Search clinical trials for: hunter's disease treatment

Total 393215 results

Meshalkin Research Institute of Pathology of Circulation

Recruiting

Efficacy and Safety Comparison of the Endovascular and the Hybrid Methods for the Treatment of Prolonged Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D

Atherosclerosis | Ischemia Limb | Superficial Femoral Artery Occlusion | Popliteal Artery Occlusion | Stent Complication

Russian Federation
Shire

Completed

An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment

Hunter Syndrome

United States, United Kingdom, Canada
Shire

Completed

A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®

Hunter Syndrome

United States, United Kingdom
Shire

Completed

Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment (AIM-IT)

Hunter Syndrome

Spain, United States, Canada, United Kingdom, France, Australia, Mexico
Shire

Completed

Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase

Hunter Syndrome | Mucopolysaccharidosis II (MPS II)

United States, France, United Kingdom, Germany, Sweden, Spain, Brazil, Canada, Italy, Romania
Shire

Completed

An Observational Study Evaluating Anti-Idursulfase Serum Antibody Response in Hunter Syndrome Patients

Hunter Syndrome

United Kingdom, United States, Brazil
Shire
Covance; PRA Health Sciences; PharmaNet

Completed

Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Therapy

Mucopolysaccharidosis II | Hunter Syndrome | MPS II

Brazil, Poland, Taiwan
Harbin Medical University
Shanghai Shenqi Medical Technology Co., Ltd

Not yet recruiting

RESTORE Imaging: an OCT-IVUS Imaging Substudy of RESTORE Trial

Acute Coronary Syndrome (ACS)

China
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

Paroxysmal Nocturnal Hemoglobinuria | PNH | Extravascular Hemolysis
Zhongda Hospital

Recruiting

Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM

Colorectal Cancer Metastatic

China
Case Comprehensive Cancer Center
AbbVie; Genmab; Recordati Rare Diseases

Not yet recruiting

Study of Cytokine Release Syndrome Prophylaxis and Treatment With Siltuximab Prior to Epcoritamab

Non-Hodgkin Lymphoma | Cytokine Release Syndrome

United States
Fudan University

Recruiting

Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer

Advanced Breast Cancer | HR+/HER2- Breast Cancer

China
Bristol-Myers Squibb

Not yet recruiting

Patient and Physician Preference Study in Resectable, Non-small Cell Lung Cancer Treatments

Non-small Cell Lung Cancer (NSCLC)

United Kingdom
Nanfang Hospital, Southern Medical University

Recruiting

Research on the Mechanisms of Treatment Non-response in Inflammatory Bowel Disease Based on Multi-omics Technology

Inflammatory Bowel Diseases

China
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia

Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia

United States
Aristotle University Of Thessaloniki

Not yet recruiting

Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not? (RCTCa(OH)2)

Endodontically Treated Teeth | Calcium Hydroxide

Greece
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease

Feasibility | Safety Issues | Therapeutic Value
Shanghai Zhongshan Hospital

Recruiting

Effects of Growth Hormone Therapy on Metabolic Function in Fatty Liver Post-Pituitary Adenoma Surgery

Growth Hormone Treatment

China
Fujian Shengdi Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Tolerability, and Preliminary Efficacy of HRS-7450 Injection in the Treatment of Acute Ischemic Stroke: a Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled Clinical Trial

Acute Ischemic Stroke

China
Xuanwu Hospital, Beijing

Not yet recruiting

Efficacy and Safety Evaluation of Hyperthermic Baths in the Treatment of Seizures in Children With CDKL5 Deficiency

CDKL5 Deficiency Disorder

China
University Hospital, Montpellier

Not yet recruiting

Identification and Characterization of Circulating Tumor Cells Before and After Treatment (Surgery and Radiotherapy) in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma (MERCCALIBI)

Merkel Cell Carcinoma
Ohio State University
Patient-Centered Outcomes Research Institute; The George Washington University...

Not yet recruiting

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes (DECIDE)

Pregnancy, High Risk | Gestational Diabetes Mellitus

United States
Huai'an First People's Hospital
The Affiliated Hospital of Xuzhou Medical University; The First People's Hospital... and other collaborators

Recruiting

A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL

Primary Central Nervous System Lymphoma

China
Shanghai East Hospital

Recruiting

Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
Islamia University of Bahawalpur

Not yet recruiting

Efficacy of Cognitive Behavior Therapy in the Treatment of Chronic Pelvic Pain in Women

Chronic Pelvic Pain Syndrome
Postgraduate Institute of Dental Sciences Rohtak

Recruiting

Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients With AP

Chronic Kidney Diseases | Apical Periodontitis

India
University Hospital, Rouen

Not yet recruiting

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND)

Metastatic Colon Cancer
Institute of Hematology & Blood Diseases Hospital...

