Search clinical trials for: Disease-modifying treatment

Total 63288 results

VA Office of Research and Development

Recruiting

Dynamic Treatment Regiments for Glucocorticoid Tapering (SMART-RA)

Rheumatoid Arthritis

United States
Abu Dhabi Stem Cells Center

Recruiting

Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis (PHOMS)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive

United Arab Emirates
Radboud University Medical Center
Michael J. Fox Foundation for Parkinson's Research

Completed

Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease (TALISMAN)

Parkinson Disease | Effect of Drug

Netherlands
Novartis Pharmaceuticals

Completed

Risk Perception in Multiple Sclerosis

Multiple Sclerosis

United States
University of Aarhus
University of Southern Denmark; Region of Southern Denmark

Completed

Early Exercise Efforts in Multiple Sclerosis

Multiple Sclerosis

Denmark
Hoffmann-La Roche

Completed

An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies

Rheumatoid Arthritis

France, Germany, Italy, Spain, Sweden, China, United States, Australia, Canada, Mexico, South Africa, United Kingdom, Czech Republic, Finland, Russian Federation, Switzerland, Thailand, Belgium, Denmark, Slovenia, Serbia, Israel, Hong... and more
National Institute of Allergy and Infectious Diseases...
Autoimmunity Centers of Excellence

Terminated

Rituximab for the Treatment of Early Rheumatoid Arthritis (RA)

Rheumatoid Arthritis

United States
Mashhad University of Medical Sciences
Roche Pharma AG

Completed

Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients With Rheumatoid Arthritis

DMARD Resistant Rheumatoid Arthritis

Iran, Islamic Republic of
Harbin Medical University
Shanghai Shenqi Medical Technology Co., Ltd

Not yet recruiting

RESTORE Imaging: an OCT-IVUS Imaging Substudy of RESTORE Trial

Acute Coronary Syndrome (ACS)

China
AstraZeneca

Not yet recruiting

Real-World Treatment Study of Soliris (Eculizumab) (SolirisPMS)

Observational

Korea, Republic of
Fudan University

Recruiting

Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer

Advanced Breast Cancer | HR+/HER2- Breast Cancer

China
Nanfang Hospital, Southern Medical University

Recruiting

Research on the Mechanisms of Treatment Non-response in Inflammatory Bowel Disease Based on Multi-omics Technology

Inflammatory Bowel Diseases

China
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

Paroxysmal Nocturnal Hemoglobinuria | PNH | Extravascular Hemolysis
Zhongda Hospital

Recruiting

Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM

Colorectal Cancer Metastatic

China
Case Comprehensive Cancer Center
AbbVie; Genmab; Recordati Rare Diseases

Not yet recruiting

Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab

Non-Hodgkin Lymphoma | Cytokine Release Syndrome

United States
Edward Via Virginia College of Osteopathic Medicine

Recruiting

Effects of Spencer's Technique on Shoulder Function

Shoulder

United States
Bristol-Myers Squibb

Not yet recruiting

Patient and Physician Preference Study in Resectable, Non-small Cell Lung Cancer Treatments

Non-small Cell Lung Cancer (NSCLC)

United Kingdom
Aristotle University Of Thessaloniki

Not yet recruiting

Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not? (RCTCa(OH)2)

Endodontically Treated Teeth | Calcium Hydroxide

Greece
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia

Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia

United States
New York University
Joon, Inc.

Recruiting

Randomized Controlled Trial of a Behavioral Training App

Depression | Stress | Anxiety | Executive Dysfunction | Behavior, Child | Disruptive Behavior | Attention-deficit

United States
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease

Feasibility | Safety Issues | Therapeutic Value
Shanghai Zhongshan Hospital

Recruiting

Effects of Growth Hormone Therapy on Metabolic Function in Fatty Liver Post-Pituitary Adenoma Surgery

Growth Hormone Treatment

China
Xuanwu Hospital, Beijing

Not yet recruiting

Efficacy and Safety Evaluation of Hyperthermic Baths in the Treatment of Seizures in Children With CDKL5 Deficiency

CDKL5 Deficiency Disorder

China
Fujian Shengdi Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Tolerability, and Preliminary Efficacy of HRS-7450 Injection in the Treatment of Acute Ischemic Stroke: a Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled Clinical Trial

Acute Ischemic Stroke

China
University Hospital, Montpellier

Not yet recruiting

Identification and Characterization of Circulating Tumor Cells Before and After Treatment (Surgery and Radiotherapy) in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma (MERCCALIBI)

Merkel Cell Carcinoma
Ohio State University
Patient-Centered Outcomes Research Institute; The George Washington University...

