Search clinical trials for: hyperpolarized xenon-129

Total 579 results

Xemed LLC
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Completed

MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects (HXe-VENT)

Healthy | Asthma | COPD

United States
Origo Biopharma

Completed

First in Human Study of ORG-129 in Healthy Volunteers

Healthy Volunteers

Spain
Air Liquide SA

Terminated

General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.

Anaesthesia

United Kingdom, France, Germany
Xenon Pharmaceuticals Inc.
Worldwide Clinical Trials

Recruiting

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

Focal Onset Seizures

United States, Spain, Italy, Croatia, Portugal, Poland, Chile, Argentina, Austria, Czechia
Xenon Pharmaceuticals Inc.
Worldwide Clinical Trials

Recruiting

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE2)

Focal Onset Seizures

United States, Spain, Australia, Poland, Canada, Bulgaria, Italy, United Kingdom
The S.N. Fyodorov Eye Microsurgery State Institution

Recruiting

RELIEF OF PSYCHOEMOTIONAL STRESS USING XENON SEDATION

Anxiety | Xenon | Anesthesia | Psychological Stress

Russian Federation
Children's Hospital Medical Center, Cincinnati
National Institutes of Health (NIH)

Recruiting

Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics (OSA-MRI)

Obstructive Sleep Apnea

United States
Agomab Spain S.L.

Completed

Relative Bioavailability and Effect of Food Study With AGMB-129 in Healthy Participants

Healthy Volunteers

Belgium
University of Kansas Medical Center
Johns Hopkins University; M.D. Anderson Cancer Center; Baylor College of Medicine and other collaborators

Recruiting

Hyperpolarized 129Xe MRI Lung Health Cohort (XeLHC)

Healthy

United States
Agomab Spain S.L.

Recruiting

STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn's Disease

Fibrostenotic Crohn's Disease

United States, Italy, Poland, Spain, Denmark, Austria, Canada, Germany
Xenon Pharmaceuticals Inc.

Completed

A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder (X-NOVA)

Major Depressive Disorder

United States
Xenon Pharmaceuticals Inc.

Completed

A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel

Acne Vulgaris

Canada
Xenon Pharmaceuticals Inc.

Completed

Single and Multiple Ascending Dose Safety Study of XPF-001 in Healthy Volunteers

Healthy Human Volunteers

Canada
The Hospital for Sick Children

Terminated

Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation (RILI)

Radiation Induced Lung Injury (RILI)

Canada
Xenon Pharmaceuticals Inc.

Terminated

An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE (EPIK-OLE)

Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Epilepsy | Epileptic Syndromes | Disease | Epilepsy; Seizure | Epilepsy in Children

United States, Australia, Belgium
Xenon Pharmaceuticals Inc.

Completed

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of XEN901

Healthy Volunteers

United Kingdom
Xenon Pharmaceuticals Inc.

Completed

Safety, Tolerability, Pharmacokinetics and Effects on Transcranial Magnetic Stimulation of Oral Doses of XEN1101

Healthy Male Volunteers

United Kingdom
Xenon Pharmaceuticals Inc.

Completed

Phase 2a, Exploratory Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of XPF-002 in Patients With Primary/Inherited Erythromelalgia

Inherited Erythromelalgia | Primary Erythromelalgia

United States
Xenon Pharmaceuticals Inc.

Completed

Study of XPF-001 in the Treatment of Pain From Primary/Inherited Erythromelalgia (IEM)

Inherited Erythromelalgia | Primary Erythromelalgia

Netherlands
Thunder Bay Regional Health Research Institute
Lakehead University; St. Joseph's Care Group; Thunder Bay Regional Health Sciences...

Recruiting

Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Bronchiectasis | Chronic Obstructive Pulmonary Disease | Asthma | Obstructive Sleep Apnea | Emphysema | Pulmonary Fibrosis | Lung Cancer | Cystic Fibrosis | Mesothelioma | Pulmonary Hypertension | Interstitial Lung Disease | Pulmonary Embolism | Lung Resection | Lung Transplant | Seasonal Allergies | Lung Infection | Asbes... and other conditions

Canada
Centre Hospitalier Universitaire de Nīmes

Completed

Anesthesia for Obese Patients: Desflurane Versus Xenon (XENON)

Obesity

France
Betta Pharmaceuticals Co., Ltd.

Recruiting

Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors

Head and Neck Cancer | Colorectal Cancer | Non-Small Cell Lung Cancer | Solid Tumor

China
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Lenalidomide Maintenance in Plasma Cell Myeloma

Plasma Cell Myeloma

United States
Five Eleven Pharma, Inc.