Recruiting

VMAC+DLI Treatment of Patients With Relapse of AML After Allo-HSCT (VMAC+DLI)

Relapse Acute Myeloid Leukemia

China
University Hospital, Clermont-Ferrand
Grünenthal GmbH

Not yet recruiting

Capsaicin in Digital Osteoarthritis Versus Control : a Randomized Study (CADOR)

Neuropathic Pain | Osteoarthritis Hand

France
Infertility Treatment Center Dortmund
Fertility Center Dortmund; novum - Center for Reproductive Medicine Essen -... and other collaborators

Not yet recruiting

Impact of Predetermined Day 5 ET vs. Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment

Infertility | Reproductive Issues
Fundacio Clinic Barcelona
University of Padova; Sheba Medical Center; Istituto Oncologico Veneto IRCCS; University... and other collaborators

Not yet recruiting

Diagnostic HER2DX-guided Treatment for patIents wIth Early-stage HER2-positive Breast Cancer (DEFINITIVE)

HER2-positive Breast Cancer | Early-stage Breast Cancer
First Affiliated Hospital of Zhejiang University

Recruiting

Efficacy and Safety of Modified Si Jun Zi Tang in Perioperative NSCLC Treatment (MSJZT-NSCLC)

Non Small Cell Lung Cancer | Perioperative Complication

China
Breast Cancer Trials, Australia and New Zealand

Not yet recruiting

Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International Validation Experience (PROSPECTIVE)

Breast Cancer | Breast Cancer Female
Ipsen

Not yet recruiting

A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment (ELFINITY)

Primary Biliary Cholangitis
Washington University School of Medicine

Not yet recruiting

Propranolol for the Treatment of Kaposi Sarcoma in Adults

Kaposi Sarcoma

United States
Sun Yat-sen University

Not yet recruiting

FOLFOX Chemotherapy Plus Fruquintinib and Sintilimab After First-line Treatment in Unresectable Hepatocellular Carcinoma (FOLFOX)

Hepatocellular Carcinoma | Immunotherapy | Second-line Treatment | Anti-angiogenic Therapy | FOLFOX Systemic Chemotherapy
Scholar Rock, Inc.

Recruiting

Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese (EMBRAZE)

Overweight and Obesity

United States
The Fourth Affiliated Hospital of Zhejiang University...

Not yet recruiting

Effects of Myoelectric Biofeedback on Upper Limb Function in Post-stroke Patients

Rehabilitation | Cerebral Infarction | Biofeedback

China
Oregon Health and Science University

Not yet recruiting

Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery

Pain, Chronic | Pain Catastrophizing | Gender Identity | Transgenderism
Fujian University of Traditional Chinese Medicine

Recruiting

Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged and Elderly Individuals

Dry Eye Disease

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy and Safety of Bezafibrate 400 mg and Bezafibrate 200 mg as Adjunctive Treatments in Patients With Primary Biliary Cholangitis and Non-optimal Biochemical Response to Ursodeoxycholic Acid Therapy (BEZURSO 2)

BPC | Non Optimal Response to UDCA

France
Taizhou Hospital

Not yet recruiting

Toripalimab Plus Anlotinib for the Maintenance of Extensive Stage Small Cell (SCLC)

SCLC | Maintenance Treatment
Nicolaus Copernicus University in Toruń, Collegium...

Recruiting

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

Knee Osteoarthritis | Knee Injuries | ACL Injury

Poland
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

Thyroid Gland Follicular Carcinoma | Thyroid Gland Papillary Carcinoma | Thyroid Gland Oncocytic Carcinoma

United States
University of Palermo

Recruiting

Effectiveness of Extracorporeal Shockwave Therapy and Nutraceutical Supplementation in the Treatment of Epicondylitis: a Clinical Trial

Tennis Elbow | Epicondylitis, Lateral | Epicondylitis of the Elbow

Italy
Halic University

Recruiting

Results of Cervical Segmental Mobilization in Patients With Chronic Lateral Epicondylitis

Epicondylitis of the Elbow | Servical Segmental Mobilization

Turkey
Taichung Veterans General Hospital
All Clean Health Co., Ltd

Not yet recruiting

The Effect of AC-134 in Chronic Kidney Diseases

Nephrology

Taiwan
Peking University Third Hospital

Recruiting

The Preventive Effect of Chemotherapy-induced Hand-foot Syndrome

Cancer

China
International Food Policy Research Institute
UNICEF; Kenyatta University

Not yet recruiting

Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya (R-SWITCH)

Wasting | Malnutrition, Child | Acute Malnutrition, Severe
Fujian Medical University Union Hospital

Recruiting

Multicenter Clinical Trial on the Effectiveness and Safety of Instillation of BCG and Alternative BCG Protocols for Intermediate and High-risk Non-muscle Invasive Bladder Cancer

Urinary Bladder Neoplasms | Treatment Outcome | Neoplasm Recurrence, Local | Multicenter Study | Immunotherapy, Active | BCG Vaccine

China

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