Search clinical trials for: Ribonucleic acid

Total 27847 results

invIOs GmbH

Recruiting

PBMC-based Leukocyte Immunotherapy (PALINDROM)

Advanced Solid Tumor

Austria
AstraZeneca

Recruiting

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

Rheumatoid Arthritis

United Kingdom, Canada
University Hospital, Montpellier

Not yet recruiting

Assessment of microRNAs Role in Familial Mediterranean Fever FMF Pathophysiology (miRinFMF)

Familial Mediterranean Fever

France
Rigshospitalet, Denmark
Innovation Fund Denmark; Ministry of Education, Denmark

Recruiting

Myopericarditis After Messenger Ribonucleic Acid (mRNA) COVID-19 Vaccination in Children 5-11 Years Old

Myocarditis | SARS-CoV2 Infection | Myopericarditis | Vaccination; Complications | COVID-19 Pandemic

Denmark
Ente Ospedaliero Ospedali Galliera
University of Genoa

Recruiting

BNT162b2 Messenger Ribonucleic Acid (mRNA) Covid-19 Vaccine in Cancer Patients on Active Treatment (UNICO)

Neoplasms | Cancer, Treatment-Related

Italy
Walvax Biotechnology Co., Ltd.
Abogen Biosciences Co. Ltd.; Yuxi Walvax Biotechnology Co., Ltd.

Recruiting

A Phase III Clinical Study of a SARS-CoV-2 Messenger Ribonucleic Acid (mRNA) Vaccine Candidate Against COVID-19 in Population Aged 18 Years and Above

COVID-19 | SARS-CoV-2

Indonesia, Mexico
Novartis Pharmaceuticals

Active, not recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial Hypercholesterolemia (ORION-16)

Familial Hypercholesterolemia - Heterozygous

United States, Germany, South Africa, Greece, Italy, Czechia, Taiwan, Slovakia, Turkey, France, Russian Federation, Canada, Spain, Jordan, Switzerland, Hungary, Poland, Netherlands, Norway, United Kingdom, Lebanon, Argentina, Brazil, ... and more
Novartis Pharmaceuticals

Active, not recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia (ORION-13)

Familial Hypercholesterolemia - Homozygous

Greece, Lebanon, Turkey, France, Canada, Malaysia, Netherlands, United States
Gritstone bio, Inc.

Completed

Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)

COVID-19 | SARS-CoV-2

South Africa
BioNTech SE
Pfizer

Active, not recruiting

Safety and Effects of an Investigational COVID-19 Vaccine as Booster in Healthy People

COVID-19 | SARS-CoV-2 Infection

United States
GlaxoSmithKline

Completed

Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan

Pulmonary Disease, Chronic Obstructive

Japan
University Hospital, Basel, Switzerland
Swiss National Science Foundation; ModernaTX, Inc.

Completed

Immunocompromised Swiss Cohorts Based Trial Platform (COVERALL)

Immunocompromised Patients

Switzerland
Merck Sharp & Dohme LLC

Completed

Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076)

Papillomavirus Infections | Coronavirus Disease (COVID-19)

United States
Pfizer

Completed

A Study To Learn About The Study Vaccine (Called Self-Amplifying Ribonucleic Acid (RNA)) For The Prevention of Influenza

Influenza, Human

United States
Hospices Civils de Lyon

Completed

Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study (miROI)

Osteogenesis Imperfecta

France
Pfizer

Withdrawn

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (EPIC-HOS)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Immunocompromised | Hospitalization | Child, Hospitalized

United States, Bulgaria
Ludwig Institute for Cancer Research
Boehringer Ingelheim; MedImmune LLC; PharmaJet, Inc.; CureVac; Cancer Research Institute...

Completed

Phase 1/2 Study of Combination Immunotherapy and Messenger Ribonucleic Acid (mRNA) Vaccine in Subjects With NSCLC

NSCLC | Metastatic Non-small Cell Lung Cancer

United States
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; National... and other collaborators

Completed

Transcriptome Assessment After Cardiac Arrest (OMECARD)

Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation

France
Albert B. Sabin Vaccine Institute
ICON plc; Oklahoma Blood Institute

Completed

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

Ebola Virus Disease | Marburg Virus Disease

United States
Sylentis, S.A.

Completed

Safety, Tolerability and Pharmacokinetic Profile of SYL1801 Eye Drops

Choroidal Neovascularization | Safety, Tolerability and Pharmacokinetic Profile in Healthy Volunteers

Spain
Janssen-Cilag International NV

Completed

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment (SALIF)

Human Immunodeficiency Virus-type 1 Infection

South Africa, Kenya, Thailand, Uganda, Cameroon, Senegal
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Phase Ib/II Study of Carboplatin + M6620 + Avelumab in PARPi-resistant Ovarian Cancer

Ovarian Cancer

Belgium, United States, United Kingdom
Tel-Aviv Sourasky Medical Center
Hebrew University of Jerusalem

Completed

Micro Ribonucleic Acid (RNA) as Cholinergic Tone and Inflammatory Regulator in Inflammatory Bowel Disease

Inflammatory Bowel Disease

Israel
National Cancer Institute (NCI)

Terminated

Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer

Melanoma | Colon Cancer | Gastrointestinal Cancer | Hepatocellular Cancer | Genitourinary Cancer

United States
University College, London
University College London Hospitals

Unknown

The Role of Lipids in Immune Cell Function in SLE Patients

Lupus Erythematosus, Systemic

United Kingdom
OPKO Health, Inc.

