Search clinical trials for: NRG1 gene fusion

Total 269019 results

Cancer Research UK
Hummingbird Bioscience

Recruiting

HMBD-001 in Advanced HER3 Positive Solid Tumours

Melanoma | Cervical Cancer | Gastric Cancer | Pancreatic Cancer | Ovarian Cancer | Hepatocellular Carcinoma (HCC) | Bladder Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Castration-resistant Prostate Cancer | Non-small Cell Lung Cancer (NSCLC) | Oesophageal Cancer | RAS Wild Type Colorectal Cancer | Squamous Cell Cancer of the Head and Neck

United Kingdom
Pfizer
The Clinical Trials Centre Cologne

Completed

Safety and Pharmacokinetics of Intravenous and Oral APX001 in Patients With Acute Myeloid Leukemia (AML) and Neutropenia

Acute Myeloid Leukemia

Germany
Hummingbird Bioscience

Recruiting

Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation

Pancreatic Cancer | Non-Small Cell Lung Cancer | Metastatic Solid Tumor | Locally Advanced Solid Tumor

Australia
Boehringer Ingelheim

No longer available

Afatinib (GILOTRIF®) in Patients Suffering From Tumors Harboring Neuregulin 1 (NRG1) Gene Alterations (Specifically NRG1 Gene Fusion-positive Advanced Solid Tumors)

Solid Tumors
Elevation Oncology

Active, not recruiting

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Sarcoma | Kidney Cancer | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Cholangiocarcinoma | Bile Duct Cancer | Bladder Cancer | Metastatic Solid Tumor | Gallbladder Cancer | Uterine Cancer | Locally Advanced Solid Tumor

United States, Korea, Republic of, Australia, Canada
CHA University
Hanlim Pharm. Co., Ltd.

Recruiting

Efficacy of Nicotinamide on Retinal Ganglion Cell Functions in Glaucoma Patients

Glaucoma

Korea, Republic of
Merus N.V.

Recruiting

A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)

NSCLC Harboring NRG1 Fusion | Solid Tumours Harboring NRG1 Fusion | Pancreatic Cancer Harboring NRG1 Fusion | NRG1 Fusion

Spain, France, Israel, Belgium, Denmark, United States, Korea, Republic of, Japan, Germany, Netherlands, Austria, Canada, Italy, Norway, Singapore, Sweden, Taiwan, United Kingdom
Samsung Medical Center

Not yet recruiting

Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion

Solid Tumor, Adult

Korea, Republic of
German Cancer Research Center
German Consortium for Translational Cancer Research

Completed

Afatinib in Advanced NRG1-Rearranged Malignancies

Metastatic and Locally Advanced NRG1-rearranged Malignancies

Germany
Merus N.V.

Recruiting

Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers

Metastatic Castration-resistant Prostate Cancer | NSCLC Harboring NRG1 Fusion

United States
Ottawa Hospital Research Institute

Completed

Single Patient Protocol for an NRG1 Fusion Positive Metastatic Pancreatic Cancer Patient Using Seribantumab

Metastatic Pancreatic Cancer

Canada
Shanghai Chest Hospital

Not yet recruiting

To Evaluate the Efficacy of Afatinib in the Treatment of Locally Advanced/Metastatic Non-Small Cell Lung Cancer With NRG1 Fusion

NRG1-fused Non-small Cell Lung Cancer

China
Merus N.V.

Available

Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor

Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Prostate Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Solid Tumor, Unspecified, Adult | Unknown Primary Tumors | NRG1 Fusion
National Taiwan University Hospital

Unknown

Trial for Antidepressant Treatment for Negative Symptom of Schizophrenia With NRG1 Risk Genotype (TANESN)

Schizophrenia

Taiwan
Rain Oncology Inc

Terminated

Study of Tarloxotinib in Pts With NSCLC (EGFR Exon 20 Insertion, HER2-activating Mutations) & Other Solid Tumors With NRG1/ERBB Gene Fusions (RAIN)

NSCLC Stage IIIB | NSCLC, Recurrent | NRG1 Fusion | EGFR Exon 20 Insertion Mutation | NSCLC, Stage IIIC | NSCLC, Stage IV | HER2-activating Mutation | ERBB Fusion

