Search clinical trials for: alpha synuclein

Total 12550 results

University of Pennsylvania

Recruiting

Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15

Tauopathies

United States
I.R.C.C.S. Fondazione Santa Lucia
Università Foro Italico Roma; CNR Pisa

Not yet recruiting

Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients

Parkinson Disease | Metabolic Disease | Gait Analysis | Therapy, Directly Observed
Huashan Hospital

Recruiting

Study of 18F-0502B PET Imaging Targeting α-synuclein in the Diagnosis of α-synuclein-related Diseases

Positron-Emission Tomography | Alpha Synuclein Pathology

China
Aswan University Hospital

Recruiting

Iron, Alpha-Synuclein, and Lymphocyte-activation Gene-3 in Ischemic Stroke

Brain Ischemia

Egypt
Danish Dementia Research Centre
Danish Reference Center for Prion Diseases, Rigshospitalet; Department of Otorhinolaryngology...

Recruiting

Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA (AROMA)

Idiopathic Anosmia | Idiopathic Hyposmia | Idiopathic Olfactory Dysfunction

Denmark
Sun Yat-sen University

Recruiting

FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients

Colorectal Cancer Metastatic

China
Asklepios Biopharmaceutical, Inc.

Recruiting

Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy

Parkinson's Disease | Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant

United States, Poland
FAScinate Therapeutics Inc.
Parexel

Recruiting

A Study to Evaluate Safety and Efficacy of KM-819 in Healthy Adults and Participants With Parkinson's Disease

Parkinson Disease

United States
Sanguine Biosciences

Recruiting

A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Heart Diseases | Stroke | Lymphoma | Multiple Sclerosis | Kidney Diseases | Diabetes | Leukemia | Age-Related Macular Degeneration | Cancer | Arthritis | Schizophrenia | Thyroid Diseases | Parkinson Disease | Hepatitis | Vasculitis | Psoriasis | Asthma | Amyloidosis | Fibromyalgia | Graves Disease | Alzheimer Disease | Celiac Disease | Cirr... and other conditions

United States
Beijing Tiantan Hospital

Recruiting

EC50 of Dexmedetomidine in Deep Brain Stimulation Implantation of Patients With Parkinson's Disease

PD - Parkinson's Disease

China
BlueRock Therapeutics

Recruiting

Noninterventional Study Evaluating Parkinson's Disease Diary Use

Parkinson's Disease

United States, Canada, Spain, Germany, Italy
Chinese University of Hong Kong

Recruiting

Gut Microbiota in the Progression of Alpha-synucleinopathies

REM Sleep Behavior Disorder

Hong Kong
Weill Medical College of Cornell University

Recruiting

Parkinson's Disease Biomarkers in Nerve Cells in the Gut (PD-ENS)

Parkinson Disease

United States
Newronika

Not yet recruiting

An Open-label Clinical Trial to Compare the Safety and Effectiveness of Adaptive Versus Conventional Deep Brain Stimulation (ADVENT)

Parkinson Disease
Beijing Tiantan Hospital

Not yet recruiting

Dexmedetomidine Prevents Postoperative Delirium After Deep Brain Stimulation in Patients With Parkinson's Disease

Postoperative Delirium | Dexmedetomidine | Deep Brain Stimulation

China
Cedars-Sinai Medical Center

Recruiting

Terazosin and Parkinson's Disease Extension Study

REM Sleep Behavior Disorder | Pre-motor Parkinson's Disease | Symptomatic Parkinson Disease

United States
Vanderbilt University Medical Center

Recruiting

Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure | Orthostatic; Hypotension, Neurogenic | Orthostatic; Hypotension, Parkinsonism

United States
Qiang Zhang

Not yet recruiting

Terazosin for Dementia With Lewy Bodies (TZ-DLB)

Dementia With Lewy Bodies

United States
University Hospital Schleswig-Holstein
University of Kiel; UCB Biopharma SRL

Recruiting

Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study (PASS-PD)

Parkinson Disease

Germany
Newronika

Recruiting

Safety and Efficacy of Adaptive Deep Brain Stimulation

Parkinson Disease

Italy, Poland
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
University Hospitals Cleveland Medical Center
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

Parkinson Disease | Parkinsonism | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Dementia With Lewy Bodies

United States
Cedars-Sinai Medical Center

Recruiting

Terazosin Effect on Cardiac Changes in Early Parkinson's Disease

REM Sleep Behavior Disorder | Pre-motor Parkinson's Disease | Symptomatic Parkinson Disease

United States
University Hospital, Bordeaux
University of Bordeaux; Centre National de la Recherche Scientifique, France; Labex Brain

Recruiting

Insulin Resistance in Multiple System Atrophy (IRAMS)

