Search clinical trials for: Modifier Genes

Total 4963 results

Mercy Health Ohio
Northeast Ohio Medical University

Recruiting

Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

Urinary Tract Infections

United States
Intima Bioscience, Inc.

Not yet recruiting

CISH Inactivated TILs in the Treatment of NSCLC (CheckCell-2)

Carcinoma, Non-Small-Cell Lung | Adenocarcinoma of Lung | Stage IV Non-small Cell Lung Cancer | Squamous Cell Lung Cancer | Metastatic Non Small Cell Lung Cancer | Large Cell Lung Cancer

United States
Affiliated Hospital of Nantong University

Recruiting

Study of H-FICB ＆ PENG Block in Elderly Patients' THA on the Post-operative Quality of Recovery

Quality of Recovery | Nerve Block

China
University of Iowa

Not yet recruiting

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

Delirium | Spinal Fusion | Pain, Back | Thoracolumbar Interfascial Plane Block

United States
Maastricht University Medical Center
Netherlands Heart Foundation

Recruiting

Worm Study: Modifier Genes in Sudden Cardiac Death

Brugada Syndrome | Long QT Syndrome 3

Netherlands
National Cancer Institute (NCI)

Completed

Study of Disease Severity in Adults With Neurofibromatosis Type 1 (NF1)

Neurofibromatosis Type 1 | Legius Syndrome

United States
Peking Union Medical College Hospital

Completed

Effect of Modified Endotracheal Intubation Protocol Combined With Early Oral Intake on Postoperative Recovery Quality in Thyroid and Parathyroid Surgery

Thyroid Tumor

China
Beacon Therapeutics

Enrolling by invitation

A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)

X-Linked Retinitis Pigmentosa

United States
Inonu University

Enrolling by invitation

Comparison of SE-TAP, M-TAPA, and Rectus Sheath Block in Abdominal Surgeries

Postoperative Pain

Turkey
National Heart, Lung, and Blood Institute (NHLBI)

Completed

COV2Base-A Rare Disease by COVID Study

Chronic Health Conditions | Older Age is Associated With Increased Pathogenicity

United States
American Gene Technologies International Inc.

Enrolling by invitation

Long-term Follow-up of Study Participant Treated With Lentiviral-Based Genetically Modified Autologous Cell Product ,AGT103-T

HIV

United States
American Gene Technologies International Inc.

Enrolling by invitation

An Antiretroviral Treatment Interruption (ATI) Study to Evaluate the Impact of Genetically Modified Autologous Cells (AGT103-T) to Suppress Human Immunodeficiency Virus Replication in the Absence of Antiretroviral Therapy

HIV

United States
IRCCS San Raffaele
Fondazione Telethon

Active, not recruiting

Gene Therapy With Modified Autologous Hematopoietic Stem Cells for the Treatment of Patients With Mucopolysaccharidosis Type I, Hurler Variant (TigetT10_MPSIH)

Mucopolysaccharidosis IH

Italy
Shanghai Public Health Clinical Center
R&D Kanglin Biotech

Unknown

An Efficacy and Safety Study of shRNA-modified CD34+ Cells in HIV-infected Patients.

HIV Infections | AIDS

China
IRCCS San Raffaele
Orchard Therapeutics; Fondazione Telethon

Unknown

Gene Therapy for Transfusion Dependent Beta-thalassemia (TIGET-BTHAL)

Beta-Thalassemia

Italy
City of Hope Medical Center

Completed

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

Recurrent High Grade Glioma | Adult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Recurrent Grade III Glioma | Adult Brain Tumor | Recurrent Grade IV Glioma | Adult Anaplastic...

United States
Nanfang Hospital of Southern Medical University
Guangdong Yike Gene Science and Technology CO.,Ltd

Unknown

Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically Modified

Beta Thalassemia Major

China
University Hospital, Montpellier
Institut National de la Santé Et de la Recherche Médicale, France; Vaincre...

Completed

DNA Methylation and Lung Disease in Cystic Fibrosis (METHYLCF)

Cystic Fibrosis

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Splenic Marginal Zone Lymphoma | Waldenström Macroglobulinemia and other conditions

United States
Assistance Publique - Hôpitaux de Paris
French National Referral Center for Neurofibromatoses

Unknown

Modifying Genes in Neurofibromatosis 1 (NFGENMODIF)

Neurofibromatosis 1

France
Hospital Universitari Vall d'Hebron Research Institute
Universitat Pompeu Fabra; IDIAPJgol

Recruiting

Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden. (StopALD)

Alcohol Use Disorder | Alcohol-related Liver Disease | Metabolic and Alcohol Related/Associated Liver Disease | Metabolic Disfunction Associated Steatotic Liver Disease

