Clinical Trials Sponsored by Sierra Neuropharmaceuticals

Total 792 results

University of Colorado, Denver
Sierra Neuropharmaceuticals

Completed

Association Between the Menstrual Cycle and Weight Loss

Obesity | Overweight

United States
Vernalis (R&D) Ltd
Cita NeuroPharmaceuticals

Completed

A Research Study of V3381 for the Treatment of Diabetic Peripheral Neuropathic Pain

Pain | Diabetic Neuropathies

United States, Canada
Vernalis (R&D) Ltd
Syneos Health; Cita NeuroPharmaceuticals

Completed

PK, PD and Safety of Multiple Doses of V1512 Tablets in PD Patients Compared to Standard Levodopa/Carbidopa Oral Tablets

Parkinson's Disease

Italy
Sierra Oncology, Inc.

Completed

Efficacy of Momelotinib Versus Best Available Therapy in Anemic or Thrombocytopenic Subjects With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF (Simplify 2)

Primary Myelofibrosis (PMF) | Post-essential Thrombocythemia Myelofibrosis (Post-ET MF) | Post-polycythemia Vera (Post-PV)

United States, Canada, France, Italy, Germany, Spain, Israel, United Kingdom
Sierra Oncology, Inc.

Completed

Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis

Primary Myelofibrosis | Post-Polycythemia Vera | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada
Sierra Oncology, Inc.

Completed

Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada, Australia
Sierra Oncology, Inc.

Terminated

Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase

Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung Cancer

United States
Cierra

Suspended

PFx Closure System in Subjects With Cryptogenic Stroke, TIA, Migraine or Decompression Illness (Paradigm IV)

Stroke | Migraine | Transient Ischemic Attack | Decompression Illness | PFO

Germany
Sierra Oncology, Inc.

Completed

Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis (Simplify 1)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, France, Germany, Spain, Israel, Bulgaria, Romania, Japan, Taiwan, Korea, Republic of, Australia, Belgium, Canada, Netherlands, Singapore, Poland, Hungary, Denmark, Sweden, United Kingdom, Czechia, Austria
Sierra Oncology, Inc.

Completed

A Study of PNT2258 in Patients With Advanced Solid Tumors

Melanoma | Lymphoma | Cancer | Prostate Cancer

United States
Sierra Oncology, Inc.

Terminated

Safety and Efficacy of Momelotinib in Subjects With Polycythemia Vera or Essential Thrombocythemia

Polycythemia Vera | Essential Thrombocythemia

United States, France, Germany, Canada, Australia
Sierra Oncology, Inc.

Terminated

Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma

Relapsed/Refractory Metastatic Pancreatic Ductal Adenocarcinoma

United States
Sierra Oncology, Inc.

Terminated

Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)

EGFR Mutated EGFR TKI Naive Metastatic NSCLC

United States
Sierra Oncology, Inc.

Completed

Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Primary Myelofibrosis | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, Canada, Australia
Cierra

Suspended

PFx Closure System in Subjects With Cryptogenic Stroke,Transient Ischemic Attack,Migraine or Decompression Illness(PFO)

Patent Foramen Ovale

France, Germany, Belgium
Cierra

Completed

The Paradigm II Trial: PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemic Attack, Migraine or Decompression Illness

Foramen Ovale, Patent

Germany
Cierra

Unknown

Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism

Patent Foramen Ovale

Germany
Sierra Oncology LLC - a GSK company

Completed

A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)

Primary Myelofibrosis | Post-polycythemia Vera Myelofibrosis | Post-essential Thrombocythemia Myelofibrosis

Korea, Republic of, Canada, Hungary, Israel, Spain, United States, Australia, Taiwan, Singapore, Germany, Italy, France, Belgium, New Zealand, Austria, United Kingdom, Denmark, Bulgaria, Poland, Czechia, Romania, Sweden
Sierra Oncology LLC - a GSK company

Terminated

PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)

Richter's Transformation

United States
Sierra Oncology LLC - a GSK company

Completed

Momelotinib in Transfusion-Dependent Adults With Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF)

Primary Myelofibrosis (PMF) | Post-polycythemia Vera (Post-PV) Myelofibrosis | Postessential Thrombocythemia (Post-ET) Myelofibrosis

United States, Canada
Sierra Oncology LLC - a GSK company

Completed

A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer

Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)

United Kingdom
Sienna Biopharmaceuticals

Completed

Safety, Efficacy, and Tolerability of SNA-120 in Subjects With Pruritus Associated With Psoriasis Vulgaris

Pruritus | Psoriasis Vulgaris

United States
Sierra Oncology LLC - a GSK company

Terminated

Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Metastatic Pancreatic Ductal Adenocarcinoma

United States
Sierra Oncology LLC - a GSK company

Completed

Study of PNT2258 for Treatment of Relapsed or Refractory Non-Hodgkin's Lymphoma

Lymphoma, Non-Hodgkin's

United States
Sierra Oncology LLC - a GSK company

Completed

PNT2258 for Treatment of Patients With r/r DLBCL (Wolverine)

