Targeted antibiotic therapy in patients with osteomyelitis is usually performed after 3 to 5 days of broad spectrum antibiotics, since this is the time required by the microbiology department to generate antimicrobial susceptibilities after the bone biopsy is performed. In regard to the route of antibiotic administration, the standard approach is to use an intravenous antibiotic.

1.3. Potential Risks A potential risk for the use of an early switch to oral antibiotics in patients with osteomyelitis is that the blood level achieved with oral antibiotics may not be high enough to attain clinical resolution of the infection.

1.4. Potential Benefits There are several potential benefits of using oral antibiotics instead of intravenous antibiotics. First, avoiding a peripherally inserted central line eliminates the risk of line infection and line---associated deep vein thrombosis. An early switch to oral antibiotics may also facilitate early hospital discharge. A shorter hospital stay will decrease the risk of hospital---associated complications such as hospital---acquired infections. Further, the patients' quality of life may be better without a central line. Finally, the total cost of therapy will be significantly reduced with oral therapy.

2. Methods 2.1. Trial design & setting This will be a prospective, randomized, unblinded clinical trial to define if the clinical outcomes of patients with osteomyelitis treated with the experimental approach of intravenous antibiotics with an early switch to oral therapy is non---inferior to the current standard approach of intravenous antibiotics for the full duration of therapy.

2.8. Sample Size & Statistical Analysis The null hypothesis for this study will be as follows: H0: πs --- πe ≤ ---Δ Where πs is the proportion of clinical failures in the intravenous therapy only group, πe is the proportion of clinical failures in the intravenous therapy plus early switch to oral therapy group, and Δ is the non---inferiority margin. The alternative hypothesis will be: HA: πs --- πe > ---Δ We expect that there will be a 20% clinical failure rate for the primary outcome in both the intravenous antibiotic therapy group and the intravenous antibiotic therapy plus early switch to oral antibiotic therapy group. The study will be powered at 80% with Δ of 0.1. A total of 396 patients will be needed to obtain a 95% confidence interval for the difference in failure rates between the two groups that has a lower limit above ---Δ. If the lower limit of this 95% confidence interval for the 10 difference in clinical failure rates between the two arms is above -Δ, non---inferiority will be met. Considering that approximately 15% of patients will be lost during study follow---up, a total of 456 patients will be enroll in the trial to obtain the 396 patients necessary for final analyses.

3. Data Quality Management Plan 3.1. Overview of the Clinical and Translational Research Support Center

The University of Louisville Clinical and Translational Research Support Center (CTRSC) will be responsible for data collection, data quality, and data analysis for this project. The CTRSC (http://www.ctrsc.net) is a multi---disciplinary team comprised of professionals in medicine, public health, statistics, and computer science. The team has considerable experience managing and supporting single---site and multi---center clinical research studies. Specifically, members of the CTRSC will be responsible for:

• Study design
• Development of data collection forms
• Development of study manual 11
• Development of electronic Internet base data entry system
• Providing instruction on use of forms and data entry system
• Development of study database
• Tracking subject enrollment
• Overseeing data transmission
• Providing data management
• Handling data validation
• Protecting confidentiality of data
• Performing feasibility evaluation The data quality team leader for this project will be Dr. Robert Kelley with assistance from Dr. Timothy Wiemken and Dr. Paula Peyrani.

The CTRSC has access to the University of Louisville's high---performance computing cluster, which consists of 312 IBM iDatplex nodes each with two Intel Xeon quad--- core processors for 2496 total cores. The cluster is equipped with a variety of statistical and bioinformatics software including SAS, R, Matlab, ClustalW, and Blast, and C, Fortran, Perl, and Python libraries. In addition, the CTRSC has several iMac and IBM---compatible workstations with several data management and analysis packages installed including R, Matlab, SQL Server 2012, SAS, SPSS, Eclipse, Visual Studio .NET 2010, MySQL Server 5.1, Tableau 8.0, and REDCap.

3.2. Purpose of Data Quality Management Plan

The purpose of this data quality management plan is outline the procedures and processes necessary to:

1. Ensure the data collection and data management for the study are conducted in a manner consistent with University of Louisville standards as well as state and federal regulations.
2. Ensure that data collected are accurate and complete when verified against source documents.
3. Provide approaches for early interception and correction of errors in data collection.
4. Identify areas where specific education and training efforts regarding data collection need to be focused.
5. Outline the tools that will be used to monitor and assess data quality.
6. Outline the Data Quality Management Team meeting schedule for this project. 3.3. Data Capture Primary data collection will be performed by a qualified study coordinator(s) who will abstract subject data from the electronic medical record onto a paper case report form. Once the paper case report form is complete, the study coordinator or other designee will enter the data into a secure, web---based clinical data management system.

