Search clinical trials for: Haemophilia A prophylaxis pharmacokinetic dosing

Total 493314 results

Hampshire Hospitals NHS Foundation Trust
Uppsala University; University of Wales Cardiff United Kingdom (UK)

Completed

Efficacy and Cost Effectiveness of Pharmacokinetic Dosing in Haemophilia A

Severe Haemophilia A

United Kingdom
Kathelijn Fischer
Radboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaborators

Recruiting

Pharmacokinetic-guided Dosing of Emicizumab (DosEmi)

Adolescent | Child | Hemophilia A With Inhibitor | Adult | Hemophilia A Without Inhibitor | Hemophilia A, Severe

Netherlands
HIV Prevention Trials Network

Completed

The ADAPT Study: Use of Emtricitabine and Tenofovir Disoproxil Fumarate for Pre-Exposure Prophylaxis (PrEP) (ADAPT)

HIV Infections

United States, South Africa, Thailand
Chulalongkorn University

Completed

Clinical Outcomes of Low Dose PK-guided EHL FVIII Concentrates Versus Standard Prophylaxis in Severe Haemophilia A

Severe Hemophilia A Without Inhibitor

Thailand
Hoffmann-La Roche
Chugai Pharmaceutical

Completed

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors (HAVEN 1)

Hemophilia A

Korea, Republic of, United States, France, Germany, Italy, South Africa, Spain, Japan, United Kingdom, Poland, Taiwan, Australia, Costa Rica, New Zealand
Novo Nordisk A/S

Completed

Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia A (pathfinder™2)

Congenital Bleeding Disorder | Haemophilia A

France, United States, Denmark, Netherlands, Sweden, Spain, Germany, Switzerland, Taiwan, Japan, United Kingdom, Croatia, Italy, Malaysia, Brazil, Australia, Hungary, Israel, Turkey, Puerto Rico, Norway, Korea, Republic of, Bulgaria, Russian...
Novo Nordisk A/S

Terminated

A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia Subjects (explorer™2)

Healthy | Congenital Bleeding Disorder | Haemophilia A

Austria, Spain, United Kingdom, France, Germany
Hampshire Hospitals NHS Foundation Trust

Completed

National Study of a Pharmacokinetic-Focused Educational Package for Patients With Severe Haemophilia A (UK-PK)

Hemophilia A

United Kingdom
Peking Union Medical College Hospital
Xiangya Hospital of Central South University; Ruijin Hospital; China-Japan Friendship...

Recruiting

The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics

Pulmonary Embolism

China
Suzhou Alphamab Co., Ltd.

Recruiting

Efficacy and Safety of KN057 Prophylaxis in Patients With Haemophilia A or B With Inhibitors

Hemophilia A With Inhibitor | Hemophilia B With Inhibitor

China
GlaxoSmithKline

Not yet recruiting

A First Time in Human Study to Evaluate the Safety and Tolerability of GSK3996401 Following Dosing With GSK4347859 in Healthy Participants

Systemic Lupus Erythematosus

United Kingdom
Central South University

Recruiting

Clinical Study of Individualized Vancomycin Dosing Based on Population PK Model

Severe Infection

China
Radboud University Medical Center

Not yet recruiting

Model Informed preciSion doSIng tO iNdividualise and Optimize Pharmacotherapeutic Treatment (MISSION)

Pharmacokinetics | Tacrolimus | Area Under Curve | Immunosuppressive Agents | Mycophenolic Acid
Merck Sharp & Dohme LLC

Recruiting

Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)

HIV | HIV Pre-exposure Prophylaxis

United States, South Africa, Israel
Assistance Publique - Hôpitaux de Paris

Recruiting

Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments (DOXY-PK)

Sexually Transmitted Diseases | Post-exposure Prophylaxis | Doxycycline

France
University of Michigan
Agency for Healthcare Research and Quality (AHRQ)

Recruiting

Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis (MorphAbxPKSurg)

