Search clinical trials for: Late Onset Lysosomal Acid Lipase (LAL) Deficiency

Total 42786 results

David Brienza

Completed

An RCT on Support Surfaces for Pressure Ulcer Prevention

Pressure Ulcer | Pressure Injury

United States
Vance Thompson Vision

Completed

Binocular Custom Vision Utilizing The Light Adjustable Lens (LAL)

Cataract | Pseudophakia

United States
Alexion

Completed

A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype

Wolman Disease | Lysosomal Acid Lipase Deficiency

United States, Canada, United Kingdom, Italy, France
Alexion Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD) | LAL-Deficiency

France, United States, United Kingdom, Czechia
Alexion Pharmaceuticals

Terminated

Clinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency

United Kingdom, Finland, United States, Italy
Alexion Pharmaceuticals

Completed

Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | LAL-Deficiency | Cholesterol Ester Storage Disease (CESD)

France, United Kingdom, United States, Canada, Czechia
Alexion Pharmaceuticals

Completed

Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency (ARISE)

Lysosomal Acid Lipase Deficiency

France, Poland, United Kingdom, Spain, Mexico, Turkey, Japan, Australia, Russian Federation, United States, Germany, Italy, Czechia, Argentina, Croatia
RxSight, Inc.

Completed

Exploratory Study to Evaluate the Use of the RxSight Light Adjustable Lens (LAL) and the Light Delivery Device (LDD) to Improve Visual Outcomes

Cataract | Aphakia

Mexico
RxSight, Inc.

Completed

Exploratory Study to Evaluate Uncorrected Distance Vision and Quality of Vision After Light Treatments of an Implanted RxSight Light Adjustable Lens (RXLAL) With The Light Delivery Device (LDD) in Subjects With Preoperative Corneal Astigmatism

Cataract | Aphakia

Mexico
Alexion Pharmaceuticals

Completed

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency

Wolman Disease | Lysosomal Acid Lipase Deficiency

United Kingdom, France, United States, Egypt, Ireland
Alexion

Recruiting

Lysosomal Acid Lipase (LAL) Deficiency Registry (ALX-LALD-501)

Wolman Disease | Cholesterol Ester Storage Disease | Lysosomal Acid Lipase Deficiency | Acid Cholesteryl Ester Hydrolase Deficiency, Type 2 | Acid Lipase Deficiency | LIPA Deficiency | LAL-Deficiency

France, Belgium, United States, Spain, Germany, Greece, Israel, Italy, Slovenia, United Kingdom, Brazil, Canada, Denmark, Australia, Croatia, Czechia, Ireland, Mexico, Netherlands, Poland, Portugal, Saudi Arabia
Alexion Pharmaceuticals

Completed

An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD)

United States, United Kingdom, France, Canada, Czech Republic, Italy, Poland, Switzerland
Ankara University
Alexion Pharmaceuticals

Completed

National Lysosomal Acid Lipase Deficiency Study (LAL-D)

Cholesteryl Ester Storage Disease

Turkey
Hill-Rom

Completed

AFT/CLP-LAL RCT Stage 3 or 4 Pressure Injuries

Pressure Ulcer

United States
Alexion Pharmaceuticals

Terminated

A Study to Identify and Characterize LAL-D Patients in High-risk Populations

Lysosomal Acid Lipase Deficiency

United States
Azidus Brasil

Completed

Efficacy and Safety of Sodium Heparin (Hipolabor) in Patients (HEPSBCCV0109)

Cardiac Surgery

Brazil
RxSight, Inc.

Recruiting

RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study

Cataract | Aphakia

United States
Banaras Hindu University

Completed

Study of the Effect of Glutamine Supplementation on Chemotherapy Induced Toxicities in Breast Cancer Patients

Breast Cancer

India
Alexion Pharmaceuticals

No longer available

An Expanded Access Protocol for Sebelipase Alfa for Patients With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency
RxSight, Inc.

Completed

Clinical Study to Evaluate the Safety and Effectiveness of the RxSight Light Adjustable Lens (LAL) in Subjects With Prior Corneal Refractive Surgery

Cataract | Aphakia

United States
Calhoun Vision, Inc.

Completed

Calhoun Vision Light Adjustable Lens (LAL) in Subjects With Pre-Existing Corneal Astigmatism

Cataract

United States
Azidus Brasil

Suspended

Efficacy and Comparative of the Association Beclomethasone Clotrimzaol + Gentamicin in Patients With Acne Contaminated (acne)

Folliculitis

Brazil
Azidus Brasil
Blau Farmaceutica S.A.

Completed

Pharmacodynamics Study of Enoxalow Compared to Clexane in Healthy Subjects After Intravenous Administration

Healthy

Brazil
Azidus Brasil

Completed

PK and PD Parallel Study After Multiple Dose, Intravenous Administration of Two Epoetin Alfa, Human Recombinant

Healthy

Brazil
Azidus Brasil

Unknown

PK and PD Parallel Study After Multiple Dose, Intravenous Administration of Two Epoetin Alfa, Eritromax and Eprex, in Healthy Subjects.

