Search clinical trials for: PTEN Loss of Function Mutation

Total 433844 results

Faeth Therapeutics

Active, not recruiting

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Advanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function Mutation

United States
M.D. Anderson Cancer Center
Aadi Bioscience

Not yet recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Leiomyosarcoma | Soft-tissue Sarcomas

United States
Taiho Oncology, Inc.

Recruiting

A Study of TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer

Advanced or Metastatic Solid Tumors

United States, France
Jessa Hospital

Recruiting

Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

Hearing Loss, Sensorineural | DFNA9 | Radiology | Bilateral Vestibular Deficiency

Belgium
Sun Yat-sen University

Recruiting

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Lymphoma, Non-Hodgkin | Pediatric Cancer | Lymphoblastic Lymphoma, Childhood | PTEN Loss | NOTCH1 Gene Mutation

China
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Novartis Pharmaceuticals

Active, not recruiting

Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss (EPIK-B3)

Triple Negative Breast Neoplasms

France, Italy, Croatia, Taiwan, Australia, Argentina, Korea, Republic of, China, Israel, Russian Federation, Slovakia, Slovenia, United Kingdom, Germany, Mexico, Switzerland, Spain, Brazil, Hungary, Malaysia, South Africa, Austria, ... and more
Endeavor Biomedicines, Inc.

Active, not recruiting

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Solid Tumors With PTCH1 Loss-of-function Mutations

United States
M.D. Anderson Cancer Center

Terminated

Single-arm Study With Bimiralisib in Patients With HNSCC Harboring NOTCH1 Loss of Function Mutations (HNSCC)

HNSCC

United States
M.D. Anderson Cancer Center
GlaxoSmithKline; National Comprehensive Cancer Network

Completed

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Solid Tumors | Advanced Cancers

United States
Rhythm Pharmaceuticals, Inc.

Completed

An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes (NHS)

POMC Deficiency Obesity | PCSK1 Deficiency Obesity | LEPR Deficiency Obesity

Turkey
UNICANCER

Terminated

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss (COPAN-ORL06)

Carcinoma, Squamous Cell of Head and Neck

France
Regeneron Pharmaceuticals
Sanofi

Completed

A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene

Hypercholesterolemia

France, United States
Samsung Medical Center

Completed

Study to Evaluate the Safety and Efficacy of Everolimus, in Subjects With PIK3CA Amplification, PTEN Loss and PIK3CA Mutation Refractory Solid Tumors

Solid Tumor

Korea, Republic of
University of Bath

Recruiting

Galactooligosaccharide and Aging

Muscle Loss

United Kingdom
Sichuan Academy of Medical Sciences

Recruiting

Dapagliflozin Delays the Loss of Renal Function in Peritoneal Dialysis Patients

Peritoneal Dialysis Complication | Renal Function Aggravated | Sodium-glucose Co-transporter-2 Inhibitors

China
MedSIR
Stemline Therapeutics, Inc.

Not yet recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i. (ADELA)

Advanced Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer | ESR1 Gene Mutation
National Cheng-Kung University Hospital

Not yet recruiting

Function Definition and Clinical Validation of Digital Health App: Using Weight Management as An Example

Weight Loss | Body Fat Rate Loss | Body Composition Change
Eduardo Schiffer
University Hospital, Geneva; Insel Gruppe AG, University Hospital Bern

Not yet recruiting

Platelet Count and Function After Usage of Two Different Cell Saver Devices During Liver Transplant Surgery (PLFLTS)

Liver Transplant | Hemorrhage, Surgical

Switzerland
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

The Development of Tinnitus in Patients With SSNHL: Insights From fMRI and Metabolomics

Tinnitus | Sudden Sensorineural Hearing Loss
Pfizer

Recruiting

A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function

Liver Diseases

United States
IRCCS Ospedale San Raffaele

Recruiting

BLANDISH (Brain, Loss of Function, Aneurism, Disease, Injury, Stroke, Hemorrhage) (BLANDISH)

Intracranial Hemorrhages

Italy
Technische Universität Dresden

Not yet recruiting

Automated Screening for Clinically Ascertained Loss of Cerebral Functions (DETECT-IVE)

Irreversible Loss of Brain Function (ILBF)

Germany
Odense University Hospital
Rigshospitalet, Denmark; Stanford University; University of Southern Denmark; Herlev... and other collaborators

Recruiting

Robot-Assisted Training Versus Standard Training in Ischemic Stroke

Stroke | Ischemic Stroke

Denmark
University of Colorado, Denver
National Institute on Aging (NIA)

Not yet recruiting

Cardiometabolic Consequences of the Loss of Ovarian Function (LILAC)

Menopause | Aging | Adiposity | Estrogen Deficiency

United States
Gødstrup Hospital

Not yet recruiting

Vestibular and Postural Function in an Unselected Group of Children With Sensorineural Hearing Loss (VASIC)

Sensorineural Hearing Loss | Children, Only | Vestibular Disorder | Vestibular Function
Nanfang Hospital, Southern Medical University

Recruiting

A Single-arm, Open-label Study of Olverembatinib, CD3/CD19 Bispecific T-cell Engager, and Chidamide in Patients With Newly Diagnosed Ph+ALL (ABC)

Acute Lymphoblastic Leukemia | Philadelphia Chromosome | Adult ALL | Philadelphia-Positive ALL | IKZF1 Gene Mutation

China
CinPhloro Pharma, LLC

Recruiting

Study of the Research Medicine CIN-103 in Adults With Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D).