• Study Type: Interventional
• Enrollment (Actual): 11
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• United States
  • Kentucky
    • Louisville, Kentucky, United States, 40202
      • University of Louisville

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 100 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Only adult patients will be invited to participate in this trial (age ≥ 18 years). A patient will be considered a candidate to participate in this trial if the following two inclusion criteria are present:

  1. Isolation of an organism from bone culture that is susceptible to intravenous and oral antibiotics.

  2. Plus at least one of the following:

     • Evidence of local inflammatory response, manifested as local pain, edema, erythema, warmth, or drainage.
     • Evidence of systemic inflammatory response, manifested as fever, elevated C---reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), or white blood cell count.

• *Osteomyelitis---compatible findings on plain radiograph, computed tomography, bone scan, magnetic resonance imaging, or positron emission tomography.

  • Pathology report indicative of osteomyelitis.

Exclusion Criteria:

• A patient will not be considered as a candidate to participate in this study if the study team expects the subject to be non---compliant with the study follow---up clinic visit.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: NONE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: Intravenous antibiotics; Intravenous antibiotics for the full duration of therapy	Procedure: intravenous antibiotics; intravenous antibiotics for the full duration of therapy, antibiotic type will be dependent on bacteria type; Other Names: Mycobutin®; Cycloserine; Isoniazid; Pyrazinamide; Levofloxacin; Moxifloxacin; Gatifloxacin; Capreomycin; Ethionamide; Cloxacillin; Erythromycin; Amoxicillin; Gentamicin; Rifampin; Rifadin®; Cefepime; Clindamycin; Fosfomycin; Meropenem; Rifapentine; Minocycline; Ampicillin; Cefuroxime; Nafcillin; Oxacillin; Polymyxin B; Zithromax®; Silver Sulfadiazine; Doxycycline; Mupirocin; Bacitracin; Penicillin V; Benzylpenicillin; Cefoxitin; Amoxil®; Biaxin®; Colistin; Dicloxacillin; Metronidazol; Nitrofurantoin; Minocin®; Monurol®; Rocephin®; Cipro®; Cefoperazone; Suprax®; Vantin®; Flagyl®; Merrem®; Zyvox®; Omnipen®; Bacampicillin; Spectrobid®; Carbenicillin Indanyl; Pyopen®, Geogen®, Geocillin®; Mezlocillin; Mezlin®; Piperacillin*; Pipracil®; Ticarcillin; Ticar®; Amoxicillin-Clavulanic Acid; Augmentin®; Ampicillin-Sulbactam*; Unasyn®; Benpen®; Tegopen®, Coxapen®; Dycill®, Dynapen®, Pathocil®; Methicillin; Staphcillin®; Prostaphilin®, Bactocil®; Penicillin G (Benzathine, Potassium, Procaine); Bicillin® C-R/L-A, Pfizerpen®, Wycellin®; Pen-Veek®, Beepen-VK®; Piperacillin+Tazobactam*; Zozyn®; Ticarcillin+Clavulanic Acid; Timentin®; Unipen®, Nafcil®; Cefaclor; Ceclor®, Ceclor CD®; Cefamandol; Mandol®; Cefonicid; Monocid®; Cefotetan; Cefotan®; Mefoxin®; Cefprozil; Cefzil®; Ceftmetazole; Zefazone®; Kefurox®, Zinacef®; Cefuroxime axetil; Ceftin®; Loracarbef; Lorabid®Cefdinir; Omnicef®; Ceftibuten; Cedax®; Cefobid®; Cefixime*; Cefotaxime*; Claforan®; Cefpodoxime proxetil; Ceftazidime*; Ceptaz®, Fortaz®, Tanicef®; Ceftizoxime*; Cefizox®; Ceftriaxone*; Maxipime®; Azithromycin*; Clarithromycin*; Cleocin®; Dirithromycin; Dynabac®; E-mycin®, Ery-tab®, Benzamycin®; Lincomycin; Lincocin®; T roleandomycin; T ao®; Cinoxacin; Cinoxacin®; Ciprofloxacin*; Enoxacin; Penetrex®; T equin®; Grepafloxacin; Levaquin®, Quixin®; Lomefloxacin; Maxaquin®; A velox®; Nalidixic acid; NegGam®; Norfloxacin*; Noroxin®; Ofloxacin; Floxin®; Sparfloxacin; Zagam®; T rovafloxacin; T rovan®; Imipenem-Cilastatin*; Primaxin®; Aztreonam*; Azactam®; Amikacin*; Amikin®; Garamycin®; Kanamycin; Kantrex®; Neomycin; Mycifradin®, Neo-Fradin®; Netilmicin; Netromycin®; Streptomycin; Streptomycin®; T obramycin*; Tobrex®, Nebcin®; Paromomycin; Humatin®; T eicoplanin; T argocid®; Vancomycin*; Vancocyn®, Lyphocin®; Demeclocycline; Declomycin®; Doxy®, Vibra®, Vibramycin®; Methacycline; Rondomycin®; Oxytetracycline; Terramycin®; T