Clinical Trials Sponsored by UNC Hospitals

Total 131494 results

Changhai Hospital
UTC Therapeutics Inc.

Recruiting

Anti-CD70 CAR-T Cell Injection in Patients With CD70-positive Advanced Urologic Neoplasms

CD70-positive Advanced Urologic Neoplasms

China
Ruijin Hospital
UTC Therapeutics Inc.

Recruiting

Anti-mesothelin CAR-T Cells With Advanced Refractory Solid Tumors (Amaretto)

Refractory Malignant Solid Neoplasm

China
Shanghai Pudong Hospital
UTC Therapeutics Inc.

Withdrawn

Novel CAR-T Cell Therapy in the Treatment of Hematopoietic and Lymphoid Malignancies

Acute Myeloid Leukemia (AML) | Multiple Myeloma (MM) | B-cell Non-Hodgkin's Lymphoma (B-NHL) | T-Cell Leukemia/Lymphoma, Adult | B-cell Acute Lymphoblastic Leukemia (B-ALL)

China
Shanghai Pudong Hospital
UTC Therapeutics Inc.

Withdrawn

Exploratory Study of Novel MSLN CAR-T Cell Therapy in Patients With MSLN-positive Advanced Refractory Solid Tumors

Mesothelin-positive Advanced Refractory Solid Tumors

China
Chinese PLA General Hospital
UTC Therapeutics Inc.

Recruiting

CD70 Targeted CAR-T Cells in CD70 Positive Advanced/Metastatic Solid Tumors

Solid Tumor, Adult

China
Chinese PLA General Hospital
UTC Therapeutics Inc.

Recruiting

CD70 Targeted CAR-T Cells in CD70 Positive Relapsed/Refractory Lymphoma

Lymphoma

China
Chinese PLA General Hospital
UTC Therapeutics Inc.

Recruiting

CD40 Ligand Expressing MSLN-CAR T Cell Therapy in MSLN Positive Advanced/Metastatic Solid Tumors

Advanced or Metastatic Solid Tumors

China
UTC Therapeutics Inc.
Peking University Cancer Hospital & Institute

Recruiting

Phase 1 Study of UCMYM802 Injection in Mesothelin-positive Advanced Malignant Solid Tumors

Colorectal Cancer | Pancreatic Cancer | Rectal Cancer | Malignant Mesothelioma | Bile Duct Cancer | Breast Cancer Female | Ovary Cancer

China
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.; Oncoceutics, Inc.

Recruiting

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

Metastasis | Endometrial Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Seagen Inc.

Completed

Induction Chemo w/ABVD Followed by Brentuximab Vedotin Consolidation in Newly Diagnosed, Non-Bulky Stage I/II Hodgkin Lymphoma

Hodgkin Lymphoma, Adult

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Terminated

Efalizumab in Treating Patients With Graft-Versus-Host Disease of the Skin That Did Not Respond to Previous Steroids (NRR)

Graft Versus Host Disease

United States
UNC Lineberger Comprehensive Cancer Center
Veracyte, Inc.

Recruiting

Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA (HARMONY)

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Seagen Inc.

Active, not recruiting

BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma

Lymphoma | Lymphatic Diseases | Adult T-Cell Leukemia/Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Completed

Cancer Patients' Performance Status Assessed Using Cardiopulmonary Exercise Testing and Wearable Data Generation

Hematologic Malignancies | Malignant Solid Tumor

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Recruiting

Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B-cell Lymphoma

United States
Mylan Pharmaceuticals Inc
Genpharm ULC

Completed

Comparative Bioavailability Study of Baclofen 20 mg Tablets in Healthy Male Volunteers / Fasting State

Healthy

Canada
Northside Hospital, Inc.

Not yet recruiting

Adding Venetoclax to the High-dose Chemotherapy Regimen Prior to Mismatche Allogeneic Stem Cell Transplant

Acute Myeloid Leukemia | Myelodysplastic Syndromes

United States
Northside Hospital, Inc.

Recruiting

GM-CSF With Post-Transplant Cyclophosphamide

Transplant-Related Hematologic Malignancy

United States
Northside Hospital, Inc.

Completed

Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant

Depression | Fatigue | Anxiety | Distress

United States
Northside Hospital, Inc.

Completed

Combination Chemotherapy, Donor Stem Cell Transplant, Tacrolimus, Mycophenolate Mofetil, and Cyclophosphamide in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia

United States
Northside Hospital, Inc.

Recruiting

Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

United States
Northside Hospital, Inc.

Recruiting

Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

United States
Gaylord Hospital, Inc

Enrolling by invitation

Does Endurance Improve With the Use of Passy-Muir Valve for Patients With Tracheostomy?

Tracheostomy | PMV | Exercise Endurance

United States
Gaylord Hospital, Inc

Completed

Safety of the Nocturnal Passy Muir Valve and Impact on Sleep Quality at an LTACH Setting

Tracheostomy

United States
Northside Hospital, Inc.

