Identification and Characterization of Circulating Tumor Cells Before and After Treatment (Surgery and Radiotherapy) in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma (MERCCALIBI)
Identification and Characterization of Circulating Tumor Cells Before and After Treatment in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma
The goal of this prospective observational study is to evaluate the presence of circulating tumoral cells in patients over 18 with a stage I-III resectable Merkel cell carcinoma after the initial therapeutic sequence of surgery and radiotherapy. The main question it aims to answer is :
Can any residual disease be found in the form of circulating tumoral cells in blood samples of patients treated with surgery and radiotherapy for a resectable, stage I to III Merkel cell carcinoma ? When possible, the circulating tumoral cells count will be compared to the one realized in a blood sample of the same patient before surgery and radiotherapy.
Participants will :
- Have a blood sample taken before surgery (if the patient is addressed to our center early enough),
- Have a blood sample taken immediately after surgery and radiotherapy (for all).
- Two additional blood samples will be taken during the 6-months and 12-months visit to set up a biobank.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The main goal of this study is to evaluate the presence of circulating tumoral cells in patients circulating tumoral cells after surgery and radiotherapy in patients with stage I to III Merkel cell carcinoma.
Another goal will be to track changes in the number of circulating tumoral cells before and after treatment in patients with stage I to III Merkel cell carcinoma, who have had a blood sample taken before starting treatment.
Investigators will also set up a biobank, which is a collection of blood samples taken every six months for one year. These samples will help with future research.
The study will include patients over 18 years old with stage I to III Merkel cell carcinoma, treated at the Dermatology Departments of Montpellier and Nimes University Hospitals. Investigators will not include pregnant or breastfeeding women, patients not covered by social security, those under court protection, those unable to give consent, or those with stage IV Merkel cell carcinoma or stage I to III Merkel cell carcinoma where complete remission is not possible. All patients will give free and informed consent to participate.
Patients will be divided into two groups based on when they are referred to the university hospital for treatment.
Group A: If the tumor is fully removed before the patient is referred to the hospital.
Group B: If the tumor is still present when referred to the hospital. This can happen if:
- Only a biopsy has been done to confirm the tumor.
- The tumor was removed but it is stage III with lymph node involvement. Both scenarios will not affect the main goal (checking for circulating tumoral cells after treatment). However, the change in circulating tumoral cell numbers before and after treatment can only be checked in Group B, where patients had a blood sample taken before treatment.
Both groups will have follow-up visits at 6 and 12 months. The main endpoint will be the circulating tumoral cell detection rate, which is the presence of circulating tumoral cells in their blood right after surgery and radiotherapy. Another measure will be the change in the number of circulating tumoral cells before and after treatment for those who had a blood sample taken before starting treatment.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Olivier Dereure, Pr
- Phone Number: 0467336906
- Email: o-dereure@chu-montpellier.fr
Study Contact Backup
- Name: Angele Lallement, Dr
- Phone Number: 0649574139
- Email: angele.lallement@chu-montpellier.fr
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients at least 18 years old
- Patients managed for stage I to III Merkel cell carcinoma,
- For whom complete remission by complete surgical resection is planned (group B) or has been achieved recently, within 6 weeks prior to the inclusion visit (group A).
Exclusion Criteria:
- Pregnant or breast-feeding women
- Failure to obtain written informed consent after a reflection period
- Participant in another research study with an ongoing exclusion period
- Not affiliated to a social security scheme
- Persons under court protection
- Patients unable to give consent, protected adults, vulnerable persons
- Stage IV disease or stage I to III disease for which complete remission is not envisaged
Study Plan
How is the study designed?
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma
Entire cohort
|
Research and quantification of Circulating Tumor Cells
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Circulating tumoral cells detection rate
Time Frame: 6 weeks or less after the therapeutic sequence of surgery and radiotherapy
|
Rate of patients with the presence of at least one CTC detected in the peripheral blood directly after the therapeutic sequence of surgery and radiotherapy, in absolute value
|
6 weeks or less after the therapeutic sequence of surgery and radiotherapy
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Change in the number of pre- and post-therapeutic circulating tumoral cells
Time Frame: 6 weeks or less after the therapeutic sequence of surgery and radiotherapy
|
Difference between the number of post-therapeutic CTCs (after surgery and radiotherapy) and the number of pre-therapeutic CTCs (for patients for whom a pre-therapeutic sample was available: group B patients), in absolute value
|
6 weeks or less after the therapeutic sequence of surgery and radiotherapy
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Virus Diseases
- Infections
- Neoplasms by Histologic Type
- Neoplasms
- Adenocarcinoma
- Neoplasms, Glandular and Epithelial
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- DNA Virus Infections
- Neoplastic Processes
- Tumor Virus Infections
- Neuroendocrine Tumors
- Neoplasm Metastasis
- Polyomavirus Infections
- Carcinoma, Neuroendocrine
- Carcinoma
- Carcinoma, Merkel Cell
- Neoplastic Cells, Circulating
Other Study ID Numbers
- RECHMPL23_0452
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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