etracycline; Sumycin®; Chlortetracycline; Mafenide; Sulfamylon®; SSD®, Silvadene®; Sulfacetamide; Sultrim®; Sulfadiazine; Sulfamethoxazole; Gantanol®; Sulfasalazine; Sulfasalazine®,Azulfidine®; Sulfisoxazole; T rimethoprim-Sulfamethoxazole; Bactrim®, Septra®, Cofatrim®, Primsol®; Sulfamethizole; Thiosulfil Forte®; Rifabutin; Priftin®; Linezolid*; Quinopristin+Dalfopristin*; Synercid®; Baci-IM; Chloramphenicol*; Chloromycetin®; Colistemetate; Coly-Mycin® M & S; Rifamate®; Methenamine; Hiprex®, Mandelamine®; Bactroban®; Macrobid®, Macrodantin®, Furantoin®; Nitrofurazone; Furacin®; Novobiocin; Albamycin®; Aerospin®; Spectinomycin; T robicin®; T rimethoprim; Proloprim®, Trimpex®; Para-aminosalicyclic acid; Erythromycin ethylsuccinate + sulfisoxazole
ACTIVE_COMPARATOR: oral antibiotics; intravenous antibiotic therapy plus early switch to oral antibiotic therapy	Drug: oral antibiotics; intravenous antibiotics with early switch to oral antibiotics, antibiotic type will be dependent on bacteria type; Other Names: Mycobutin®; Cycloserine; Isoniazid; Pyrazinamide; Levofloxacin; Moxifloxacin; Gatifloxacin; Capreomycin; Ethionamide; Cloxacillin; Erythromycin; Amoxicillin; Gentamicin; Rifampin; Rifadin®; Cefepime; Clindamycin; Fosfomycin; Meropenem; Rifapentine; Minocycline; Ampicillin; Cefuroxime; Nafcillin; Oxacillin; Polymyxin B; Zithromax®; Silver Sulfadiazine; Doxycycline; Mupirocin; Bacitracin; Penicillin V; Benzylpenicillin; Cefoxitin; Amoxil®; Biaxin®; Colistin; Dicloxacillin; Metronidazol; Nitrofurantoin; Minocin®; Monurol®; Rocephin®; Cipro®; Cefoperazone; Suprax®; Vantin®; Flagyl®; Merrem®; Zyvox®; Omnipen®; Bacampicillin; Spectrobid®; Carbenicillin Indanyl; Pyopen®, Geogen®, Geocillin®; Mezlocillin; Mezlin®; Piperacillin*; Pipracil®; Ticarcillin; Ticar®; Amoxicillin-Clavulanic Acid; Augmentin®; Ampicillin-Sulbactam*; Unasyn®; Benpen®; Tegopen®, Coxapen®; Dycill®, Dynapen®, Pathocil®; Methicillin; Staphcillin®; Prostaphilin®, Bactocil®; Penicillin G (Benzathine, Potassium, Procaine); Bicillin® C-R/L-A, Pfizerpen®, Wycellin®; Pen-Veek®, Beepen-VK®; Piperacillin+Tazobactam*; Zozyn®; Ticarcillin+Clavulanic Acid; Timentin®; Unipen®, Nafcil®; Cefaclor; Ceclor®, Ceclor CD®; Cefamandol; Mandol®; Cefonicid; Monocid®; Cefotetan; Cefotan®; Mefoxin®; Cefprozil; Cefzil®; Ceftmetazole; Zefazone®; Kefurox®, Zinacef®; Cefuroxime axetil; Ceftin®; Loracarbef; Lorabid®Cefdinir; Omnicef®; Ceftibuten; Cedax®; Cefobid®; Cefixime*; Cefotaxime*; Claforan®; Cefpodoxime proxetil; Ceftazidime*; Ceptaz®, Fortaz®, Tanicef®; Ceftizoxime*; Cefizox®; Ceftriaxone*; Maxipime®; Azithromycin*; Clarithromycin*; Cleocin®; Dirithromycin; Dynabac®; E-mycin®, Ery-tab®, Benzamycin®; Lincomycin; Lincocin®; T roleandomycin; T ao®; Cinoxacin; Cinoxacin®; Ciprofloxacin*; Enoxacin; Penetrex®; T equin®; Grepafloxacin; Levaquin®, Quixin®; Lomefloxacin; Maxaquin®; A velox®; Nalidixic acid; NegGam®; Norfloxacin*; Noroxin®; Ofloxacin; Floxin®; Sparfloxacin; Zagam®; T rovafloxacin; T rovan®; Imipenem-Cilastatin*; Primaxin®; Aztreonam*; Azactam®; Amikacin*; Amikin®; Garamycin®; Kanamycin; Kantrex®; Neomycin; Mycifradin®, Neo-Fradin®; Netilmicin; Netromycin®; Streptomycin; Streptomycin®; T obramycin*; Tobrex®, Nebcin®; Paromomycin; Humatin®; T eicoplanin; T argocid®; Vancomycin*; Vancocyn®, Lyphocin®; Demeclocycline; Declomycin®; Doxy®, Vibra®, Vibramycin®; Methacycline; Rondomycin®; Oxytetracycline; Terramycin®; T etracycline; Sumycin®; Chlortetracycline; Mafenide; Sulfamylon®; SSD®, Silvadene®; Sulfacetamide; Sultrim®; Sulfadiazine; Sulfamethoxazole; Gantanol®; Sulfasalazine; Sulfasalazine®,Azulfidine®; Sulfisoxazole; T rimethoprim-Sulfamethoxazole; Bactrim®, Septra®, Cofatrim®, Primsol®; Sulfamethizole; Thiosulfil Forte®; Rifabutin; Priftin®; Linezolid*; Quinopristin+Dalfopristin*; Synercid®; Baci-IM; Chloramphenicol*; Chloromycetin®; Colistemetate; Coly-Mycin® M & S; Rifamate®; Methenamine; Hiprex®, Mandelamine®; Bactroban®; Macrobid®, Macrodantin®, Furantoin®; Nitrofurazone; Furacin®; Novobiocin; Albamycin®; Aerospin®; Spectinomycin; T robicin®; T rimethoprim; Proloprim®, Trimpex®; Para-aminosalicyclic acid; Erythromycin ethylsuccinate + sulfisoxazole

