Search clinical trials for: THerapy for acute moderate to severe flares

Total 488544 results

Children's Hospital of Philadelphia
Novartis Pharmaceuticals

Completed

Combination Therapy for Atopic Dermatitis

Atopic Dermatitis

United States
Janssen-Cilag Ltd.

Completed

A Study to Evaluate Efficacy and Safety of Ustekinumab Re-induction Therapy in Participants With Moderately to Severely Active Crohn's Disease (POWER)

Crohn Disease

United States, Korea, Republic of, Netherlands, France, Austria, Italy, United Kingdom, Germany, Russian Federation, Spain, Czechia, Sweden
Galapagos NV
Gilead Sciences

Completed

Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease (DIVERSITY1)

Crohn's Disease

Hong Kong, United States, Netherlands, Belgium, France, Israel, Spain, Korea, Republic of, Taiwan, Germany, Australia, United Kingdom, Italy, India, Singapore, Portugal, Malaysia, New Zealand, Serbia, Ireland, Poland, Romania, Japan, ... and more
R-Pharm

Completed

Study of Efficacy and Safety of TL-FVP-t vs. SOC in Patients With Mild to Moderate COVID-19

COVID-19

Russian Federation
Kowa Research Institute, Inc.

Completed

Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment

Severe Hypertriglyceridemia

United States, Czechia, Belarus, Hungary, Russian Federation, Poland, Bulgaria, Georgia, Ukraine
St. Jude Children's Research Hospital
Assisi Foundation; Cookies for Kids' Cancer

Completed

Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma

Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood B-Lymphoblastic Lymphoma

United States
GlaxoSmithKline

Terminated

Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Australia, Argentina, France, Germany, Poland, Romania, Russian Federation, Spain, United States, Netherlands, Sweden, Korea, Republic of, Canada, United Kingdom, Italy, Mexico
Shire

Terminated

Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis (FIGARO UC 301)

Ulcerative Colitis

United States, Australia, Russian Federation, Romania, Brazil, Israel, Germany, Italy, Croatia, Netherlands, Poland, United Kingdom, Austria, Japan, Lithuania, Serbia, South Africa, Czechia
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Childhood B Acute Lymphoblastic Leukemia

United States, Canada, Australia, New Zealand, Switzerland
Gilead Sciences
Galapagos NV

Completed

Study to Evaluate the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Ulcerative Colitis (SELECTION)

Ulcerative Colitis

United States, Netherlands, Israel, Spain, Taiwan, Germany, Australia, Italy, Hong Kong, India, Singapore, Canada, Korea, Republic of, United Kingdom, New Zealand, Ireland, France, Poland, Japan, Switzerland, Croatia, Belgium, Malaysia and more
Microbiome Health Research Institute
University of Cape Town

Terminated

Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition (THRIVE)

Moderate Acute Malnutrition | Severe Acute Malnutrition

South Africa
University Hospital, Basel, Switzerland

Completed

Amotosalen-Ultraviolet A Pathogen-Inactivated Convalescent Plasma in Addition to Best Supportive Care and Antiviral Therapy on Clinical Deterioration in Adults Presenting With Moderate to Severe COVID-19

Coronavirus Disease 2019 Infectious Disease (COVID-19 Infection)

Switzerland
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma

Lymphoma | Leukemia

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Leukemia

United States, Australia, Canada
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

Completed

Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma

Lymphoma | Leukemia

United States, Egypt, India
Brigham and Women's Hospital

Not yet recruiting

Study of Novel Therapeutics for Acute Remedy of Colitis (SHARC)

Ulcerative Colitis | Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

United States
China National Center for Cardiovascular Diseases

Not yet recruiting

Exploring the Clinical Efficacy of Remote Management Applications Through Comprehensive Physical Therapy for Patients With Moderate to Severe Sleep Apnea

Aerobic Exercise | M-health | OSAHS | Oropharyngeal Muscle Training | Comprehensive Physical Therapy
Novartis Pharmaceuticals

Not yet recruiting

NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.

Metastatic Neuroendocrine Prostate Cancer
The George Institute
Changhai Hospital; University of Calgary

Not yet recruiting

Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial (ENCHANTED3/MT)

Ischemic Stroke, Acute
Wuhan Union Hospital, China

Not yet recruiting

CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
The Fourth Affiliated Hospital of Zhejiang University...

Not yet recruiting

Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

Postoperative Pain
Xiyuan Hospital of China Academy of Chinese Medical...

Recruiting

Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(PDT) With Chlorin-e6 in Treating Moderate to Severe Acne

Acne | Photodynamic Therapy

China
UNICEF - Venezuela

Recruiting

Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort Research

Wasting | Acute Malnutrition in Childhood | Child Malnutrition

Venezuela
Innovaderm Research Inc.

