Clinical Trials Sponsored by Hoffman Oncology

Total 6959 results

OvaGene Oncology, Inc.

Unknown

DNA Single Nucleotide Polymorphisms as Predictors of Toxicity

Ovarian Neoplasms | Fallopian Tube Neoplasms | Peritoneal Neoplasms

United States
Maastricht Radiation Oncology

Completed

PET-CT Based Radiotherapy in Esophageal Cancer Patients

Esophageal Neoplasms

Netherlands
Genus Oncology, LLC

Completed

Study of GO-203-2C Given Intravenously in Patients With Advanced Solid Tumors Including Lymphomas

Solid Tumors

United States
Oncology Specialists, S.C.

Completed

Non-Hodgkin Lymphoma in Elderly Patients Above the Age of 80 in the Rituximab Era

Non-Hodgkin's Lymphoma
Clovis Oncology, Inc.

Terminated

A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin

Lung Cancer | Solid Tumor | Non-small-cell Lung Cancer

United States, United Kingdom
Light Sciences Oncology

Completed

Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma

Glioma | Glioblastoma Multiforme | Anaplastic Astrocytoma

Serbia
Taiho Oncology, Inc.

Completed

A Phase 1, Open-Label, Randomized, Cross-Over, Pharmacokinetic Study Evaluating the Effect of S-1 on Advanced Solid Tumors

Tumors

United States
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Maastricht Radiation Oncology

Completed

HI-CHART:Feasibility of High-Dose Accelerated Conformal Radiotherapy

Non-Small-Cell Lung Carcinoma

Netherlands
Oncology Specialties, Alabama

Terminated

Protocol for Radiofrequency Ablation of Pulmonary Neoplasms

Pulmonary Neoplasms

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology; Eastern Cooperative Oncology Group

Completed

Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III Bladder Cancer

Bladder Cancer

United States
Hoffmann-La Roche

Recruiting

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Participants With Thyroid Eye Disease (SatraGO-2) (SatraGO-2)

Thyroid Eye Disease

Korea, Republic of, United Kingdom, United States, Canada, China, Israel, France, Spain
Hoffmann-La Roche

Recruiting

A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma (GLOBRYTE)

Lymphoma

Korea, Republic of, United States, Spain, France, Brazil, China, Canada, Australia, Sweden, Taiwan, Italy, United Kingdom
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Effectiveness and Safety of Polatuzumab in Real World Clinical Practice Among Adult Chinese Participants With Diffuse Large B-Cell Lymphoma

Diffuse Large B-Cell Lymphoma

China
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United States, Belgium, Australia, Israel, Spain, France, United Kingdom, Denmark, Argentina, Germany, New Zealand, South Africa, Korea, Republic of, Poland, Bulgaria, Canada, Chile, Czechia, Netherlands, Romania, Sweden, Mexico
Hoffmann-La Roche

Recruiting

A Study of Participants in China With Non-Small-Cell Lung Cancer That is Unable to be Treated With Surgery

Carcinoma, Non-Small-Cell Lung

China
Hoffmann-La Roche

Recruiting

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study (UmbrellaMAX)

Cancer

Korea, Republic of, United Kingdom, Japan, Costa Rica, Thailand, Belgium, Taiwan, Russian Federation, Mexico, Poland, France
Hoffmann-La Roche

Recruiting

A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy (PUPFISH)

Muscular Atrophy, Spinal

Germany, United States, Belgium
Hoffmann-La Roche

Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7565020 in Healthy Participants and in Participants With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B

Korea, Republic of, United States, Thailand, Hong Kong, Spain, New Zealand, Bulgaria, Taiwan, France
Hoffmann-La Roche

Recruiting

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease.