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical Failures	Clinical failure will be defined as clinical or laboratory evidence of infection collected from the patient's medical record documents.	1 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluation of adverse events related to the use of antibiotics	Antibiotic---related adverse events will be defined according to the Food and Drug Administration adverse events listed in the package insert of the antibiotic prescribed for each subject.	1 month
Cost of care from the hospital perspective	Costs will be calculated from the hospital perspective and will include the costs of the antibiotic therapy, home healthcare (nursing--- and infusion---related), and length of hospital stay.	12 months

Collaborators and Investigators

• Sponsor: Julio Ramirez
• Collaborators: University of Louisville
• Investigators: Principal Investigator: Julio Ramirez, MD, University of Louisville

Publications and helpful links

General Publications

• Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004 Jul 24-30;364(9431):369-79. doi: 10.1016/S0140-6736(04)16727-5.
• Haas DW, McAndrew MP. Bacterial osteomyelitis in adults: evolving considerations in diagnosis and treatment. Am J Med. 1996 Nov;101(5):550-61. doi: 10.1016/s0002-9343(96)00260-4.
• Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. N Engl J Med. 1970 Jan 22;282(4):198-206. doi: 10.1056/NEJM197001222820406. No abstract available.
• Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis. 2005 May;9(3):127-38. doi: 10.1016/j.ijid.2004.09.009.
• Conterno LO, da Silva Filho CR. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD004439. doi: 10.1002/14651858.CD004439.pub2.
• Peyrani P, Allen M, Seligson D, Roberts C, Chen A, Haque N, Zervos M, Wiemken T, Harting J, Christensen D, Ramirez R. Clinical outcomes of osteomyelitis patients infected with methicillin-resistant Staphylococcus aureus USA-300 strains. Am J Orthop (Belle Mead NJ). 2012 Mar;41(3):117-22.

