Clinical Trials Sponsored by Merck Canada Inc.

Total 851 results

McMaster University
Merck Canada Inc.

Recruiting

Assessing Knowledge, Beliefs and Attitudes Toward HPV Vaccination Among Parents in North West, Cameroon

Vaccine Refusal

Cameroon
University of Alberta
Merck Canada Inc.

Not yet recruiting

Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?

Vaccine Response Impaired | Vaccination Failure
University Health Network, Toronto
Merck Canada Inc.

Completed

Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications (Sugammadex)

Obstructive Sleep Apnea

Canada
Merck KGaA, Darmstadt, Germany
EMD Inc., Canada

Completed

Treatment Adherence When Using RebiSmart™ in Relapsing Multiple Sclerosis Subjects (MEASURE)

Multiple Sclerosis | MS

Canada
Sunnybrook Health Sciences Centre
Merck Canada Inc.

Active, not recruiting

In the Era of the HPV Vaccine, What Are The Current HPV Subtypes Contributing to High Grade Cervical Dysplasia, Adenocarcinoma in Situ, and Early Cervical Cancer?

HSIL, High-Grade Squamous Intraepithelial Lesions | Adenocarcinoma in Situ | Early Cervical Cancer

Canada
University Health Network, Toronto
Merck Canada Inc.

Enrolling by invitation

Can INSTI-associated Weight Gain be Halted or Reversed With a Switch to Doravirine/Lamivudine/Tenofovir DF? (DeLiTE)

Hiv | Weight Gain

Canada
University of British Columbia
Merck Canada Inc.

Completed

Long Term Immune Memory Responses to HPV Vaccination Following 2 vs 3 Doses of Quad-HPV Vaccine (Merck08)

Human Papillomavirus

Canada
Canadian Urology Research Consortium
Merck Frosst Canada Ltd.; Abbott

Terminated

Cancer and Osteoporosis Research With Alendronate and Lupron (C.O.R.A.L )

Osteoporosis
Merck KGaA, Darmstadt, Germany
EMD Serono Canada Inc.

Completed

A Prospective Study Looking at the Use of Rebif® in Subjects With Clinically Isolated Syndrome (CIS-ON)

Clinically Isolated Syndrome

Canada
Canadian Heart Research Centre
Merck Frosst Canada Ltd.; Schering-Plough

Completed

Guidelines Based Undertaking for Improvement in Dyslipidemia Related Events (GUIDE ) (GUIDE)

Cardiovascular Diseases

Canada
Otsuka Canada Pharmaceutical Inc.
Lundbeck Canada Inc.

Recruiting

Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE) (INITIATE)

Schizophrenia | Schizo Affective Disorder | Bipolar I Disorder

Canada
Ciusss de L'Est de l'Île de Montréal
Merck Canada Inc.

Recruiting

Impact of Intraoperative Deep Neuromuscular Blockade on NOL-guided Opioid Requirement in LSC Colorectal Surgeries

Laparoscopic Colorectal Surgeries

Canada
ATGen Canada Inc

Terminated

Analysis of Natural Killer Cell Activity (NKA) in Whole Blood in High Risk Subjects Undergoing Colonoscopy (ANKA-HR)

Colorectal Cancer | Immunity, Innate

Canada
ATGen Canada Inc

Terminated

Measurement of Natural Killer Cell Activity in Whole Blood in Men Being Screened for Prostate Cancer With Biopsy (ANKA-PCA)

Prostatic Neoplasm | Immunity, Innate

Canada
Lundbeck Canada Inc.

Completed

Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetine (AtWoRC)

Major Depressive Disorder

Canada
Biotronik Canada Inc

Completed

Clinical Investigation Plan for the AVOPT Data Collection Clinical Study

Cardiac Pacemaker, Artificial

Canada
Biotronik Canada Inc

Completed

BIOFLOW-III Canada Satellite Registry

Myocardial Ischemia | Coronary Artery Disease

Canada
Lundbeck Canada Inc.

