Search clinical trials for: BRCA1 mutation

Total 3340 results

Jazz Pharmaceuticals

Completed

Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer

Colorectal Neoplasms

United States, Canada
Pearl Network

Completed

Assessing the Effects of Three Oral Care Regimens

Gingivitis | Dental Plaque

United States
Chung-Ang University

Completed

BReast CAncer Genes(BRCA) Expressions in Metastatic Gastric Cancer

BRCA Gene Rearrangement

Korea, Republic of
Institut Paoli-Calmettes

Unknown

Triple Negative Breast Cancer: Study of Molecular and Genetic Factors

Breast Cancer

France
Data Collection Analysis Business Management
PAS Research Services

Unknown

Increase Surveillance for Breast and Ovarian Cancers, Also to Determine Targeted Risk-reducing and Preventative Strategies

Hereditary Cancer

United States
Lund University

Completed

Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast Cancer (BRCAsearch)

Hereditary Breast Cancer

Sweden
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

BRCA and NACT in TNBC Patients (Light-Bright)

Triple-Negative Breast Cancer

Italy
University of Utah
National Cancer Institute (NCI)

Completed

Risk Education and Assessment for Cancer Heredity (REACH)

Breast Cancer | Ovarian Cancer | Genetic Predisposition

United States
Cancer Trials Ireland

Active, not recruiting

Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study

Fallopian Tube Cancer | Primary Peritoneal Carcinoma | Serous Ovarian Tumor | Endometrioid Carcinoma Ovary

Ireland
Centre Georges Francois Leclerc

Not yet recruiting

Use of an Ultra-rapid BRCA1/2 Status Screening Test in Theranostic Indication: Performance and Interest for Patients and Practitioners (TURBO)

Breast Cancer
Alexandru Eniu
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival

To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer

Romania
Memorial Sloan Kettering Cancer Center
Memorial Health University Medical Center

Completed

BRCA1 Haploinsufficiency and Gene Expression

BRCA1 Mutations

United States
University of Pennsylvania
Inovio Pharmaceuticals

Recruiting

INO 5401 Vaccination in BRCA1/2 Mutation Carriers

BRCA1/2 Mutation

United States
Weill Medical College of Cornell University
Basser Research Center for BRCA

Recruiting

FaCT Trial (Facilitated Cascade Testing Trial)

BRCA1 Mutation | BRCA2 Mutation

United States
University of Pennsylvania

Recruiting

Evaluating Cascade Communication Methods (ECHO)

BRCA1 Mutation | BRCA2 Mutation

United States
National Cancer Institute (NCI)

Completed

A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

BRCA1 Gene | BRCA2 Gene

United States
Azienda Ospedaliera Universitaria Policlinico Paolo...

Unknown

BRCA Main Home Nutritional Intervention-random Study

BRCA1 Mutation | BRCA2 Mutation

Italy
Memorial Sloan Kettering Cancer Center
Phenogen Sciences

Recruiting

Responses to Genetic Risk Modifier Testing Among Women With BRCA1/2 Mutations

Genetic Testing | BRCA1/2

United States
Memorial Sloan Kettering Cancer Center
University of Pennsylvania; University of California, Los Angeles; Dana-Farber... and other collaborators

Active, not recruiting

BRCA Founder OutReach (BFOR) Study (BFOR)

BRCA1 Mutation | BRCA2 Mutation

United States
Massachusetts General Hospital

Recruiting

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Lynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR Mutation

United States
Institut Curie

Recruiting

COsegregation of VARiants in Panel of Genes (COVAR)

Genetic Predisposition | Gene Mutation-Related Cancer

France, Guadeloupe, Martinique, Réunion
Memorial Sloan Kettering Cancer Center
Yale University; Weill Medical College of Cornell University; New York Presbyterian...

Recruiting

Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations

Breast Cancer

United States
Medical College of Wisconsin

Active, not recruiting

Evaluating the Effects of Genetic Testing on Patients' Stress Levels

Breast Cancer

United States
pharmaand GmbH

Terminated

A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes (LODESTAR)

Solid Tumor

United States
Georgetown University

Completed

The Genetic Education for Men Trial: Web-Based Education vs. Standard Care (GEM)

Pancreatic Cancer | Breast Neoplasm | BRCA1 Mutation | BRCA2 Mutation | Prostate Carcinoma

United States
zr Pharma & GmbH
Foundation Medicine

Completed

A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer | Advanced Solid Tumor With Evidence of Germline or Somatic BRCA

United States, Israel, Spain, Canada, United Kingdom
National Human Genome Research Institute (NHGRI)
Johns Hopkins Bloomberg School of Public Health

Completed

Adaptation to Living With a BRCA1/2 Mutation

Cancer Genetics

United States
Pomeranian Medical University Szczecin
Maria Sklodowska-Curie National Research Institute of Oncology

Completed

Open-Label,Non-Randomized Trial of Cisplatin Chemotherapy in BRCA1-Positive Metastatic Breast Cancer Patients (Cisplatin)

Metastatic Breast Cancer | BRCA1 Mutation

Poland
Rabin Medical Center

Unknown

The Link Between BRCA Mutation and Endothelial Function

BRCA1 Gene Mutation | BRCA2 Gene Mutation

Israel
Nuvation Bio Inc.

