Search clinical trials for: Proof of Principle

Total 429950 results

University of Calgary

Recruiting

A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11) (POST 11)

Syncope | Vasovagal Syncope (VVS)

Canada
Kepler University Hospital

Recruiting

Immuno-Positron Emission Tomography (PET)-Glioma Study, a Proof-of-principle Imaging Study

Glioblastoma

Austria
University Hospital, Strasbourg, France

Recruiting

Personalized Repetitive Transcranial Magnetic Stimulation (rTMS) in Cognitive Fluctuations of Dementia With Lewy Bodies (DLB): Proof of Concept (STIMLEWY)

Dementia With Lewy Bodies Diagnosis | Significant Cognitive Fluctuations in DLB

France
St. Jude Children's Research Hospital

Recruiting

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

Brain Tumor | Medulloblastoma

United States
University Hospital Bispebjerg and Frederiksberg
Proff Dr Jürgen Popp, Leibniz Institute, IPHT, Jena, Germany; Karin Mogensen... and other collaborators

Recruiting

In Vivo Proof-of-principle Study of Raman Spectroscopy in Trial Participants With Bladder Tumours

Endoscopic Bladder Cancer Diagnosis With Raman

Denmark
Algenis SpA
Oncoclínicas

Recruiting

Proof of Principle Study Evaluating Gonyautoxins NEURO SERUM, on Chemotherapy-induced Peripheral Neuropathy

Chemotherapy-induced Peripheral Neuropathy

Brazil
SyneuRx International (Taiwan) Corp

Recruiting

Proof of Principle Study to Evaluate the Safety, PK, Viral Shedding and Efficacy of Pentarlandir™ UPPTA for Patients With Early COVID-19

Coronavirus Disease 2019

United States
Maastricht University Medical Center

Recruiting

Non Invasive Cancer Test (NICT): a Proof of Principle Study. (NICT-NIPT-CA)

Neoplasmata

Netherlands
GlaxoSmithKline

Completed

A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis

Gingivitis

Canada
Dartmouth-Hitchcock Medical Center

Terminated

Metformin Pharmacology in Human Cancers: A Proof of Principle Study

Thoracic Neoplasm

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Terminated

Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study (DECO)

Colon Cancer

Netherlands
Great Ormond Street Hospital for Children NHS Foundation...

Completed

Newborn Screening for Spinal Muscular Atrophy (SMA) - a Proof of Principle Study Using Anonymised Blood Spots.

Spinal Muscular Atrophy

United Kingdom
Dartmouth-Hitchcock Medical Center

Completed

A Proof-of-principle Study of HBO-SRS for Brain Metastases

Brain Metastases

United States
Sunnybrook Health Sciences Centre
Merck Sharp & Dohme LLC; Ozmosis Research Inc.

Completed

A Proof of Principle Study of Pembrolizumab With SBRT in TKI mRCC Patients (OZM-065)

Stage IV Renal Cell Cancer AJCC V7

Canada
Novo Nordisk A/S

Completed

A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function

Diabetes | Diabetes Mellitus, Type 1

United States, Israel, Italy, Poland, Russian Federation, United Kingdom, Canada, Denmark, Sweden, Austria, Belgium, Spain, Ireland, Norway, Serbia, Finland, Portugal, Ukraine
Istituto Scientifico Romagnolo per lo Studio e...

Unknown

Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumor Lysate or Homogenate Combined With Immunomodulating Radiotherapy and/or Preleukapheresis IFN-alfa in Patients With Metastatic Melanoma: a Randomized "Proof-of-principle" Phase II Study (ABSIDE)

Malignant Melanoma of Skin Stage III | Malignant Melanoma of Skin Stage IV

Italy
Corindus Inc.

Completed

GRX With ReMOTE: First in Human in India

Percutaneous Coronary Intervention

India
University of Minnesota

Completed

Proof of Principle Study of Pulse Dosing of IL-15 to Deplete the Reservoir in HIV Infected People (ALT-803)

HIV | Stable ART

United States
Barts & The London NHS Trust

Unknown

Development and Validation of a Fast, Semi-Automated Hybrid Imaging Platform to Assess Coronary Atherosclerotic Plaque Morphology, Endothelial Shear Stress and Arterial Inflammation: A Proof of Principle Study (VALID-PET-CT) (VALID-PET-CT)

Coronary Artery Disease | Stable Angina
Genervon Biopharmaceuticals, LLC
Columbia University

Completed

Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease (GAP-PD)

Parkinson's Disease

United States
Cognizance Biomarkers, LLC
University of Pennsylvania

Completed

Proof of Principle for a Diagnostic Blood Test of Recurrent Seizures

Epilepsy

United States
University at Albany

Completed

Decision-Making Processes While Online Grocery Shopping

Nutrition Poor
Dartmouth-Hitchcock Medical Center
Dartmouth College

Completed

Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue

Breast Cancer

United States
Dartmouth-Hitchcock Medical Center
Merck Sharp & Dohme LLC

Completed

A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer

Head and Neck Cancer | Esophageal Cancer | Lung Cancer | Aerodigestive Tract Cancer

United States
Novo Nordisk A/S

Completed

A Randomised Proof-of-Principle Trial Investigating Pharmacodynamics, Pharmacokinetics, and Safety of NNC0143-0406 in Subjects With Type 1 Diabetes Mellitus