Huntington Disease

United States, Australia, Argentina, Canada, Germany, Italy, Spain, France, United Kingdom, Portugal, New Zealand, Austria, Poland, Switzerland, Denmark
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Safety and Pharmacokinetics of the Intravenous Fixed-Dose Combination (IV FDC) of Tiragolumab and Atezolizumab in Participants With Locally Advanced, Recurrent or Metastatic Solid Tumors (SKYSCRAPER-11)

PD-L1-selected Solid Tumors

Korea, Republic of, United States, Spain, Taiwan, Turkey, Greece, Canada, Croatia, Serbia, Mexico, Cyprus, Georgia
Hoffmann-La Roche

Recruiting

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

Urothelial Cancer

Korea, Republic of, United States, Brazil, China, France, Germany, Mexico, Poland, Denmark, Italy, Turkey, Australia, Greece, Spain, United Kingdom
Hoffmann-La Roche

Recruiting

A Study to Investigate Vamikibart in Participants With Uveitic Macular Edema (Meerkat)

Uveitic Macular Edema

United States, Korea, Republic of, United Kingdom, China, Netherlands, Canada, Israel, Austria, Brazil, Italy, Taiwan, Poland, Portugal, Mexico
Hoffmann-La Roche

Recruiting

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of RO7616789 in Advanced Small Cell Lung Cancer and Other Neuroendocrine Carcinomas

Small Cell Lung Cancer | Neuroendocrine Carcinoma

United States, Japan, Denmark, Spain, Poland
Hoffmann-La Roche

Recruiting

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (ARNASA)

Chronic Obstructive Pulmonary Disease (COPD)

United States, China, Spain, Italy, Germany, Belgium, Korea, Republic of, Poland, Taiwan, Israel, New Zealand, Sweden, United Kingdom, Japan, Czechia, Philippines, Hong Kong, Greece, Australia, Thailand, Netherlands, Argentina, Brazil, Fran... and more
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma (PLYCOM)

Multiple Myeloma

Korea, Republic of, Australia, Spain, France, Poland
Hoffmann-La Roche

Recruiting

A Study Of The Efficacy, Safety, And Pharmacokinetics Of The Port Delivery System With Ranibizumab In Chinese Patients With Neovascular Age-Related Macular Degeneration

Neovascular Age Related Macular Degeneration | nAMD

China
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

Locally Advanced or Metastatic Breast Cancer

France, Belgium, United States, Korea, Republic of, Taiwan, Brazil, China, Italy, Argentina, Jordan, Mexico, Germany, Portugal, Spain, Thailand, Turkey, United Kingdom, Kenya, Hungary, Poland, Colombia, India, Oman, Uganda, United Arab... and more
Hoffmann-La Roche

Recruiting

A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD) (SAkuraSun)

Neuromyelitis Optica Spectrum Disorder | NMOSD

Poland, United Kingdom, Argentina, Italy, France, United States
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

United States, Israel, Italy, Spain, United Kingdom
Hoffmann-La Roche

Recruiting

An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C)

Neoplasms

China
Hoffmann-La Roche

Recruiting

A Study of Atezolizumab in High PD-L1 Expression, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus (ALLEGORY)

Systemic Lupus Erythematosus

Brazil, United States, Argentina, United Kingdom, New Zealand, Spain, Italy, Peru, Poland, South Africa, France, Mexico, Russian Federation, Czechia
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Metastatic Colorectal Cancer

United States, Korea, Republic of, United Kingdom, Australia, Germany, Taiwan, Spain, Canada, Italy, Poland, Denmark, France
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). (CROSSWALK-a)

Sickle Cell Disease

United States, Brazil, Italy, Spain, Kenya, Netherlands, United Kingdom, France, South Africa
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy (Astefania)

Breast Cancer

Korea, Republic of, United States, Australia, China, Ukraine, Spain, United Kingdom, Turkey, Mexico, Brazil, Austria, Belgium, Denmark, Germany, Greece, Russian Federation, Taiwan, France, Kenya, New Zealand, Portugal, Thailand, Rom... and more
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma (Celestimo)

