Search clinical trials for: pragmatic trials

Total 10374 results

Bayer

Recruiting

A Study to Learn About How Much Emodepside Gets Absorbed in the Blood and How Food Affects Its Absorption When Given as a New Type of Tablet to Healthy Participants

Soil-transmitted Helminth Infection | Onchocerciasis (River Blindness)

Germany
GlaxoSmithKline

Not yet recruiting

A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Moderate to Severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

United States
Children's University Hospital Cologne, Germany
University of Cologne; University of Geneva, Switzerland; The Clinical Trials...

Not yet recruiting

Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders (ZINCGNAO1)

Epilepsy | Dystonia | Development Delay | GNAO1 | Developmental and Epileptic Encephalopathy 17 | Neurodevelopmental Disorder With Involuntary Movements | Choreoathetosis
GlaxoSmithKline

Recruiting

A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE) (BE-EARLY)

Systemic Lupus Erythematosus

United States, Brazil, Mexico, Portugal, Spain, Argentina, France, Germany, Greece, Italy, Japan
Celgene

Recruiting

A Study to Evaluate the Safety, Tolerability, and Drug Levels of Orally Administered BMS-986368 in Healthy Participants, Healthy Elderly Participants, and Healthy Participants of Japanese Ethnicity

Healthy Participants

United States
Mayo Clinic

Recruiting

Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Mayo Clinic

Recruiting

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

Soft Tissue Sarcoma | Bone Sarcoma

United States
Aliada Therapeutics

Recruiting

A Phase 1 Trial to Assess Safety, Tolerability and Pharmacokinetics of ALIA-1758 in Healthy Participants

Alzheimer Disease

United States
St. Joseph's Healthcare Hamilton
University Health Network, Toronto; University of British Columbia; McGill University and other collaborators

Recruiting

An Innovative Master Platform for Clinical Trials in Mood Disorders (ENABLE)

Depressive Disorder | Mood Disorders | Bipolar and Related Disorders

Canada
ETS Wound Care, LLC
Professional Education and Research Institute

Recruiting

Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers (BGWM)

Diabetic Foot | Diabetic Foot Ulcer | Ulcer Foot

United States
GlaxoSmithKline

Not yet recruiting

Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Patient-derived Organoids and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)

Lung Cancer, Non-Small Cell

United Kingdom
University of North Carolina, Chapel Hill
American Diabetes Association

Not yet recruiting

Pragmatic Delivery of Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes (ChargeUp)

Diabetes Mellitus | Diabetes Mellitus, Type 1 | Diabetes type1 | Distress, Emotional | Diabetes, Autoimmune

United States
University of North Carolina, Chapel Hill
American Diabetes Association

Not yet recruiting

Pilot of Pragmatic Delivery of Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes (ChargeUp)

Diabetes Mellitus | Diabetes Mellitus, Type 1 | Diabetes type1 | Distress, Emotional | Diabetes, Autoimmune

United States
Bayer

Recruiting

A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Chronic Kidney Disease | Hepatic Impairment

United States
Mayo Clinic

Not yet recruiting

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage 0 Breast Cancer AJCC v8 | Breast Adenocarcinoma | Estrogen Receptor-Positive Breast Carcinoma | Progesterone Receptor-Positive Breast Carcinoma

United States
Fusion Pharmaceuticals Inc.

Recruiting

FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC) (AlphaBreak)

Metastatic Castration-resistant Prostate Cancer

United States
Regeneron Pharmaceuticals

Not yet recruiting

An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting (SPECTRUM-US)

Visual Impairment | Diabetic Macular Edema (DME) | Neovascular Age-related Macular Degeneration (nAMD) | Wet Age-related Macular Degeneration (AMD)
Children's National Research Institute
Steven & Alexandra Cohen Foundation; Clinical Trials Network for Lyme and Other...

Recruiting

Navigating Pregnancy and Parenthood With Lyme Disease

Pregnancy Complications | Parenting | Tick-Borne Diseases | Lyme Disease | Chronic Lyme Disease | Tick-Borne Infections | Post Treatment Lyme Disease

United States
Heidelberg Engineering GmbH

Recruiting

The Heidelberg Engineering ANTERION Software Comparison Precision and Agreement Study

Eyes With Normal Anterior Segment | Eyes With Abnormal Anterior Segment

United States
Western University, Canada
Unity Health Toronto; Lawson Health Research Institute; Queen Elizabeth II Health...