Healthy

Brazil
Azidus Brasil

Completed

PK and PD Crossover Study After Single Dose, Intravenous Administration of Two Epoetin Alfa, Human Recombinant Epoetin and Eprex, in Healthy Subjects.

Healthy

Brazil
Azidus Brasil

Completed

Pharmacodynamics Study of Enoxalow Compared to Clexane in Healthy Subjects After Subcutaneous Single Dose

Healthy

Brazil
National Research Center for Hematology, Russia

Recruiting

MRD-associated Non-intensive But Non-interruptive Treatment of Ph-negative Acute Lymphoblastic Leukemia Adult Patients

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Russian Federation
Azidus Brasil

Unknown

Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Somatropin Produced by Laboratory Blausiegel Indústria e Comércio Ltda., Compared to Saizen® From Laboratory Merck Serono S.A.

Growth Retardation | GH Deficiency (GHD)

Brazil
Azidus Brasil

Unknown

Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache.

Treatment of Episodic Tension Headache

Brazil
Azidus Brasil

Completed

Efficacy Study of the Combination Mometasone + Salicylic Acid in Patients With Psoriasis (Psoriasis)

Psoriasis

Brazil
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Sebelipase Alfa in Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency

Spain, Germany, Italy, United States, Croatia, Canada, Russian Federation, Denmark, United Kingdom, Belgium, Mexico, Australia, Netherlands, Brazil, Turkey
Azidus Brasil

Suspended

Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers

Ulcers

Brazil
Azidus Brasil

Unknown

PK and PD Study After Single Dose, Intravenous Administration of Two Epoetin Alfa, Eritromax and Eprex, in Healthy Subjects

Healthy

Brazil
Azidus Brasil

Completed

Effectiveness and Safety of Topical Halobetasol Propionate in the Treatment of Patients With Psoriasis (halobetasol)

Psoriasis

Brazil
Igefarma Laboratorios S.A.

Completed

Safety and Efficacy Study of Association Between Tretinoin and Clindamycin on the Treatment of Acne Mild and Moderate

Acne Vulgaris

Brazil
PETHEMA Foundation

Completed

LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia (LAL-AR-N-2005)

Acute Lymphoblastic Leukemia

Spain
Azidus Brasil

Unknown

PHARMACODYNAMICS ASSESSMENT PRODUCT HEPARIN SODIUM (INTRAVENOUSLY) OF THE SWINE 5.000UI/ML OF BLAU FARMACÊUTICA S/A IN HEALTHY SUBJECTS IN COMPARISON OF SODIUM HEPARIN APP PHARMACEUTICALS

Healthy

Brazil
Aarhus University Hospital

Active, not recruiting

Reconstruction of the Anterolateral Ligament (ALL) With Revision Anterior Cruciate Ligament (ACL) Surgery

Rupture of Anterior Cruciate Ligament | Anterolateral Ligament Reconstruction

Denmark
Riphah International University

Completed

Eccentric Tyler Twist Wrist Extensor Strengthening in Lateral Epicondylitis

Lateral Epicondylitis

Pakistan
New Mexico Cancer Care Alliance

Terminated

Acute Lymphoblastic Leukemia Therapies Informed by Genomic Analyses

Leukemia, Acute Lymphoblastic

United States
Alexion Pharmaceuticals

Terminated

Screening for Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency

United States
Tata Memorial Centre

Terminated

Correlation Between Intraocular Pressure Measurement by Tomometer and Anterior Chamber Depth Measurement by Ultrasound

Gastrointestinal Cancer | Malignant Female Reproductive System Neoplasm | Urological Cancer

India
Nantes University Hospital

Withdrawn

Study Evaluating the Efficacy of 90Yttrium-epratuzumab in Adults With CD22+ Relapsed/Refractory B-ALL (RITEPRALL)

CD22+ Relapsed/Refractory B-ALL

France
Azidus Brasil

Suspended

Safe Use of Heparin Sodium in Patients With Chronic Renal Failure. (Heparin)

Chronic Renal Failure

Brazil
Azidus Brasil

Completed

Clinical Assessment Of Association Pharmacokinetics Atorvastatin + Losartana + Hydrochlorothiazide

Healthy Subjects

Brazil
Azidus Brasil

Completed

Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Filgrastim (G-CSF)Produced by Blausiegel Indústria e Comércio Ltda. Compared to Granulokine Produced by Produtos Roche Químicos e Farmacêuticos S/A.

Healthy Subjects

Brazil
Azidus Brasil
Laboratório Químico Farmacêutico Bergamo Ltda.

Completed

Efficacy and Safety of a New Botulinum Toxin Type A for Treatment of Facial Expression Lines

Wrinkles

Brazil
Azidus Brasil

Completed

Efficacy and Safety of Sodium Heparin in Patients

Cardiac Surgery

Brazil
Azidus Brasil

Completed

Efficacy and Safety of Sodium Heparin (Eurofarma)

Cardiac Surgery

Brazil

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