Diabetes | Diabetes Mellitus, Type 1

Austria
Mead Johnson Nutrition
Midwest Children's Health Research Institute

Completed

Exploratory/Proof of Principle Microbiota Study

Fecal Microbiota

United States
NYU Langone Health
United States Department of Defense

Completed

Breast Cancer Chemoprevention by SOM230, an IGF-I Action Inhibitor: A Proof of Principle Trial

Atypical Ductal Breast Hyperplasia | Lobular Carcinoma in Situ (LCIS) | Atypical Lobular Hyperplasia (ALH) of Breast

United States
Mayo Clinic

Completed

Use of Tolvaptan to Reduce Urinary Supersaturation: a Pilot Proof of Principle Study

Nephrolithiasis, Calcium Oxalate | Nephrolithiasis, Calcium Phosphate

United States
Radboud University Medical Center

Completed

Effects of Oxygen Status on Hypoxia Inducible Factor 1-α and Inflammation. A Pilot Proof of Principle Study.

Hypoxia | Hyperoxia

Netherlands
Bayer

Completed

ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial (ODiXaHip)

Thromboembolism | Prevention

Belgium, Denmark, Austria, Germany, Netherlands, Poland, Sweden, Israel, France, Norway, United Kingdom
Dartmouth-Hitchcock Medical Center

Withdrawn

A Proof of Principle Study of Aminolevulinic Acid (ALA) - Induced Fluorescence Detection in Resectable Non-Small Cell Lung Cancer

Lung Cancer in Normal and Malignant Tumors

United States
Targacept Inc.

Completed

Proof-of-Principle Study of TC-6499 in the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome

United Kingdom
Astellas Pharma Inc

Completed

A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831 (ASTER)

Non-Alcoholic Steatohepatitis

United Kingdom, Belgium, Switzerland, Germany, France, Romania, Czech Republic
Abbott Nutrition

Completed

Post Prandial Glucose Control Proof-of-Principle

Diabetes Mellitus, Type 2

United States
AstraZeneca

Completed

14473 - D9126C00001 Proof of Principle Study - Effect of AZD2066 on Transient Lower Esophageal Sphincter Relaxations

Reflux Episodes

Netherlands
Heidelberg University

Completed

Efficacy of Methylene Blue for Malaria Treatment in Adults of Burkina Faso: Proof of Principle Study in Semi-Immune Adults of Burkina Faso in the Frame of the A8 Project of the SFB 544

Malaria

Burkina Faso
PulseNmore
University of Michigan

Recruiting

Self Biophysical Profile Using a Home Ultrasound Device Proof of Concept

Perinatal Care

United States
Fondazione Don Carlo Gnocchi Onlus
Istituto Italiano di Tecnologia; Istituto Nazionale di Ricovero e Cura per...

Not yet recruiting

Proof of Concept of Hybrid Robotics for Gait Rehabilitation of Persons Post-stroke (PoCH-Rehab)

Stroke Sequelae | Gait, Hemiplegic

Italy
Yale University
Roivant Sciences (HekaHeart)

Not yet recruiting

HekaHeart Phase 1 Proof of Concept (HekaHeart POC)

Heart Failure With Reduced Ejection Fraction

United States
Benha University

Recruiting

Articaine Plus Dexmedetomidine in Supraclavicular Block

Post Operative Pain, Acute

Egypt
Indivior Inc.

Not yet recruiting

Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorder

Opioid Use Disorder
Galderma R&D

Not yet recruiting

Comparing Pain, Safety and Effectiveness of Restylane Skinboosters Vital Lido and Vital Without Lido in Dorsal Hand

Skin Aging of Dorsal Hands

China
Qiong Fu

Not yet recruiting

A Prospective, Single Arm, Open Label, Proof of Concept Clinical Study of Sulfasalazine in the Treatment of Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Hadassah Medical Organization

Recruiting

Using Chronobiology to Improve Lenvatinib Efficacy

Lenvatinib Treatment

Israel
Chulalongkorn University

Not yet recruiting

Prevalence of FGIDs and Probiotics Study (PROOF)

Functional Gastrointestinal Disorders | Infant Conditions
Universiteit Antwerpen
McGill University; Aragon Institute of Health Sciences

Not yet recruiting

Comparative Study of the Mechanism of Action of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity: a Proof of Concept Controlled Trial (STROKEPOC)

Stroke | Spasticity as Sequela of Stroke
University College, London
Moorfields Eye Hospital NHS Foundation Trust

Recruiting

Red Light Ptosis Proof-of-Concept

Mitochondrial Diseases | Blepharoptosis

United Kingdom
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis

Bronchiectasis

United Kingdom, Japan, United States, Israel, Canada
Ferring Pharmaceuticals

Recruiting

A Phase 1b Proof-of-concept Trial Exploring the Effects of FE 999322 and FE 999324 in Adults With Mild to Moderate Ulcerative Colitis

Ulcerative Colitis

United States
Dartmouth-Hitchcock Medical Center
National Cancer Institute (NCI)

Recruiting

A Randomized Two-Arm Proof of Concept Study Testing A Novel Approach to Exercise Promotion Based on Affect-regulation

Breast Cancer

United States

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