Latest Trials

Total 21380 results

Beth Israel Deaconess Medical Center
University of Stellenbosch

Recruiting

Testing Health Workers At Risk to Advance Our Understanding of TB Infection (THWART-TB)

Tuberculosis | Tuberculosis Infection

South Africa
NYU Langone Health
JOHN E FOGARTY INTERNATIONAL CENTER FOR ADVANCED STUDY IN THE HEALTH SCIENCES...

Not yet recruiting

E-cigarette Harm Reduction Among PLWHA in South Africa

Tobacco Smoking

South Africa
University College, London
London School of Hygiene and Tropical Medicine; Radboud University Medical... and other collaborators

Recruiting

Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB (PARADIGM4TB)

Pulmonary Tuberculosis

South Africa
Professor Francois Venter
Merck Sharp & Dohme LLC; Africa Health Research Institute

Recruiting

A Randomised, Phase 3 Non-inferiority Study of DOR/3TC/TDF Compared to DTG/TAF/FTC in Participants Infected With HIV-1 Starting First-line Antiretroviral Therapy (Opti-DOR)

HIV-1-infection

South Africa
Shabir Madhi

Not yet recruiting

Pertussis Vaccination Among HIV-infected and HIV-uninfected Pregnant Women

dTap Vaccine

South Africa
New York State Psychiatric Institute
National Institute of Allergy and Infectious Diseases (NIAID); Columbia University and other collaborators

Recruiting

Effectiveness and Cost-Effectiveness of Depression Treatment for Individuals With TB in South Africa

Depression | Tuberculosis

South Africa
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Obesogenic Origins of Maternal and Child Metabolic Health Involving Dolutegravir (ORCHID)

Obesity | HIV | Maternal Obesity During Childbirth | Maternal Obesity Complicating Pregnancy | Obesity, Infant

South Africa
Columbia University
National Institute of Mental Health (NIMH); University of Cape Town

Recruiting

A Randomized Trial of ImpACT+, a Coping Intervention for HIV Infected Women With Sexual Trauma in South Africa (ImpACT+)

HIV | Trauma Exposure

South Africa
Brown University

Completed

Schools Championing Safe South Africa

Prevention or Reduction of HIV Risk Behavior | Prevention or Reduction of Intimate Partner Violence

South Africa
Wits Health Consortium (Pty) Ltd
Discovery Vitality

Active, not recruiting

The Vitality Mammography Messaging Study (VMS)

Breast Cancer Female

South Africa
University of Witwatersrand, South Africa

Active, not recruiting

A Cross-sectional, Observational Study to Characterise Long COVID-19 in an Urban Sample of South African Adults (ChaLOC)

Long COVID

South Africa
Johns Hopkins University
National Institute of Allergy and Infectious Diseases (NIAID); University of...

Completed

Prevent TB: Choice Architecture for TPT Delivery

HIV/AIDS | Tuberculosis

South Africa
University of California, Los Angeles
Gilead Sciences; University of Cape Town; Desmond Tutu HIV Foundation

Completed

PK of TAF and TDF for PrEP in Pregnant and Postpartum Women (PrEP-PP PK)

Hiv

South Africa
Vanderbilt University Medical Center
National Institute of Mental Health (NIMH)

Completed

Traditional Healer-initiated HIV Counseling and Testing in South Africa

HIV Infection

South Africa
University of California, Los Angeles
University of Cape Town; Desmond Tutu HIV Foundation

Completed

Evaluation of Pre-exposure Prophylaxis Cascade in Pregnant and Breastfeeding Women in Cape Town (Formative Study) (PrEP-PP)

Hiv

South Africa
GlaxoSmithKline

Completed

An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis

Tuberculosis

South Africa
Cryonove Pharma
CEISO; Dermatech

Completed

Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Post-inflamamatory Hyperpigmentation (PIH).

Post-inflammatory Hyperpigmentation

South Africa
Wits Health Consortium (Pty) Ltd
Discovery Vitality

Active, not recruiting

Testing the Effectiveness of Different Messaging Approaches to Increase Doctor Visits Amongst Individuals With Risk Factors for Diabetes

Type 2 Diabetes | Pre-diabetes

South Africa
The Aurum Institute NPC
Johns Hopkins University; University of California

Completed

Safety Tolerability DDI Short Course Treatment of LTBI Infection With High-dose Rifapentine and Isoniazid or Standard Isoniazid Preventive Therapy in HIV+ Patients (DOLPHIN & DOLPHIN TOO) (IMPAACT4TB)

HIV Infections | Respiratory Tract Infections

South Africa
PATH
Bill and Melinda Gates Foundation; Children's Hospital Medical Center, Cincinnati and other collaborators

Completed

Mixed Schedule Study of Live Oral Rotavirus Vaccines and Trivalent P2-VP8 Subunit Rotavirus Vaccine

Rotavirus Vaccine

South Africa
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Withdrawn

Evaluation of Six-month HIV Treatment Dispensing in South Africa

HIV

South Africa
University of Pennsylvania
Bill and Melinda Gates Foundation; Wits Reproductive Health and HIV Institute

Completed

Incentives to Promote Sustained Linkage to HIV Care

HIV/AIDS | Human Immunodeficiency Virus

South Africa
University of Witwatersrand, South Africa
SynaVir

Completed

Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19 (DuACT)

