Search clinical trials for: direct oral challenge

Total 24451 results

Sinew Pharma Inc.

Completed

A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study

Acetaminophen Toxicity

Taiwan
Insel Gruppe AG, University Hospital Bern

Completed

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial (ELAN)

Ischaemic Stroke

Belgium, Ireland, Israel, Germany, India, United Kingdom, Austria, Switzerland, Finland, Norway, Italy, Portugal, Slovakia, Japan, Greece
Bavarian Nordic
Emergent BioSolutions

Completed

Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera

Cholera

United States
VarmX B.V.

Completed

Study of Intravenous VMX-C001 in Healthy Subjects and in Combination With Selected Direct Oral Anticoagulants in Healthy Older Subjects

Coagulation Disorder

Netherlands
University of Maryland, Baltimore

Completed

GlideScope Versus Direct Laryngoscope for Emergency Intubation

Oral Intubation

United States
Monopar Therapeutics

Terminated

Clonidine HCl MBT vs. Placebo to Prevent Chemoradiotherapy-Induced Severe Oral Mucositis in Oropharyngeal Cancer. (VOICE)

Chemoradiotherapy-Induced Severe Oral Mucositis

United States, Spain, Germany, France, Puerto Rico
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Terminated

Safety and Efficacy of NF135 CPS Immunization (CPS135)

Malaria,Falciparum | Controlled Human Malaria Infection | Immunization; Infection

Netherlands
Regeneron Pharmaceuticals

Completed

Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants

Healthy Volunteer

United Kingdom
CHAD

Terminated

The Portuguese Survey on Anticoagulated Patients Register (START-Portugal-Register) (START-Portugal)

Atrial Fibrillation | Venous Thromboembolism | Heart Valve Diseases or Prosthesis

Portugal
SK Life Science, Inc.

Completed

A Randomized, Open-label, Three-way Crossover Study to Evaluate the Relative Bioavailability of 200 mg Cenobamate Administered Orally

Healthy Volunteers

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Avatar-Directed Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma

United States
Groupe Hospitalier Paris Saint Joseph

Completed

Interest of the Second Phase of the Oral Challenge Test in Patients With Suspected Long-standing Penicillin Allergy (PENI)

Allergy Penicillin

France
Groupe Maladies hémorragiques de Bretagne

Completed

Vitamin K Antagonist Versus Direct Oral Anticoagulant Treatments in Hemophilia (KADOAH)

Hemophilia A | Hemophilia B | Anticoagulant-induced Bleeding

France
National Cancer Institute (NCI)

Completed

Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

United States
Hacettepe University

Completed

Precision of Three Different Scanbodies Used for Direct Digitalization Technique

Prosthesis User | Digitalism

Turkey
Laval University

Withdrawn

DOAC Versus VKA After Cardiac Surgery (DOAC/VKA)

Anticoagulant-induced Bleeding

Canada
University of Florida
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Delineating Swallowing Impairment and Decline in ALS

Amyotrophic Lateral Sclerosis

United States
Arbor Pharmaceuticals, Inc.

Completed

An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension

Hypertension

United States, Brazil, Turkey, Poland, Mexico, Colombia, Italy, Argentina, Bulgaria, Hungary, South Africa, Ukraine
Cardioangiologisches Centrum Bethanien

Completed

Effectivity and Safety of Different Anticoagulants in Patients With Thromboembolic Antiphospholipid Syndrome

Venous Thromboembolism | Antiphospholipid Syndrome | Major Bleed | Arterial Thromboembolism

Germany
Mahidol University

Completed

Incidence of Compliance to the ASA Preoperative Fasting Guidelines in Elective Surgery

Compliance, Treatment

Thailand
Actelion

Completed

Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis (OPTIMUM)

Multiple Sclerosis

United States, Belarus, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Finland, France, Georgia, Germany, Greece, Hungary, Israel, Italy, Latvia, Lithuania, Mexico, Poland, Portugal, Romania, Russian Federation, Serbia, S... and more
University Hospital, Basel, Switzerland
Swiss Heart Foundation

Completed

Novel Oral Anticoagulants in Stroke Patients (NOACISP)

Ischemic Stroke | Intracranial Hemorrhages

Switzerland
University Hospital, Basel, Switzerland
University of Basel; Clinical Trial Unit, University Hospital Basel, Switzerland

Completed

Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients (MAAESTRO)

Stroke, Ischemic | Adherence, Patient

Switzerland
AstraZeneca

Completed

To Determine the Effect of Food on the Pharmacokinetics of Olaparib and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours

Solid Tumours

Denmark, Belgium, United Kingdom, Netherlands
University of California, San Francisco
Patient-Centered Outcomes Research Institute; Kaiser Permanente

Completed

Anticoagulation Length of ThErapy and Risk of New Adverse evenTs In Venous thromboEmbolism Study (ALTERNATIVE)

Venous Thromboembolism | Anticoagulants and Bleeding Disorders

United States
Soonchunhyang University Hospital

Completed

Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope

Choledocholithiasis | Bile Duct Stricture

Korea, Republic of
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France

Terminated

Venous Thromboembolism in Renally Impaired Patients and Direct Oral Anticoagulants (VERDICT)

