Search clinical trials for: Phase I Studies

Total 493919 results

Endeavor Biomedicines, Inc.

Not yet recruiting

A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

Idiopathic Pulmonary Fibrosis | Progressive Fibrosing Interstitial Lung Disease | Progressive Pulmonary Fibrosis

United States, Switzerland, Canada, Australia, Austria, United Kingdom, Malaysia, Mexico, Germany, Ireland, Korea, Republic of
Eli Lilly and Company

Recruiting

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity

United States, Australia, Italy, Hungary, Spain, Canada, Germany, Argentina, Belgium, Czechia, Greece, Israel, Austria, Brazil, Mexico, Netherlands, Romania, India, United Kingdom, Slovakia, Poland, Turkey, Puerto Rico, France, Denmark
Beijing Union Pharmaceutical Factory Ltd
R&G Pharma Studies Co.,Ltd.

Recruiting

Phase Ⅲ Clinical Trial of Buagafuran Capsules in the Treatment of GAD (BGFN-2022-01)

Generalized Anxiety Disorder

China
Beijing Union Pharmaceutical Factory Ltd
R&G Pharma Studies Co.,Ltd.

Recruiting

Phase 3 Clinical Trial of Buagafuran Capsules in the Treatment of GAD (BGFN-2022-02)

Generalized Anxiety Disorder

China
Institut de Recherches Internationales Servier

Not yet recruiting

Phase 2 Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Levoleucovorin in Japanese Participants Not Previously Treated for Metastatic Adenocarcinoma of the Pancreas

Metastatic Adenocarcinoma of the Pancreas

Japan
Servier Bio-Innovation LLC
Regeneron Pharmaceuticals; Institut de Recherches Internationales Servier

Not yet recruiting

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer (NSCLC)

Hong Kong, United States, Australia
Nektar Therapeutics

Recruiting

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis (REZOLVE-AD)

Moderate to Severe Atopic Dermatitis

United States, Australia, Canada
Amgen

Recruiting

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

Sjogren's Syndrome

United States, Argentina, Japan
Virginia Commonwealth University
National Institute on Drug Abuse (NIDA)

Recruiting

Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion

Addiction | Opioid Use Disorder | Substance Use Disorders | Opioid Use

United States
Neogap Therapeutics AB
Karolinska University Hospital; CTC Clinical Trial Consultants AB; Region Västmanland and other collaborators

Recruiting

A First-In-Human Trial of pTTL in Advanced Colorectal Cancer

Colorectal Cancer

Sweden
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation in Patients With Severe Alcohol Use Disorder: a Phase ii Trial (CBD-OH)

Severe Alcohol Use Disorder (DSM 5)

France
Eli Lilly and Company

Recruiting

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)

Cardiovascular Diseases | Obesity | Overweight | Type 2 Diabetes | Chronic Kidney Disease | Overweight or Obesity

United States, Italy, Spain, Korea, Republic of, India, Turkey, Austria, Puerto Rico, Mexico, Romania, Brazil, Czechia, Germany, Argentina, Greece, Slovakia
Novartis Pharmaceuticals

Recruiting

A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Primary Prevention of Atherosclerotic Cardiovascular Disease

United States, China, Italy, Spain, France, Netherlands, Poland, Switzerland, Taiwan, Greece, Thailand, Brazil, India, Hungary, Latvia, Mexico, Israel, Malaysia, Turkey, Argentina, Singapore, Australia, Belgium, Bulgaria, Denmark, Croatia, South... and more
LG Chem

Recruiting

Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients (EURELIA2)

Hyperuricemia | Gout | Gout Flare | Tophi

United States
St. Jude Children's Research Hospital

Recruiting

Exploring The Role Of Palliative Care In Phase 1 Enrolled Pediatric Oncology Patients

Quality of Life

United States
Pfizer

Recruiting

Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults. (RENOIR)

Lower Respiratory Tract Illness

United States, Argentina, Canada, Finland, Japan, Netherlands, South Africa
The University of Queensland
Chinese University of Hong Kong; University of Malaya; The Alfred; Centre Hospitalier... and other collaborators

Recruiting

PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) (PNEUDOS)

Pneumonia

Hong Kong, France, Belgium, Australia, Malaysia
Averitas Pharma, Inc.

Recruiting

Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery

Post Surgical Neuropathic Pain

United States, Spain, France, Netherlands, Poland, United Kingdom
Inventiva Pharma

Recruiting

A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 ) (NATiV3)

NASH - Nonalcoholic Steatohepatitis

United States, Argentina, Australia, Austria, Belgium, France, Germany, Israel, Portugal, Spain, United Kingdom, Canada, Italy, China, Brazil, Netherlands, Hungary, Bulgaria, Chile, Czechia, Mexico, Poland, Puerto Rico, South Africa, Uk...
Ospedale San Carlo Borromeo
Associazione Oncologica Milanese AmoLaVita ONLUS

Not yet recruiting

Antibiotics Continuous Infusion at Home (TAID)

Severe Bacterial Infections

Italy
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Recruiting

Phase I/II Trial of S65487 Plus Azacitidine in Acute Myeloid Leukemia

Acute Myeloid Leukemia

France, Korea, Republic of, Spain, United Kingdom, Hungary, Poland
Biohaven Pharmaceuticals, Inc.

