Search clinical trials for: Opioid receptor antagonist

Total 46068 results

Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences; Brooke Army Medical Center

Not yet recruiting

Ketamine for Sedation in Severe Traumatic Brain Injury (Ketamine)

Intracranial Hypertension | Severe Traumatic Brain Injury | Intracranial Hemorrhage, Hypertensive
University of Ioannina

Recruiting

Opioid-free Anaesthesia in Breast Cancer Surgery

Pain, Postoperative | Breast Cancer | Anesthesia | Pain, Chronic | Cancer Recurrence | Opioid Free Anaesthesia

Greece
Ain Shams University

Not yet recruiting

Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free Anesthesia

Pain, Postoperative | Quality of Recovery | Elective Laparoscopic Cholecystectomy

Egypt
Washington State University

Not yet recruiting

Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment (MIRROM)

Stimulant Use Disorder
Ciusss de L'Est de l'Île de Montréal

Not yet recruiting

Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception. (ESMONOL)

Anesthesia | Opioid Use, Unspecified | Nociceptive Pain

Canada
Universidad Simón Bolívar

Not yet recruiting

Intraoperative Autonomic Neural Blockade (ANB)

Pain, Postoperative | Analgesia | Opioid Use | Nausea, Postoperative | Vomiting, Postoperative
Assiut University

Not yet recruiting

Prevention of Shivering Associated With Spinal Anesthesia

Shivering, Spinal Anesthesia
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Recruiting

Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids

Opioid Withdrawal (Disorder)

United States
University of Pennsylvania

Recruiting

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal (UH3)

Opioid Use | Opiate Withdrawal Syndrome

United States
Ryan Stephenson

Recruiting

Naltrexone and Propranolol Combined With Immunotherapy

Advanced Melanoma

United States
Salem Anaesthesia Pain Clinic

Recruiting

Kratom Use Disorder Management Using Clonidine and/or Buprenorphine

Withdrawal Syndrome

Canada
Hospital Universitario La Fe

Recruiting

The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section. (TRON)

Cesarean Section | Post Operative Pain | Quality of Recovery | Postoperative Recovery | Ondansetron | Tramadol | QoR-15 | ObsQor-10 | Postcesarean Recovery

Spain
Johns Hopkins University
DEKA S.r.l.

Not yet recruiting

Blood Naloxone Levels Following Intradermal Injection in Humans

Opioid Overdose
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder Arthroscopy

Rotator Cuff Tears
Emory University
National Institute on Drug Abuse (NIDA)

Recruiting

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 (VNS in OUD UH3)

Opioid Use Disorder | Opioid Use | Withdrawal Symptoms

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

Measuring Acute Drug Demand in Humans

Opioid Use Disorder | Opioid Dependence

United States
Loyola University

Recruiting

Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Pain, Postoperative

United States
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA); Yale University; Clinilabs, Inc.; BioXcel...

Recruiting

Sublingual Dexmedetomidine for Treating Opioid Withdrawal

Opioid Use Disorder | Opioid Withdrawal

United States
Aretaieion University Hospital

Recruiting

Opioid Sparing Anesthesia in Lumbar Spine Surgery

Pain, Postoperative | Analgesia | Pain, Acute | Ketamine | Dexmedetomidine | Pain, Chronic | Lidocaine | Analgesics | Lumbar Spine Surgery | Pain, Nociceptive

Greece
National Cancer Institute, Egypt

Recruiting

Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries

Analgesia

Egypt
Johns Hopkins University

Recruiting

Suvorexant for Opioid/Stimulant Co-use

Opioid Use Disorder | Stimulant Use Disorder

United States
University of Pennsylvania

Recruiting

Multi-System Analysis of Opioid Receptor Binding

Healthy

United States
Johns Hopkins University

Recruiting

Evaluating Buspirone to Treat Opioid Withdrawal

Anxiety | Opioid Use Disorder | Opioid Withdrawal | Opioid Craving

United States
Henry Ford Health System

Recruiting

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Shoulder Pain | Shoulder Arthropathy

United States
Brigham and Women's Hospital

Recruiting

Endocannabinoids, Stress, Craving And Pain Effects Study (ESCAPE)

Opioid Use Disorder

United States
University of Florida
Consortium for Medical Marijuana Clinical Outcomes Research

Recruiting

Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control

Myopia | Hyperopia | Photorefractive Keratectomy

United States
Go Medical Industries Pty Ltd
National Institute on Drug Abuse (NIDA); Columbia University; University at Buffalo and other collaborators

Not yet recruiting

Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons (GM0020)

Opioid Use Disorder
Gerhild Becker

Recruiting

Protreat-Trial: Prophylactic Antiemetic Treatment of Opioid-induced Nausea and Vomiting (OINV) in Palliative Care (ProTreat)

Pain | Nausea | Vomiting | Advanced Cancer

Germany
Sheikh Zayed Medical College

Not yet recruiting

Comparsion of IV Dexmedetomidine, Tramdol and Ketamine for Post Spinal Anesthesia Shivering.

