Search clinical trials for: Intravenous to oral switch

Total 478258 results

Hoffmann-La Roche

Active, not recruiting

A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis (Ocarina II)

Relapsing Multiple Sclerosis | Primary Progressive Multiple Sclerosis

Spain, United States, Italy, Poland, Turkey, New Zealand, Czechia, Brazil
Maimonides Medical Center

Completed

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Analgesia | Depressive Symptoms | Major Depressive Disorder | Treatment Resistant Depression | Ketamine | Physiological Effects of Drugs | Analgesics, Non-Narcotic | Peripheral Nervous System Agents | Central Nervous System Depressants | Neurotransmitter Agents | Sensory System Agents | Anti-Inflammatory Agents and other conditions

United States
Jules Bordet Institute

Active, not recruiting

Neoadjuvant Regorafenib in Combination With Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer (REGINA)

Rectal Cancer Stage II | Rectal Cancer Stage III

Belgium, France
State University of New York at Buffalo
Gilead Sciences

Active, not recruiting

Bictegravir in the Elderly Living With HIV (BICEP)

HIV-1-infection

United States
National Institute on Alcohol Abuse and Alcoholism...

Completed

Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

Normal Physiology

United States
Arcus Biosciences, Inc.

Completed

Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile With Oral AB521 in Healthy Volunteers (ARC-14)

Healthy Participants

Netherlands
Stanford University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Comparison of Oral Ferrous Sulfate to Intravenous Ferumoxytol in Antepartum Iron Deficiency Anemia

Pregnancy Related | Anemia, Iron Deficiency

United States
Benha University

Completed

Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair

Inguinal Hernia Repair

Egypt
AbbVie

Completed

A Study to Assess Change in Patient Experience in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Venetoclax Tablets + Intravenous Rituximab or Bruton's Tyrosine Kinase Inhibitors Tablets in the United Kingdom (ELECTRIC)

Chronic Lymphocytic Leukemia

United Kingdom
Basilea Pharmaceutica
The Clinical Trials Centre Cologne

Completed

Safety and Pharmacokinetics of Intravenous and Oral APX001 in Patients With Acute Myeloid Leukemia (AML) and Neutropenia

Acute Myeloid Leukemia

Germany
Yale University

Completed

Switching to Potential Reduced Exposure Products in Adult Smokers (ZYN)

Tobacco Use Disorder | Carcinogenesis | Harm Reduction | Smoking Behaviors | Oral Nicotine Pouch Use | Toxic Effect of Tobacco and Nicotine

United States
Zuyderland Medisch Centrum

Enrolling by invitation

Switching From Intravenous to Subcutaneous Infliximab in Adult Patients With Inflammatory Bowel Disease (SHUFFLE)

Crohn Disease | Ulcerative Colitis | IBD | Infliximab

Netherlands
Pfizer

Completed

A Safety And Efficacy Study Of The Combination Of Oral PF-00299804 And Intravenous CP-751,871 Given Every 3 Weeks

Neoplasm Metastasis | Carcinoma, Non-Small Cell

United States, France, Spain
UCB Pharma

Completed

A Trial to Investigate the Safety, Tolerability and Pharmacokinetics of Intravenous SPM 927

Epilepsy
UCB Biopharma SRL

Terminated

A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures

Electroencephalographic Neonatal Seizures

Belgium, France, Germany, Ireland, United Kingdom, Czechia, Italy
Hospital for Special Surgery, New York
Mallinckrodt

Enrolling by invitation

IV vs Oral Acetaminophen in Spine Fusion Perioperative Care

Multimodal Analgesic Approach

United States
Amicus Therapeutics

Active, not recruiting

First-In-Human Study to Evaluate Safety, Tolerability, and PK of Intravenous ATB200 Alone and When Co-Administered With Oral AT2221

Pompe Disease

United States, Netherlands, United Kingdom, Australia, Germany, New Zealand
Epizyme, Inc.

Completed

Open-Label, Multi-Center, Two-Part, Ph1 Study to Characterize the PKs of an Intravenous Micro-Dose of [14C]-Tazemetostat (EPZ 6438) and the ADME of an Oral [14C]-Labeled Dose of Tazemetostat in Subjects With B-Cell Lymphomas or Adv Solid Tumors

Follicular Lymphoma | Marginal Zone Lymphoma | Advanced Solid Tumors | Mantle-Cell Lymphoma | Diffuse Large B Cell Lymphoma | Primary Mediastinal Lymphoma

United Kingdom
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients

Hematological Malignancy

United States
University of Washington

Active, not recruiting

Effect of Testosterone Treatment on Drug Metabolism and Transport

Transgender Persons

United States
Mansoura University

Active, not recruiting

Assessing the Clinical Utility of Adding Pentoxifylline to Neoadjuvant Chemotherapy Protocols in Breast Cancer Patients"

Breast Cancer Female

Egypt
OHSU Knight Cancer Institute
Oregon Health and Science University

Terminated

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Primary Myelofibrosis | Anemia | Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Anatomic Stage IV Breast Cancer AJCC v8 | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic... and other conditions