Study record dates

Study Major Dates

• Study Start (ACTUAL): March 6, 2014
• Primary Completion (ACTUAL): November 7, 2018
• Study Completion (ACTUAL): November 7, 2018

Study Registration Dates

• First Submitted: March 18, 2014
• First Submitted That Met QC Criteria: March 27, 2014
• First Posted (ESTIMATE): March 28, 2014

Study Record Updates

• Last Update Posted (ACTUAL): April 6, 2021
• Last Update Submitted That Met QC Criteria: April 2, 2021
• Last Verified: April 1, 2021

More Information

Terms related to this study

• Keywords: Osteomyelitis; Oral Antibiotics; IV Antibiotics
• Additional Relevant MeSH Terms: Infections; Musculoskeletal Diseases; Bone Diseases; Bone Diseases, Infectious; Osteomyelitis; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents, Local; Anti-Infective Agents; Central Nervous System Depressants; Peripheral Nervous System Agents; Nucleic Acid Synthesis Inhibitors; Enzyme Inhibitors; Analgesics; Sensory System Agents; Anesthetics; Anti-Inflammatory Agents, Non-Steroidal; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antirheumatic Agents; Antimetabolites; Antineoplastic Agents; Gastrointestinal Agents; Protease Inhibitors; Carbonic Anhydrase Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors; Dermatologic Agents; Hypolipidemic Agents; Lipid Regulating Agents; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Leprostatic Agents; Anesthetics, Local; Protein Synthesis Inhibitors; Cytochrome P-450 Enzyme Inducers; Contraceptive Agents, Hormonal; Contraceptive Agents; Reproductive Control Agents; Contraceptives, Oral, Combined; Contraceptives, Oral; Contraceptive Agents, Female; Antiprotozoal Agents; Antiparasitic Agents; Cytochrome P-450 CYP3A Inducers; Antitubercular Agents; Pharmaceutical Solutions; Antimalarials; Folic Acid Antagonists; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP1A2 Inhibitors; beta-Lactamase Inhibitors; Anti-Dyskinesia Agents; Ophthalmic Solutions; Anti-Infective Agents, Urinary; Renal Agents; Cytochrome P-450 CYP2C8 Inhibitors; Fatty Acid Synthesis Inhibitors; Coccidiostats; Vancomycin; Linezolid; Moxifloxacin; Metronidazole; Ceftriaxone; Norgestimate, ethinyl estradiol drug combination; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate; Ampicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Mupirocin; Doxycycline; Rifapentine; Rifampin; Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Gentamicins; Ciprofloxacin; Imipenem; Cilastatin; Benzoyl Peroxide; Rifabutin; Amoxicillin; Clarithromycin; Meropenem; Azithromycin; Levofloxacin; Ofloxacin; Tobramycin; Gatifloxacin; Fluoroquinolones; Cycloserine; Neomycin; Colistin; Trimethoprim; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination; Sulfasalazine; Aztreonam; Clavulanic Acid; Clavulanic Acids; Amoxicillin-Potassium Clavulanate Combination; Paromomycin; Amikacin; Nitrofurantoin; Cefuroxime; Cefuroxime axetil; Polymyxins; Bacitracin; Polymyxin B; Isoniazid; Pyrazinamide; Streptomycin; Ethionamide; Kanamycin; Capreomycin; Piperacillin; Tetracycline; Ceftazidime; Lincomycin; Cefprozil; Methenamine; Methenamine hippurate; Methenamine mandelate; Cloxacillin; Penicillins; Penicillin G Benzathine; Penicillin G; Penicillin G Procaine; Cefpodoxime; Cefpodoxime proxetil; Fosfomycin; Cefotaxime; Cefoxitin; Tazobactam; Piperacillin, Tazobactam Drug Combination; Dicloxacillin; Cefaclor; Minocycline; Ceftibuten; Cefixime; Cefdinir; Demeclocycline; Sulfadiazine; Silver Sulfadiazine; Cefmetazole; Cefepime; Sulbactam; Cefoperazone; Sulperazone; Penicillin V; Cilastatin, Imipenem Drug Combination; Cephalosporins; Sultamicillin; Procaine; Nafcillin; Norfloxacin; Methicillin; Oxacillin; Ticarcillin; Ticarcillin-clavulanic acid; Ceftizoxime; Cefotetan; Sulfacetamide; Netilmicin; Dirithromycin; Mafenide; Sulfisoxazole; Quinupristin-dalfopristin; Chloramphenicol; Novobiocin; Chloramphenicol succinate; Oxytetracycline; Virginiamycin; Enoxacin; Bacampicillin; Carbenicillin; Carbenicillin indanyl; Mezlocillin; Benzathine benzylpenicillin, procaine benzylpenicillin, drug combination; Cefamandole; Cefamandole nafate; Cefonicid; Loracarbef; Grepafloxacin; Lomefloxacin; Nalidixic Acid; Sparfloxacin; Methacycline; Chlortetracycline; Dalfopristin; Spectinomycin; Cinoxacin; Nitrofurazone; Sulfamethizole
• Other Study ID Numbers: 14.0185