Search clinical trials for: PK study of morphine in patients with pain

Total 490511 results

Halozyme Therapeutics

Completed

INFUSE Morphine Study (INFUSE)

Pain

United States
Gilead Sciences
Merck Sharp & Dohme LLC

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (ASCENT-04)

Triple Negative Breast Cancer | PD-L1 Positive

United States, Taiwan, Belgium, Australia, Austria, Israel, Spain, Italy, Korea, Republic of, Japan, France, Netherlands, Canada, Turkey, Germany, Malaysia, Singapore, United Kingdom, Hong Kong, Hungary, Mexico, Switzerland, Puerto... and more
Forma Therapeutics, Inc.

Recruiting

A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease

Sickle Cell Disease | Thalassemia

United States, Lebanon, Canada
Hoffmann-La Roche
Genentech, Inc.; Breast International Group

Active, not recruiting

A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer (APHINITY)

Breast Cancer

United States, Belgium, Canada, Australia, Austria, Bulgaria, China, Croatia, Denmark, France, Germany, Guatemala, Hungary, Ireland, Italy, Korea, Republic of, Panama, Slovenia, Spain, Taiwan, United Kingdom, Colombia, Czechia, El Salvador and more
Pacira Pharmaceuticals, Inc

Completed

Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

Osteoarthritis of the Knee

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore
Paion UK Ltd.
Chiltern International Ltd.; HFL Ltd.

Completed

An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours

Postoperative Pain

France, Germany, Netherlands, Poland, United Kingdom, Czechia
Brigham and Women's Hospital
National Institute on Drug Abuse (NIDA)

Active, not recruiting

Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain

Low Back Pain

United States
University Hospital, Bordeaux

Completed

Are Standard Dosing Regimens of Piperacillin-Tazobactam Suitable in Critically Ill Patients With Open Abdomen and Negative Pressure Wound Therapy? A Population Pharmacokinetic Study. (PK-LAP)

Critical Illness | Laparotomy | Piperacillin, Tazobactam Drug Combination

France
AstraZeneca

Completed

A Single Dose PD & PK Study With Two Formulations of Abediterol in Patients With Asthma

Asthma

Germany
Amgen
Takeda

Completed

A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck
INSYS Therapeutics Inc

Withdrawn

Study to Explore Effectiveness of Sublingual Fentanyl Spray in Emergency Department Patients With Acute Pain

Acute Pain

United States
Mario Negri Institute for Pharmacological Research

Completed

Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain (RER)

Neuropathic Pain | Tumor | Cancer Pain | Breakthrough Cancer Pain

Italy
Stony Brook University

Unknown

Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients

Acute Pain

United States
Labtec GmbH

Withdrawn

A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer

Chronic Pain
Pfizer

Terminated

Safety Study to Assess Opiate Withdrawal Signs and Symptoms in Opioid Dependent Patients

Chronic Pain

United States
Hospital Clinic of Barcelona

Unknown

Study to Evaluate the Pharmacokinetics of Vitamin D (Cholecalciferol) in Patients Undergoing Obesity Surgery in a Deficit Situation and After Standardization (PK-VIT-D)

Obesity | Gastrectomy | Gastric Bypass

Spain
Diffusion Pharmaceuticals Inc

Completed

Safety, Efficacy, and Pharmacokinetics (PK) Study of Trans Sodium Crocetinate (TSC) in Patients With Intermittent Claudication

Intermittent Claudication

United States
AstraZeneca

Completed

A Study to Assess Safety, Tolerability and PK of AZD2171 and Chemotherapy on Patients With Solid Tumors

Advanced Solid Tumor

United States
Hamilton Health Sciences Corporation

Completed

Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study (MOBILE)

Postoperative Pain | Total Hip Replacement

Canada
University of Turku

Unknown

A Comparative Study With Parenteral Oxycodone, Morphine and Dexamethasone in Postoperative Pain in Paediatric Patients (DOM)

Post Tonsillectomy Pain

Finland
University of Florence
Azienda Ospedaliera Città della Salute e della Scienza di Torino; University... and other collaborators

Recruiting

Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients (STAR)

Migraine | Chronic Migraine | Migraine Without Aura | Migraine With Aura

Italy
Sohag University

Not yet recruiting

Prospective Comparative Study Between Ultrasound-guided Quadratus Lumborum Block Versus Fascia Iliaca Compartment Block for Postoperative Pain and Cognitive Dysfunction Management in Patient Undergoing Hip Surgery

Pain and Cognitive Dysfunction Management in Hip Surgery
University of Washington
National Institute of Nursing Research (NINR)

Not yet recruiting

Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain (AIM-CP)

