Search clinical trials for: amendement du facteur C5 du complément

Total 372020 results

Zentera Therapeutics HK Limited

Completed

A PHASE 1B STUDY OF ZN-C5 IN CHINESE SUBJECTS

Breast Neoplasms

China
Alexion Pharmaceuticals, Inc.

Recruiting

Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

Generalized Myasthenia Gravis

China, United States, Spain, United Kingdom, Korea, Republic of, Italy, Germany, Japan, Brazil, France, Netherlands, Taiwan, Turkey, Israel, Poland, Austria, Denmark, Portugal, Canada, Serbia, Argentina, Switzerland
Marmara University

Not yet recruiting

Effect of Cervical Multifidus Muscle Area on Interlaminar Epidural Steroid Injection Outcomes

Cervical Radiculopathy
Bionor Immuno AS

Completed

Immunotherapy With Vacc-C5 With Adjuvant GM-CSF or Alhydrogel in HIV-1-infected Subjects on ART

HIV-1 Infection

Norway
Alexion Pharmaceuticals, Inc.

Completed

Danicopan as Add-on Therapy to a C5 Inhibitor in Paroxysmal Nocturnal Hemoglobinuria (PNH) Participants Who Have Clinically Evident Extravascular Hemolysis (EVH)(ALPHA)

Paroxysmal Nocturnal Hemoglobinuria

France, Italy, Spain, United States, Taiwan, Thailand, Korea, Republic of, Japan, Malaysia, Brazil, Germany, Israel, Czechia, Netherlands, Greece, United Kingdom, Canada, Poland
University of Washington
Philips Healthcare

Terminated

Chest Ultrasound of ER Patients With Cough or SOB

Cough | Dyspnea | Wheezing

United States
Zeno Alpha Inc.

Completed

A Food Effect Study With ZN-c5 in Healthy Post-Menopausal Subjects

Healthy

New Zealand
Kevin Kilgore
National Institute of Neurological Disorders and Stroke (NINDS); Case Western... and other collaborators

Recruiting

Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury (NNP-UE+T)

Spinal Cord Injuries | Spinal Cord Injury at C5-C7 Level | Spinal Cord Injury Cervical | Spinal Cord Injury at C5-C7 Level With Complete Lesion | Spinal Cord Injury at C5-C7 Level With Incomplete Lesion

United States
Assistance Publique Hopitaux De Marseille
Innate Pharma

Completed

C5a Receptor Expression - COVID-19 (C5-COV) (C5-COV)

COVID-19

France
Zeno Alpha Inc.

Completed

A Study of ZN-c5 in Participants With Breast Cancer

Breast Cancer

United States, Australia, Bosnia and Herzegovina
The Cleveland Clinic
University of Southern California

Recruiting

Can Prophylactic Foraminotomy Prevent C5 Palsy

Radiculopathy, Cervical | Myelopathy, Compressive | C5 Palsy

United States
CARE Pharma Shanghai Ltd.

Recruiting

A Study on the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of CAN106 in Subjects With PNH

Hemolysis | PNH

China
Alexion

Recruiting

Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN) (SANCTUARY)

Lupus Nephritis | Immunoglobulin A Nephropathy

United States, Australia, Canada, France, Germany, Italy, Korea, Republic of, Netherlands, Poland, Singapore, Spain, Sweden, Taiwan, United Kingdom
Statens Serum Institut

Completed

Trial on the Safety of a New Liposomal Adjuvant System, CAF01, When Given With the Tuberculosis Subunit Vaccine Ag85B-ESAT-6 as Two Injections With Two Months Interval to Healthy Adult Volunteers

Tuberculosis

Netherlands
JongHae Kim
Research Institute of Medical Science, Daegu Catholic University

Recruiting

Assessment of the C8 Dermatomal Block With Photoplethysmographic Amplitude After Interscalene Brachial Plexus Block

Oximetry | Brachial Plexus Block

Korea, Republic of
University of Pittsburgh

Active, not recruiting

Adjacent Segment Mechanics in Cervical Arthrodesis Patients

Intervertebral Disc Degeneration

United States
Zeno Alpha Inc.