Renal Insufficiency

France
Vaxart
Biomedical Advanced Research and Development Authority

Completed

A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine

Influenza

United States
National Cheng-Kung University Hospital
National Taiwan University Hospital; Ministry of Science and Technology, Taiwan

Enrolling by invitation

A Cue-based Developmental Approach Toward the Preterm Infants During Feeding Transition Period

Feeding Behavior | Preterm Infant | Feeding Patterns

Taiwan
PATH

Completed

Inactivated Poliovirus Vaccine (IPV) With or Without E.Coli Double Mutant Heat-Labile Toxin (dmLT) Challenge Study in Healthy Adults

Polio

Belgium
Kansas City Heart Rhythm Institute
Kansas City Heart Rhythm Research Foundation

Completed

DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation (STROKE-VT)

Stroke | Ventricular Tachycardia | Premature Ventricular Contraction

United States, India
Doasense GmbH

Active, not recruiting

Pharmacokinetics and Point of Care Testing of Direct Oral Anticoagulants Subjects (PHAPOCU)

Anticoagulant Therapy

Germany
Daiichi Sankyo UK Ltd, a Daiichi Sankyo Company

Completed

Study to Evaluate the Use of Direct Oral Anticoagulants in UK Clinical Practice For Patients With a First Stroke Attributable to Nonvalvular Atrial Fibrillation

Atrial Fibrillation

United Kingdom
Instituto de Investigación Hospital Universitario...
Vegenat, S.A.

Completed

Coverage of Requirements After Consumption of a Nutritional Formula in Patients With Chewing/Swallowing Problems. (VEGENAT MED)

Deglutition Disorders | Nutritional Deficiency | Chew Problems | Swallowing Disorder

Spain
Medical College of Wisconsin
Ohio State University; Versiti

Completed

Post-thrombotic Syndrome & Predictors of Recurrence in Catheter-related Thrombosis

Neoplasms | Venous Thrombosis

United States
Dana-Farber Cancer Institute

Completed

EHR-embedded OCDT in Breast or GI Cancer

Breast Cancer | Gastrointestinal Cancer | Oral Cancer Directed Therapy | Oral Chemotherapy

United States
Doasense GmbH
Clinical Research Services, Mannheim, Germany; Institute Medical Statistics... and other collaborators

Completed

In Vitro Diagnostic Test for DOAC in Urine (PADOASU)

Anticoagulant Therapy

Germany
University of Edinburgh
NHS Lothian

Completed

Start or STop Anticoagulants Randomised Trial (SoSTART) (SoSTART)

Atrial Fibrillation | Intracranial Hemorrhages | Subarachnoid Hemorrhage | Intraventricular Hemorrhage | Atrial Flutter | Small Vessel Cerebrovascular Disease | Intracranial Hemorrhage, Hypertensive | Subdural Hematoma | Microhaemorrhage

United Kingdom
Science Valley Research Institute
Bayer

Completed

Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial (MICHELLE)

Covid19 | Venous Thromboembolism

Brazil
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Completed

Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist (TICH-NOAC)

Intracerebral Hemorrhage

Switzerland
Assistance Publique - Hôpitaux de Paris

Completed

Benefit/Risk in Real Life of New Oral Anticoagulants and Vitamin K Antagonists in Patients Aged 80 Years and Over (PRESAGE-ACO)

Atrial Fibrillation

France
Alexion Pharmaceuticals
Population Health Research Institute; Portola Pharmaceuticals, LLC (a wholly...

Completed

A Study in Participants With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

Bleeding

United States, Belgium, Canada, France, Germany, Japan, Netherlands, Spain, United Kingdom
M.D. Anderson Cancer Center
The University of Texas Health Science Center, Houston; Baylor College of Medicine

Completed

Non Invasive Oral Cancer Screening Among HIV Infected Individuals

Human Immunodeficiency Virus | Malignant Neoplasms of Mesothelial and Soft Tissue

United States
University of Liverpool
Gynuity Health Projects; Government Medical College, Nagpur

Completed

qMOLI- A Qualitative Assessment of Misoprostol or Oxytocin for Labour Induction (qMOLI)

Pre-Eclampsia

India
University Hospital, Strasbourg, France

Completed

Study of Hemostasis During the Atrial Fibrillation Ablation Procedure (EHPAFAVE)

Hemostasis

France
Hospices Civils de Lyon

Completed

Impact of the COVID-19 Pandemic on Drug Use and Monitoring of Cancer Patients (ONCORAL-Covid)

Cancer

France
Otsuka Pharmaceutical Development & Commercialization...

Terminated

To Assess the Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder (MDD)
Methodist Health System

Completed

Efficacy and Safety of Direct Oral Anticoagulants for the Treatment of Mural Thrombus

Acute Myocardial Infarction

United States
Methodist Health System

Completed

Evaluating Off-label Use of Direct Oral Anticoagulants (DOACs) in Hypercoagulable States

Hypercoagulable States

United States
University of Dundee

Completed

A Direct obserVed therApy vs fortNightly CollEction Study for HCV Treatment - ADVANCE HCV Study (ADVANCE)

Hepatitis C

United Kingdom

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