Search clinical trials for: QT interval prolongation

Total 2281 results

Celgene

Completed

A Phase I Study to Assess the Safety, Pharmacokinetics, and Potential Effects of Amrubicin on the QT/QTc Interval in Cancer Patients With Advanced Solid Tumors.

Advanced Solid Tumors

United States
Pfizer

Completed

A Study To Determine The Effect Of Single-dose PF-04965842 On QTc Interval In Healthy Volunteers Compared With Placebo and Moxifloxacin

Healthy Volunteers

Belgium
Entasis Therapeutics

Completed

Study Evaluating the Effect of ETX2514 on Cardiac Repolarization in Healthy Male or Female Volunteers

Acinetobacter Baumannii-calcoaceticus Complex Infections

United States
Mitsubishi Tanabe Pharma Corporation

Completed

A Study to Evaluate the Effect of MCI-186 at Therapeutic and Supra-Therapeutic Doses on the QT Interval(QT)/Corrected QT Interval(QTc) Interval in Healthy Subjects

Healthy Adult Subjects

Japan
Daiichi Sankyo, Inc.

Completed

The Effect of CS-3150 Exposure on Corrected QT (QTc) Interval Duration in Healthy Volunteers

Hypertension | Mineralocorticoid Receptor Antagonist

United States
University of Wisconsin, Madison
National Heart, Lung, and Blood Institute (NHLBI); Medical College of Wisconsin and other collaborators

Completed

Fetal and Neonatal Magnetophysiology

Long QT Syndrome | Fetal Arrhythmia | Abnormality in Fetal Heart Rate or Rhythm

United States
Tel-Aviv Sourasky Medical Center
Tel Aviv Medical Center

Completed

Effect of Grapefruit on QT Interval in Healthy Volunteers and Patients With Congenital Long QT Syndrome

Long QT Syndrome

Israel
Grünenthal GmbH

Completed

Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women

Prolonged QTc Interval | Pharmacokinetic

Germany
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Effect of MK-8669 (Ridaforolimus) on QTc Interval in Participants With Advanced Cancer (MK-8669-037)

Metastatic or Locally Advanced Cancer
Duzce University

Completed

The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA

Qt Interval, Variation in

Turkey
AstraZeneca
Quintiles, Inc.

Completed

Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer

Solid Tumours

United States
Yonsei University

Completed

The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability

Mandibular Retrognathism | Mandibular Prognathism

Korea, Republic of
Medicines Development for Global Health

Completed

Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers

QT Effects in Healthy Volunteers

United States
Pfizer

Completed

A Study to Evaluate the PF-06700841 Effect on QTc Interval in Healthy Volunteers

Healthy

Belgium
Yonsei University

Completed

The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval

Anesthesia, General

Korea, Republic of
Daiichi Sankyo, Inc.
Medpace, Inc.

Completed

Effect of Tivantinib on the QTC Interval in Cancer Subjects

Solid Tumors

United States
Yonsei University

Completed

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Robotic-assisted Laparoscopic Radical Prostatectomy

Korea, Republic of
Cassiopea SpA

Completed

A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart

Healthy Volunteers

United Kingdom
Samsung Medical Center

Completed

Clinical Study to Evaluate Effect on QT/QTc Interval After Multiple Dose of Celecoxib

Qt Interval, Variation in

Korea, Republic of
Copenhagen University Hospital at Herlev

Unknown

Drug-induced Repolarization ECG Changes

Depression | Pathologic Processes | Heart Diseases | Cardiovascular Diseases | Congenital Abnormalities | Death | Death, Sudden | Arrhythmias, Cardiac | ADHD | Heart Arrest | Heart Defects, Congenital | Cardiovascular Abnormalities | Genetic Disease | Death, Sudden, Cardiac | Psychiatric Disorder | Genetic Syndrome | Long... and other conditions

Denmark
Pfizer

Completed

A Study To Evaluate The Effect Of PF-04447943 On Qtc Interval In Healthy Adult Subjects

Healthy

United States
University of California, San Francisco

Terminated

The Relation of GnRH Treatment to QTc Interval in Transgender Females

Gender Dysphoria

United States
Akebia Therapeutics

Completed

Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers

Healthy Volunteers

United States
Janssen Scientific Affairs, LLC
Bausch Health Americas, Inc.; Cipher Pharmaceuticals Inc.

