Search clinical trials for: ex vivo drug sensitivity assay

Total 305292 results

Florida International University
National Institute on Minority Health and Health Disparities (NIMHD); Nicklaus... and other collaborators

Recruiting

Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling

Recurrent Childhood Ependymoma | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Recurrent Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Childhood Large... and other conditions

United States
Florida International University
Nicklaus Children's Hospital f/k/a Miami Children's Hospital

Completed

Ex Vivo Drug Sensitivity Testing and Mutation Profiling

Recurrent Childhood Ependymoma | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Recurrent Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Childhood Large... and other conditions

United States
Florida International University
Nicklaus Children's Hospital f/k/a Miami Children's Hospital; Cornelia T. Bailey...

Completed

Drug Sensitivity and Mutation Profiling

Osteosarcoma | Ewing Sarcoma | Rhabdomyosarcoma | Wilms Tumor | Sarcoma, Spindle Cell | Sarcoma Rhabdoid | Childhood Sarcoma of Soft Tissue

United States
German Cancer Research Center
University Hospital Heidelberg

Completed

Systematic and Mechanism-based Approach to Rational Treatment Trials of Blood Cancer (SMART)

Hematologic Diseases | Treatment

Germany
Pennington Biomedical Research Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding (EAT 2)

Metabolic Syndrome | Overweight and Obesity

United States
Helsinki University Central Hospital

Active, not recruiting

Study of Venetoclax in Combination With Azacytidine in AML Patients Selected Using Ex Vivo Drug Sensitivity Screening (VenEx)

Acute Myeloid Leukemia

Finland
University of Washington
National Cancer Institute (NCI)

Completed

High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia | Refractory Acute Leukemia of Ambiguous Lineage | Recurrent Acute Leukemia of Ambiguous Lineage

United States
Edward Kim
National Cancer Institute (NCI)

Completed

Oxaliplatin Microdosing Assay in Predicting Exposure and Sensitivity to Oxaliplatin-Based Chemotherapy

Colon Adenocarcinoma

United States
Nilogen Oncosystems
Henry Ford Health System

Unknown

Pilot Study of Nilogen 3D-EX and Its Ability to Predict Therapeutic Response to Anti-PD1 or Anti-PDL1 in NSCLC (NO3DEXPL)

Non Small Cell Lung Cancer

United States
Haining Health-Coming Biotech Co., Ltd.
Alphacait, LLC

Unknown

Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor

Metastatic Cancer

China
University of Washington
National Cancer Institute (NCI)

Completed

Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia... and other conditions

United States
University of Pennsylvania
Eli Lilly and Company

Completed

Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B

Healthy

United States
Sheba Medical Center

Unknown

Ex Vivo Laboratory Assays Application for Therapy Tailoring in Patients With Severe Bleeding Disorders

Severe Hemophilia

Israel
Helsinki University Central Hospital

Unknown

Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines (Ty21a-ASC)

Healthy

Finland
Jeanette Marketon, MD

Terminated

Ex Vivo Stimulation of Whole Blood as a Means to Determine Glucocorticoid Sensitivity to Mild-to-Moderate and Refractory Asthmatics

Asthma

United States
Samsung Medical Center

Completed

Diagnosis of Tuberculosis Infection in Health Care Workers Using Ex-vivo Interferon-gamma Assay

Latent Tuberculosis Infection

Korea, Republic of
University of Wuerzburg
medac GmbH; Hiege-Stiftung gegen Hautkrebs; DCS Innovative Diagnostik Systeme

Unknown

Comparative Study of Individualized Sensitivity-Directed Chemotherapy Versus DTIC (ChemoSensMM)

Melanoma

Germany
Liu Huang
Beijing GeneX MedLab Co., Ltd

Recruiting

Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing

Breast Cancer | Gastric Cancer | Colorectal Cancer | Lung Cancer

China
Complement Theory Inc.

Recruiting

A Randomised Controlled Trial to Evaluate the Impact of Complement Theory's Live 1:1 Exercise Coaching and Personalised Digital Application on Cancer Survivors' Cost of Care

Breast Cancer | Colorectal Cancer | Lung Cancer | Prostate Cancer | Other Cancer

United States
New Valley University

Not yet recruiting

Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections

Immunocompromised ICU Patients With Respiratory Tract Infections
University Ghent
University Hospital, Ghent

Not yet recruiting

Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD (CENSORIAL)

Exercise Therapy | Metabolic Dysfunction-associated Steatotic Liver Disease
Active Genomes Expressed Diagnostics, Corp
Walter Reed National Military Medical Center; Arizona Clinical Trials

Not yet recruiting

AGED Diagnostics Liver Disease Assessment (AGEDDX)

Healthy | NAFLD | NASH With Fibrosis

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Not yet recruiting

Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors

Breast Cancer | Colon Cancer

United States
Jianjun Yang,MD

Recruiting

Research on the Correlation Between Organoid Drug Sensitivity Testing and Precise Treatment of Gastrointestinal Tumors

Gastrointestinal Tumors，3D Organoids，Drug Sensitivity

China
Hospices Civils de Lyon

Not yet recruiting

Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care (OTEndo)

Endometriosis

France
Ottawa Hospital Research Institute
LEAF Weight Loss Clinic

Not yet recruiting

Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity (FLOWERS-PCOS)

