Search clinical trials for: Mechanism of Action

Total 429195 results

Memorial Sloan Kettering Cancer Center
Seagen Inc.

Recruiting

A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

Hodgkin Lymphoma

United States
Post Graduate Institute of Medical Education and...

Not yet recruiting

A RCT to Compare the Effectiveness of Nebulized Anticholinergics for Cough Suppression During Flexible Bronchoscopy (NAFCOF)

Subjects Undergoing Flexible Bronchoscopy

India
Shirley Ryan AbilityLab
Rady Children's Hospital, San Diego

Not yet recruiting

Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy

Cerebral Palsy | Contracture
University Health Network, Toronto

Not yet recruiting

A Study to Test the Benefit of Vitamin B5 in Patients With Melanoma

Melanoma (Skin)

Canada
American Society of Clinical Oncology
Patient-Centered Outcomes Research Institute

Not yet recruiting

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Metastatic Breast Cancer
Aurora Health Care

Not yet recruiting

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR (ATRIUM)

Atrial Fibrillation | Tachycardia Atrial | Atrial Flutter With Rapid Ventricular Response

United States
Fundació Eurecat
Centre de Diagnosi per la Imatge; Instituto de Investigación Biomédica de Girona... and other collaborators

Not yet recruiting

Effect of Multi-ingredient on Visceral Adiposity & Non-alcoholic Fatty Liver Disease in Postmenopausal Women With Abdominal Obesity (FATHIS+)

Visceral Obesity | Non-alcoholic Fatty Liver | Postmenopausal

Spain
Amany Ahmed Eissa

Recruiting

The Efficacy of Thoracic Erector Spinae Plane Block For Perioperative Analgesia in Laparoscopic Bariatric Surgery for Super Obese Patients: Randomized Controlled Trial.

Erector Spinae Plane Block | Bariatric Surgery | Super Obese Patients

Egypt
National Medical Research Center for Cardiology...

Recruiting

Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI (ESMO-VASCMI)

Myocardial Infarction | Coronary Stenosis | Coronary Microvascular Dysfunction

Russian Federation
Beijing Tongren Hospital

Recruiting

Linperlisib Combined With Camrelizumab and Pegaspargase in Advanced or Relapsed/Refractory NK/T-cell Lymphoma

T-lymphoblastic Lymphoma | Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type

China
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Efficacy and Safety of Telitacicept in the Treatment of Systemic Sclerosis

Diffuse Cutaneous Systemic Sclerosis

China
R-Evolution Worldwide S.r.l. Impresa Sociale
University Ghent; National Institute for Medical Research, Tanzania; University... and other collaborators

Not yet recruiting

Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis (NeuroSolve)

Neurocysticercosis
Catharina Ziekenhuis Eindhoven
Maastricht University

Not yet recruiting

The Contractile Response of the Thoracic Aorta to Vasoactive Substances (AorticContract)

Human Thoracic Aorta Contractility

Netherlands
Austin Institute for Clinical Research
SkinCeuticals

Recruiting

Single-Blind Study Assessing the Use of a Topical Antioxidant With A Series of Laser Procedures to Reduce Sebum Production

Acne

United States
Dokuz Eylul University

Not yet recruiting

Sequential Intravesical Gemcitabine and Docetaxel for Rescue Therapy in BCG Unresponsive Non-muscle Invasive Bladder Cancer Patients

Bladder Cancer | Gemcitabine | BCG | Docetaxel | Intravesical Instillation

Turkey
Peking Union Medical College Hospital

Not yet recruiting

Treatment of Irinotecan Hydrochloride Liposome Injection II in China: a Real World Study of Pancreatic Cancer Patients (MA-PC-RWS-011)

Pancreatic Cancer

China
LLS PedAL Initiative, LLC
Kura Oncology

Not yet recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

Relapsed/Refractory KMT2A-r Acute Leukemia | Relapsed/Refractory NUP98-r Acute Leukemia | Relapsed/Refractory NPM1-m Acute Leukemia
Second Affiliated Hospital, School of Medicine,...

Recruiting

A Prospective Study of Whole-Brain RT Combined With Thiotepa Sheath Injection Combined With Systemic Therapy for the Primary Disease in the Treatment of Meningeal Metastases in Solid Tumors

Solid Tumor Leptomeningeal Metastasis

China
Beijing Chest Hospital, Capital Medical University

Not yet recruiting

PD-L1/PD-1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone for the Neoadjuvant Treatment of Limited-stage SCLC (NeoSCLC-001)

Limited-stage Small-cell Lung Cancer
Cairo University
Theodor Bilharz Research Institute

Not yet recruiting

Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery.