Irritable Bowel Syndrome With Diarrhea

United States
University of Cambridge

Recruiting

Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG) (CANCOG)

Cancer | Weight Loss | Cachexia | Appetite Loss | Cachexia-Anorexia Syndrome

United Kingdom
Stanford University

Not yet recruiting

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome | PTEN Hamartoma Syndrome

United States
Epizyme, Inc.
Ipsen

Not yet recruiting

A Study to Assess Efficacy and Safety of Oral Tazemetostat in Adult Participants With Relapsed/Refractory Follicular Lymphoma That Does Not Have an "EZH2 Gain-of-function" Genetic Mutation (Mandolin)

Follicular Lymphoma | Refractory Follicular Lymphoma
Pfizer

Recruiting

A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Renal Impairment

United States
HuidaGene Therapeutics Co., Ltd.
Eye & ENT Hospital of Fudan University

Not yet recruiting

a Study in Subjects With Otoferlin Mutation-related Hearing Loss Using RNA Base-eDiting Therapy(SOUND) (SOUND)

Congenital Hearing Loss

China
Aalborg University Hospital

Recruiting

Characterisation of Low Frequency Hearing and Vestibular Function in Patients Undergoing Cochlear Implantation

Hearing Loss, Sensorineural | Hearing Loss, Bilateral

Denmark
Regeneron Pharmaceuticals

Recruiting

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations (ENSEMBLE)

Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF) | Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes

United States
The Hong Kong Polytechnic University
The University of Hong Kong; University of Leicester; University of Waterloo

Recruiting

Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE

Glaucoma | Visual Impairment

Hong Kong
The University of Texas Health Science Center,...
Bank of America Foundation

Recruiting

Financial Coaching and Lifestyle Intervention for Diabetes Prevention in Low-income Families

Weight Loss

United States
University of Illinois at Chicago

Recruiting

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

Traumatic Amputation of Lower Extremity

United States
University of Nottingham
University of East Anglia

Recruiting

Effect of Modified Cellulose on Colonic Fermentation of Inulin (COCOA2)

Irritable Bowel Syndrome

United Kingdom
Alzheimer's Prevention and Reversal Project, Inc.
Four Winds Foundation

Recruiting

Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment (EVANTHEA)

Mild Cognitive Impairment | Dementia, Mild

United States
Pfizer

Recruiting

A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.

COVID-19

United States
Mayo Clinic
National Institute on Drug Abuse (NIDA)

Recruiting

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Respiratory Complication | Respiratory Function Loss

United States
The Bionics Institute of Australia

Recruiting

Improving Early Intervention in Hearing Impaired Children Using Functional Near-Infrared Spectroscopy (fNIRS)

Hearing Impairment

Australia
Federal State Budgetary Scientific Institution...
Federal Stare Budgetary Scientific Institution, Mental Health Research Center

Recruiting

Effects of Weight Loss Management on Cognitive Function in Elderly Women With Obesity

Obesity | Cognitive Change

Russian Federation
University of Stavanger
Stavanger Municipality, Norway

Recruiting

Health Determinants in Older Adults Living at Home

Frailty | Healthy Aging | Alcohol Use, Unspecified | Mental Health Issue | Social Functioning | Vision and Hearing Loss | Cognitive Function, Social 1

Norway
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Study of Genotype and Phenotype Characterization in Duchenne Muscular Dystrophy With Small Mutations

Muscular Dystrophy, Duchenne

Italy
Mario Negri Institute for Pharmacological Research

Recruiting

Functional Implications of Rare Gene Mutations in aHUS Open the Door to Personalized Therapy (aHUS-iPSC-EC)

Atypical Hemolytic Uremic Syndrome

Italy
Mayo Clinic
AbbVie; Cedars-Sinai Medical Center; Ironwood Pharmaceuticals, Inc.

Not yet recruiting

A Study of Virtual Reality and Linaclotide for IBS-C (IBSC-VR)

Irritable Bowel Syndrome With Constipation

United States
Regeneron Pharmaceuticals

Recruiting

A Study of DB-OTO, an Adeno-associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations (CHORD)

Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

Spain, United Kingdom, United States
National Cancer Centre, Singapore
Taiho Pharmaceutical Co., Ltd.

Recruiting

A Phase 2 Study of Osimertinib and S-1 in Treatment Resistant EGFR Mutant NSCLC

NSCLC

Singapore

Search clinical trials for: PTEN Loss of Function Mutation

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