United States, Canada, Hong Kong
National Taiwan University Hospital
National Science Council, Taiwan

Unknown

A Neurobiological Study on Heterogeneity of Schizophrenia: Genetic Variations and Neurobiological Differentiations (SONPOS)

Schizophrenia

Taiwan
Amsterdam UMC, location VUmc

Recruiting

Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy (FUSION-HCM)

Hypertrophic Cardiomyopathy | Hypertrophic Cardiomyopathy, Obstructive

Netherlands
University of Missouri-Columbia

Recruiting

Baker Gordon Syndrome Natural History Study (BAGOS)

Epilepsy, Generalized | Sleep Disorder | Rare Diseases | Development Delay | Motor Delay | Autism or Autistic Traits | SYT-SSX Fusion Protein Expression

United States
CSL Behring

Not yet recruiting

Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Chinese Subjects With Hemophilia B Previously Treated With FIX Therapy

Hemophilia B
Potsawat Surabotsopon

Not yet recruiting

Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF : Double Blinded, Randomized Control Trial (MIS-TLIF)

Surgery | Disc Degeneration | Spinal Stenosis Lumbar | Fusion of Spine | Disc Disease
Histograft Co., Ltd.
Petrovsky National Research Center of Surgery

Recruiting

Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion

Spinal Stenosis | Cervical Disc Disorder With Radiculopathy | Biomechanical Lesion, Unspecified | Lumbar and Other Intervertebral Disc Disorders With Radiculopathy

Russian Federation
IWK Health Centre

Not yet recruiting

Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery

Anesthesia | Spinal Fusion | Nausea and Vomiting, Postoperative
Foundation for Orthopaedic Research and Education
Pacira Pharmaceuticals, Inc

Not yet recruiting

Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion

Back Pain | Post Operative Pain | Physical Stress | Narcotic Use | Surgery-Complications

United States
Azienda Usl di Bologna

Recruiting

Decompression Versus Instrumented Fusion for Lumbar Degenerative Disease. Clinical and Biomechanical Outcome Study (ARCHIMEDE)

Lumbar Spinal Stenosis | Degenerative Lumbar Spinal Stenosis

Italy
Nationwide Children's Hospital
Pfizer

Not yet recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | WHO Grade III Glioma | WHO Grade IV Glioma | Infant Type Hemispheric Glioma | Diffuse Midline Glioma, H3K27-altered

United States, Australia, Canada, Germany, Netherlands
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Recruiting

Efficacy of Combination of Hdroxyurea and Thalidomide Over Either Hydroxyurea or Thalidomide Alone in the Treatment of Transfusion Dependent Thalassemia in Children: A Quasi-Randomised Clinical Trial

Transfusion-dependent Thalassemia

Bangladesh
Eli Lilly and Company

Recruiting

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Elevated Lp(a) | Atherosclerotic Cardiovascular Disease (ASCVD)

Taiwan, United States, Spain, Argentina, China, Italy, Australia, France, Canada, Japan, Belgium, Denmark, Germany, Hungary, Israel, Austria, Korea, Republic of, Brazil, Mexico, Netherlands, Romania, United Kingdom, Greece, Czechia, India, Slovak... and more
University of California, Los Angeles

Recruiting

Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery

Spinal Fusion | Chronic Lower Back Pain

United States
Inozyme Pharma

Recruiting

The SEAPORT 1 Study: Evaluation of the Safety and Tolerability of INZ-701 in Adults With End-Stage Kidney Disease Undergoing Hemodialysis

Calciphylaxis

United States
Sanatmetal Orthopaedic and Traumatologic Equipment...

Recruiting

Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in TLIF

Spondylolisthesis | Degenerative Instability | Post-discectomy Syndrome | Post-traumatic Instability

Hungary
Chengdu University of Traditional Chinese Medicine

Not yet recruiting

Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion

Lumbar Spondylolisthesis | Arthrosis; Spine
Poznan University of Medical Sciences

Recruiting

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery

Spinal Stenosis | Erector Spinae Plane Block | Spinal Fusion | Spine Disease

Poland
Freundeskreis Für Internationale Tuberkulosehilfe...

