Clinical Trials Sponsored by Merck KGaA, Darmstadt, Germany

Total 491 results

Merck KGaA, Darmstadt, Germany

Completed

A Canadian Study Assessing the Utility of the Treatment Optimization Recommendations in Multiple Sclerosis (CanTOR)

Multiple Sclerosis, Relapsing-Remitting
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study of Multiple Sclerosis (MS) Patients Starting or Restarting Baseline Treatment With Interferon Beta 1a After the Use of Escalation Treatment With Mitoxantrone (RETURN)

Relapsing-Remitting Multiple Sclerosis
Merck KGaA, Darmstadt, Germany

Completed

Metabolic Endocrinology and Growth Hormone in Adults (MEGHA FRANCE)

Adult Growth Hormone Deficiency
Merck KGaA, Darmstadt, Germany

Terminated

TRUST Study: Raptiva ® in Hand & Foot Psoriasis (TRUST)

Chronic Plaque Psoriasis

Austria
Merck KGaA, Darmstadt, Germany

Completed

Study of Therapeutic Options for Subjects Discontinuing Efalizumab and Experiencing Disease Recurrence

Psoriasis
Merck KGaA, Darmstadt, Germany

Completed

Study To Evaluate The Immunogenicity And Safety Of r-hIFN Beta-1a (Rebif®) Using Clone 484-39 In Multiple Sclerosis

Relapsing Remitting Multiple Sclerosis
Merck KGaA, Darmstadt, Germany

Completed

EMD 640 744 in Montanide ISA 51 VG Administered in Subjects With Advanced Solid Tumors

Advanced Solid Tumors
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study to Examine the Patients With Isolated Systolic Hypertonia (ISH) Under Therapy With Eneas® (NIS ENEAS ISH)

Hypertension
Merck KGaA, Darmstadt, Germany

Completed

Safety Study of EMD 72000 in Combination With ECX (Epirubicin, Cisplatin and Capecitabine) in Oesophagogastric Cancer

Gastric Cancer | Esophageal Cancer

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

Investigation of a Long-Acting Follicle Stimulating Hormone in Infertile Women Undergoing Assisted Reproductive Technology (ART)

Infertility

United States
Merck KGaA, Darmstadt, Germany

Terminated

AS900672-Enriched in Ovulation Induction

Ovulation Induction

Switzerland
Merck KGaA, Darmstadt, Germany

Completed

Pharmacokinetics in Subjects With Renal Impairment

Renal Impairment

Germany
Merck KGaA, Darmstadt, Germany

Completed

Observational Study With Prospective and/or Retrospective Follow-up, Without Modifying Patient Treatment and Follow-up Practices for the Initial Treatment of Hypothyroidism in France (ORCHIDEE)

Hypothyroidism

France
Merck KGaA, Darmstadt, Germany

Completed

AS703569 and Gemcitabine Combination in Advanced Malignancies

Pancreatic Cancer

Belgium, France
Merck KGaA, Darmstadt, Germany

Terminated

Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS] (RECYCLINE)

Multiple Sclerosis, Relapsing-Remitting

Denmark
Merck KGaA, Darmstadt, Germany

Completed

To Assess the Prevalence of Spasticity and the Impact on the Quality of Life in Multiple Sclerosis Patients

Multiple Sclerosis, Relapsing Remitting

Argentina
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2)

Malaria Infection

Kenya, Burkina Faso, Gambia, Zambia
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Chemoprophylactic Activity of M5717 in PfSPZ Challenge Model

Healthy

Netherlands
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Active, not recruiting

A Study to Learn About the Study Medicine (Called Avelumab) in People With Advanced Urothelial Cancer After Chemotherapy

Urothelial Cancer

United Kingdom
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Bioequivalence of 5 Tablets of 100 mg Versus 2 Tablets of 250 mg TF3 of Tepotinib

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

GXR RM China BE Study (Darmstadt - Jiangsu)

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites)

Healthy

China
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Pergoveris FD and Liquid China BE Study

Healthy

China
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Study of M5049 in Healthy Japanese and Caucasian Participants

Healthy

United Kingdom
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Enpatoran Human Mass Balance and Absolute Bioavailability Study