Completed

Bendamustine Hydrochloride (HCl) in Indolent Non-Hodgkin's Lymphoma That Has Progressed During or Following Treatment With a Rituximab Regimen or Previously Untreated Chronic Lymphocytic Leukemia (BENDACT)

Chronic Lymphocytic Leukemia | Indolent Non-Hodgkin's Lymphoma

Canada
BioSyntech Canada Inc.

Terminated

BST-DERMON Versus Standard of Care in the Treatment of Diabetic Foot Ulcers

Diabetic Foot Ulcer

Canada
Oncothyreon Canada Inc.

Completed

Safety and Immunological Response Rate Study of THERATOPE® Vaccine in Metastatic Breast Cancer Patients

Breast Neoplasms

United States
University of British Columbia
Merck Frosst Canada Ltd.; Health Canada

Terminated

The Use of Finasteride to Reduce Hematuria and Hematospermia Following TRUS Prostate Biopsy

Hematuria | Hematospermia

Canada
NCIC Clinical Trials Group
Merck Frosst Canada Ltd.

Completed

MK-0646, Etoposide, and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Lung Cancer

Canada
Janssen-Ortho Inc., Canada
Ortho Biotech Canada

No longer available

A Study to Further Assess Safety and Effectiveness Data of the Bortezomib(Velcade)/Melphalan/Prednisone (BMP) Regimen in Previously Untreated and Transplant Ineligible Multiple Myeloma Patients

Multiple Myeloma

Canada
Organon and Co
Merck Frosst Canada Ltd.

Terminated

Ezetimibe Plus Simvastatin Versus Simvastatin in Patients With Hypercholesterolemia and Coronary Risk Factors (P03405)

Atherosclerosis | Hypercholesterolemia
University of Alberta
Merck Frosst Canada Ltd.

Withdrawn

On Label, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Finasteride in Patients Undergoing Transurethral Resection of the Prostate (TURP)

Benign Prostatic Hyperplasia

Canada
SBI ALApharma Canada, Inc.

Recruiting

Fluorescence Imaging of Carcinoma During Breast Conserving Surgery

Breast Cancer | Breast Neoplasm Female

United States
Aquinox Pharmaceuticals (Canada) Inc.

Completed

Oral AQX-1125 and Combination Oral Contraceptive Drug-Drug Interaction Study (DDI-COC)

Healthy Volunteer

Netherlands
Aquinox Pharmaceuticals (Canada) Inc.

Completed

Efficacy and Safety of AQX-1125 in Unstable COPD (FLAGSHIP)

COPD

United States, New Zealand, Poland, Australia, Denmark, Finland, Hungary, Sweden
Janssen-Ortho Inc., Canada

Terminated

A Study of Risperidone Long-Acting Injection Versus Oral Antipsychotics in Schizophrenia Participants With a History of Being Poorly Compliant With Taking Their Medication

Schizophrenia

Canada, United Kingdom, Australia, Ireland
Janssen-Ortho Inc., Canada

Completed

Impact of Tolerability Issues on Chronic Pain

Pain
Janssen-Ortho Inc., Canada

Completed

A Study to Explore Plasma Levels of CONCERTA, Ritalin-SR and Novo-Methylphenidate ER-C in Healthy Volunteers

Pharmacokinetics
Janssen-Ortho Inc., Canada

Completed

A Study Assessing Safety and Effectiveness of BORTEZOMIB Combination Therapy (Bortezomib + Doxorubicin Hydrochloride + Dexamethasone) in Previously Untreated Multiple Myeloma Patients

Multiple Myeloma
Janssen-Ortho Inc., Canada

Completed

An Open-label, Multicentre Study on Preference and Satisfaction of Canadian Women for the Transdermal Contraceptive Patch vs. Previous Primary Contraceptive Method

Female Contraception
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Canada Pharmaceutical Inc.; Lundbeck Canada Inc.

Completed

Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder

Major Depressive Disorder

Canada
Aquinox Pharmaceuticals (Canada) Inc.

