Clinical Trials Sponsored by Defense Medical Research and Development Program

Total 937 results

Achaogen, Inc.
Defense Medical Research and Development Program

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ACHN-975 in Healthy Volunteers

Healthy Volunteer

United States
Terumo BCTbio
United States Department of Defense; U.S. Army Medical Research and Development... and other collaborators

Terminated

Efficacy and Safety of RBCs Derived From Mirasol-treated Whole Blood in Patients Requiring Chronic Transfusion (PRAISE) (PRAISE)

Transfusion Dependent Thalassemia

United States, Israel, Italy, Turkey
Johns Hopkins University
Department of Defense Congressionally Directed Medical Research Program

Not yet recruiting

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Depression | Insomnia | Sleep | Traumatic Brain Injury | Memory Impairment | Head Injury | Cognitive Behavioral Therapy | Concussion, Brain | Post-traumatic Stress | Brain Injury Traumatic Mild
U.S. Army Medical Research and Development Command
United States Agency for International Development (USAID); Naval Medical Research... and other collaborators

Completed

NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1

Plasmodium Falciparum

United States
U.S. Army Medical Research and Development Command
Military Infectious Diseases Research Program (MIDRP)

Completed

Safety and Efficacy Study of IV Artesunate to Treat Malaria

Malaria

Kenya
Humanetics Corporation
United States Department of Defense; Joint Warfighter Medical Research Program

Completed

BIO 300 Oral Powder Safety and Pharmacokinetics

Acute Radiation Syndrome

United States
University of Calgary
Defence Research and Development Canada

Completed

Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach (PTSD)

Brain Injuries | Transcranial Magnetic Stimulation | Stress Disorders, Post-Traumatic | Biomarkers | Depression, Anxiety | Magnetic Resonance Spectroscopy

Canada
Unity Health Toronto
Defence Research and Development Canada

Completed

Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury

Trauma, Nervous System | Reperfusion Injury | Traumatic Brain Injury | Ischemia, Brain

Canada
Unity Health Toronto
Defence Research and Development Canada

Unknown

RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study

COVID | Ischemia Limb | Acute Respiratory Distress Syndrome | Acute Lung Injury | Corona Virus Infection
VA Office of Research and Development
Defense Advanced Research Projects Agency

Recruiting

Peripheral Interfaces in Amputees for Sensorimotor Integration (iSens)

Upper Extremity Amputee

United States
University of California, San Diego
Department of Defense Congressionally Directed Medical Research Program

Enrolling by invitation

Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy

Mastectomy; Lymphedema

United States
Sunnybrook Health Sciences Centre
Defence Research and Development Canada

Completed

The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial (TOPHR HIT) (TOPHR HIT)

Traumatic Brain Injury
Johns Hopkins University
United States Department of Defense; Congressionally Directed Medical Research...

Terminated

RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain

Acute Pain | Posttraumatic Stress Disorder | Wound Care

United States
Orient Pharma Co., Ltd.
National Defense Medical Center, Taiwan; National Research Program for Biopharmaceuticals...

Completed

Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis

Pulmonary Tuberculosis

Taiwan
Pennington Biomedical Research Center
United States Department of Defense; Defence Research and Development Canada; United States Army Research Institute of Environmental Medicine and other collaborators

Completed

Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery (OPS)

Exercise | Caloric Restriction

United States
SAb Biotherapeutics, Inc.
Biomedical Advanced Research and Development Authority; Joint Program Executive...

Active, not recruiting

Safety, Tolerability, and Pharmacokinetics of SAB-185 in Ambulatory Participants With COVID-19

COVID-19 | SARS-CoV2

United States
Children's Hospital of Fudan University
National Key Research and Development Program of China

Completed

The Early Integrated Intervention for Child Brain-developmental Disorders in China

Autism Spectrum Disorder | Attention Deficit-Hyperactivity Disorder | Global Developmental Delay | Brain Developmental Diseases

China
Dr. Andrew Baker
Defence Research and Development Canada

Unknown

Ketamine Infusion in Neurologic Deficit (KIND)

Subarachnoid Hemorrhage

Canada
Heidi Stephany
CMI's Early-Stage Medical Technology Research and Development 2015 PILOT...

Withdrawn

Pilot Study: Foot Neuromodulation for Nocturnal Enuresis in Children

Bedwetting
University of Miami
Broad Medical Research Program Crohn's and Colitis Foundation

Completed

Diet Study on Ulcerative Colitis

Ulcerative Colitis

United States
National Center for Telehealth and Technology
United States Department of Defense; U.S. Army Medical Research and Development...