Completed

A Study of ZN-c5 and Abemaciclib in Participants With Breast Cancer

Breast Cancer

United States, Poland
Alexion Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of Eculizumab in Guillain-Barré Syndrome

Guillain-Barre Syndrome

Japan
University Health Network, Toronto
Sunnybrook Health Sciences Centre; Unity Health Toronto

Recruiting

Conventional-therapy & FES-therapy In-Veritas Effects Study (C-FIVE)

C5 Palsy

Canada
Riphah International University

Completed

Intensive Therapy of Shoulder External Rotators in Erb's Palsy

Erbs Palsy

Pakistan
Ophthotech Corporation

Withdrawn

ZIMURA in Combination With Eylea in Patients With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV)

Idiopathic Polypoidal Choroidal Vasculopathy

United States
Ophthotech Corporation

Completed

ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)

Wet Age-related Macular Degeneration

United States, Hungary, Latvia
Azienda Ospedaliero, Universitaria Pisana

Completed

Cognitive Rehabilitation and FES for Hand Functionality in Persons With Cervical Spinal Cord Injury

Spinal Cord Injury at C5-C7 Level
Hospices Civils de Lyon

Completed

Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Tetraplegia C5-C6 | Tetraplegia C6-C7

France
BioCryst Pharmaceuticals

Terminated

BCX9930 for Treatment of PNH in Subjects With Inadequate Response to C5 Inhibitor Therapy (REDEEM-1)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Hungary, France, Italy, Spain
Technical University of Munich
Charite University, Berlin, Germany; University Hospital, Geneva; Ludwig-Maximilians... and other collaborators

Unknown

Multicentric Registry for the Detection of C5 Palsy After Anterior Cervical Discectomy and Fusion (C5registry)

Cervical Disc Herniation | Degenerative Cervical Spinal Stenosis | Suspected Cervical Spine Instability

Germany
Assistance Publique - Hôpitaux de Paris
Leeds Cancer Centre at St. James's University Hospital

Completed

Hematological Response in Patients With Paroxysmal Nocturnal Hemoglobinuria Treated With Anti-C5 Antibody: an External Control Arm Study for Iptacopan Use in Anti-C5 naïve Patients (APPEX)

Paroxysmal Nocturnal Hemoglobinuria

France
Universidade Federal de Sao Carlos

Withdrawn

Manual Therapy and Exercises Applied to Cervical Spine in Patients With Temporomandibular Disorders

Temporomandibular Joint Dysfunction Syndrome
KU Leuven

Suspended

Telemonitoring of Hypertensive Patients (LAPTOHP)

Hypertension

Belgium
Nicholls Spinal Injury Foundation
University College, London; Poznan University of Medical Sciences; Wroclaw Medical... and other collaborators

Recruiting

Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection

Spinal Cord Injury at C5-Th10 Level With Complete Lesion | Spinal Cord Transection

Poland
Zeno Alpha Inc.

Completed

A Study of ZN-c5 in Subjects With Breast Cancer

Breast Cancer

United States, Belarus, Bosnia and Herzegovina, Czechia, Hungary, Lithuania, Russian Federation, Serbia, Ukraine
MetroHealth Medical Center
National Institute of Neurological Disorders and Stroke (NINDS); Case Western...

Recruiting

Grasp-Release Assessment of a Networked Neuroprosthesis Device (GRANND)

Spinal Cord Injuries | Spinal Cord Injury at C5-C7 Level | Spinal Cord Injury Cervical

United States
Hope Biosciences
The University of Texas Health Science Center, Houston

No longer available

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Treatment of SCI

Spinal Cord Injury at C5-C7 Level

United States
Astellas Pharma Global Development, Inc.