Completed

Study to Evaluate the Effects of Tramadol Hydrochloride on Cardiac Repolarization in Healthy Participants

Healthy

United States
Hamilton Health Sciences Corporation
The Physicians' Services Incorporated Foundation

Completed

Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients

Venous Thrombosis | Atrial Fibrillation | Heart Valve Diseases

Canada
Universiti Sains Malaysia

Completed

KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT)

Opioid Dependence | Methadone Toxicity | HERG Gene Mutation

Malaysia
Wockhardt

Completed

Evaluate the Effect of WCK 5222 on the QT/QTc Interval in Healthy Volunteers

QT/QTc Interval in Healthy Volunteers

United States
Royal Prince Alfred Hospital, Sydney, Australia
Merck Sharp & Dohme LLC

Completed

QT Interval Abnormalities in Sulfonylurea Treated Type 2 Diabetes: Relationship to Treatment Induced Hypoglycaemia

Diabetes Related Complications
Gilead Sciences

Terminated

Effect of Eleclazine on Shortening of the QT Interval, Safety, and Tolerability in Adults With Long QT Syndrome Type 3

Long QT Syndrome Type 3

United States, Germany, Canada, Netherlands, Italy, France, Israel, United Kingdom
TaiGen Biotechnology Co., Ltd.

Completed

A Study Evaluating the Effect of a Single-dose Oral Administration of Nemonoxacin Capsule on QTc Intervals and Heart Rhythms of Healthy Subjects and the Influence of Food Intake on QTc Intervals and Pharmacokinetic Characteristics

Healthy Volunteers
Jazz Pharmaceuticals

Completed

An Open Label Phase II Pharmacokinetic and Pharmacodynamic Assessment of the Potential for QTc Prolongation Following First Induction Treatment With CPX-351 (Cytarabine:Daunorubicin) Liposome Injection in Acute Leukemias and MDS Patients

Acute Myeloid Leukemia (AML) | Acute Lymphoblastic Leukemia (ALL) | Myelodysplastic Syndrome (MDS)

United States
Galera Therapeutics, Inc.
Syneos Health

Completed

A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers

Healthy | Healthy Volunteers

Australia
GlaxoSmithKline

Completed

VEG111485: A QTc Study of Pazopanib

Carcinoma, Renal Cell

United States
GlaxoSmithKline

Completed

A Study to Evaluate the Effect of Repeat Oral Dosing of GSK2118436 on Cardiac Repolarization in Subjects With V600 BRAF Mutation-Positive Tumors

Cancer

United States, Australia, United Kingdom
University of Southampton

Completed

Effect of Antenatal SSRI Exposure on the QT Interval of Neonates (SSRIs)

Qt Interval, Variation in | Adverse Effect of Selective Serotonin Reuptake Inhibitors

United Kingdom
Alexza Pharmaceuticals, Inc.

Completed

ADASUVE 2-dose Thorough QT/QTc Study

Healthy Volunteers

Netherlands
University of Michigan
Gilead Sciences

Completed

Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients

Cardiovascular Disease | End-stage Renal Disease

United States
Fuji Yakuhin Co., Ltd.

Completed

Clinical Pharmacology of FYU-981 (Effect on QT/QTc Interval)

Healthy

Japan
Pfizer

Completed

A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers

Healthy Male Volunteers

United States
Donald Krogstad
University of the Sciences, Techniques and Technologies of Bamako

Completed

Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)

Malaria

Mali
GlaxoSmithKline

Completed

Albiglutide Thorough ECG Study in Healthy Volunteers

Diabetes Mellitus, Type 2
Northwestern University

Completed

Evaluation of QTc Interval by Continuous Holter ECG Recording in Antipsychotic Drug-treated Patients With Schizophrenia

Schizophrenia | Bipolar Disorder | Schizoaffective
Assiut University

Unknown

Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients

Liver Cirrhosis
Genentech, Inc.

Withdrawn

A Study to Evaluate Corrected QT Interval From Clinical Studies Conducted With Bevacizumab

Carcinoma
Trevena Inc.

Completed

Study of the Effects of TRV130, at Therapeutic and Supra Therapeutic Doses, on QTc Intervals

Healthy

United States
Northwell Health
Gilead Sciences

Terminated

Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation

Hemorrhage | Ventricular Tachycardia | Atrial Fibrillation New Onset | Prolonged QTc Interval | Medical Care; Complications, Late Effect of Complications

United States
University of California, Los Angeles
National Institute of Nursing Research (NINR); Columbia University; University... and other collaborators

Completed

Home Electrocardiogram (ECG) Monitoring After Heart Transplantation (NEW HEART)

Cardiac Transplant Rejection | Qt Interval, Variation in

United States
Genentech, Inc.

Completed

A Study to Investigate the Effect of GDC-0449 on the QT/QTc Interval in Healthy Female Subjects

Healthy Volunteer
Poxel SA

Completed

Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects

Qt Interval, Variation in

United Kingdom
Cubist Pharmaceuticals LLC

Completed

Safety Study Designed to Study the Effects of Two Different Doses of CXA-101/Tazobactam, a Low Dose and a High Dose, on the QT/QTc Intervals in Healthy Subjects

Healthy

United States

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