Post-Surgical Complication
Beth Israel Deaconess Medical Center

Recruiting

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (PATHFINDERII)

Pain | Postoperative Delirium | Neurocognitive Dysfunction | Hemodynamic Instability

United States
Aretaieion University Hospital

Recruiting

Opioid-free Anesthesia in Thyroidectomies

Analgesia | Pain, Acute | Pain, Post Operative | Ketamine | Dexmedetomidine | Pain, Chronic | Fentanyl | Pain, Neuropathic | Lidocaine | Analgesics | Pain, Nociceptive | Analgesics Non-narcotic

Greece
Mclean Hospital
National Institute of Mental Health (NIMH); Massachusetts General Hospital; Brown... and other collaborators

Not yet recruiting

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

Depressive Disorder, Major | Anxiety Disorder
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

Suvorexant as an Adjunct to Buprenorphine in Persons Who Use Fentanyl

Opioid Use Disorder | Placebo | Suvorexant

United States
Aretaieion University Hospital

Recruiting

Opioid-free Anesthesia in Laparoscopic Cholecystectomies

Pain, Postoperative | Analgesia | Pain, Acute | Ketamine | Dexmedetomidine | Pain, Chronic | Cholecystectomy | Lidocaine | Central Nervous System Depressants | Analgesics | Analgesic Non-narcotic

Greece
Duke University
Food and Drug Administration (FDA)

Recruiting

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC) (OPTIC)

Critically Ill | Cardiac Disease | Children, Adult

United States
Spark Biomedical, Inc.
Hazelden Betty Ford Foundation; Gaudenzia, Inc.

Recruiting

Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder (RESTORE)

Opioid-use Disorder | Opioid Withdrawal

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Opioid Use Disorder | Opioid Withdrawal | Opioid Craving

United States
Aretaieion University Hospital

Recruiting

Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine

Pain, Postoperative | Analgesia | Pain, Acute | Ketamine | Dexmedetomidine | Pain, Chronic | Pain, Neuropathic | Lidocaine | Central Nervous System Depressants | Analgesics | Pain, Nociceptive | Analgesics Non-narcotic

Greece
Ajay Wasan, MD, Msc
Mayo Clinic; National Institute of Arthritis and Musculoskeletal and Skin Diseases... and other collaborators

Recruiting

Treating Negative Affect in Low Back Pain Patients (TNA-LBP)

Chronic Low Back Pain | Negative Affectivity

United States
Massachusetts General Hospital

Recruiting

The Effect of Opioid-Free Anesthesia in TMJ Surgery

Temporomandibular Joint Disorders

United States
Jennifer Holder-Murray
Berry Consultants

Recruiting

Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data

Perioperative Optimization

United States
Second Hospital of Shanxi Medical University

Recruiting

Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia

Opioid Analgesic Adverse Reaction

China
Pharmacotherapies for Alcohol and Substance Use...
United States Department of Defense; Michael E. DeBakey VA Medical Center; RTI... and other collaborators

Recruiting

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Post Traumatic Stress Disorder | Opioid-use Disorder

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

An Innovative Intervention for OUD Treatment (Bridge)

Opioid-Related Disorders | Opioid Dependence | Opioid Withdrawal | Opioid Addiction

United States
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

Sleep Disturbance | Opioid-use Disorder

United States
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

Heart Failure | Pain | Pneumonia | Hypertension | Edema | Hemophilia | Insomnia | Pulmonary Arterial Hypertension | Coagulation Disorder | Asthma in Children | Down Syndrome | Attention Deficit Hyperactivity Disorder | Bronchopulmonary Dysplasia | Hypokalemia | Hyperphosphatemia | Primary Hyperaldosteronism | Adrenal Insufficiency and other conditions

United States, Canada
Wayne State University
Henry Ford Health System; Ascension Brighton Center for Recovery

Recruiting

Dual-Orexin Antagonism as a Mechanism for Improving Sleep and Drug Abstinence in Opioid Use Disorder

Sleep | Opioid-use Disorder

United States
Medical University of Warsaw

Recruiting

Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy

Obesity | Postoperative Pain | Opioid Use | Postoperative Nausea | Postoperative Vomiting

Poland
Wayne State University

Not yet recruiting

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

Opioid Use Disorder

United States
EMS

Recruiting

Efficacy and Safety of Flamboyant 125/12 Association in the Treatment of Adults With Moderate Asthma

Asthma

Brazil

Search clinical trials for: Opioid receptor antagonist

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