Completed

Initial Investigation of [18F]P16-129 in Alzheimer's Disease Patients and Healthy Volunteers

Alzheimer Disease

United States
University of Kansas Medical Center
American Heart Association

Recruiting

Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

United States
University of Kansas Medical Center

Active, not recruiting

Hyperpolarized 129Xe MRI of Survivors of COVID-19

Covid19

United States
Bastiaan Driehuys

Recruiting

Xenon MRI Pulm Hypertension (Jupiter PH)

Pulmonary Arterial Hypertension | Pulmonary Hypertension

United States
Children's Hospital Medical Center, Cincinnati
University of Iowa; University of Virginia; University of Kansas

Recruiting

BEGIN Novel ImagiNG Biomarkers (BEGINNING)

Cystic Fibrosis

United States
Xenon Pharmaceuticals Inc.

Terminated

XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy (EPIK)

Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Epilepsy | Epileptic Syndromes | Disease | Epilepsy; Seizure | Epilepsy in Children

United States, Spain, Australia, Belgium, Italy
Xenon Pharmaceuticals Inc.

Completed

Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of XEN1101.

Healthy Volunteers

United Kingdom
Xenon Pharmaceuticals Inc.

Completed

Single-dose Mass Balance Recovery and Metabolite Profile and Identification of 14C-XEN1101

Healthy Volunteers

United Kingdom
Xenon Pharmaceuticals Inc.

Completed

A Crossover Study to Evaluate the Safety, Tolerability and Efficacy of XPF-002 in Subjects With Postherpetic Neuralgia (PHN) (XEN402)

Postherpetic Neuralgia

United States
Xenon Pharmaceuticals Inc.

Completed

Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction

Dental Pain

United States
Oxford University Hospitals NHS Trust
University of Sheffield; National Institute for Health Research, United Kingdom

Completed

Regional Lung Imaging Using Hyperpolarized Xenon Gas

Lung Disease

United Kingdom
Xenon Pharmaceuticals Inc.
Worldwide Clinical Trials

Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures (X-ACKT)

Primary Generalized Tonic-Clonic Seizures

United States, Australia, Spain, United Kingdom, Bulgaria, Poland, Czechia, Canada, Portugal, Croatia, Italy
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI

Cystic Fibrosis

United States
Foundation for Innovative New Diagnostics, Switzerland
The National Center for Disease Control and Public Health; Health Research...

Completed

Evaluation of HCV Viremia Testing Approaches Among PWID in Georgia (HEAD-Start)

Hepatitis C, Chronic

Georgia
Papworth Hospital NHS Foundation Trust
University of Sheffield

Suspended

Hyperpolarized Xenon Imaging in Patients With Cystic Fibrosis

Cystic Fibrosis

United Kingdom
Mario Castro, MD, MPH

Recruiting

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Asthma | Cystic Fibrosis | Pulmonary Hypertension | Interstitial Lung Disease | COPD | Pulmonary Infection | Other Lung Disease

United States
Air Liquide Santé International

Completed

Sympathetic Neural Outflow During Xenon Anesthesia in Humans

Sympathetic Nervous System

Germany
Swiss Federal Institute of Technology
University Hospital, Zürich; Swiss Federal Food Safety and Veterinary Office

Completed

Iodine-129 Tracer Method for Investigating Human Iodine Metabolism

Healthy Volunteers

Switzerland
Xemed LLC
Washington University School of Medicine; National Heart, Lung, and Blood Institute... and other collaborators

Completed

Bronchial Thermoplasty for Severe Asthmatics Guided by HXe MRI (HXe-BT)

Asthma

United States
Cyclomedica Australia PTY Limited

Terminated

A Comparison of Technegas and Xenon-133 Planar Lung Imaging in Subjects Referred for Ventilation Scintigraphy

Lung Structure Determination

United States
Oxford University Hospitals NHS Trust
National Institute for Health Research, United Kingdom

Completed

Hyperpolarized Xenon Gas MR Imaging in NSCLC Radiotherapy

Non-small Cell Lung Cancer

United Kingdom
RWTH Aachen University
Air Liquide Santé International

Completed

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia (XABP)

Postoperative Nausea | Postoperative Vomiting | Depth of Anaesthesia | Anaesthetics Gases, Xenon | Anaesthetics Volatile, Sevoflurane

Germany
McMaster University
Foresee Pharmaceuticals Co., Ltd.

Recruiting

Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum

Emphysema

Canada
Bastiaan Driehuys
Regeneron Pharmaceuticals

Withdrawn

Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN)

Pulmonary Artery Hypertension
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Assessment of New Magnetic Resonance Imaging (MRI) Pulse Sequences for Imaging Hyperpolarised Xenon in Lung, Heart and Brain in Volunteers

Healthy Volunteers

United Kingdom
University of North Carolina, Chapel Hill
Cystic Fibrosis Foundation

Completed

Comparison of 129Xe MRI With 19F MRI in CF Lung Disease

Cystic Fibrosis

United States
Beijing Anzhen Hospital

Unknown

Xenon Against Postoperative Oxygen Impairment

Acute Lung Injury

China

Search clinical trials for: hyperpolarized xenon-129

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