Active, not recruiting

Zimura Compared to Sham in Patients With Autosomal Recessive Stargardt Disease (STGD1)

Stargardt's Macular Dystrophy

Italy, United States, Israel, United Kingdom, Germany, Spain, Hungary, France
University of Leipzig
German Research Foundation

Completed

Longitudinal Assessment of Cardiovascular and Metabolic Parameters in Obese and Lean Children

Obesity

Germany
Alexion

Active, not recruiting

Study of the Oral Factor D (FD) Inhibitor ALXN2050 in PNH Patients as Monotherapy

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Italy, Canada, Korea, Republic of, New Zealand, Spain, Turkey
Alexion Pharmaceuticals, Inc.

Recruiting

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

Neuromyelitis Optica Spectrum Disorder | NMOSD | AQP4+ NMOSD

United States
IVERIC bio, Inc.

Completed

A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)

Macular Degeneration | Geographic Atrophy

United States, Spain, France, Germany, Austria, Belgium, Israel, Poland, Canada, Italy, Estonia, Australia, United Kingdom, Hungary, Argentina, Brazil, Colombia, Croatia, Czechia, Latvia
Marmara University
National Institute of Allergy and Infectious Diseases (NIAID)

Unknown

Transcriptome and Metabolic Analyses of CHAPLE Disease (CHAPLEOMIC)

Protein-Losing Enteropathies | CD55 - Cluster of Differentiation Antigen 55 Deficiency | Primary Intestinal Lymphangiectasis | Complement Regulatory Factor Defect

Turkey
Alexion Pharmaceuticals, Inc.

Active, not recruiting

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Paroxysmal Nocturnal Hemoglobinuria

France, Italy, Spain, United States, Thailand, Korea, Republic of, United Kingdom, Israel, Czechia, Greece, Poland, Brazil, Japan, Canada, Malaysia
AKARI Therapeutics

Enrolling by invitation

Coversin in PNH in Patients With Resistance to Eculizumab Due to Complement C5 Polymorphisms (CONSENTII)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States
Alexion Pharmaceuticals, Inc.

Recruiting

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Generalized Myasthenia Gravis

United States
S.Biomedics Co., Ltd.
Yonsei University; Linical Co., Ltd.

Recruiting

Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI (SB-SCI-001)

Spinal Cord Injury, Acute | Spinal Cord Injury at C5-C7 Level With Complete Lesion | Spinal Cord Injury at C4 Level With Complete Lesion

Korea, Republic of
IVERIC bio, Inc.

Completed

Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

Macular Degeneration | Geographic Atrophy

United States, Israel, Estonia, Hungary, Latvia, Czechia, Croatia
Bronx VA Medical Center
New York State Department of Health

Completed

Brain Plus Spinal Stimulation for Cervical SCI

Spinal Cord Injuries | Spinal Cord Injury at C5-C7 Level | Tetraplegia/Tetraparesis

United States
University of Portsmouth
University of Sheffield; University of Bath; Portsmouth Hospitals NHS Trust; The... and other collaborators

Completed

The HIP-HOP Flooring Study: Helping Injury Prevention in Hospitalised Older People

Accidental Falls

United Kingdom
University of Manitoba

Recruiting

Neuromodulation With Spinal Stimulation Methods

Spinal Cord Injuries | Spinal Cord Injury at C5-C7 Level | Paraplegia, Spinal | Paraplegia, Incomplete

Canada
The Alfred E. Mann Foundation for Scientific Research
Walter Reed Army Medical Center

Terminated

Use of Implanted Microstimulators for Decreasing Spasticity and Improving Motion Following Spinal Cord Injury

Spinal Cord Injury at C5-C7 Level With Incomplete Lesion

United States
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Study of the C5a/C5aR1 Axis in IgG4-associated Disease: a Potential Therapeutic Target (C5-MAG4)

Immunoglobulin G4-Related Disease
University of British Columbia
University of Toronto; Queen's University; Dalhousie University; Wings for Life

Recruiting

Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury

Upper Extremity Dysfunction | Cervical Spinal Cord Injury | Spinal Cord Injury | Spinal Cord Injury at C5-C7 Level | SCI - Spinal Cord Injury | Upper Extremity Paralysis | Tetraplegia | Upper Extremity Paresis

Canada

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