Not yet recruiting

Evaluating the Accuracy of New Tests for TB Infection Diagnosis (TB infection)

Latent Tuberculosis | Tuberculosis | TB Infection

Vietnam
Konya Meram State Hospital

Recruiting

Pectointercostal Fascial Plane Block Chronic Pain Sternotomy (PIFB)

Chronic Pain

Turkey
Fudan University

Recruiting

Predicting Tumor Metastasis by Employing a Target Organ/Primary Lesion Fusion Radiomics Model

Metastasis | Predictive Cancer Model

China
Rashmi Mueller

Not yet recruiting

Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery

Pain, Postoperative | Postoperative Delirium | Degenerative Disc Disease
Clover Biopharmaceuticals AUS Pty Ltd

Recruiting

First-in-human Safety and Immunogenicity Study of SCB-1019 in Healthy Adults

Respiratory Syncytial Virus Infection

Australia
Oslo University Hospital
Vestre Viken Hospital Trust; Haukeland University Hospital; St. Olavs Hospital; University Hospital, Akershus and other collaborators

Recruiting

The Lumbar Interbody Fusion vs. Multidisciplinary Rehabilitation (LIFEHAB) Trial (LIFEHAB)

Chronic Low-back Pain

Norway
SOTIO Biotech AG

Recruiting

A Study to Assess Safety and Efficacy of SOT201 in Patients With Advanced/Metastatic Cancer

Advanced Solid Tumor | Metastatic Solid Tumor

United States, Spain, Czechia, Belgium, France
Tyra Biosciences, Inc

Recruiting

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations (SURF201)

Solid Tumor | Intrahepatic Cholangiocarcinoma | Metastatic Cholangiocarcinoma | Locally Advanced Cholangiocarcinoma

United States
William Beaumont Hospitals

Recruiting

Randomized Controlled Comparison of Pre-op TLIP vs Intra-op TLIP

Pain | Spine Fusion

United States
Theradaptive, Inc

Recruiting

OsteoAdapt SP Advanced Bone Graft Feasibility Study - Transforaminal Interbody Lumbar Fusion (OASIS)

Lumbar Disc Herniation | Degenerative Disc Disease | Lumbar Spinal Stenosis | Spinal Stenosis | Lumbar Spondylolisthesis | Lumbar Radiculopathy | Lumbar Disc Disease | Spine Disease | Lumbar Spine Degeneration | Degenerative Spondylolisthesis

Australia
Biomea Fusion Inc.

Recruiting

Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus (BF-MNN-112)

Type 1 Diabetes Mellitus

United States, Canada
University of California, San Francisco

Recruiting

Effect of Ketamine on Intraoperative Motor Evoked Potentials

Spinal Stenosis | Spine Fusion | Spine Tumor

United States
Jiangsu Gensciences lnc.

Recruiting

Phase 3 Clinical Project of Pegylated Recombinant Human Coagulation Factor VIII-Fc Fusion Protein

Severe Hemophilia A

China
Xuanwu Hospital, Beijing

Recruiting

Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery (PRACTICE)

Frailty Syndrome | Spine Degeneration | Spine Fusion

China
Jiangsu Gensciences lnc.

Not yet recruiting

Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A

Severe Hemophilia A

China
Guangzhou JOYO Pharma Co., Ltd

Recruiting

Study of Oral JYP0322 in Patients With Locally Advanced or Metastatic Cancer Targeting ROS1 Molecular Fusion.

Lung Neoplasms | Brain Neoplasms | Protein Kinase Inhibitors | Other Protocol Specified Criteria

China
Dartmouth-Hitchcock Medical Center

Recruiting

Pulse-Width Modulation

Spinal Stenosis | Spinal Fusion

United States
Duzce University

Recruiting

Examination of the Effect of Early Mobilization on Postoperative Recovery, Pain, Quality of Life and Complication Development in Elective Minimally Invasive Spine Surgery

Lumbar Disc Herniation | Cervical Disc Disease | Spine Fusion

Turkey

Search clinical trials for: NRG1 gene fusion

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