Terminated

Use of Convalescent Plasma for COVID-19

COVID

United States
Gaylord Hospital, Inc

Completed

Explorations of the Benefits of the ZeroG TRiP System to Improve Balance in Patients Following Stroke

Stroke | Balance; Distorted

United States
Northside Hospital, Inc.

Terminated

MOSTEGRA TRIAL:MO-(Dified) STE-(nt) GRA(-ft): Surgeon-modified Fenestrated-branched Stent-grafts (MOSTEGRA)

Complex Aortic Aneurysms

United States
Northside Hospital, Inc.

Recruiting

Reduced Intensity Fludarabine and TBI Prior to Haplo-Identical Transplantation

Hematologic Malignancy

United States
Northside Hospital, Inc.

Terminated

Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte Globulin (ATG) in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm

United States
Mylan Pharmaceuticals Inc
Genpharm ULC

Completed

Fed, Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Subjects

Therapeutic Equivalency

Canada
Mylan Pharmaceuticals Inc
Genpharm ULC

Completed

Fasting Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Normal Healthy Subjects

Therapeutic Equivalency

Canada
Mylan Pharmaceuticals Inc
Genpharm ULC

Completed

Comparative Bioavailability Study of Clarithromycin 250 mg Tablets

Healthy

Canada
The Affiliated People's Hospital of Ningbo University
UTC Therapeutics Inc.

Recruiting

Study of CAR-T Cell Therapy in the Treatment of Relapsed/Refractory Hematological Malignancies

Lymphoma | Leukemia | Myeloma | Relapsed/Refractory Hematological Malignancies

China
UNC Lineberger Comprehensive Cancer Center
AstraZeneca; Rgenix, Inc.

Recruiting

Abequolixron (RGX-104) and Durvalumab in Lung Cancer

Non-Small Cell Lung Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Millennium Pharmaceuticals, Inc.

Terminated

A Phase I Study of Alisertib + R-EPOCH for Treatment of Myc-Positive Aggressive B-cell Lymphomas

Follicular Lymphoma | Burkitt Lymphoma | Diffuse Large B-cell Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
G1 Therapeutics, Inc.

Recruiting

Study of Trilaciclib and Lurbinectidin

Lung Cancer | Small-cell Lung Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Cerulean Pharma Inc.

Terminated

Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer

Rectal Cancer

United States
Northside Hospital, Inc.
Millennium Pharmaceuticals, Inc.

Completed

Nonmyeloablative Haploidentical Transplant Followed by MLN9708

Multiple Myeloma | Acute Leukemia | Myelodysplastic Syndrome | Lymphomas | Chronic Leukemia

United States
Daiichi Sankyo, Inc.
UMC Utrecht

Completed

Edoxaban in Peripheral Arterial Disease (ePAD)

Peripheral Arterial Disease

United States, Germany, Switzerland, Israel, Netherlands, Austria, Belgium
Peking University
UTC Therapeutics Inc.

Not yet recruiting

UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Solid Tumor
Zhejiang University
UTC Therapeutics Inc.

Recruiting

UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Mesothelin-positive Advanced Malignant Solid Tumors

China
Hartford Hospital
Shionogi Inc.

Active, not recruiting

Cefiderocol Plasma Concentrations in Patients Receiving Renal Replacement Therapy

Pharmacokinetics

United States
Griffin Hospital
ISOThrive Inc.

Completed

Effects of ISOThrive on Bodyweight, Body Composition, Hunger/Satiety and Cardiac Risk Measures in Overweight Adults (ISOThrive)

Obesity

United States
Genomictree, Inc.
Severance Hospital

Completed

Clinical Validation of Stool DNA-based SDC2 Methylation Test for Colorectal Cancer Detection

Healthy | Colorectal Cancer | Polyps | Other Cancers

Korea, Republic of
UNC Lineberger Comprehensive Cancer Center
American Cancer Society, Inc.

Completed

Chemotherapy-related Cognitive Impairment and Acute Leukemia

Acute Myeloid Leukemia

United States
Northside Hospital, Inc.
Sanofi

Recruiting

Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease

Chronic Graft Versus Host Disease

United States
BeamWorks Inc.
Severance Hospital

Active, not recruiting

Multi-Reader Multi-Case, Retrospective Study to Evaluate Effectiveness of CadAI-B for Breast

Breast Cancer

Korea, Republic of
Danbury Hospital
Ethicon, Inc.

Completed

Surgicel Snow in Gynecological Surgery

Laparoscopic Hysterectomy

United States
Griffin Hospital
Viocare, Inc.

Completed

Community Web Health Portal for Diabetes Prevention (NnoLEDGE)

Obesity | Health Knowledge
Rijnstate Hospital
Ethicon, Inc.

Completed

The Results and Outcomes of the Modified Swedish Adjustable Gastric Band (SAGB-VC) (ROS)

Weight Loss

Netherlands

Clinical Trials Sponsored by UNC Hospitals

Sponsors and Collaborators

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CROs in Chile

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