Relapsed or Refractory Follicular Lymphoma

United States, Korea, Republic of, Taiwan, China, Spain, United Kingdom, Australia, France, Germany, Japan, Turkey, Brazil, Poland, Ukraine, Italy, Russian Federation
Hoffmann-La Roche

Recruiting

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

Alzheimers Disease

Korea, Republic of, United States, Canada, Poland, Spain, Australia, Japan, Chile, United Kingdom
Hoffmann-La Roche

Recruiting

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases

Carcinoma, Non-Small-Cell Lung

Brazil, China, France, Croatia, Greece, Italy, Mexico, Spain, India, Netherlands, Romania, Sweden, Thailand, Lebanon, Turkey, Slovakia, Jordan, Russian Federation, Germany
Hoffmann-La Roche

Recruiting

A Study to Evaluate Safety and Anti-Tumor Activity of Eciskafusp Alfa (RO7284755) Alone or in Combination With Atezolizumab in Participants With Advanced and/or Metastatic Solid Tumors

Solid Tumors

Belgium, Denmark, Spain, Canada, Netherlands, Poland
Hoffmann-La Roche

Recruiting

Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households

Influenza

China, Turkey, United States, Brazil, Japan, Mexico, Costa Rica, South Africa, Argentina, Bulgaria, Chile, Greece, Hong Kong, Hungary, India, Israel, New Zealand, Poland, Spain, United Kingdom, France, Singapore, Puerto Rico
Hoffmann-La Roche

Completed

A Study of Atezolizumab in Combination With Bevacizumab in Patients With EGFR Mutation Positive Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

China
Hoffmann-La Roche

Terminated

A Study to Evaluate the Safety and Efficacy of Basmisanil Treatment in Children Aged 2-14 Years With Dup15q Syndrome

Dup15q Syndrome

United States, Spain, United Kingdom, Poland, Portugal
Hoffmann-La Roche

Active, not recruiting

A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis (Ocarina II)

Relapsing Multiple Sclerosis | Primary Progressive Multiple Sclerosis

Spain, United States, Italy, Poland, Turkey, New Zealand, Czechia, Brazil
Hoffmann-La Roche

Terminated

A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis (STARSCAPE-OLE)

Idiopathic Pulmonary Fibrosis

United States, France, Israel, Spain, Belgium, Australia, Czechia, Denmark, Taiwan, Italy, Japan, Singapore, Turkey, Korea, Republic of, Germany, China, New Zealand, Argentina, Portugal, South Africa, Hungary, Canada, Poland, Greece, Ne... and more
Hoffmann-La Roche

Active, not recruiting

A Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Patients With Unresectable Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy-Amethista (AMETHISTA)

Carcinoma, Hepatocellular

Italy
Hoffmann-La Roche

Active, not recruiting

A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants (ALEX)

Non-Small Cell Lung Cancer

United States, Korea, Republic of, Canada, Taiwan, Australia, France, Hong Kong, Italy, Portugal, Spain, United Kingdom, Brazil, Poland, Guatemala, Singapore, Thailand, Serbia, Ukraine, Bosnia and Herzegovina, China, Costa Rica, E... and more
Hoffmann-La Roche

Active, not recruiting

A Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or Recurrent PD-L1-Positive Cervical Cancer (SKYSCRAPER-04)

Cervical Cancer

Italy, Korea, Republic of, Canada, United States, Brazil, France, United Kingdom, Spain, Costa Rica, Russian Federation, Panama, Australia, Mexico, Peru, Poland, Taiwan, Thailand
Hoffmann-La Roche

Active, not recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma

Follicular Lymphoma

United Kingdom, United States, China, France, Spain
Hoffmann-La Roche

Active, not recruiting

RVT-3101 for the Treatment of Moderate to Severe Active Crohn's Disease

Crohn Disease

United States, France, Poland, Hungary, Spain

Clinical Trials Sponsored by Hoffman Oncology

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