Unknown

Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome (LEADERSHIP 301)

Interstitial Cystitis | Painful Bladder Syndrome | Bladder Pain Syndrome | Chronic Interstitial Cystitis

United States, Belgium, Canada, Czechia, Denmark, Hungary, Latvia, Netherlands, Poland, Romania, Spain, United Kingdom
Aquinox Pharmaceuticals (Canada) Inc.

Completed

Efficacy and Safety of AQX-1125 in IC/BPS (LEADERSHIP)

Interstitial Cystitis | Bladder Pain Syndrome

United States, Canada
Janssen-Ortho Inc., Canada

Terminated

An Efficacy and Safety Study of Bortezomib in Participants Previously Treated for Multiple Myeloma With Limited Kidney Function

Multiple Myeloma

Canada
Janssen-Ortho Inc., Canada

Completed

A Study to Monitor Intragastric pH in Patients Taking Rabeprazole vs. Patients Taking Pantoprazole

GERD
Janssen-Ortho Inc., Canada

Completed

Open Label Study Evaluating Different Dosing Regimens of Rabeprazole in Gastro-esophageal Reflux Disease (GERD) Patients With Night-time Heartburn Symptoms.

Gastroesophageal Reflux | Heartburn
Janssen-Ortho Inc., Canada

Completed

A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.

Anemia | Kidney Failure | Left Ventricular Hypertrophy
Janssen-Ortho Inc., Canada

Completed

A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Children With Autistic Disorder and Other Pervasive Developmental Disorders (PDD)

Autistic Disorder | Developmental Disabilities | Rett Syndrome | Asperger Syndrome | DCild Development Disorders, Pervasive
Janssen-Ortho Inc., Canada

Completed

An Open-label Study Evaluating the Maintenance of Clinical Effect in Adult Schizophrenia Patients Switched From Risperidone Tablets to an Equivalent Dose of a Rapidly-dissolving Tablet Formulation of Risperdone

Schizophrenia
Otsuka Canada Pharmaceutical Inc.

Recruiting

Canadian Medical Assessment of JINARC™ Outcomes Registry (C-MAJOR)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Canada
Aquinox Pharmaceuticals (Canada) Inc.

Terminated

Efficacy and Safety of AQX-1125 in Subjects With Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Chronic Prostatitis | Chronic Pelvic Pain Syndrome

Canada, United States
Janssen-Ortho Inc., Canada

Withdrawn

A Study to Determine an Effective Dose of Epoetin Alfa to Decrease the Number of Units of Blood Required to be Transfused During Hip Replacement Surgery.

Anemia | Blood Transfusion | Orthopedic Surgery
Janssen-Ortho Inc., Canada

Completed

A Study to Determine the Short-Term Safety of Continuous Dosing of Abiraterone Acetate and Prednisone in Modified Fasting and Fed States to Patients With Metastatic Castration-Resistant Prostate Cancer

Prostate Cancer | Prostate Neoplasms

Canada
Janssen-Ortho Inc., Canada

Completed

A Trial Comparing Risperidone Long-Acting Injection With Oral Antipsychotic in the Treatment of Early Psychosis

Psychotic Disorders | Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder

Canada
Janssen-Ortho Inc., Canada

Completed

CONCERTA (OROS Methylphenidate Hydrochloride) for the Treatment of Attention Deficit Hyperactivity Disorder in Adults

Attention Deficit Disorder With Hyperactivity
Janssen-Ortho Inc., Canada

Completed

A Study to Evaluate the Safety and Efficacy of Epoetin Alfa Versus Placebo to Reduce the Need for Blood Transfusions and Reduce the Occurrence of Severe Anemia During the Time Period Surrounding Total Hip Replacement Surgery

Anemia
Janssen-Ortho Inc., Canada

Completed

An Open-label Study to Evaluate Topiramate Therapy in Migraine Patients, and Its Effects on Subject Responsiveness to Migraine Treatment With Triptans

Headache

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