Chronic Pain

United States
Children's Oncology Group

Not yet recruiting

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

Stage I Kidney Wilms Tumor | Stage II Kidney Wilms Tumor | Stage III Kidney Wilms Tumor | Stage IV Kidney Wilms Tumor
PHARMENTERPRISES LLC

Not yet recruiting

Study to Evaluate the Efficacy and Safety of XC243 in Patients With Exacerbation of Chronic Cystitis

Cystitis

Russian Federation
Hannover Medical School
Boehringer Ingelheim

Not yet recruiting

Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD) (EMPA-PKD)

Autosomal Dominant Polycystic Kidney
Fudan University
Shanghai Zhongshan Hospital; RenJi Hospital; First Hospital of China Medical... and other collaborators

Not yet recruiting

Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study

Rectal Cancer | RECTAL NEOPLASMS
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Not yet recruiting

PK/PD Study of SHR-2017 Injection in Patients With Bone Metastases

Patients With Bone Metastases

China
Zhejiang Hanmai Pharmaceutical Technology Co.,...

Not yet recruiting

Multiple-Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of YJ001 for Spray Use in Patients With Diabetic Peripheral Neuropathic Pain

Diabetic Peripheral Neuropathic Pain

United States
Cosima Locher
Brown University; University of Basel

Not yet recruiting

Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Chronic Non-cancer Pain (ROM)

Chronic Non-cancer Pain
Aarhus University Hospital
Danish Cancer Society

Recruiting

The FEMA Study: Feasibility of Exercise in Patients With Metastatic Breast Cancer and Adiposity (FEMA)

Metastatic Breast Cancer | Adiposity | Estrogen-receptor-positive Breast Cancer

Denmark
University of Pisa

Recruiting

Treatment Outcomes in Patients With Muscular Temporo-mandibular Joint Disorders

TMD | TMD/Orofacial Pain

Italy
BioNTech SE
DualityBio Inc.

Not yet recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Endometrial Cancer
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy (KIN-ATTACK-FMF)

FMF

France
Novo Nordisk A/S

Recruiting

A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Help People With Excess Body Weight Lose Weight

Obesity

United States, Australia, Japan
Suzhou Genhouse Bio Co., Ltd.
Shanghai East Hospital; Shandong Tumor Hospital

Recruiting

A Phase I/II Clinical Study to Evaluate The Safety, PK, PD of GH55 in Patients With MAPK Mutant Advanced Solid Tumors

Advanced Solid Tumors With MAPK Signal Pathway Mutant

China
Tenaya Therapeutics
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Recruiting

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (RIDGE)

Arrhythmogenic Right Ventricular Cardiomyopathy

United States, Italy, United Kingdom, France, Sweden, Germany
Tubulis GmbH

Not yet recruiting

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC (NAPISTAR1-01)

Ovarian Cancer | Non-small Cell Lung Cancer

United States
Servier Affaires Médicales

Recruiting

Effectiveness of a Combination of Trimetazidine With One Hemodynamic Agent in Patients Recently Diagnosed With Stable Angina and Still Symptomatic Despite First Line Hemodynamic Therapy

Stable Angina

Romania
Rege Nephro Co., Ltd.

Recruiting

Study of Tamibarotene in Patients With ADPKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Japan
Regor Pharmaceuticals Inc.

Recruiting

A Study of RGT001-075 in Adult Patients With Obesity

Obesity

United States
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

Safety, Tolerability, and Pharmacokinetic Study of TV-44749 in Chinese Patients With Schizophrenia

Schizophrenia

China
Aristotle University Of Thessaloniki

Recruiting

Study of Analgesic Action of Pregabalin, Duloxetine and Tramadol in Patients With Different Neuropathic Pain Phenotypes

Neuropathic Pain

Greece
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

Phase Ib Study of Rocbrutinib in Combination With R-CHOP in Patients With Newly Diagnosed B-cell Non-Hodgkin Lymphoma

B-cell Non-Hodgkin Lymphoma

China
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University

Not yet recruiting

Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma

Diffuse Large B-Cell Lymphoma | High Grade B-Cell Lymphoma

United States
Strand Therapeutics Inc.

Recruiting

Study of IT STX-001 in Patients With Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

Advanced Solid Tumor

United States, Australia
Kutahya Health Sciences University

Recruiting

Evaluation of the Effectiveness of Dry Needling Treatment in Patients Diagnosed With Greater Trochanteric Pain Syndrome

Greater Trochanteric Pain Syndrome

Turkey
Rhythm Pharmaceuticals, Inc.

Recruiting

A Study of RM-718 in Healthy Subjects and in Patients With HO

Hypothalamic Obesity

United States

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