Multiple System Atrophy

France
Ain Shams University

Recruiting

Predictors of Parkinson's Disease Progression (PDPROG-EGY)

Parkinson Disease | Cognitive Dysfunction | Biomarkers

Egypt
Michele Tagliati, MD

Recruiting

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)

REM Sleep Behavior Disorder | Symptomatic Parkinson Disease | Pre-motor Parkinson Disease

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Automated Abdominal Binder for Orthostatic Hypotension

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Prof. Dr. Volker Arnd Coenen
University of Freiburg

Recruiting

Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease

Parkinson Disease

Germany
Vanderbilt University Medical Center

Recruiting

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Parkinson Disease | Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
University Hospital, Bordeaux

Recruiting

Biomarkers in Parkinsonian Syndromes (BIOPARK)

Parkinson's Disease | Multiple System Atrophy | Progressive Supranuclear Palsy | Parkinsonian Syndromes

France
Örebro University, Sweden
Aston University; Region Örebro County; VHIR

Enrolling by invitation

Early Signs of Parkinsons Disease in IBS

Parkinson Disease | Irritable Bowel Syndrome

Sweden
Azienda Socio Sanitaria Territoriale degli Spedali...

Completed

Alpha tACS in Dementia With Lewy Bodies (Alpha-DLB)

Lewy Body Disease | Dementia With Lewy Bodies

Italy
Cedars-Sinai Medical Center

Enrolling by invitation

Cardiac Changes in Early Parkinson's Disease: A Follow up Study

REM Sleep Behavior Disorder | Symptomatic Parkinson Disease | Pre-motor Parkinson Disease

United States
Ain Shams University

Completed

Differences Between Patients With Vascular Parkinsonism and Parkinson's Disease

Parkinson's Disease | Vascular Parkinsonism

Egypt
Nathaniel M. Robbins

Withdrawn

The Role of the Noradrenergic System in the Nonmotor Symptoms of Parkinson's Disease (NAinPD)

Parkinson Disease

United States
State University of New York at Buffalo

Completed

Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.

Parkinson Disease

United States
EIP Pharma Inc
Worldwide Clinical Trials

Completed

Cognitive Effects of Oral p38 Alpha Kinase Inhibitor Neflamapimod in Dementia With Lewy Bodies (AscenD-LB)

Dementia With Lewy Bodies (DLB)

United States, Netherlands
Orient Pharma Co., Ltd.

Completed

A Relative Efficacy and Safety Study of OC Oral Solution for Sialorrhoea in Patients With Parkinson's Disease

Sialorrhoea

United States
MODAG GmbH
Teva Pharmaceutical Industries, Ltd.; Quotient Sciences; Aptuit

Completed

A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)

Healthy Volunteers

United Kingdom
MODAG GmbH
Nottingham University Hospitals NHS Trust; Quotient Sciences; Aptuit

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's Disease

Parkinson Disease

United Kingdom
University of Edinburgh
Weston Brain Institute

Withdrawn

Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder

Sleep Disorder Rem Sleep Behavior | Parkinson's Disease, Lewy Body

United Kingdom
GWT-TUD GmbH
Michael J. Fox Foundation for Parkinson's Research; Prothena Biosciences Limited

Completed

Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease (CAPTURE-PD)

Parkinson's Disease

United States, Germany, Hungary
Corporación de Rehabilitación Club de Leones Cruz...
Universidad del Rosario; Colombian School of Engineering Julio Garavito

Completed

Usability Study of a Neuropsychological Intervention Program Based on Virtual Reality in Adults With Parkinson's Disease

Parkinson Disease

Chile
Jordan Schultz
University of Iowa

Completed

A Pilot Study of Terazosin for Parkinson's Disease (TZ-PD)

Parkinson Disease

United States
Stony Brook University

Active, not recruiting

A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies

Parkinson Disease | Multiple System Atrophy | Normal Pressure Hydrocephalus | Rapid Eye Movement Sleep Behavior Disorder

United States
Avanir Pharmaceuticals
Michael J. Fox Foundation for Parkinson's Research

Completed

Safety and Efficacy of AVP-923 in the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease Patients (LID in PD)

Parkinson's Disease | Dyskinesia

Canada, United States
University of Colorado, Denver

Completed

Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain

Parkinson's Disease

United States
Biogen

Terminated

Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Participants With Parkinson's Disease (SPARK)

Parkinson's Disease

United States, Italy, Spain, United Kingdom, Austria, Israel, Germany, France, Canada
Hospices Civils de Lyon

Completed

Study of Clonidine Efficacy for the Treatment of Impulse Control Disorders in Parkinson's Disease: (ID-CLO)

Parkinson's Disease | Mpulse Control Disorders

France

Search clinical trials for: alpha synuclein

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