Not yet recruiting

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity | Chronic Kidney Disease

Canada
Mayo Clinic

Not yet recruiting

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Summit Therapeutics
Akeso

Recruiting

Phase III Study of AK112 for NSCLC Patients

Non-Squamous Non-small Cell Lung Cancer

Canada, United States, Spain, Italy, France, United Kingdom
Pelage Pharmaceuticals, Inc.

Recruiting

Safety, Pharmacokinetics and Efficacy of PP405 in Adults With AGA

Androgenetic Alopecia

United States
Canadian Cancer Trials Group

Not yet recruiting

Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy for Painful Non-Spine Bone Metastases

Cancer Metastatic
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies

Glioma

United States
Novo Nordisk A/S

Not yet recruiting

A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Obesity

United Kingdom, Germany, Canada, United States, France
Mayo Clinic

Recruiting

DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Metastatic Breast Cancer Patients

Metastatic Breast Cancer | HER2-negative Breast Cancer | Hormone-receptor-positive Breast Cancer

United States
GlaxoSmithKline

Recruiting

A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above

Respiratory Syncytial Virus Infections

United States, Canada, Japan, Germany, Australia, South Africa
Mayo Clinic

Recruiting

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

Localized Prostate Carcinoma | Stage I Prostate Cancer AJCC v8 | Stage II Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Oligometastatic Prostate Carcinoma

United States
Karolinska Institutet
Region Stockholm; Danderyd Hospital

Recruiting

Electronic Decision-support System to Improve Detection and Care of Patients With Chronic Kidney Disease in Stockholm (ALMA-CKD)

Chronic Kidney Diseases

Sweden
Mayo Clinic

Recruiting

Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma

Indolent B-Cell Non-Hodgkin Lymphoma | Recurrent Indolent Non-Hodgkin Lymphoma | Refractory Indolent Non-Hodgkin Lymphoma | Recurrent Indolent B-Cell Non-Hodgkin Lymphoma | Refractory Indolent B-Cell Non-Hodgkin Lymphoma

United States
Tolmar Inc.
ICON plc

Recruiting

A Phase 4 Study to Evaluate Adrenal Function in Hypogonadal Men Treated With JATENZO® for 12 Months

Hypogonadism

United States
Eli Lilly and Company

Recruiting

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity

United States, Australia, Italy, Hungary, Spain, Canada, Germany, Argentina, Belgium, Czechia, Greece, Israel, Austria, Brazil, Mexico, Netherlands, Romania, India, United Kingdom, Slovakia, Poland, Turkey, Puerto Rico, France, Denmark
Regeneron Pharmaceuticals

Not yet recruiting

Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC)

Cutaneous Squamous Cell Carcinoma
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

A Study to Evaluate Pregabalin in Painful Diabetic Peripheral Neuropathy

Painful Diabetic Neuropathy
Tufts Medical Center
University of California, Los Angeles; The Cleveland Clinic; Boston Medical Center and other collaborators

Not yet recruiting

Remote Tai Chi for Knee Osteoarthritis (TAICHIKNEE)

Knee Osteoarthritis

United States
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
Mayo Clinic

Recruiting

Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)

Recurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate Carcinoma

United States
Regeneron Pharmaceuticals
Intellia Therapeutics

Not yet recruiting

A Trial to Learn if REGV131-LNP1265 is Safe and Works to Help the Body Make Clotting Factor in Pediatric, Adolescent and Adult Patients With Hemophilia B (BEYOND-9)

Hemophilia B
Shanghai JMT-Bio Inc.

Not yet recruiting

JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Exon 20ins Mutations

Local Advanced or Metastatic NSCLC
JHSPH Center for Clinical Trials
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

Multi-Center Clean Air Randomized Controlled Trial in COPD (Clean Air)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Bayer

Recruiting

A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United States
Mayo Clinic

Recruiting

Remote Cognitive Assessment Battery and Wearable Device Monitoring Platform While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

Malignant Brain Neoplasm

United States
Brigham and Women's Hospital

Not yet recruiting

Time-limited Trials in the Emergency Department

Emergencies

United States
Amgen

Recruiting

A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma

Asthma

United States
IRCCS San Raffaele

Not yet recruiting

The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them (FRAME)

Schizophrenia; Psychosis
Closed Loop Medicine
Pharmanovia

Recruiting

Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment (OptiZest)

Uncomplicated Hypertension

United Kingdom
GlaxoSmithKline

Recruiting

A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a COVID-19 mRNA Vaccine in Adults Aged 50 Years and Above

Respiratory Syncytial Virus Infections

Netherlands, Spain, Belgium, United States
Intra-Cellular Therapies, Inc.

Recruiting

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

Bipolar Depression

United States

Search clinical trials for: pragmatic trials

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