Spain
Peking Union Medical College Hospital

Not yet recruiting

A Study to Evaluate the Safety and Tolerability of GEN6050X in Duchenne Muscular Dystrophy. (GEN6050XIIT)

Duchenne Muscular Dystrophy (DMD)
China National Center for Cardiovascular Diseases

Recruiting

Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive Cardiomyopathy

Minimally Invasive Surgery | Cardiomyopathy, Hypertrophic Obstructive

China
Ocugen

Recruiting

A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa (liMeliGhT)

Retinitis Pigmentosa

United States
The Affiliated Hospital Of Guizhou Medical University

Not yet recruiting

Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Ceryx Medical Australia
Avania

Not yet recruiting

Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF (RSA-PACE)

Heart Failure With Reduced Ejection Fraction

New Zealand
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Bioavailability Study of Two Different PEG-rhGH Preparations.

Pediatric Growth Hormone Deficiency (PGHD)

China
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
Ataturk University

Not yet recruiting

The Effect of Mobile-Based Education on Postoperative Recovery and Quality of Life in Thyroidectomy Patients

Thyroid Diseases | Thyroid | Healthy Lifestyle
VA Office of Research and Development

Not yet recruiting

Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury (TABM)

Alcohol Use Disorder | Mild-Moderate Traumatic Brain Injury

United States
Stéphanie Baggio
University Hospital, Geneva; Leiden University; University of Bern; School of Health...

Not yet recruiting

Testing a New Method to Improve Informed Consent in Prison Research (Spark BATIR)

ADHD

Switzerland
Hematology department of the 920th hospital

Recruiting

Clinical Study on Modified Allogeneic Hematopoietic Stem Cell Transplantation Regimen for Severe Aplastic Anemia

Severe Aplastic Anemia

China
Sensorion

Not yet recruiting

A Phase I/II Clinical Trial With SENS-501 in Children Suffering From Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations (AUDIOGENE)

Otorhinolaryngologic Diseases | Ear Diseases | Hearing Disorders | Deafness | Hearing Loss, Sensorineural | Congenital Deafness | DFNB9 | OTOF Gene Mutation

France
Johns Hopkins University
American Heart Association

Not yet recruiting

Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet

Epilepsy | Dyslipidemia
Washington University School of Medicine

Not yet recruiting

Evaluating the Human Immune Response to the JYNNEOS Vaccine

Virus Diseases | Vaccinia

United States
Children's Hospital of Philadelphia

Not yet recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

Beta-Thalassemia

United States
National Cancer Institute (NCI)

Not yet recruiting

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL)

Leukemia, Lymphocytic, Chronic, B-Cell | B-Cell Chronic Lymphocytic Leukemia | B-Lymphocytic Leukemia, Chronic

United States
Stanford University

Not yet recruiting

Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth

Autism Spectrum Disorder | Autism | Restricted Behavior
Chinese University of Hong Kong

Not yet recruiting

Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents

Adolescent | Depression | Insomnia

Hong Kong
Ceryx Medical Ltd
Cardiff and Vale University Health Board

Not yet recruiting

Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF (RSA-PACE)

Heart Failure With Reduced Ejection Fraction

United Kingdom
University of Texas at Austin
Arcade Therapeutics

Not yet recruiting

Confirmatory Efficacy Trial of Attention Bias Modification for Depression

Depression

United States
Amgen

Recruiting

A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion

Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers

United States
Dokuz Eylul University

Not yet recruiting

Evaluation of the Effects of Different Ventilation Modes Used During Anesthesia Awakening on the Frequency of Postoperative Atelectasis

Atelectasis, Postoperative Pulmonary
Sanofi

Not yet recruiting

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (SubQSA)

Plasma Cell Myeloma Refractory
Capital Medical University
The Second People's Hospital of Dali Bai Autonomous Prefecture; Wuhu Fourth... and other collaborators

Not yet recruiting

Esketamine Treatment for Depressive Episodes With Suicidal Ideation in Mood Disorders

Mood Disorders | Suicidal Ideation | Depressive Episode
Navy General Hospital, Beijing

Not yet recruiting

Smart Technology Facilitated Venous Thromboembolism Prophylaxis Based on Bundled Evidence-based Prevention Strategies (SmaVTE-BEST)

Venous Thromboembolism | Clinical Decision Support Systems | Digital Health
Peking University Third Hospital

Recruiting

The Efficacy of Modified Olfactory Training for Patients With Olfactory Dysfunction

Olfactory Impairment

China
Ractigen Therapeutics.

Recruiting

A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) Therapy

Non-Muscle-Invasive Bladder Cancer (NMIBC)

Australia
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Federico II University; Istituto Auxologico Italiano; Università degli Studi...

Recruiting

Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks

Beckwith-Wiedemann Syndrome

Italy
Marmara University

Not yet recruiting

Comparing Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery

Postoperative Pain | Opioid Use

Turkey

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