Surgical Prophylaxis

United States
Octapharma

Not yet recruiting

Nuwiq Dosing and Outcomes In the ManagEment of Women/Girls With Haemophilia A Needing FVIII Treatment for Surgery

Hemophilia A

Spain, France, Finland, Germany, Italy, Serbia
Octapharma

Recruiting

Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study (NuPOWER)

Severe Hemophilia A

Spain, Croatia, Italy, North Macedonia, Serbia
Moi University
Amsterdam UMC, location VUmc; Princess Maxima Center for Pediatric Oncology

Recruiting

CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA And Toxicity of Targeted Therapy In Pediatric Oncology Patients. (CHAPATI)

Pediatric Cancer

Kenya
University of Mississippi Medical Center
Eli Lilly and Company

Recruiting

Empagliflozin in ESKD - A Feasibility Study

Heart Failure | Kidney Failure, Chronic

United States
Children's Hospital Medical Center, Cincinnati
Jinja Regional Referral Hospital (JRRH), Sickle Cell Clinic, Jinja, Uganda

Recruiting

Alternative Dosing And Prevention of Transfusions (ADAPT)

Sickle Cell Disease

Uganda
Amsterdam UMC, location VUmc

Not yet recruiting

Alternative Dosing Scheme of Pomalidomide 4 mg Every Other Day Versus Pomalidomide 2 mg and 4 mg Every Day; the POMAlternative Study (POMAlternative)

Multiple Myeloma | Multiple Myeloma in Relapse | Multiple Myeloma, Refractory
AstraZeneca
Parexel

Recruiting

AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease

Healthy Subjects | Crohns Disease

United Kingdom
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

A Study of the Safety, Tolerability, and Pharmacokinetics of Dolutegravir in Neonates Exposed to HIV-1

HIV

United States, Brazil, Puerto Rico, South Africa, Thailand
Biopharma Plasma LLC
Ivano-Frankivsk National Medical University; State Institution, Zaporizhzhia...

Recruiting

Human Anti-D (rh) Immunoglobulin (Rhesoglobin) Efficacy, Safety and Some Pharmacokinetics Parameters in Pregnant Women

Pregnancy Related

Ukraine
MorphoSys AG

Recruiting

Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients (MINDway)

Diffuse Large B Cell Lymphoma

Korea, Republic of, Czechia, Spain, Israel, Italy, Austria, Poland, United States, France
Makerere University

Recruiting

Pharmacogenetics-guided Isoniazid Dosing in TB-HIV (PHINX)

Tuberculosis

Uganda
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) (CROSSWALK-c)

Sickle Cell Disease

United States, Spain, Brazil, United Kingdom, Italy, Turkey, Kenya, Netherlands, France, South Africa, Lebanon
Eledon Pharmaceuticals

Recruiting

Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant

Kidney Transplant

Canada, Australia, United Kingdom
The University of Queensland
Chinese University of Hong Kong; University of Malaya; The Alfred; Centre Hospitalier... and other collaborators

Recruiting

PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) (PNEUDOS)

Pneumonia

Hong Kong, France, Belgium, Australia, Malaysia
Bambino Gesù Hospital and Research Institute
Radboud University Medical Center; University of Exeter; Consorzio per Valutazioni...

Recruiting

A New Posaconazole Dosing Regimen for Paediatric Patients With Cystic Fibrosis and Aspergillus Infection (cASPerCF)

Cystic Fibrosis | Aspergillosis

Ireland, Spain, Netherlands, France, United Kingdom, Czechia, Germany, Greece, Italy, Portugal, Switzerland
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). (CROSSWALK-a)

Sickle Cell Disease

United States, Brazil, Italy, Spain, Kenya, Netherlands, United Kingdom, France, South Africa
University of Sarajevo
KU Leuven; Amsterdam UMC, location VUmc; Leiden University Medical Center; University...

