Search clinical trials for: dose finding

Total 21559 results

Boehringer Ingelheim

Completed

An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 400/mm3)

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Procept

Completed

Safety and Tolerability of the Vaginal Gel PRO 2000/5

HIV Infections

United States
Alcon Research

Completed

Dose Response Study of AL-37807 Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
MedImmune LLC

Completed

Open-Label, Dose-Escalation Study of 2 to 5 IM Doses of MEDI-524 at 3 mg/kg or 15 mg/kg; Children to be Followed for 90 Days After Their Last Dose of MEDI-524

Respiratory Syncytial Virus Infections

Chile, Argentina
Academy Military Medical Science, China
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Unknown

A Randomised,Multi-Center Study of Docetaxol Plus Capecitabine or Cisplatin in Anthracycline-Pretreated Patients With Advanced Breast Cancer

Advanced Breast Cancer
OPKO Health, Inc.

Completed

Open Label Study for the Evaluation of Tolerability of Five Dose Levels of Cand5

Macular Degeneration

United States
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Docetaxel or Paclitaxel in Treating Women With Unresectable Locally Advanced or Metastatic Breast Cancer

Breast Cancer

France, Luxembourg
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Gemcitabine and Docetaxel in Treating Patients With Inoperable Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Lung Cancer

France
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Docetaxel and Oxaliplatin in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer

Ovarian Cancer

France
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Docetaxel and Epirubicin as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Adenocarcinoma of the Stomach

Gastric Cancer

France
Targacept Inc.

Completed

A Safety and Tolerability Single Ascending Dose Study in Healthy Volunteers (SRD)

Healthy

France
Hadassah Medical Organization
International Anesthesia Research Society (IARS)

Completed

Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction

Pre-Eclampsia | Fetal Growth Retardation

Israel
University of Cologne
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; German Hodgkin...

Terminated

Study of Bortezomib (Velcade) in Combination With Dexamethasone to Treat Patients With Relapsed Hodgkin's Lymphoma

Hodgkin Disease

Germany
YM BioSciences

Completed

Study of Single and Multiple Doses of Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Healthy Subjects (LEF-2495)

Healthy

Canada
Avant Immunotherapeutics

Completed

Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects

Typhoid Fever

United States
Pacgen Biopharmaceuticals Corporation
Quintiles, Inc.

Completed

Phase 2B Dose-Ranging Study of PAC113 Mouthrinse in HIV Seropositive Individuals With Oral Candidiasis

Oral Candidiasis

United States
AstraZeneca

Completed

Study to Investigate Safety, Tolerability and Pharmacokinetics of a Single Ascending Dose of AZD1704

Pain

United Kingdom
Novartis

Completed

Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.

Healthy

United States
Sanofi

Completed

Evaluate the Role of Adding Amaryl to Non-Insulin Dependent Diabetes Mellitus Patients Unresponsive to Maximum Dose Metformin & Thiazolidinedione

Diabetes Mellitus, Non-Insulin-Dependent

United States
GlaxoSmithKline

Completed

Immunogenicity and Safety of GSK Biologicals' HBV-MPL Vaccine (2 Doses), and of Engerix™-B (3 Doses) in Healthy Adults

Hepatitis B

Belgium
Orion Corporation, Orion Pharma

Terminated

PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding

Parkinson´s Disease

Finland
Assaf-Harofeh Medical Center

Unknown

Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance (TEG)

Acute ST SEgment Elevation Myocardial Infarction

Israel
Novartis
Novartis Vaccines

Completed

Evalution of Immunogenicity, Safety and Booster Response of a Rabies Vaccine Administered Concomitantly With Japanese Encephalitis Vaccine in Toddlers

Japanese Encephalitis | Rabies | Pre-Exposure Prophylaxis

Thailand
Herbert Irving Comprehensive Cancer Center

Completed

Study of High-Dose Melphalan and Autologous Stem Cell Transplantation in Patients With Primary Light Chain Amyloidosis

Amyloidosis

United States
University Hospital Freiburg

Completed

Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation

Hyperlipidemias | Hypopituitarism | Secondary Hypothyroidism

Germany
University of South Florida

Completed

MRI and Ultrasound Findings in Patients With Gout and Normal Plain Radiographs

Gout

United States
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study With Repeated Doses of Stalevo