Obesity | Polycystic Ovary Syndrome

Canada
McGill University Health Centre/Research Institute...
Dairy Farmers of Canada

Not yet recruiting

Effect of Dairy Product Matrices on Insulin Resistance in People With Overweight and Obesity and Prediabetes

PreDiabetes | Overweight and Obesity

Canada
University of Alabama at Birmingham

Not yet recruiting

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway (VITAL-IMPACT)

Cardiovascular Diseases | Obesity | Insulin Sensitivity/Resistance | Metabolic Disease | Energy Expenditure | Metabolism

United States
Hospices Civils de Lyon
Exeliom Biosciences

Recruiting

Evaluation of EXL01, a New Live Biotherapeutic Product to Prevent Recurrence of Clostridioides Difficile Infection in High-risk Patients (LIVEDIFF)

Clostridioides Difficile Infection | Recurrent Infection

France
Roswell Park Cancer Institute

Recruiting

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8

United States
University of Colorado, Denver

Recruiting

Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes (TExIS)

Obesity | PreDiabetes | Inactivity/Low Levels of Exercise

United States
Cairo University

Not yet recruiting

Bleaching Effect of Strawberry Extract Versus Hydrogen Peroxide in Patients With Extrinsic Staining

Bleaching Effect and Postoperative Sensitivity of Strawberry Extract
Samuel Lunenfeld Research Institute, Mount Sinai...

Recruiting

Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium

Postpartum Hemorrhage

Canada
University of Virginia

Not yet recruiting

Exercise Training Study Before Bariatric Surgery (BaSE)

Bariatric Surgery Candidate

United States
Pure Biologics S.A.
Presage Biosciences

Recruiting

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Triple Negative Breast Cancer | Head and Neck Squamous Cell Carcinoma | Soft Tissue Sarcoma Adult

United States
University of Zurich
Swiss HIV Cohort Study

Recruiting

Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study (DOXY-MEN)

Doxycycline STI PEP

Switzerland
Xijing Hospital
Beijing GD Initiative Cell Therapy Technology Co., Ltd.

Not yet recruiting

Allogeneic Gammadelta T Cells Combined With Interferon-α1b or PD-1 Monoclonal Antibody in Stage III-IV Amenable to Surgical Resection Melanoma

Melanoma
University of Toronto

Recruiting

Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States (BTLP)

Physical Inactivity | Resistance Exercise | Amino Acids | Dietary Protein

Canada
University of Utah

Recruiting

Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

Sleep | Type 2 Diabetes | Sleep Deprivation | Overweight and Obesity | Insulin Sensitivity | Sleep Hygiene | Eating Habit | Lifestyle Factors | Insufficient Sleep Syndrome

United States
Pichamol Jirapinyo, MD, MPH

Not yet recruiting

ESG vs GLP-1RA vs ESG + GLP-1RA in Patients With Obesity, NAFLD and Advanced Fibrosis: A Randomized Controlled Trial

Liver Diseases | Metabolic Diseases | Obesity | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Insulin Resistance | Weight Loss | Liver Fat | NAFLD | Insulin Sensitivity/Resistance | Insulin Sensitivity | Liver Fibrosis | Non-Alcoholic Fatty Liver Disease | Non-alcoholic Steatohepatitis | Non Alcoholic Fatty... and other conditions

United States
Assiut University

Not yet recruiting

Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to Antibiotics

Acute Exacerbation COPD
University of Toronto

Recruiting

Oral Contraceptive vs Menstrual Cycle Ex Vivo Model (OCEV)

Contraceptives, Oral | Sex Hormone

Canada
Dr. med. Marcus Herdener
University of Zurich; University of Vienna; University of Campania "Luigi Vanvitelli...

Recruiting

Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction (Co-Boost)

Cocaine Use Disorder | Cocaine Dependence

Switzerland
Larena SAS
Université Paris-Saclay

Not yet recruiting

Ex-vivo Evaluation of the Effect of 2 Probiotic Solutions (Lactibiane ATB and Lactibiane Enfant) and 5 Classes of Drugs on the Intestinal Microbiota (EPROMED)

Dysbiosis
Medical University of Vienna
XVIVO Perfusion

Recruiting

Evaluating the Addition of Hemodiafiltration to EVLP - Impact on the Regeneration of Marginal Donor Lungs

Lung Diseases

Austria
Aalborg University

Recruiting

Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity

Sleep Deprivation | Histamine | Cowhage

Denmark
University of Toronto

Recruiting

Does Biological Sex Influence Insulin Sensitivity and Muscle Metabolism Following High-intensity Interval Exercise?

Exercise

Canada
Exscientia GmbH
AGO Research GmbH

Recruiting

Association of Ex Vivo Drug Response (EVDR) and Clinical Outcome in Ovarian Cancer (EXCYTE-1)

Epithelial Ovarian Cancer

Austria, Germany
Hoffmann-La Roche

Recruiting

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Belgium, Korea, Republic of, United States, Canada, China, Italy, France, Brazil, Australia, Argentina, Hong Kong, Portugal, Spain, Taiwan, Costa Rica, Israel, Thailand, Germany, New Zealand, Poland, Chile, Colombia, Guatemala, Hungary, Indi...
University of Guadalajara

Recruiting

Effect of Celery Seed on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

Metabolic Syndrome

Mexico

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