Not yet recruiting

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes (DECIDE)

Pregnancy, High Risk | Gestational Diabetes Mellitus

United States
Huai'an First People's Hospital
The Affiliated Hospital of Xuzhou Medical University; The First People's Hospital... and other collaborators

Recruiting

A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL

Primary Central Nervous System Lymphoma

China
Shanghai East Hospital

Recruiting

Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
Islamia University of Bahawalpur

Not yet recruiting

Efficacy of Cognitive Behavior Therapy in the Treatment of Chronic Pelvic Pain in Women

Chronic Pelvic Pain Syndrome
Postgraduate Institute of Dental Sciences Rohtak

Recruiting

Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients With AP

Chronic Kidney Diseases | Apical Periodontitis

India
University Hospital, Rouen

Not yet recruiting

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND)

Metastatic Colon Cancer
Community Pharmacology Services Ltd
Kaneka Americas Holding Inc.

Not yet recruiting

Menopausal Symptoms Probiotic Study

Menopause
Institute of Hematology & Blood Diseases Hospital...

Recruiting

VMAC+DLI Treatment of Patients With Relapse of AML After Allo-HSCT (VMAC+DLI)

Relapse Acute Myeloid Leukemia

China
University Hospital, Clermont-Ferrand
Grünenthal GmbH

Not yet recruiting

Capsaicin in Digital Osteoarthritis Versus Control : a Randomized Study (CADOR)

Neuropathic Pain | Osteoarthritis Hand

France
Infertility Treatment Center Dortmund
Fertility Center Dortmund; novum - Center for Reproductive Medicine Essen -... and other collaborators

Not yet recruiting

Impact of Predetermined Day 5 ET vs. Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment

Infertility | Reproductive Issues
Fundacio Clinic Barcelona
University of Padova; Sheba Medical Center; Istituto Oncologico Veneto IRCCS; University... and other collaborators

Not yet recruiting

Diagnostic HER2DX-guided Treatment for patIents wIth Early-stage HER2-positive Breast Cancer (DEFINITIVE)

HER2-positive Breast Cancer | Early-stage Breast Cancer
First Affiliated Hospital of Zhejiang University

Recruiting

Efficacy and Safety of Modified Si Jun Zi Tang in Perioperative NSCLC Treatment (MSJZT-NSCLC)

Non Small Cell Lung Cancer | Perioperative Complication

China
Breast Cancer Trials, Australia and New Zealand

Not yet recruiting

Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International Validation Experience (PROSPECTIVE)

Breast Cancer | Breast Cancer Female
Ipsen

Not yet recruiting

A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment (ELFINITY)

Primary Biliary Cholangitis
Washington University School of Medicine

Not yet recruiting

Propranolol for the Treatment of Kaposi Sarcoma in Adults

Kaposi Sarcoma

United States
Sun Yat-sen University

Not yet recruiting

FOLFOX Chemotherapy Plus Fruquintinib and Sintilimab After First-line Treatment in Unresectable Hepatocellular Carcinoma (FOLFOX)

Hepatocellular Carcinoma | Immunotherapy | Second-line Treatment | Anti-angiogenic Therapy | FOLFOX Systemic Chemotherapy
Scholar Rock, Inc.

Recruiting

Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese (EMBRAZE)

Overweight and Obesity

United States
The Fourth Affiliated Hospital of Zhejiang University...

Not yet recruiting

Effects of Myoelectric Biofeedback on Upper Limb Function in Post-stroke Patients

Rehabilitation | Cerebral Infarction | Biofeedback

China
Oregon Health and Science University

Not yet recruiting

Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery

Pain, Chronic | Pain Catastrophizing | Gender Identity | Transgenderism
Fujian University of Traditional Chinese Medicine

Recruiting

Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged and Elderly Individuals

Dry Eye Disease

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy and Safety of Bezafibrate 400 mg and Bezafibrate 200 mg as Adjunctive Treatments in Patients With Primary Biliary Cholangitis and Non-optimal Biochemical Response to Ursodeoxycholic Acid Therapy (BEZURSO 2)

BPC | Non Optimal Response to UDCA

France
RAND
Innovations for Poverty Action; Clinton Health Access Initiative, Nigeria

Not yet recruiting

The Impact of Pre-emptive Home Delivery of ORS + Zinc on Treatment for Child Diarrhea

Diarrhea Toddler
Rethink Wellbeing
Maastricht University

Not yet recruiting

Global Controlled Trial on Effects of an Online Self-Help Program for of Ambitious Altruists on Their Mental Health, Wellbeing, and Productivity: Comparing Versions With IFS vs. CBT, Buddy- vs. Group-, Standard- vs. Minimum-Guidance Intensity. (CT_DoBetter)

Depression | Quality of Life | Cognitive Dysfunction | Anxiety | Loneliness | Treatment Adherence and Compliance | Mental Health Issue | Self Esteem | Interpersonal Relations | Functioning, Psychosocial | Social Functioning | Well-Being, Psychological | Functioning, Social

Netherlands
Taizhou Hospital

Not yet recruiting

Toripalimab Plus Anlotinib for the Maintenance of Extensive Stage Small Cell (SCLC)

SCLC | Maintenance Treatment
Nicolaus Copernicus University in Toruń, Collegium...

Recruiting

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

Knee Osteoarthritis | Knee Injuries | ACL Injury

Poland

Search clinical trials for: Disease-modifying treatment

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