Completed

4Kscore Using Serum Stored Uncentrifuged

Prostate Cancer

United States
Radboud University Medical Center
Rotterdam Eye Hospital

Terminated

Messenger Ribonucleic Acid (mRNA) Transfected Dendritic Cell Vaccination in High Risk Uveal Melanoma Patients

Uveal Melanoma

Netherlands
Assiut University

Unknown

The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients

Chronic Hepatitis c
Hoffmann-La Roche

Completed

A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)

Carcinoma, Hepatocellular

United States
Hoffmann-La Roche

Completed

Pertuzumab in Platinum-Resistant Low Human Epidermal Growth Factor Receptor 3 (HER3) Messenger Ribonucleic Acid (mRNA) Epithelial Ovarian Cancer (PENELOPE)

Ovarian Cancer

Italy, Austria, Belgium, France, Germany, Spain, Netherlands, Sweden, Denmark, Norway
St. Joseph's Hospital and Medical Center, Phoenix
Translational Genomics Research Institute

Terminated

Micro Ribonucleic Acid (miRNA) Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH)

Intraventricular Hemorrhage | Spina Bifida

United States
Janssen Scientific Affairs, LLC

Completed

An Efficacy and Safety Study of Simeprevir and Sofosbuvir With and Without Ribavirin in Participants With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver Transplant (GALAXY)

Hepatitits C

United States
Christoph Stephan
University Hospital Heidelberg

Completed

Impact of Raltegravir on HIV-1 cDNA Slope Following Antiretroviral Therapy (ART) Initiation

HIV-1

Germany
Janssen Scientific Affairs, LLC

Completed

A Study to Examine Patient Characteristics, Health Care Management and Health Outcomes of Hepatitis C Virus (HCV) Patients Treated With Simeprevir

Hepatitis C Virus

United States
Merck Sharp & Dohme LLC

Completed

Effect of Vicriviroc on HIV Ribonucleic Acid (RNA) Levels in Cerebrospinal Fluid (Study P05241)

HIV Infections
Quark Pharmaceuticals

Completed

I5NP for Prophylaxis of Delayed Graft Function in Kidney Transplantation

Delayed Graft Function | Other Complication of Kidney Transplant

United States, Spain, Germany, France, Canada
Vertex Pharmaceuticals Incorporated
Tibotec, Inc

Completed

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

Hepatitis C

United States, France, United Kingdom, Germany, Canada, Netherlands, Austria, Puerto Rico
Janssen Pharmaceutical K.K.

Completed

A Study of TMC435 in Participants With Genotype 1 Hepatitis C Virus (HCV) Infection

Hepatitis C, Chronic

Japan
Shanghai Mental Health Center
National Natural Science Foundation of China; Shanghai Municipal Science and...

Unknown

The Study of microRNA 107 (miRNA 107) and Beta-amyloid Precursor Protein-cleaving Enzyme 1 (BACE1) Messenger Ribonucleic Acid (mRNA) Gene Expression in Cerebrospinal Fluid and Peripheral Blood of Alzheimer's Disease

Alzheimer's Disease

China
Hamamatsu University

Unknown

Comparison of Fecal Ribonucleic Acid (RNA) Test With Fecal Occult Blood Test (FOBT) for Detecting Colorectal Cancer and Adenoma

Colorectal Cancer

Japan
OPKO Health, Inc.

Completed

Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration

Macular Degeneration

United States
Finis Terrae University

Recruiting

Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity (RESTORENAD)

Metabolic Diseases | Healthy Aging | Lifestyle-related Condition

Chile
Cairo University

Not yet recruiting

Microfragmented Adipose Tissue Injection Compared to Hyaluronic Acid for Treatment of Temporomandibular Joint Osteoarthritis

Temporomandibular Joint Osteoarthritis
Semmelweis University

Recruiting

Digital vs Conventional Impression in Capturing the Emergence Profile Around Maxillary Anterior Implant-supported Crowns

Dental Implants, Single-Tooth | Dental Impression Technique

Hungary
Hospital Universitario 12 de Octubre

Not yet recruiting

Registry of Patients in Shock Treated With Vasopressin

Shock | Vasopressor Adverse Reaction | Vasopressin Causing Adverse Effects in Therapeutic Use | Vasopressin Deficiency

Spain
Ascentage Pharma Group Inc.

Not yet recruiting

A Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients With CML (POLARIS-2)

Chronic Myeloid Leukemia | CML | CML, Chronic Phase

United States
McGill University

Recruiting

Accuracy of a Continuous Ketone Monitoring (CKM) System in Individuals With Type 1 Diabetes on Insulin Pump Therapy. (CKM 1)

type1diabetes

Canada
Qianfoshan Hospital

Not yet recruiting

Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery

Postoperative Complications | Ventilator-Induced Lung Injury | Humans | Ascorbic Acid | Neurosurgical Procedures

China
National Cheng-Kung University Hospital

Not yet recruiting

Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding: A Randomized Controlled Trial

Bleed Ulcer
Ain Shams University

Recruiting

Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females

Polycystic Ovary Syndrome | Infertility, Female

Egypt

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