Recruiting

Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder

Obsessive-Compulsive Disorder

United States
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Recruiting

MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease

Liver Failure | Acute-On-Chronic Liver Failure | Liver Disease | Cirrhosis of the Liver

Switzerland, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Recruiting

Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients With Pulmonary Hypertension (FIT-PH) (FIT-PH)

Pulmonary Hypertension

United Kingdom
Canadian Cancer Trials Group
AstraZeneca

Recruiting

A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies

Cancer

Canada
Centre Hospitalier Universitaire Dijon

Recruiting

Patient-caregiver Collaboration for Better Cardiovascular Care for Patients With Long-term Mental Disorders: Multicentre Qualitative and Feasibility Studies (COPsyCAT)

Long-term Mental Disorders

France
NewAmsterdam Pharma
Monash University

Active, not recruiting

Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease (PREVAIL)

Atherosclerotic Cardiovascular Disease

Spain, United States, Israel, Italy, Denmark, United Kingdom, Canada, Poland, Latvia, Japan, Croatia, Netherlands, Australia, Finland, Slovakia, China, Czechia, Bulgaria, Georgia, Hungary, Jordan, Germany, South Africa
Cassava Sciences, Inc.

Enrolling by invitation

Open-label Extension for Phase 3 Clinical Trials of Simufilam

Alzheimer Disease

United States, Canada, Puerto Rico
Oslo University Hospital
Sunnaas Rehabilitation Hospital; South-Eastern Norway Regional Health Authority

Completed

Self-management Program for Patients in the Sub-acute Phase After Traumatic Injury - a Feasibility Study (SMS_trauma)

Brain Injuries | Spinal Cord Injuries | Feasibility Studies | Self-management

Norway
Amgen

Completed

Apremilast as a Direct Treatment for Mild-to-moderate Plaque Psoriasis Versus Placebo: an Analysis of Clinical Safety and Efficacy (ADVANCE)

Psoriasis

United States, Canada
Ohio State University Comprehensive Cancer Center
MorphoSys AG

Active, not recruiting

Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL

Recurrent Small Lymphocytic Lymphoma | Prolymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia | Stage III Small Lymphocytic Lymphoma | Stage IV Small Lymphocytic Lymphoma | Stage I Chronic Lymphocytic Leukemia | Stage II Chronic Lymphocytic Leukemia | Contiguous Stage II Small Lymphocytic... and other conditions

United States
Escient Pharmaceuticals, Inc

Active, not recruiting

Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of EP262 in Subjects With Atopic Dermatitis (EASE)

Atopic Dermatitis

United States, Canada
ModernaTX, Inc.

Active, not recruiting

A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥50 Years of Age (RSVictory)

Respiratory Syncytial Virus

United States
ASLAN Pharmaceuticals

Completed

Phase 2b Study of ASLAN004 in Adults With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis

United States, Australia, Singapore, India, Canada, New Zealand, Dominican Republic, Poland
Pfizer

Completed

A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older

Influenza, Human

United States, Brazil, South Africa, Philippines, New Zealand, Chile, Argentina
National Institute of Allergy and Infectious Diseases...

Completed

A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z)

Ebola Disease | Immunisation

United States
AbbVie
Endo Pharmaceuticals; Allergan Sales, LLC; Acerus Pharmaceuticals Corporation; Upsher-Smith...

Completed

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men (TRAVERSE)

Cardiovascular Diseases | Hypogonadism

United States, Puerto Rico
Immunic AG

Terminated

Phase 2 Dose-finding IMU-838 for Ulcerative Colitis (CALDOSE-1)

Ulcerative Colitis

United States, Russian Federation, Serbia, Belarus, Netherlands, Spain, United Kingdom, Croatia, Poland, Albania, Bosnia and Herzegovina, Bulgaria, Czechia, Georgia, North Macedonia, Portugal, Romania, Turkey, Ukraine
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Terminated

Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer (COLSTAR)

Metastatic Colorectal Cancer

Denmark, Japan, Belgium, Finland, Hungary, United States
Principia Biopharma, a Sanofi Company

Completed

Phase 2a Study of the Safety, Tolerability, and Pharmacokinetics of Topically Administered PRN473 (SAR444727) in Patients With Mild to Moderate Atopic Dermatitis

Atopic Dermatitis

United States, Canada
Hoffmann-La Roche

Completed

A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531

Hepatitis B, Chronic

Thailand, Taiwan, United Kingdom, Hong Kong, Netherlands, New Zealand, Bulgaria, Italy
ModernaTX, Inc.

Completed

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

Seasonal Influenza

Spain, United States, Denmark, Poland, United Kingdom, Germany, Canada, Taiwan, Bulgaria, Netherlands, Estonia
Alvogen Korea

Completed

Phase IV Study of Qsymia in Obese Patients

Obesity

Korea, Republic of
Edward Patz

Active, not recruiting

Phase Ib First in Human Dose Escalation of GT103 in Refractory, Advanced Stage Non-Small Cell Lung Cancer (TOP 1902)

Non-small Cell Lung Cancer

United States
Institut de Recherches Internationales Servier
ADIR, a Servier Group company; Les Laboratoires Servier (L.L.S), Russia

Completed

A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL) (ALL)

Acute Lymphoblastic Leukemia

Russian Federation
University of Nebraska
National Cancer Institute (NCI)

Completed

Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific

United States
M.D. Anderson Cancer Center
Bristol-Myers Squibb; Susan G. Komen Breast Cancer Foundation

Active, not recruiting

Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer

Breast Cancer

United States
Santen Inc.

Terminated

LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye

Non Infectious Uveitis

United States, India, Italy, Argentina
Satsuma Pharmaceuticals, Inc.

Completed

A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine (SUMMIT)

Migraine | Migraine Without Aura | Migraine With Aura

United States
Biohaven Pharmaceuticals, Inc.

Enrolling by invitation

Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder

Obsessive Compulsive Disorder

Canada, United States, Spain, United Kingdom, Italy, Netherlands

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