Recruiting

NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors

Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Breast Carcinoma | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Advanced Solid Tumor | Cancer of the Ovary | Pancreas Cancer | Triple-negative Breast Cancer | Cancer of Pancreas | Pancreas Neoplasm | Prostate Neoplasm | Cancer... and other conditions

United States, Australia
Second Affiliated Hospital, School of Medicine,...

Recruiting

Prophylactic Irradiation to the Contralateral Breast for BCAs Patients (PICB)

Breast Cancer

China, Singapore
General Oncology, Inc.
Myriad Genetics, Inc.

Recruiting

SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Pancreatic Cancer Stage IV | Breast Cancer Stage IV | BRCA1 Mutation | BRCA2 Mutation | Pancreatic Acinar Cell Carcinoma | Metastatic Pancreatic Cancer | Breast Cancer Metastatic | HER2-negative Breast Cancer | Metastatic Pancreatic Ductal Adenocarcinoma and other conditions

United States
AbbVie

Completed

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

Metastatic Breast Cancer

United States, Argentina, Australia, Austria, Belarus, Belgium, Canada, Chile, Colombia, Czechia, Denmark, Estonia, Finland, France, Germany, Hungary, Israel, Italy, Korea, Republic of, Latvia, Lithuania, Mexico, Netherlands, Norway, Po... and more
Artios Pharma Ltd

Active, not recruiting

A Study of ART4215 for the Treatment of Advanced or Metastatic Solid Tumors

Breast Cancer | Metastatic Cancer | Advanced Cancer

United States, United Kingdom
Georgetown University
George Washington University

Enrolling by invitation

Genetic Education in BRCA Families

BRCA1 Mutation | BRCA2 Mutation

United States
AstraZeneca

Completed

To Study Clinical Effectiveness and Safety of Olaparib Monotherapy in Metastatic Breast Cancer Patients.

HER2-ve Metastatic Breast Cancer | Germline BRCA1/2 Mutations | Somatic BRCA1/2 Mutations

Italy, Spain, Poland, Taiwan, Canada, France, Germany, Korea, Republic of, Hungary, Japan, Russian Federation, Turkey, United Kingdom, United States, Bulgaria
Centre Hospitalier Universitaire de Besancon

Completed

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA) (IMBASSA)

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

France
Placon Therapeutics

Unknown

A Study to Determine the Safety of BTP-114 for Treatment in Patients With Advanced Solid Tumors With BRCA Mutations

Breast Neoplasms | Prostatic Neoplasms | Pancreatic Neoplasms | Ovarian Neoplasms

United States
Women's College Hospital
BioResponse

Unknown

The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers

Breast Cancer

Canada
Memorial Sloan Kettering Cancer Center
American Cancer Society, Inc.

Completed

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Breast Cancer

United States
Abramson Cancer Center at Penn Medicine

Recruiting

BRCA1/2 Flu Vaccine

BRCA1 Mutation | BRCA2 Mutation

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

BRCA1 Gene Mutation | BRCA2 Gene Mutation

United States
University of California, San Francisco
American Cancer Society, Inc.

Completed

Prospective Research of Outcomes After Salpingo-oophorectomy (PROSper)

BRCA1 Gene Mutation | BRCA2 Gene Mutation

United States
European Institute of Oncology

Completed

Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing (BRCA-MEN)

BRCA1 Mutation | BRCA2 Mutation | Psychosocial Factors

Italy
Pfizer
Medivation, Inc.

Completed

A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study) (EMBRACA)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

Korea, Republic of, United States, Australia, Spain, Belgium, France, Ireland, Taiwan, Poland, Germany, Israel, Brazil, United Kingdom, Italy, Russian Federation, Ukraine
Pfizer
Medivation, Inc.; Myriad Genetic Laboratories, Inc.

Terminated

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study) (ABRAZO)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

United States, Spain, United Kingdom, Germany, France
nVision Medical

Completed

Pre-Salpingo-Oophorectomy Pilot Study of MAKO 7 Device Performance

BRCA1 Mutation | BRCA2 Mutation | Atypia Suspicious for Malignancy

United States
Sierra Oncology LLC - a GSK company

Completed

A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer

Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)

United Kingdom
Priyanka Sharma
Bristol-Myers Squibb; Celgene Corporation

Active, not recruiting

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Breast Cancer | Triple-Negative Breast Cancer

United States
Georgetown University
National Cancer Institute (NCI); National Human Genome Research Institute (NHGRI)

Completed

Decision Support Following Genetic Testing for Breast-Ovarian Cancer Susceptibility

Breast Cancer | Ovarian Cancer

United States

Search clinical trials for: BRCA1 mutation

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