- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03463434
AFT/CLP-LAL RCT Stage 3 or 4 Pressure Injuries
A Randomized Controlled Pilot Study Comparing Air Fluidized Therapy (AFT) to a Continuous Low Pressure (CLP) Low Air Loss (LAL) Support Surface in the Treatment of Stage 3 or 4 Pressure Injuries
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Patients admitted to the LTACH with at least one stage 3 or 4 PI will be evaluated for possible inclusion/exclusion criteria. Patients will be approached by the investigator, or their designee to acquire patient informed consent. If provided, patients will be randomized to their designated support surface, the bed will be ordered and patients will begin the study with a baseline study visit (week 0) that will include:
- Date and time of study bed placement
- A brief medical history, that includes current diagnoses, assessment of co-morbidities, an assessment of neurologic status, nutritional status, level of mobility, history of current PI's, documentation of treatments that have been applied to PI(s) prior to study entry
- Braden PU risk assessment (overall and subscores)
- Assessment of pain associated with the PI using a pain numeric rating scale (NRS), where patients rate their current pain intensity from 0 ("no pain") to 10 ("worst possible pain") [21]
- Blood for CBC, Albumin, Pre-Albumin, CRP will be collected.
- PI assessments: all PI's located on the lower truncal region of the patient's body will be assessed both subjectively by the treating clinicians for clinical signs of infection, as well as by a 3D wound assessment tool.
- Overall health status assessment
Subsequent weekly study visits will continue for a maximum of 12 weeks. The interim study visit documentation will include:
- Overall health status assessment of health (whether the patient's health is improving, maintaining, or worsening)
- Skin assessment to document any new PI's that may have developed,
- Braden PU risk assessment (overall and subscores)
- 3D Wound assessments of all lower truncal PI's,
- Clinical Assessment of signs and symptoms of wound infection
- Confirmation of support surface type,
- Documentation of adverse device effects, device-related complaints (within 24 hours of effect/complaint).
Clinical Resource Utilization Data: documentation of the following data will aim to achieve estimated clinical resources associated with caring for PIs:
- Documentation of dressing supplies,
- Debridement method, duration and frequency
- Type of antibiotics dosage, frequency, and duration
- Other pharmacologic agents used for wounds with dosage, frequency, and duration
- Assessment of pain
- Rental bed cost estimates
- Documentation of professional healthcare visits and/or types of healthcare services in the preceding week.
- Documentation of acute care hospitalizations
- An estimate of LTACH staff time devoted to wound care per day for that study week.
At study discharge, which may occur at the time of study PI healing, LTACH discharge, or upon stepdown from the randomized study surface) or for other reasons, a final study visit will be completed that includes:
- Date and time of study bed removal
- Overall health status assessment,
- Skin assessment to document any new PI's that may have developed,
- Braden PU risk assessment (includes subscores),
- 3D wound assessments of all truncal PI's,
- Clinical assessment of signs and symptoms of wound infection
- Confirmation of bed support surface type
- Documentation of adverse device effects, device related complaints (within 24 hours of effect/complaint).
Clinical Resource Utilization Data:
- documentation of dressing supplies,
- debridement method, duration and frequency
- type of antibiotics, dosage, frequency, and duration
- other pharmacologic agents used for wounds with dosage, frequency, and duration,
- rental bed cost estimates
- documentation of professional healthcare visits and/or types of healthcare services in the preceding week.
- documentation of acute care hospitalizations
- an estimate of LTACH staff time devoted to wound care per day for that study week.
- Assessment of pain
- A patient bed satisfaction assessment will be completed if the patient is able to communicate
- Blood for CBC, Albumin, Pre-Albumin, CRP will be collected
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Alabama
-
Anniston, Alabama, United States, 36207
- Noland Health Anniston
-
Birmingham, Alabama, United States, 35242
- Noland Health
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patient's treatment goals are curative or maintaining, and not palliative in nature.
- Patient is compliant with standard clinical care for their admitted condition.
- Patient's age is between 18 and 85 years
- Patient is expected to have at least a 3-4-week length of stay (from date of assessment) in the treating LTACH
- Patient must have at least one stage 3 or 4 PI located on the weight bearing aspect of the patient's truncal /pelvic region
- Patients or their legal authorized representative must be willing and able to provide written informed consent.
Exclusion Criteria:
- Patient has an unstable spinal cord injury
- Patient weighs less than 70 lbs or more than 350 lbs.
- The primary study PI site has had previous flaps or grafts with significant associated scarring which is clinically thought to impede wound contracture.
- Patients with PIs where bone exposure is > 2 cm2 in area.
- Patients with active osteomyelitis (via clinical assessment) or patients who have been diagnosed with osteomyelitis and have not yet completed a 6-8-week course of antibiotics
- The primary study PI is located over the trochanteric head of the femur.
- Patients that are currently taking or have taken in the last 6 weeks chemotherapy which is known to be cyto-toxic, or anti-angiogenic
- Patients currently require immune modulating drugs (Humira (alalimumab), Orencia (abatacept), etc.)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Air Fluidized Therapy
Patients will be placed on the Envella AFT bed
|
AFT bed used for pressure injury treatment
|
Active Comparator: Continuous Low Pressure-LAL
Patients will receive a Continuous low pressure mattress with low air loss
|
Continuous Low Pressure/Low Air Loss Mattress for Pressure injury treatment
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pressure ulcer healing
Time Frame: up to 12 weeks
|
Volume (mm3)
|
up to 12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
New Pressure Ulcers
Time Frame: up to 12 weeks
|
new pressure ulcers
|
up to 12 weeks
|
Length of stay
Time Frame: up to a year
|
Length of stay in the Long-term Acute Care Hospital
|
up to a year
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CR-SS2017-007
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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