Search clinical trials for: Pharmacologic actions

Total 95420 results

North Florida Foundation for Research and Education
University of Florida; Brooks Rehabilitation; North Florida/South Georgia Veterans...

Recruiting

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

Central Nervous System Diseases | Nervous System Diseases | Wounds and Injuries | Endocrine System Diseases | Gonadal Disorders | Trauma, Nervous System | Spinal Cord Diseases | Hypogonadism | Spinal Cord Injuries | Gait Disorders, Neurologic | Spinal Cord Injury | Wounds and Injury | Testosterone Deficiency | Hormone... and other conditions

United States
University of Minnesota
Minneapolis Veterans Affairs Medical Center

Recruiting

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

Major Depressive Disorder | Post-Traumatic Stress Disorders

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Terminated

Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer

Colorectal Cancer

United States
Ariad Pharmaceuticals
United BioSource, LLC

Terminated

An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG® (OMNI)

Myeloid Leukemia, Chronic-Phase, Accelerated-Phase, Blast-Phase, Ph+ALL

United States
Imperial College London
King's College London; University College, London; University of Oxford; University... and other collaborators

Completed

Antidepressant Controlled Trial for Negative Symptoms in Schizophrenia (ACTIONS)

Schizophrenia

United Kingdom
Emergent BioSolutions
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Safety and Pharmacokinetics of UV-4B Solution Administered Orally as Multiple Ascending Doses to Healthy Subjects

Viral Infection

United States
Emergent BioSolutions
Quintiles, Inc.; Unither Virology

Completed

Study to Determine the Safety, Tolerability and Pharmacokinetics of UV-4B Solution Administered Orally in Healthy Subjects (UV)

Viral Infection

United States
University of Pennsylvania

Active, not recruiting

Abatacept for the Treatment of Giant Cell Arteritis

Giant Cell Arteritis

United States, Canada
City of Hope Medical Center
Sangamo Therapeutics; California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients

HIV

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of LEE011 in Men and Postmenopausal Women With Advanced Breast Cancer. (MONALEESA-3)

Advanced Breast Cancer

Belgium, Italy, Czechia, Hungary, Canada, Netherlands, Germany, Singapore, Australia, Denmark, Poland, Switzerland, Korea, Republic of, Spain, Thailand, Lebanon, Austria, Bulgaria, Russian Federation, Norway, Jordan, United States, ... and more
St. James's Hospital, Ireland
Göteborg University; University College Dublin; University of Dublin, Trinity...

Completed

Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer

Stomach Neoplasms | Malnutrition | Esophageal Neoplasms | Weight Loss

Ireland, Sweden
VA Office of Research and Development
University of Florida

Terminated

Testosterone Plus Finasteride Treatment After Spinal Cord Injury

Central Nervous System Diseases | Nervous System Diseases | Wounds and Injuries | Endocrine System Diseases | Gonadal Disorders | Trauma, Nervous System | Spinal Cord Diseases | Hypogonadism | Spinal Cord Injuries | Spinal Cord Injury | Genital Diseases, Male

United States
Neuroscience Trials Australia
The Florey Institute of Neuroscience and Mental Health

Completed

STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

Intracerebral Haemorrhage

Australia, Finland, Taiwan, New Zealand, Vietnam
University of South Florida
Bristol-Myers Squibb; University of Pennsylvania; National Institute of Arthritis... and other collaborators

Active, not recruiting

Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)

Wegener's Granulomatosis | Granulomatosis With Polyangiitis | ANCA-Associated Vasculitis | Granulomatosis With Polyangiitis (Wegener's)

United States, United Kingdom, Ireland, Canada, Germany
Johns Hopkins University

Active, not recruiting

Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion

Healthy

United States
Northwestern University
United States Department of Defense

Completed

12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)

Osteoporosis | Bone Loss | Spinal Cord Injury

United States
Northwestern University

Completed

Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide

Osteoporosis | Bone Loss | Spinal Cord Injury

United States
VA Office of Research and Development

Completed

Coenzyme Q10 Phase III Trial in Gulf War Illness

Gulf War Illness | Chronic Fatigue | Coenzyme Q10 | Ubiquinol

United States
University of South Florida
National Heart, Lung, and Blood Institute (NHLBI); National Institute of Arthritis... and other collaborators

Active, not recruiting

The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach (TAPIR)

Vasculitis | Granulomatosis With Polyangiitis | Wegener Granulomatosis

United States
Medical University of Gdansk

Completed

Gender Influence on Torsadogenic Actions of Droperidol.

Arrhythmia, Droperidol

Poland
Mesoblast, Ltd.
Quintiles, Inc.

