Search clinical trials for: Sigma-1 receptor agonist

Total 65661 results

Stanford University

Active, not recruiting

Reliability of [18F]-FTC-146 Brain Uptake in Healthy Controls (rSIG)

Healthy Controls

United States
Royal Marsden NHS Foundation Trust
Pelican Cancer Foundation

Completed

Surgical Anatomy and 'Waisting' of the sIgmoid SpEcimen (WISE)

Sigmoid, Sigmoid Colon, Neoplasm, Cancer

United Kingdom
DePuy International

Completed

Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEM

Osteoarthritis | Post-traumatic Arthritis | Gout | Pseudo-gout

Switzerland, Italy
Stanford University
University of Mississippi Medical Center

Completed

[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica

Sciatica | Complex Regional Pain Syndrome

United States
DePuy International

Completed

Sigma CR150 Versus Sigma CR Knee RCT

Osteoarthritis

Singapore, United Kingdom, India
Seoul National University Hospital

Completed

Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty

Osteoarthritis, Knee

Korea, Republic of
University of Oxford
National Institute for Health Research, United Kingdom; Zogenix International...

Completed

Fenfluramine and Cognition (FEN&Cognition)

Cognitive Function

United Kingdom
Axsome Therapeutics, Inc.

Completed

Assessing Symptomatic Clinical Episodes in Depression (ASCEND)

Major Depressive Disorder

United States
DePuy International

Terminated

P.F.C. Sigma Fixed Versus P.F.C. RP Mobile Bearing Total Knee Systems

Osteoarthritis, Knee

United Kingdom
Radboud University Medical Center
Canisius-Wilhelmina Hospital; Johnson & Johnson Medical BV, The Netherlands

Completed

Functional Evaluation of a Standard and a High-flexion Knee Prosthesis Using Thigh-calf Contact Force Measurements

Arthroplasty, Replacement, Knee

Netherlands
Tecnoquimicas

Recruiting

Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye

Dry Eye Disease

Colombia
Isfahan University of Medical Sciences

Completed

Comparing Fixed-bearing Versus Mobile-bearing Prosthesis in Total Knee Arthroplasty: A Prospective Randomized Trial

Osteoarthritis

Iran, Islamic Republic of
DePuy International

Completed

The Press Fit Condylar (P.F.C.) Sigma Metal-backed Versus All-poly

Knee Osteoarthritis

United Kingdom
DePuy International

Terminated

Long-term Study of The Press Fit Condylar (P.F.C.) Sigma Total Knee Replacement System

Knee Osteoarthritis

United Kingdom
DePuy International

Terminated

A Study to Compare the Press Fit Condylar (P.F.C.) Sigma Rotating-platform High-flexion (RP-F) Versus the Press Fit Condylar (P.F.C.) Sigma Rotating-platform (RP) Knee Implants

Knee Osteoarthritis

Spain, United Kingdom
Maidstone & Tunbridge Wells NHS Trust

Active, not recruiting

All Polyethylene Versus Metal Backed Tibial Components in Knee Replacement

Osteoarthritis, Knee

United Kingdom
Ewha Womans University

Completed

Comparison of Nonposterior- and Posterior-Stabilized Mobile-Bearing Total Knee Arthroplasty

Osteoarthritis

Korea, Republic of
DePuy International

Terminated

The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty (TC3)

Osteoarthritis

France, Switzerland, Germany, United Kingdom
Mississippi Sports Medicine and Orthopaedic Center
DePuy Orthopaedics

Completed

A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis

Osteoarthritis | Unicompartmental Knee Arthroscopy

United States
Prof. Dr. Carsten Perka
Julius Wolff Institute

Unknown

In-vivo Comparison of Different Levels of Femoral Rollback in a Primary Total Knee Arthroplasty (DePuyAttune)

Gonarthrosis

Germany
DePuy International

Terminated

PFC Sigma Fixed and Mobile Knee Study

Osteoarthritis, Knee

United Kingdom
University of Aarhus
Regionshospitalet Silkeborg; Gigtforeningen; Protesekompagniet

Completed

Rehabilitation After Total Knee Arthroplasty (TKA) - PFC Rotating Versus Fixed Bearing

Osteoarthritis

Denmark
DePuy Orthopaedics

Completed

Randomized Fixed Bearing vs Mobile Bearing Cruciate Retaining TKA

Osteoarthritis | Rheumatoid Arthritis | Post-traumatic Arthritis | Juvenile Rheumatoid Arthritis | Avascular Necrosis of Bone

United States
Regional Hospital Holstebro

Completed

Comparison of Oxford UKA and Sigma UKA With RSA.

Knee Osteoarthritis | Knee Replacement | RSA
Mayo Clinic

Completed

Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty

Degenerative Joint Disease

United States
DePuy Orthopaedics

Completed

Does Implant Design Improve Postoperative Flexion?