Lymphoma, Diffuse Large B-Cell

United States, Puerto Rico
Sierra Oncology LLC - a GSK company

Completed

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Advanced Solid Tumors

Spain, United Kingdom
Sierra Oncology LLC - a GSK company

Completed

Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Post-Polycythemia Vera Myelofibrosis | Post-Essential Thrombocythemia Myelofibrosis

United States, France, Canada, Germany, Australia
VA Sierra Nevada Health Care System

Completed

Use of a Smart-phone Based Medication Adherence Platform to Improve Outcomes in Uncontrolled Non-insulin Dependent Diabetes Among Veterans

Diabetes | Diabete Type 2

United States
Sienna Biopharmaceuticals

Completed

Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene

Psoriasis | Pruritus

United States, Canada
Sierra Varona SL
Universidad Europea de Madrid

Not yet recruiting

Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength and Heart Rate Variability

Healthy
Sierra Varona SL
Universidad Europea de Madrid

Not yet recruiting

Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength, Vertical Jump Performance and Muscle Oxygen Saturation

Healthy
Sierra Varona SL
Universidad Europea de Madrid

Not yet recruiting

Influence of an Inspiratory Muscle Fatigue Protocol on Older Adults on Respiratory Muscle Strength and Heart Rate Variability

Healthy
Sierra Varona SL
Universidad Europea de Madrid

Not yet recruiting

Influence of an Inspiratory Muscle Fatigue Protocol on Older Adults on Respiratory Muscle Strength, Muscle Oxygen Saturation, and Functional Capacity

Healthy
Arshad Khanani
Genentech, Inc.

Completed

Evaluation of Pain and Inflammation After Injection of Lucentis vs Eylea for Treatment of Wet Macular Degeneration

Neovascular Age-Related Macular Degeneration

United States
Sierra Varona SL
Universidad Europea de Madrid

Not yet recruiting

Effects of Dry Needling on Vertical Jump Performance

Sports Physical Therapy
Arshad Khanani
Genentech, Inc.

Completed

Evaluation of Inflammation and Pain Post Injection of Ranibizumab vs Aflibercept in Patients With DME

Diabetic Macular Edema

United States
Associazione Salentina Angela Serra

Unknown

Palonosetron Plus Aprepitant Versus Palonosetron in Preventing Nausea and Vomiting in Leukemic Patients

Chemotherapy Induced Nausea and Vomiting

Italy
Sientra, Inc.

Active, not recruiting

Sientra Post-Approval Study

Breast Augmentation | Breast Reconstruction | Breast Revision

United States
Sientra, Inc.

Completed

Sientra Sponsored Silimed Gel-Filled Breast Implant Core Clinical Study

Breast Augmentation | Breast Reconstruction | Breast Revision

United States
Sientra, Inc.

Terminated

Post Market Clinical Experience Study of Sientra 207 Breast Implants

Breast Augmentation | Breast Revision-Augmentation

United States
Sienna Labs

Completed

Long-term Follow-up Study of Subjects Who Completed Clinical Studies 755.1100_FA, 810.1100_FA, or 1064.1100_FA

Acne Vulgaris

United States
Sixera Pharma

Recruiting

A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome

Netherton Syndrome

France
Sientra, Inc.

Active, not recruiting

AuraClens™ System in Processing of Lipoaspirate for Autologous Fat Grafting to the Breast (AuraGen)

Breast Fat Grafting Retention

United States
PATH
Tulane University; Sustainable Health Systems Sierra Leone

Not yet recruiting

A Short Period of Proactive Community Case Management (ProCCM) to Improve Early Care-seeking for Fever in Sierra Leone

Health Services Research
Pierre Fabre Medicament
Pierre Fabre Pharma GmbH

Completed

Oral Chemotherapy And Platinum With Radiotherapy Followed Or Not By Consolidation With The Same Chemotherapy In Locally Advanced Non Small Cell Lung Cancer

NSCLC

Germany
Pierre Fabre Medical Devices

Completed

Xerotic Dermatitis in Aged People

Itching Symptoms | Xerotic Dermatitis

France
Fundação Educacional Serra dos Órgãos

Completed

Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo

Vertigo

Brazil
Washington University School of Medicine
Project Peanut Butter, Sierra Leone; Ministry of Health and Sanitation, Government...

Completed

Effect of an Alternative RUTF on Intestinal Permeability in Children With Severe Acute Malnutrition

Malnutrition, Child

Sierra Leone
Pierre Fabre Pharma GmbH
Pierre Fabre Pharma Austria; Pierre Fabre Pharma AG

Recruiting

Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment (BERING)

Melanoma Stage IV | Melanoma Stage III

Austria, Germany, Switzerland
Fundação Educacional Serra dos Órgãos

Completed

Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis

Urinary Tract Infections

Brazil

Clinical Trials Sponsored by Sierra Neuropharmaceuticals

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