United States
University of Illinois at Urbana-Champaign
Carle Foundation Hospital

Terminated

Alcohol and Bariatric Surgery (ABS)

Obesity

United States
Alexandria University

Active, not recruiting

Effects on Recovery of Children of Intravenous Formulation of Fentanyl Citrate and Midazolam Orally for Premedication

Separation Anxiety

Egypt
AbbVie

Terminated

Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome

Acute Myeloid Leukemia (AML) | Myelodysplastic Syndrome (MDS)

United States, Australia, Germany, Israel, Italy, Japan, Spain
Henry Ford Health System

Completed

Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery

Blood Loss, Surgical | Blood Loss Anemia

United States
Arrevus Inc.
Arnasi Group

Completed

Oral ARV-1801 Given in Combination With Intravenous Ceftazidime or Meropenem for Treatment of Melioidosis in Hospitalized Patients

Melioidosis

Thailand
Stony Brook University

Completed

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Laparoscopic Sleeve Gastrectomy | Post-operative Nausea and Vomiting

United States
University Hospital, Basel, Switzerland

Completed

LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects (LSD-Bio)

Healthy

Switzerland
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

Phase I Dose Escalation Study of Intravenously Administered S64315 in Combination With Orally Administered Venetoclax in Patients With Acute Myeloid Leukaemia.

Acute Myeloid Leukaemia

France, United States, Australia
Reata, a wholly owned subsidiary of Biogen
Covance

Completed

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Healthy Adult Subjects

United States
University of Missouri-Columbia
University of Illinois at Urbana-Champaign

Terminated

Surgical Weight Loss and Alcohol Perception (SWAP)

Bariatric Surgery Candidate

United States
Antonios Likourezos

Completed

An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache

Pain

United States
Merck Sharp & Dohme LLC

Completed

Letermovir Treatment in Pediatric Participants Following Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) (MK-8228-030)

Cytomegalovirus (CMV) Infection

United States, Australia, Colombia, France, Germany, Israel, Japan, Mexico, Poland, Spain, Turkey
Auerbach Hematology Oncology Associates P C
AMAG Pharmaceuticals, Inc.

Completed

Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA)

Restless Legs Syndrome | Iron Deficiency Anemia

United States
Sobi, Inc.

Completed

Safety and Treatment Satisfaction in Adults With Chronic ITP After Switching to Avatrombopag From Eltrombopag or Romiplostim

Immune Thrombocytopenia

United States
Groupe d'Etude Therapeutique des Affections Inflammatoires...
Celltrion

Active, not recruiting

A 24-month Real Life PErsistence Efficacy and Safety Study in IBD Patients in REMission Switched From Intravenous Infliximab to Subcutaneous Infliximab CT-P13 Remsima®SC (PEREM)

Inflammatory Bowel Diseases

France
University of Washington

Completed

Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years

Dental Caries in Children | Hydroxyzine | Pediatric Dental Sedation | Meperidine | Midazolam

United States
Northwell Health

Withdrawn

Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial

Cancer of Head and Neck | Mucositis Oral | Pharyngeal Mucositis

United States
Mitsubishi Tanabe Pharma Corporation

Completed

Bioequivalence Study of Oral Suspension and Intravenous Formulation of Edaravone in Healthy Adult Subjects

Healthy Adult Subjects

Japan
Merck Sharp & Dohme LLC

Completed

Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104)

Invasive Aspergillosis

Belgium, United States, Greece, Hungary, Israel, Italy, Korea, Republic of, Mexico, Peru, Russian Federation
King's College London
Wellcome Trust; The Royal Society

Completed

Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk (BENZOGAP)

Prodromal Schizophrenia

United Kingdom
Children's Hospital of Fudan University
Second Affiliated Hospital of Wenzhou Medical University; Guangzhou Women and... and other collaborators

Terminated

Levetiracetam Treatment of Neonatal Seizures

Neonatal Seizures

China
University of Miami
Clarus Therapeutics

Completed

Patient Satisfaction After Switching to Oral Testosterone Undecanoate

Testosterone Deficiency

United States
Stanford University
Washington University School of Medicine; Duke University; University of Washington and other collaborators

Enrolling by invitation

Antibiotic Prophylaxis in Rhinoplasty

Nasal Obstruction | Nasal Surgical Procedures

United States
West Virginia University

Enrolling by invitation

Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT)

Skin and Soft Tissue Infection | Gastrointestinal Infection | Pulmonary Infection | Bone and Joint Infection | Endovascular Infection | Genitourinary Infection

United States
Hellenic Institute for the Study of Sepsis

Completed

Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia (ACCESS)

Sepsis | Mortality | Inflammatory Response | Biomarkers | SIRS | Community-acquired Pneumonia

Greece
National Cancer Institute (NCI)

Active, not recruiting

Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis

Gastric Cancer | Gastric Adenocarcinoma | Peritoneal Carcinomatosis | Esophagogastric Junction

United States
Vinay Badhwar

Enrolling by invitation

Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) (OPTIMAL)

Endocarditis

United States
Viatris Specialty LLC

Completed

Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience

Abuse Potential

United States

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