Non-inflammatory Arthritis

United States
DePuy Orthopaedics

Completed

Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Juvenile Rheumatoid Arthritis | Post-Traumatic Arthritis | Other Inflammatory Arthritis

United States
Urgotech
ESPCI Paris

Completed

Validation of the EEG Signal Quality Measured by the URGOnight Device and Comparison With a Clinical Device (SIGMA)

Healthy Volonteers

France
Tem Innovations GmbH

Unknown

ROTEM® Sigma Performance Evaluation - Method Comparison With Predicate Device and Reference Intervals (ROSI-EVA)

Blood Coagulation Disorders

United States, Austria, Switzerland
Intuitive Surgical

Completed

Robotic-assisted Versus Laparoscopic Sigmoid Resection

Sigmoid Diseases

United States
DePuy Orthopaedics

Completed

PS150 Total Knee Arthroplasty Outcomes Registry

Osteoarthritis | Rheumatoid Arthritis

Korea, Republic of, Australia
The University of Tennessee, Knoxville
DePuy Orthopaedics

Completed

Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA (Sigma MB TKA)

Knee Replacement Arthroplasty | Knee Prosthesis

United States
IHU Strasbourg

Completed

Perfusion Evaluation by Real-time Fluorescence-based Enhanced Reality of Anastomosis (PERFECT)

Sigmoid Diverticulosis | Sigmoid Diverticulitis | Colorectal Malignancy

France
Societa Italiana di Chirurgia ColoRettale

Recruiting

Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR). (SIGMA-D)

Acute Diverticulitis | Stoma Ileostomy | Stoma Colostomy

Italy
DePuy International

Completed

Survivorship of the Press Fit Condylar (P.F.C.) Sigma Fixed Bearing Knee With a Cobalt Chrome Tibial Tray

Knee Osteoarthritis

United Kingdom, Germany, Italy
DePuy International

Terminated

A Study to Determine the Performance of the Press Fit Condylar (P.F.C.) Sigma RP-F Knee System

Osteoarthritis

India, Japan, Korea, Republic of, New Zealand, Singapore, Thailand, United Kingdom
DePuy Orthopaedics

Completed

Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study

Arthritis, Rheumatoid | Osteoarthritis, Knee

United States
Minneapolis Veterans Affairs Medical Center
Depuy, Inc.

Terminated

Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty

Osteoarthritis, Knee

United States
Anavex Life Sciences Corp.
Cognitive Research Corporation; COGNISION; Hassman Research Institute

Recruiting

A Study of ANAVEX3-71 in Adults With Schizophrenia (SZ-001)

Schizophrenia

United States
University Hospital, Geneva

Completed

Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease

Diverticulitis

Switzerland
Cantonal Hospital of St. Gallen

Completed

Laparoscopic Transvaginal Hybrid Anterior Resection: a Prospective Data Collection

Sigmoid Diverticulitis (Hinchey I and II) | Sigmoid Diverticulosis With Two or More Attacks of Diverticulitis

Switzerland
Sahlgrenska University Hospital, Sweden

Unknown

Total Knee Replacement With the Attune vs. the Press Fit Condylar (PFC) Sigma. (Att16SM)

Osteoarthrosis, Knee

Sweden
Abramson Cancer Center of the University of Pennsylvania

Terminated

Imaging of in Vivo Sigma-2 Receptor Expression With 18F-ISO-1 Positron Emission Tomography in Metastatic Breast Cancer

METASTATIC BREAST CANCER

United States
Queen's University
DePuy Orthopaedics

Completed

Computer-Assisted Total Knee Replacement Kinematics: DePuy Sigma Posterior Cruciate Substituting Knee and the DePuy Sigma RP Rotating Platform Knee

Osteoarthritis, Knee

Canada
BUZZZ Pharmaceuticals Limited
Veristat, Inc.

Completed

Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee

Osteoarthritis, Knee

Canada
Helsinki University Central Hospital

Active, not recruiting

LASER Trial. LAparoscopic Elective Sigmoid Resection Following divERticulitis - a Multicenter, Prospective, Randomized Clinical Trial (LASER)

Diverticulum | Colon, Sigmoid

Finland
Peking Union Medical College Hospital
Beijing Normal University

Recruiting

Clinical Applications of (S)-[18F]FBFP PET/CT in Healthy Volunteers and Patients With Central Nervous System Diseases

Patients With Central Nervous System Diseases

China
Leiden University Medical Center
Medical Center Haaglanden; DePuy International

Completed

RSA RCT: ATTUNE™ TKA Versus PFC Sigma TKA (APKnee)

Joint Diseases | Musculoskeletal Diseases | Rheumatic Diseases | Osteoarthritis Arthritis

Netherlands
Klinikum Hanover-Siloah Hospital

Unknown

Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis

Acute Disease | Diverticulitis, Colonic

Germany
Peter den Hollander
Leiden University Medical Center

Recruiting

RSA-RCT: Attune S+ TKA Versus Sigma TKA (APKnee2-S+)

Rheumatic Diseases | Musculoskeletal Disease | Joint Disease | Osteoarthritis Arthritis

Netherlands

Search clinical trials for: Sigma-1 receptor agonist

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