Postoperative Pain

Egypt
Adicet Bio, Inc

Not yet recruiting

A Phase 1 Study of ADI-001 in Lupus Nephritis

Autoimmune Diseases | Lupus Nephritis
King Chulalongkorn Memorial Hospital
Health Systems Research Institute,Thailand

Recruiting

Investigating Neurocognitive Disorders Epidemiology (INDE)

Dementia | Alzheimer Disease | Cognitive Decline

Thailand
Francesco De Cobelli
A.O. Ospedale Papa Giovanni XXIII; Cardarelli Hospital; AOU Pisana, Pisa, Italy

Recruiting

Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy (PM-CARE)

Intrahepatic Cholangiocarcinoma

Italy
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage

Psoriasis
Second Affiliated Hospital, School of Medicine,...
Ningbo Medical Center Lihuili Hospital; The Second Affiliated Hospital of Jiaxing... and other collaborators

Not yet recruiting

Real-world Study of Efficacy and Safety of Zonisamide in add-on Therapy for Patients With Focal Epilepsy

Epilepsies, Partial

China
Shen Lei

Not yet recruiting

Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI

Sepsis

China
Zhejiang Genfleet Therapeutics Co., Ltd.

Recruiting

A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

Large B-cell Lymphoma

China
Convalife (Shanghai) Co., Ltd.

Not yet recruiting

Nilatinib Maleate Tablets Combined With Capecitabine in the Treatment of HER2-positive Advanced Esophageal/Esophagogastric Junction/Gastric Adenocarcinoma With Brain Metastases

Her2-positive Advanced Esophageal/Esophagogastric Junction/Gastric Adenocarcinoma With Brain Metastasis
G.ST Antivirals GmbH

Recruiting

A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults

Acute Nasopharyngitis

Netherlands
University of Missouri-Columbia
Gilead Sciences

Recruiting

Accelerated ART Initiation for PWHIV Who Are Out of Care (ACCELERATE)

HIV Infections | ART | Noncompliance, Patient

United States
Nanfang Hospital, Southern Medical University

Not yet recruiting

A Clinical Study on the Efficacy and Safety of ABCD in the Treatment of Patients With Invasive Fungal Disease

Invasive Fungal Disease
Yehua Shen

Not yet recruiting

HAIC Combined With PD-L1 Plus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma After Immunotherapy Failure

HCC - Hepatocellular Carcinoma
Galderma R&D

Not yet recruiting

Comparing Pain, Safety and Effectiveness of Restylane Skinboosters Vital Lido and Vital Without Lido in Dorsal Hand

Skin Aging of Dorsal Hands

China
Post Graduate Institute of Medical Education and...

Not yet recruiting

MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin (SHIELD)

Non-Alcoholic Fatty Liver Disease | Hepatic Steato-Fibrosis

India
VarmX B.V.

Recruiting

Single Dose Trial of VMX-C001 in Healthy Subjects With and Without FXa Direct Oral Anticoagulant

Coagulation Disorder

Netherlands
Closed Loop Medicine
Pharmanovia

Recruiting

Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment (OptiZest)

Uncomplicated Hypertension

United Kingdom
University of Pennsylvania
National Cancer Institute (NCI)

Not yet recruiting

Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

Tobacco Use | Harm Reduction | Cigarette Smoking | E-cigarette Use
Zhongming Qiu
The Second Affiliated Hospital of Chongqing Medical University; Mianyang Central... and other collaborators

Not yet recruiting

Tirofiban for Successful Endovascular Stroke Thrombectomy (ADJUVANT-2)

Stroke, Acute Ischemic
The University of Texas Health Science Center,...

Recruiting

Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

Smoking Cessation

United States
Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Not yet recruiting

A Single Dose Escalation Study of HHT201 in Healthy Subjects

Alzheimer Disease

China
Fondazione Evidence per Attività e Ricerche Cardiovascolari...

Not yet recruiting

SPAGO: Sirolimus Paclitaxel Angiographic Gain Objective (SPAGO)

Coronary Artery Disease | Percutaneous Coronary Intervention | Coronary Artery Lesion | Stenosis Coronary
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Not yet recruiting

Study of ZG005 in Combination With Etoposide and Cisplatin in Participants With Advanced Neuroendocrine Carcinoma.

Neuroendocrine Carcinoma

China
Saint Petersburg State University, Russia

Recruiting

Efficacy of Pembrolizumab and Lenvatinib in Patients With Anaplastic Thyroid Cancer

Anaplastic Thyroid Cancer

Russian Federation
Washington University School of Medicine
United States Department of Defense; Aclaris Therapeutics, Inc.

Not yet recruiting

Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer

United States
EdiGene Inc.
The First Affiliated Hospital of Henan University of Science and Technology; Changping Laboratory

Recruiting

A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic

China
The Cleveland Clinic

Not yet recruiting

NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

Chronic Pain | Elbow Pain

United States
Novartis Pharmaceuticals

Not yet recruiting

Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction (V-ACCELERATE)

Plaque, Atherosclerotic
Steen Hvitfeldt Poulsen

Recruiting

Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy (DobAttrAS)

Aortic Stenosis | Transthyretin Amyloid Cardiomyopathy

Denmark
Apollo Therapeutics Ltd

Not yet recruiting

A Study to Investigate APL-4098 Alone and/or in Combination With Azacitidine in R/R AML and High-Risk MDS

Myelodysplastic Syndrome With Excess Blasts | Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory | Myelodysplastic Syndrome Acute Myeloid Leukemia
Kasr El Aini Hospital

Recruiting

Evaluation of Lidocaine Spray Versus Dexmetomidine Spray on Stress Response

To Measure Systolic Blood Pressure Postintubation

Egypt

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