Not yet recruiting

Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy

Chronic Hand Eczema

Canada
Takeda

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis

United States, France, Hungary, Korea, Republic of, Belgium, Japan, Germany, Canada, Italy, Poland, Czechia, Denmark, Greece, Norway, Romania, Slovakia, United Kingdom
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor (AQUA)

Dermatitis Atopic

Chile, United Kingdom, United States, Canada, Turkey, Israel, Korea, Republic of
Shanghai 6th People's Hospital

Not yet recruiting

Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care

Traumatic Brain Injury | Cerebrovascular Disease | Neurocritical Care | Moderate or Severe Coma

China
Takeda

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Crohn's Disease

United States
McMaster University
Center for Medicinal Cannabis Research

Not yet recruiting

Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study (PSI_CUD)

Cannabis Use Disorder, Moderate | Cannabis Use Disorder, Severe
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Effects on Biotrauma of NMBAs and PP Association During ARDS (CURA-PRONE)

Moderate to Severe Acute Respiratory Distress Syndrome

France
Takeda

Recruiting

A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period

Plaque Psoriasis

United States, Canada, Bulgaria, Hungary
Takeda

Recruiting

A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 52 Weeks of Treatment

Plaque Psoriasis

United States, Canada, Poland, Italy, Japan
Erasmus Medical Center
Maasstad Hospital

Recruiting

FCV vs PCV in Moderate to Severe ARDS

Acute Respiratory Distress Syndrome | Ventilator Lung

Netherlands
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients (ICRAKI)

Acute Kidney Injury
Third Wave Therapeutics

Recruiting

Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal Congestion

Nasal Congestion

United States
Washington University School of Medicine
Thrasher Research Fund; Project Peanut Butter; Ministry of Health and Sanitation...

Recruiting

Eggs for Gut Health

Environmental Enteric Dysfunction | Moderate Acute Malnutrition | Stunting | Severe Acute Malnutrition

Sierra Leone
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA); Columbia University

Not yet recruiting

rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder

Cocaine Use Disorder | Cocaine Dependence | Cocaine Use | Cocaine Use Disorder, Moderate | Cocaine Use Disorder, Severe
LEO Pharma

Recruiting

A 32-week Trial to Evaluate the Efficacy and Safety of Tralokinumab in Subjects With Moderate-to-severe Atopic Hand Eczema Who Are Candidates for Systemic Therapy (ADHAND)

Atopic Dermatitis | Atopic Hand Eczema

United States, Canada, United Kingdom, Korea, Republic of, Belgium, Netherlands
60P Australia Pty Ltd

Not yet recruiting

A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression

Infectious Disease | SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID 19 Disease | Mild to Moderate COVID 19 Disease
BioAegis Therapeutics Inc.

Not yet recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

Infections | Acute Respiratory Distress Syndrome
Aqualung Therapeutics Corp.

Not yet recruiting

Study of Safety and Efficacy of ALT-100mAb in Participants With Moderate/Severe ARDS

Acute Respiratory Distress Syndrome (ARDS)
Academy of Nutrition and Dietetics
Hartford Hospital; University of New Mexico; Meals on Wheels Central Texas

Not yet recruiting

Essential Connections: Hospital to Community Impacting Malnutrition Outcomes in Older Adults

Malnutrition; Protein
AbbVie

Recruiting

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy (Step-Up HS)

Hidradenitis Suppurativa

United States, Japan, Australia, Canada, Korea, Republic of, New Zealand, Puerto Rico, Spain, Austria, Italy, Bulgaria, Israel, Taiwan, Croatia, Hungary, Netherlands, Switzerland, Germany, Portugal, France, United Kingdom, Czechia, ... and more
Amgen

Recruiting

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-ASCEND)

Atopic Dermatitis

United States, Japan, Korea, Republic of, Australia, Taiwan, Spain, Switzerland, Germany, Croatia, Austria, Bulgaria, France, Denmark, China, Netherlands, Hungary, Czechia, Poland, Brazil, Greece, Portugal, Italy, Finland, Argentina, Sl... and more
Xiaotong Hou

Not yet recruiting

A Pilot Study of Sivelestat Sodium to Shorten Mechanical Ventilation in Acute Aortic Dissection

Acute Aortic Dissection

China
Emory University

Recruiting

Arginine Replacement Therapy in COVID-19 (ART-COVID19)

COVID-19

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Recruiting

Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine

Migraine Prophylaxis

Bangladesh
Takeda

Recruiting

A Study of Vedolizumab in Adult Participants With Moderate to Severe Crohn's Disease

Crohn's Disease

China
Stephen Robert Marder

Not yet recruiting

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Post Traumatic Stress Disorder

United States

Search clinical trials for: THerapy for acute moderate to severe flares

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