Pharmacokinetics

Finland
AstraZeneca

Completed

Study to Investigate the Effects Single Oral Dose of AZD1386 (Capsaicin)

Capsaicin Evoked Pain | Heat Sensitivity
French National Agency for Research on AIDS and...
Aventis Pharmaceuticals

Completed

AIDS Vaccine Study Comparing Immunogenicity and Safety of 3 Doses of Lipopeptides Versus Placebo in Non Infected HIV Volunteers

HIV Infections

France
St. Justine's Hospital

Completed

Impact of Procalcitonin on the Management of Children Aged 1 to 36 Month Presenting With a Fever Without a Source

Bacteremia | Bacterial Infection | Procalcitonin | Fever Without Source

Canada
The Netherlands Cancer Institute
Erasmus Medical Center; Dutch Cancer Society

Completed

Radiotherapy for Prostate Cancer: Conventional Dose Versus High Dose

Prostatic Neoplasms

Netherlands
University of Vermont
Naval Medical Research Center; TD Vaccines A/S

Unknown

Campylobacter Jejuni Challenge Model Development: Dose Ranging Study

Campylobacter Infections

United States
Urologic Consultants of Southeastern PA

Unknown

A Study to Determine the Improvement of the Symptoms of Benign Prostatic Hyperplasia (BPH) When Switching Subjects From Proscar to Avodart

Benign Prostatic Hyperplasia

United States
Vanderbilt University

Completed

Interpretation of Transnasal Esophagoscopy Findings (TNE)

Larynx Disease

United States
University of California, San Francisco

Completed

Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus

Patent Ductus Arteriosus

United States
AstraZeneca

Completed

Study to Investigate Safety and Tolerability of a Single Dose of AZD6482

Antiplatelet Effect
Rigshospitalet, Denmark

Completed

Mycophenolate vs Azathioprin in Autoimmune Hepatitis

Autoimmune Hepatitis

Denmark
Jeroen Bosch Ziekenhuis

Unknown

Docetaxel - Carboplatin as Second Line Treatment in Patients With Small Cell Lung Cancer (DOCAR)

Small Cell Lung Cancer

Netherlands
Abbott

Completed

A Study to Evaluate the Safety and Effectiveness of Three Asoprisnil Doses in the Treatment of Women With Endometriosis

Endometriosis
Movetis

Completed

Efficacy and Safety Study of the Effect of Dose-Titration of Prucalopride for The Treatment of Chronic Constipation

Constipation
Hamilton Health Sciences Corporation
University Health Network, Toronto; Dartmouth-Hitchcock Medical Center; Ottawa... and other collaborators

Terminated

Strategies for Transfusion of Platelets (SToP)

Thrombocytopenia

United States, Norway, Canada
Mackay Memorial Hospital

Unknown

Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults

Airway Obstruction

Taiwan
University of Oulu
Bayer; Kuopio University Hospital; Tampere University

Completed

Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments

Pregnancy | Preeclampsia | Intrauterine Fetal Growth Restriction | Miscarriage Less Than 12 Gestational Weeks | Extrauterine Pregnancy

Finland
Medical University of Vienna
Polymun Scientific, Vienna, Austria

Completed

Recombinant Human Superoxide Dismutase (rhSOD) and Vascular Reactivity

Inflammation

Austria
Neosil, Inc.

Unknown

Dose-Ranging Efficacy Study of Topical NEOSH101 to Treat Male Pattern Hair Loss

Androgenetic Alopecia

Germany
University of California, San Francisco

Completed

A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose Naltrexone

Multiple Sclerosis

United States
LungenClinic Grosshansdorf

Unknown

Erlotinib Versus Carboplatin/Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) (TIE)

Non-Small Cell Lung Cancer

Germany
Shiraz University of Medical Sciences

Completed

Low Doses of Cholestyramine in the Treatment of Hyperthyroidism

Graves Disease

Iran, Islamic Republic of
GlycaNova Norge AS
Centre for clinical studies, Bergen, Norway

Unknown

Dose Escalation Safety Study of MM-10-001 in Healthy Subjects

Healthy

Norway
Danish Breast Cancer Cooperative Group
Sanofi; Hoffmann-La Roche

Unknown

Vinorelbine Plus (+) Trastuzumab vs Docetaxel Plus (+) Trastuzumab as 1 Line Treatment for HER2 Positive (+) Metastatic Breast Cancer

Breast Cancer

Denmark

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