Completed

Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain (MSB-DR003)

Degenerative Disc Disease

United States, Australia
NYU Langone Health
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users

Alcohol Dependence | Alcohol Use Disorder

United States
Hospital for Special Surgery, New York

Completed

Pregabalin for the Treatment of Pain After Posterior Spinal Fusions

Lumbar Spinal Fusions

United States
Washington University School of Medicine
Centers for Disease Control and Prevention

Completed

Probiotics to Promote Intestinal Health

Communicable Diseases | Infection | Therapeutic Uses | Anti-Infective Agents | Pharmacologic Actions

United States
NYU Langone Health

Completed

The Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Religious Professionals

Religious or Spiritual Problem

United States
Organon and Co

Completed

Investigate Dose of Org 36286 to Initiate Multiple Follicular Growth in a Controlled Ovarian Hyperstimulation Protocol for IVF or IVF/ICSI (P07015)

Infertility | In Vitro Fertilization
Organon and Co

Completed

Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714) (Trust)

In Vitro Fertilization
Organon and Co

Completed

To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001) (Ensure)

Infertility
Organon and Co

Terminated

A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)

Ovulation Induction
Organon and Co

Completed

A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)

In Vitro Fertilization
Organon and Co

Completed

Study to Investigate the Optimal Dose of Org 36286 to Induce Monofollicular Ovulation in Women With WHO Group II Anovulatory Infertility (P07016)

Infertility
M.H.H. Kramer

Active, not recruiting

Renal Actions of Combined Empagliflozin and LINagliptin in Type 2 diabetES (RACELINES)

Type2 Diabetes

Netherlands
Cedars-Sinai Medical Center

Completed

Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma

Glioma | Glioblastoma | Astrocytoma | Brain Tumor | Glioblastoma Multiforme

United States
Massachusetts General Hospital

Completed

Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa (814)

Disorder of Bone Density and Structure, Unspecified

United States
University of California, San Diego

Completed

Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.

Schizophrenia

United States
Northwestern University
United States Department of Defense

Completed

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

Osteoporosis | Bone Loss | Spinal Cord Injury | Acute Spinal Cord Injury

United States
Washington University School of Medicine
James S McDonnell Foundation

Completed

Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia (RCC2)

Depression | Delirium | Seizures | Cognitive Disorders

United States
Shire

Completed

Safety and Efficacy Study of VP20621 for Prevention of Recurrent Clostridium Difficile Infection

Clostridium Difficile Infection

United States, Belgium, Canada, Germany, Switzerland, Spain
Shire

Completed

Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers

Hereditary Angioedema (HAE)

United States
Pfizer

Completed

A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia

Leukemia, Myelogenous, Chronic, Breakpoint Cluster Region-Abelson Proto-oncogene (BCR-ABL) Positive

France, United States, Canada, Spain, Czechia, Singapore, Thailand, Denmark, Norway, Korea, Republic of, Finland, Hungary, Sweden, Netherlands, Italy, Germany, Ukraine, South Africa, Taiwan, Australia, Belgium, Israel, Mexico, Poland, S... and more
Merck Sharp & Dohme LLC

Completed

Study of Vorinostat (MK-0683) or Placebo, in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-088 AMN)

Multiple Myeloma
Incyte Corporation

Completed

Prospective Observational Study Of Patients With Polycythemia Vera In US Clinical Practices (REVEAL)

MPN (Myeloproliferative Neoplasms)

United States, Puerto Rico
Millennium Pharmaceuticals, Inc.

Completed

A Study of Brentuximab Vedotin in Participants With Relapsed or Refractory Hodgkin Lymphoma

Hodgkin Lymphoma

Poland, Spain, Malaysia, Turkey, Germany, Czechia, Thailand
TSI, LLC

Terminated

Research Into the Effect of a Clot-dissolving Agent and Its Inhibitor

Acute Ischemic Stroke

Netherlands
University of Texas Southwestern Medical Center
Astellas Pharma US, Inc.

Completed

Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers (Micafungin)

Obesity | Nutrition Disorders | Overweight

United States
Scynexis, Inc.

Completed

Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis

Mycoses | Candidemia | Candidiasis, Invasive

United States, El Salvador, Germany, Guatemala, Honduras
Weill Medical College of Cornell University
National Institute of Mental Health (NIMH)

Completed

Emotional and Cognitive Control in Late-Onset Depression

Depression

United States
Circadian Technologies Ltd.

Completed

Study of VGX-100 Administered Alone and Co-administered With Bevacizumab in Adult Subjects With Advanced Solid Tumors

Neoplasms | Cancer

United States
Gilead Sciences

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Voxilaprevir in Adults With Chronic Hepatitis C Virus Infection

Hepatitis C Virus Infection

United States, Puerto Rico
Isofol Medical AB

Completed

An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer

Rectal Cancer

Sweden

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