Completed

Caring Letters for Military Suicide Prevention

Suicide, Attempted | Suicide

United States, Germany
U.S. Army Medical Research and Development Command

Recruiting

An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample

Stress Disorders, Post-Traumatic

United States
U.S. Army Medical Research and Development Command

Not yet recruiting

Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis (VEE) Vaccine as Booster Vaccine in Adults (VEE)

Venezuelan Equine Encephalomyelitis

United States
U.S. Army Medical Research and Development Command

Active, not recruiting

Comparison of Tetravalent Dengue Virus Purified Inactivated Vaccine and Tetravalent Dengue Virus Live Attenuated Vaccine

Dengue Virus

United States
U.S. Army Medical Research and Development Command

Unknown

The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Trauma Patients (NIRS)

Anterior Tibial Compartment Syndrome

United States
U.S. Army Medical Research and Development Command

Completed

A Single-blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Hantaan Puumala Virus DNA Vaccine

Hantaan Virus

United States
U.S. Army Medical Research and Development Command

Completed

Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR)

Shigellosis | Bacillary Dysentery

United States
U.S. Army Medical Research and Development Command

Unknown

Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine

Western Equine Encephalitis

United States
U.S. Army Medical Research and Development Command

Completed

Safety Evaluation of a Q-fever Vaccine, NDBR 105

Q Fever

United States
U.S. Army Medical Research and Development Command

Completed

Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine

Tularemia

United States
U.S. Army Medical Research and Development Command

Completed

Booster Dose (50 µg) of Recombinant Ricin Toxin Vaccine (RVEc™) in Previously Vaccinated Healthy Adults (RVEc)

Ricin Poisoning

United States
U.S. Army Medical Research and Development Command

Completed

Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine (EEE)

Eastern Equine Encephalitis

United States
U.S. Army Medical Research and Development Command

Completed

Reference Values for Non-invasive Hydration Status Markers H10-14

Value Orientation

United States
U.S. Army Medical Research and Development Command

Completed

Western Equine Encephalitis Vaccine, Inactivated (WEE)

Virus

United States
U.S. Army Medical Research and Development Command

Completed

Phase 1 Safety and Immunogenicity of Meningococcal Vaccine (HOPS)

Meningococcal Infection, Group B

United States
U.S. Army Medical Research and Development Command

Completed

Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults

HIV Infections

United States
U.S. Army Medical Research and Development Command

Completed

Challenge Study of an ETEC Vaccine

Enteritis; Escherichia Coli, Enterotoxigenic

United States
U.S. Army Medical Research and Development Command

Completed

Invaplex 50 Vaccine Dose-Ranging

Diarrhea

United States
U.S. Army Medical Research and Development Command

Completed

Weekly Dosing of Malarone ® for Prevention of Malaria (MALWEEK)

Malaria

United States
U.S. Army Medical Research and Development Command

Recruiting

Safety and Immunogenicity of a Hantaan Virus DNA Vaccine and a Puumala Virus DNA Vaccine, For The Prevention of Hemorrhagic Fever With Renal Syndrome

Hantaan Virus Nephropathy | Puumala Virus Nephropathy

United States
U.S. Army Medical Research and Development Command

Recruiting

Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine (RVF)

Rift Valley Fever

United States
U.S. Army Medical Research and Development Command

Recruiting

Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever

Viral Hemorrhagic Fever

Germany
U.S. Army Medical Research and Development Command

Available

Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure

Smallpox | Monkeypox
U.S. Army Medical Research and Development Command

Completed

Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated (RVF)

Rift Valley Fever

United States
U.S. Army Medical Research and Development Command

Completed

Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54

Malaria,Falciparum

United States
U.S. Army Medical Research and Development Command

Completed

Safety Study of Chimeric Vaccine to Prevent ETEC Diarrhea

Escherichia Coli Infection

United States
U.S. Army Medical Research and Development Command

Active, not recruiting

Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine (VEE TC-83)

Venezuelan Equine Encephalomyelitis

United States
U.S. Army Medical Research and Development Command

Completed

Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine

Eastern Equine Encephalitis

United States
U.S. Army Medical Research and Development Command

Withdrawn

Chloroquine (CQ) and Azithromycin (AZ) Combination for Malaria Prophylaxis

Malaria

United States
U.S. Army Medical Research and Development Command

Withdrawn

Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany (HFRS)

Hemorrhagic Fever With Renal Syndrome

Germany

Clinical Trials Sponsored by Defense Medical Research and Development Program

Sponsors and Collaborators

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