Recruiting

Amikacin Pharmacokinetics to Optimize Dosing Recommendations in Neonates With Perinatal Asphyxia Treated With Hypothermia (Amicool)

Asphyxia Neonatorum

Bosnia and Herzegovina
University of Geneva, Switzerland
University of Lausanne

Recruiting

Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies (AMA)

Periodontal Diseases | Pharmacokinetics | Antibiotics

Switzerland
Duke University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Not yet recruiting

Pharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With Arthritis (PRECISE)

Obesity | Rheumatoid Arthritis | Juvenile Idiopathic Arthritis

United States
University Hospital, Ghent

Recruiting

Antibiotic Dosing in Geriatric Patients at the Emergency Department (AGED)

Frail Elderly Syndrome | Frailty | Infection, Bacterial | Elderly Infection

Belgium
Boston Children's Hospital
Bristol-Myers Squibb

Recruiting

Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis (ABA3)

Graft Vs Host Disease

United States
University of Manitoba
The Kidney Foundation of Canada

Recruiting

Is Cefazolin, Ceftazidime and Ciprofloxacin Dosing Optimal in Hemodialysis Patients?

End Stage Renal Disease | Hemodialysis Complication | Infectious Disease

Canada
Melbourne Health
Merck Sharp & Dohme LLC

Recruiting

Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants (POPULAR)

Fungal Infection | Pharmacokinetics | Invasive Aspergillosis | Prophylaxis | Invasive Candidiases | Posaconazole | Invasive Mycosis

Australia
McMaster University

Recruiting

Personalized Medicine for Canadians With Hemophilia (PMCH)

Hemophilia A | Hemophilia B

Canada
Université Catholique de Louvain

Recruiting

Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units (Pop-PK/PD)

Pharmacokinetics | Infection | Infection, Bacterial | Anti-Bacterial Agents | Drug Monitoring | Infections, Respiratory

Belgium
PedNet Haemophilia Research Foundation
Lund University Hospital

Recruiting

The European Paediatric Network for Haemophilia Management ( PedNet Registry) (PedNet)

Factor IX Deficiency | Factor VIII Deficiency

Norway, Austria, Belgium, Canada, Czechia, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom
West Virginia University

Recruiting

Prospective Evaluation of Adjusted Body Weight Dosing of Acyclovir in Obesity

Obesity

United States
Brugmann University Hospital

Recruiting

Does the Thrombin Generation Test Performed During the Pharmacokinetic Profile of the Substitutive Factor VIII Bring Benefits to the Personalized Treatment of Pediatric Patients and Adult Hemophilia A Patients Under Prophylaxis ?

Hemophilia

Belgium
University Hospital, Ghent
University Hospital, Antwerp; Queen Fabiola Children's University Hospital,...

Recruiting

Antibiotic Dosing in Pediatric Intensive Care (ADIC)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin

Belgium
Pfizer
Biohaven Pharmaceutical Holding Company Ltd.

Active, not recruiting

Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens

Migraine

Spain, United States, France, Canada, Germany, United Kingdom, Poland, Austria, Sweden, Italy
University of Maryland, Baltimore
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Active, not recruiting

Clinical Decision Support Tool for Vancomycin Dosing in Children

Gram-Positive Bacterial Infections | Pharmacokinetics | Pharmacodynamics | Vancomycin

United States
Sharon Hillier
National Cancer Institute (NCI)

Completed

Safety and Acceptability of Q GRFT Nasal Spray for COVID-19 Prophylaxis

COVID-19 | Pharmacokinetics | Safety

United States
Kancera AB
LINK Medical Research AB; CRST Oy; Q&Q Labs AB

Completed

Evaluation of Safety, Tolerability, Pharmacokinetics, Food Effect and Interaction With Midazolam in Healthy Volunteers After Oral Single and Multiple Ascending Dosing of KAND145

Ovarian Cancer

Finland
Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab Prophylaxis (Beyond ABR)

Severe Hemophilia A | Moderate Hemophilia A

Brazil, Germany, Italy, Spain, United States, Turkey, United Kingdom, Tunisia, Canada, Hungary, Morocco, Serbia

Search clinical trials for: Haemophilia A prophylaxis pharmacokinetic dosing

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in New Zealand

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations