Search clinical trials for: Thrombin

Total 249 results

Aronora, Inc.
Celerion

Completed

Safety and Efficacy Study of AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Thrombosis | End Stage Renal Disease

United States
University Hospital, Bordeaux

Completed

Targeting TFPI With Concizumab to Improve Haemostasis in Glanzmann Thrombasthenia Patients: an in Vitro Study (GLAT)

Glanzmann Thrombasthenia

France
Sealantium Medical Ltd.
Sintesi Research Srl; Home Medics Consulting Ltd.

Completed

A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery

General Surgery | Hemostasis

Austria, United States, Slovenia
Oregon Health and Science University

Active, not recruiting

Prehospital Kcentra for Hemorrhagic Shock

Trauma Injury

United States
NYU Langone Health

Terminated

Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

Opioid Pain Medication

United States
Universiti Sains Malaysia
Malaysia Palm Oil Board; Avantsar Sdn. Bhd.

Terminated

Topical Palm Tocotrienols on Skin Biophysical Properties

Wrinkle

Malaysia
Centre Hospitalier Universitaire de Saint Etienne

Completed

Normal Values of Parameters of Thrombin Generation in Function of Different Tissue Factor Concentrations (NUAGE)

Healthy Volunteers

France
Centre Hospitalier Universitaire de Nīmes

Completed

Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs (GT-PT)

Deep Vein Thrombosis | Knee Prosthesis | Total Hip Prosthesis

France
IRCCS Policlinico S. Donato

Active, not recruiting

Identification of Predictors for the Evolution of COVID-19 Related Pneumonia by Transcriptomic and Seroproteomic (COVID_OMICS)

Covid19 | Interstitial Pneumonia

Italy
Johnson & Johnson Consumer Inc. (J&JCI)

Completed

A Study of Virtually Supervised Mouthwash and Interdental Brushes

Healthy

United States
HealthPartners Institute

Completed

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal (kcentra)

Hemorrhage | Acute Bleeding on Long-Term Anticoagulation Therapy | Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time) | Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

United States
Aarhus University Hospital Skejby

Completed

Miniaturized Extracorporeal Circulation Study

Coronary Artery Disease

Denmark
Janssen Research & Development, LLC

Completed

A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants

Healthy

Netherlands
Bristol-Myers Squibb
Clovis Oncology, Inc.

Completed

A Study to Test Combination Treatments in Participants With Advanced Gastric Cancer (FRACTION-GC)

Advanced Gastric Cancer

United States, Israel, Netherlands, Canada, Italy, Australia, Germany, Singapore, Switzerland
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis. (AH2023)

Alcoholic Hepatitis

Italy
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

FEIBA Reconstitution Volume Reduction and Faster Infusion Study (FEIBA STAR)

Hemophilia A or B With Inhibitors

Croatia, North Macedonia, Ukraine
Germans Trias i Pujol Hospital

Completed

Observational Pilot Study With TachoSil as a Ventricular Sealant

Intraventricular Neoplasm

Spain
Assiut University

Active, not recruiting

Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease

COVID-19

Egypt
Octapharma

Completed

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Reversal of Anticoagulant Treatment

United States
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

Safety and Efficacy of Topical Recombinant Human Thrombin(rhThrombin) for Surgical Hemostasis

Surgical Hemostasis

China
University Hospital, Grenoble

Completed

Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma (PROCOAG)

Shock, Hemorrhagic

France
HaEmek Medical Center, Israel

Completed

Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Ischemic Heart Disease | Coagulation Disorder | Artery Coronary Stenosis

Israel
Centre Hospitalier Universitaire de Nīmes

Completed

Analysis of the Coagulopathy Developed by COVID-19 Infected Patients (COVID-TGT)

COVID-19 | Sepsis | Blood Coagulation Disorders | Disseminated Intravascular Coagulation | Thrombin

France
Inova Health Care Services
Merck Sharp & Dohme LLC

Completed

Vorapaxar on Thrombin Generation and Coagulability

Myocardial Infarction | Coronary Artery Disease | Peripheral Vascular Disease

United States
Mayo Clinic
CSL Behring

Completed

PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding

Bleeding | Blood Loss, Surgical | Cardiovascular Surgical Procedures | Prothrombin Complex Concentrates | Fresh Frozen Plasma

United States
Octapharma

Completed

Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

Significant Bleeding Risk

Russian Federation, United States, Romania, Ukraine, Belarus, Bulgaria, Georgia, Germany, Moldova, Republic of, Poland, Spain
University of Edinburgh
NHS Lothian

Completed

Start or STop Anticoagulants Randomised Trial (SoSTART) (SoSTART)

Atrial Fibrillation | Intracranial Hemorrhages | Subarachnoid Hemorrhage | Intraventricular Hemorrhage | Atrial Flutter | Small Vessel Cerebrovascular Disease | Intracranial Hemorrhage, Hypertensive | Subdural Hematoma | Microhaemorrhage

United Kingdom
Yonsei University

Completed

Collagen-thrombin Matrix Efficacy During Cardiac Surgery: a Prospective Randomized Controlled Trial

Coronary Artery Disease

Korea, Republic of
Rambam Health Care Campus

Completed

The Thrombotic Potential of Heart Chambers in the Presence or Absence of Atrial Fibrillation.

Atrial Fibrillation | Thrombosis Cardiac | Left Atrial Thrombosis

Israel
Hospital of South West Jutland

Completed

Meal-induced Thrombin Generation Before and After Gastric Bypass

Weight Loss | Morbid Obesity

Denmark
IRCCS Policlinico S. Donato

Terminated

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery (ZEPLAST-PED)

Bleeding | Surgery--Complications | Congenital Heart Disease | Transfusion-Related Acute Lung Injury | Cardiac Defect | Fibrinogenopenia; Acquired | Transfusion-Associated Circulatory Overload

Italy
Chang Gung Memorial Hospital

Completed

Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty

Osteoarthritis, Knee

Taiwan
Octapharma

Completed

Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

Emergency Care for Severe Bleeding While on Anticoagulants

France
Angel Augusto Perez Calatayud
Grupo Mexicano para el Estudio de la Medicina Intensiva

Completed

Patient Blood Management for Massive Obstetric Hemorrhage

Post Partum Hemorrhage | Transfusion Related Complication | Fibrinogenolysis; Hemorrhage | Fibrinogen; Deficiency, Acquired | Massive Hemorrhage

Mexico
CSL Behring
Kaiser Permanente

Completed

An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major Bleeding

Hemorrhage

United States
Baxalta now part of Shire

Completed

Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal

Prothrombin Complex Factor Deficiency

Hungary, Austria
University Health Network, Toronto

Unknown

Thrombin Generation in Liver Transplant Surgery

Liver Transplantation | Blood Coagulation Disorders | Thrombin | Hemostasis, Surgical | Blood Coagulation Disorder Due to Liver Disease

Canada
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

Topical rhThrombin as an Adjunct to Hemostasis During Segmental Hepatectomy

Hepatectomy

China
Queen Fabiola Children's University Hospital

Active, not recruiting

Study of Biological Markers in Children With Sickle Cell Disease

Sickle Cell Disease

Belgium
Lithuanian University of Health Sciences

Completed

Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury (THROMBIN)

Bleeding | Brain Injuries, Traumatic | Coagulation Disorder

Lithuania
Medical University of Vienna
Medical Scientific Fund of the Mayor of Vienna

Completed

Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections

Critical Illness | Covid19 | Sars-CoV2 | Viral Infection | Disseminated Intravascular Coagulation | Coagulation Disorder, Blood

Austria
University Hospital, Strasbourg, France

Completed

Thrombin Generation as a New Test for Anticoagulation Management in Patients With ECMO (ECMOstase)

Implantation of a Veno-arterial or Veno-venous ECMO

France
University Health Network, Toronto

Completed

Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. (THROMBIN)

Cardiac Surgery

Canada
Queen Mary University of London
British Heart Foundation

Completed

Trial of PCC Versus FFP in Patients Undergoing Heart Surgery (PROPHESY)

Bleeding | Surgery | Transfusion

United Kingdom
University Hospital, Geneva

Completed

Prothrombotic Biomarkers and Ovarian Stimulation (HEMOSTIM)

Sterility, Female | Reproductive Technology, Assisted

Switzerland
Wuhan Union Hospital, China

Unknown

The Early Coagulopathy for the Prognosis in Sepsis

Sepsis | Outcome, Fatal | Coagulopathy
University Health Network, Toronto

Unknown

Factor Replacement in Surgery (FARES)

Bleeding in Cardiac Surgery

Canada
Turku University Hospital
Helsinki University Central Hospital; Tampere University Hospital

Completed

Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery

Adolescent Idiopathic Scoliosis

Finland
University Medical Centre Ljubljana

Unknown

The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury

Brain Injuries, Traumatic | Coagulopathy | Coagulation Defect; Bleeding | Coagulation Defect; Acquired | Fibrinolytic Hemorrhage, Acquired
Abbott Medical Devices

Terminated

Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation (TACTIC AF)

Atrial Fibrillation

United States

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