Covid19 | SARS-CoV Infection

South Africa
University of California, Los Angeles

Active, not recruiting

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

Nutrition Disorders | HIV | Fetal Alcohol Syndrome

South Africa
University of Pretoria

Completed

A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT) (AHAvsSIM)

Supra-ventricular Tachycardia

South Africa
Boston University
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Completed

Non-Communicable Diseases and Antiretroviral Therapy Outcomes in the RapIT Study Population (RapIT-NCD)

Cardiovascular Diseases | Diabetes Mellitus, Type 2 | Antiretroviral Therapy, Highly Active

South Africa
Rigshospitalet, Denmark

Completed

Feasibility and Usability of Intraoperative Fluorescent Angiography With Indocyanine Green in Penetrating Abdominal Trauma

Abdominal Injuries

South Africa
Duke University
National Institute of Mental Health (NIMH); University of Cape Town

Completed

Improving the Health of South African Women With Traumatic Stress in HIV Care (ImpACT)

HIV | Trauma Exposure

South Africa
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Latency and Early Neonatal Provision of Antiretroviral Drugs Clinical Trial (LEOPARD)

HIV

South Africa
University of Witwatersrand, South Africa

Unknown

Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine (MV/VV/Hep-AV)

Measles | Hepatitis A | Varicella

South Africa
University of Witwatersrand, South Africa
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Completed

Effectiveness of a Pre-adolescent Inter-generational Intervention to Address HIV and Obesity

Obesity | Hiv

South Africa
Harvard School of Public Health (HSPH)
University of Heidelberg Medical Center; University of Witwatersrand, South...

Unknown

Home HIV Testing for Older Adults in South Africa (Test@Home)

HIV Infections | Knowledge, Attitudes, Practice

South Africa
University of California, San Francisco
National Institutes of Health (NIH); ANOVA Health Institute

Completed

Peer Navigation to Improve Engagement in Care for HIV-Positive Men Who Have Sex With Men in Ehlanzeni, South Africa

Hiv

South Africa
University of North Carolina, Chapel Hill
University of Pretoria; SADC Research Centre

Completed

Impact Evaluation of a School-Based Sexuality and HIV Prevention Education Activity in South Africa

HIV Infections | Pregnancy Related | HSV-2 Infection

South Africa
Aeras
Sanofi Pasteur, a Sanofi Company; Statens Serum Institut; HIV Vaccine Trials...

Completed

Safety and Immunogenicity Study of BCG, H4:IC31, and H56:IC31 Revaccination in Healthy Adolescents

Tuberculosis

South Africa
The Aurum Institute NPC
London School of Hygiene and Tropical Medicine; Johns Hopkins University; Aurum...

Completed

Evaluation of the Effect of 3HP vs Periodic 3HP vs 6H in HIV-Positive Individuals (WHIP3TB)

HIV | Tuberculosis

South Africa
BioGaia AB

Completed

Evaluation and Comparison of 2 Cosmetic Investigational Products in Adults With Atopic Dermatitis

Atopic Dermatitis

South Africa
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Innovations in HIV Testing (TI)

Human Immunodeficiency Virus

South Africa
Chris Hani Baragwanath Academic Hospital

Terminated

High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis

Bronchiolitis, Viral

South Africa
National Institute of Environmental Health Sciences...

Completed

Study of DDT and Loss of Clinically-Recognized Pregnancies in South Africa

HIV Infections | Malaria | Pregnancy Outcome | Stillbirth | Spontaneous Abortion

South Africa
Medicines for Malaria Venture
University of Cape Town

Completed

Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers

Malaria

South Africa
University of California, Los Angeles
University of Cape Town

Completed

Contingency Management for Meth in South Africa Methamphetamine Abuse in South Africa

Methamphetamine Abuse

South Africa
Desmond Tutu HIV Centre

Unknown

A Study to Evaluate the Acceptability and Preference for Contraceptive Options as Proxy for HIV Prevention Methods (UChoose)

HIV

South Africa
Radboud University Medical Center
European and Developing Countries Clinical Trials Partnership (EDCTP); Department... and other collaborators

Completed

Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB (HR1)

Pulmonary Tuberculosis (TB)

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Phase 2a EBA Trial of AZD5847

Tuberculosis

South Africa
University of Witwatersrand, South Africa
University of Colorado, Denver; Emory University; Bill and Melinda Gates Foundation

Completed

Influenza Vaccine Trial in HIV Uninfected Pregnant Women (MatfluHIVneg)

Influenza

South Africa
Medtronic BRC

Completed

Respiration Patterns With Impedance in LINQ (EPIQ)

Breathing Exercises

South Africa
FHI 360
Foundation for Professional Development; Future Families

Completed

Evaluation of an Integrated Economic Strengthening and HIV Prevention Program for Vulnerable Youth in South Africa (ASPIRES)

HIV Infections | HIV

South Africa
Wellcome Trust Liverpool Glasgow Centre for Global...
Professor David Lalloo; Professor Hamish Simpson; Professor William J Harrison; Professor Sithombo Maqungo

Unknown

HIV in Orthopaedic Skeletal Trauma Study (HOST)

Fracture Healing in HIV-positive Patients

South Africa
University of Witwatersrand, South Africa
Department for International Development, United Kingdom; Medical Research... and other collaborators

Unknown

Multilevel Intervention for Preventing Men's Use of Violence in Urban South Africa (Sonke CHANGE Trial) (Sonke CHANGE)

Domestic Violence | Masculinity | Sexual Assault and Rape

South Africa

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