Healthy

Netherlands
Pfizer
Merck KGaA, Darmstadt, Germany

Active, not recruiting

A NON-INTERVENTIONAL STUDY ON AVELUMAB USE IN PATIENTS WITH ADVANCED OR METASTATIC UROTHELIAL CARCINOMA (AVENANCE)

Urothelial Carcinoma

France
Merck KGaA, Darmstadt, Germany
Pfizer

Approved for marketing

Expanded Access to Avelumab for Treatment of Metastatic Merkel Cell Carcinoma (mMCC)

Metastatic Merkel Cell Carcinoma

France
Sanofi
Merck KGaA, Darmstadt, Germany

Completed

A Safety and Efficacy Study of SAR405838 and Pimasertib in Cancer Patients

Neoplasm Malignant

Netherlands, France
Merck KGaA, Darmstadt, Germany
Merck Ltd.

Completed

A Korean Post-Marketing Surveillance Study On Pergoveris® (Follitropin Alfa + Lutropin Alfa)

Infertility

Korea, Republic of
Merck KGaA, Darmstadt, Germany
Merck Ltd.

Completed

Phase 4 Study to Assess the Effect of Bisoprolol on Glycemic Level in Type II Diabetic Subjects With Suboptimal Blood Pressure Control (GIANT)

Hypertension | Diabetes Mellitus, Type II

Korea, Republic of
Merck KGaA, Darmstadt, Germany
Merck Ltd.

Completed

An Active-controlled, Clinical Trial to Assess Central Hemodynamic Effects of Bisoprolol in Hypertensive Patients (Central Hemodynamic Assessment Measured in Patient With HypertensION [CHAMPION])

Hypertension

Korea, Republic of
Merck KGaA, Darmstadt, Germany
Merck Ltd.

Completed

Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients. (ABBA)

Chronic Heart Failure

Korea, Republic of
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

JAVEMACS: Japan AVElumab Maintenance And Continuous Treatment Study

Urothelial Carcinoma

Japan
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

M1774 Human Mass Balance Study (DDRIVER Solid Tumors 303)

Solid Tumor

Hungary
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Cladribine Tablets Level of Response Predictors in Clinical Practice (CLODINA)

Multiple Sclerosis

Greece, Czechia, Portugal, Belgium, Netherlands, Poland
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)

Acute Malaria

Burkina Faso, Gabon, Mozambique, Uganda
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Extension to the MAGNIFY MS Trial on Mavenclad® (Magnify MS Extension)

Multiple Sclerosis

United Kingdom, Germany, Finland, Israel, Spain, Canada, France, Australia, Czechia, Austria, Sweden, Poland, Hungary, Italy
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)

Multiple Sclerosis

Spain, France, Czechia, Slovakia, Italy, Hungary, Austria, Denmark, Netherlands, Poland
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Berzosertib Human Mass Balance Study (DDRiver Solid Tumors 208)

Advanced Solid Tumor

Hungary
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Effect of Hepatic Impairment on M2951 (BTK Inhibitor) PK

Hepatic Impairment

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Effect of Food on Peposertib PK

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Drug-drug Interaction Study of Evobrutinib With Midazolam in Healthy Participants

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Deflox Tablets Bioequivalence (BE) Trial

Healthy

Mexico
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers

Healthy

Mexico
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Bioequivalence of Two Formulations of Levothyroxine Sodium 200 Micrograms (mcg) Under Tablet Form

Healthy

Brazil
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Relative Bioavailability (rBA) of Evobrutinib Intended Commercial and Clinical Tablets, and Effect of Food on Intended Commercial Tablets

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)

Systemic Lupus Erythematosus

United States, Spain, China, Korea, Republic of, Argentina, Bulgaria, Chile, Greece, Japan, Mauritius, Mexico, Moldova, Republic of, Poland, South Africa, Australia, Colombia, Philippines, Serbia
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Study of M5049 in CLE and SLE Participants

Systemic Lupus Erythematosus | Cutaneous Lupus Erythematosus

Spain, Bulgaria, Germany, Moldova, Republic of, North Macedonia, Ukraine

Clinical Trials Sponsored by Merck KGaA, Darmstadt, Germany

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